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Search Results for " hepatoprotective activity "

3

抑制剂 & 化合物

41

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TF0106	Cholesteryl Hemisuccinate Tris Salt	Apoptosis	Apoptosis
	Cholesteryl Hemisuccinate Tris Salt 是一种具有保肝和抗癌活性的酸性胆固醇酯，是一种含有柴胡皂苷-d的二棕榈酰磷脂酰胆碱脂质体中的膜稳定剂，可增强顺铂的抗癌功效。Cholesteryl hemisuccinate 具有抗肿瘤活性，抑制肿瘤生长，抑制对乙酰氨基酚 (AAP) 的肝毒性，预防 AAP 诱导的肝细胞凋亡。Cholesteryl hemisuccinate 可保护啮齿动物免受对乙酰氨基酚、阿霉素、四氯化碳、氯仿和半乳糖胺的毒性作用。
T68390	Nivocasan
	Nivocasan, also known as GS-9450 and LB-84451, a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. GS-9450 treatment induced significant reductions in ALT levels in NASH patients.
T63009	NF-κB/PON1-IN-1
	NF-κB/PON1-IN-1 (Compound 16) 是一种 NF-κB/PON1 通路抑制剂，具有抗氧化作用 (IC50: 45.76 μM) 和保护肝脏活性。

化合物

Cholesteryl Hemisuccinate Tris Salt

Cat.No: TF0106

Target: Apoptosis

Cat.No: T68390

NF-κB/PON1-IN-1

Cat.No: T63009

Cat. No.	Product Name	Target	Signaling Pathways
T7934	7-Methylcoumarin	Others	Others
	7-Methylcoumarin 具有很强的保肝活性。
T6S0413	Pectolinarigenin 柳穿鱼黄素,Pectolinaringenin	Others; Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience; Others
	Pectolinarigenin (Pectolinaringenin) 是 COX-2/5-LOX 的双重抑制剂，可抑制炎症病变中类花生酸的形成，具有抗炎活性。
T5S1408	Pteryxin 北美芹素,(+)-Pteryxin	Others; AChE	Neuroscience; Others
	Pteryxin ((+)-Pteryxin) 是一种白花前胡叶中的香豆素，是一种有效的丁酰胆碱酯酶(BChE)抑制剂，IC50=12.96 μg/ml，具有抗肥胖作用。
TC0039	Vasicinone	Others	Others
	Vasicinone 是一种喹唑啉类生物碱，分离自凡士林植物中。它是具有研究帕金森病和其他氧化应激相关神经退行性疾病的潜力。
TN1656	Ganoderenic acid A 灵芝烯酸A,灵芝烯酸 A	Others	Others
	Ganoderenic acid A 是三萜类化合物。它对 CCl4 诱导的肝损伤具有保护作用。它是β-葡萄糖醛酸酶抑制剂。
TN2179	Saponarin Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside	ERK; P450; NF-κB; AMPK	Chromatin/Epigenetic; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Saponarin (Petrocomoside) 是一种从 Gypsophila trichotoma 中分离出的天然的黄酮类化合物，具有抗氧化、抗炎和保护肝脏的作用。Saponarin 以钙依赖的方式激活AMPK，从而调节糖异生和葡萄糖摄取。
TN1472	Cassiaside	Beta-Secretase; BACE	Neuroscience
	Cassiaside 是一种萘甲酮糖苷，抑制 BACE1 (IC50= 4.45 μM; Ki=9.85 μM)。Cassiaside 对半乳糖胺损伤具有明显的肝脏保护作用，具有潜在的抗阿尔茨海默病 (AD) 活性。
T7917	4'-Hydroxychalcone 4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone	Proteasome	Proteases/Proteasome; Ubiquitination
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) 是从甘草根中分离的一种查尔酮，具有保护肝脏的作用。它能诱导大鼠离体肝线粒体囊泡快速释放钾，并引起其线粒体呼吸控制和氧化磷酸化衰退。它能通过抑制蛋白酶体 (proteasome)，抑制TNFα 诱导的 NF-κB 活性。
TN1557	Decursinol angelate	ERK; VEGFR; PKC; JNK	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物，是 PKC 激酶的激活剂，有细胞毒性，抗肿瘤和抗炎活性。
T3S2296	Gardenoside 羟异栀子苷,栀子苷	Others	Others
	Gardenoside 是一种发现于栀子中的天然化合物，具有保肝作用。它对 FFA 诱导的细胞脂肪变性有抑制作用。它可以调节 P2X3 和 P2X7 受体来抑制慢性缩痛。
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
T41095	(E)-3-(4-Methoxyphenyl)acrylic acid (E)-3-(4-甲氧基苯基)丙烯酸	Glucosidase	Metabolism
	(E)-3-(4-Methoxyphenyl)acrylic acid 是从 Etlingera pavieana (Pierre ex Gagnep.) R. M. Sm. 的根茎中分离出来的一种小分子化合物。它是一种新型 α-葡萄糖苷酶抑制剂。(E)-3-(4-甲氧基苯基)丙烯酸具有保肝活性、抗失水活性、增强认知效果，并可用于降低血压血糖。
T5S2254	Swertianolin Bellidifolin-8-O-Glucoside,当药醇苷	Others; HBV; Antibacterial; AChE	Microbiology/Virology; Neuroscience; Others
	Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。
T4749	Squalene 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species; Endogenous Metabolite; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Squalene (AddaVax) 是胆固醇合成的中间产物，具有降血脂、保肝、心脏保护、抗氧化和抗毒活性等多种药理特性。它还具有抗真菌活性，可用于毛癣菌治疗的相关研究。
T3822	Bellidifolin Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮，它能作为病毒蛋白 R 的抑制剂，具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。
T4115	Auraptene 橙皮油内酯,7-geranyloxycoumarin,橙皮油素	MMP; BACE	Neuroscience; Proteases/Proteasome
	Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
TN4560	Methylisopelletierine	Others	Others
	N-Methylisopelletierine has hepatoprotective activity.
TN5040	Soyasaponin IV	Others	Others
	Soyasaponin IV has hepatoprotective activity.It also has antimutagenic activity in mammalian cells.
TN2543	1β-Hydroxyeuscaphic acid 1beta-Hydroxyeuscaphic acid	Others	Others
	1beta-Hydroxyeuscaphic acid demonstrates notable hepatoprotective activity, effectively minimizing the leakage of intracellular enzymes, attenuating protein oxidation, and reducing apoptosis rates.
T38536	Neopuerarin A
	Neopuerarin A, an isoflavone derived from the aqueous extraction of dried roots of Pueraria lobata (Willd.), displays notable hepatoprotective activity.
TN1322	6''-O-Malonylgenistin 丙二酰染料木苷,6''-O-丙二酰染料木苷	Others	Others
	6''-O-Malonylgenistin 是一种黄酮衍生物。
T83062	Anti-inflammatory agent 28
	Compound 9 (Anti-inflammatory agent 28) 是一种具备肝脏保护活性的抗炎剂。
TN4711	Onitin	Others	Others
	Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
T11365	Ganodermanontriol	Others	Others
	Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulation of HO-1 expression.
T82334	Garcinielliptone HD
	Garcinielliptone HD为从Garcinia subelliptica Merr.心材中提取的化学物质。
T83061	Anti-inflammatory agent 29
	Anti-inflammatory agent 29 (Compound 7)是一种具备肝脏保护活性的抗炎剂。
TN3133	5-O-Methylgenistein	Others	Others
	5-O-Methylgenistein may show free radical scavenging activity, it also may have hepatoprotective property on the model of toxic hepatitis induced by carbon tetrachloride damage.
T83060	Anti-inflammatory agent 30
	Compound 5（Anti-inflammatory agent 30）是一种具备肝脏保护作用的抗炎药物。
TN3726	Cudraflavone B	IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
T83353	3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside
	3'-Methoxy-3,5,4'-triHydroxyflavone-7-neheesperidoside，一种从Cleome droserifolia中分离的黄酮类化合物，显示出中等程度的保肝活性。
TN4303	Isokaempferide	ATPase; Potassium Channel; Calcium Channel; TNF; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.
TN2487	1,3,5,6-Tetrahydroxyxanthone	Others	Others
	1,3,5,6-Tetrahydroxyxanthone shows moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM against tacrine-induced cytotoxicity in HepG2 cells. It can inhibit angiotensin-I-converting-enzyme activity in a dose-dependent manner.
TN4388	Kielcorin	Antifection	Microbiology/Virology
	Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
TN4185	Hautriwaic acid
	Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl
TN3348	(+)-Acuminatin Acuminatin	PAFR	GPCR/G Protein
	(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. (+)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the huma...
T4S0083	Protostemonine	Others	Others
	Protostemonine 是一种主要从 Stemona sesslifolia 根中分离得到的生物碱，对哮喘及革兰氏阴性菌所致急性肺损伤有抗炎作用。
TN4223	Homopterocarpin	Antifection	Microbiology/Virology
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

7-Methylcoumarin

Cat.No: T7934

Target: Others

Pectolinarigenin

Cat.No: T6S0413

Synonym: 柳穿鱼黄素,Pectolinaringenin

Target: Others, Lipoxygenase, COX

Cat.No: T5S1408

Synonym: 北美芹素,(+)-Pteryxin

Target: Others, AChE

Cat.No: TC0039

Target: Others

Ganoderenic acid A

Cat.No: TN1656

Synonym: 灵芝烯酸A,灵芝烯酸 A

Target: Others

Cat.No: TN2179

Synonym: Petrocomoside,Saponaretin-7-O-glucoside,Isovitexin-7-O-glucoside

Target: ERK, P450, NF-κB, AMPK

Cat.No: TN1472

Target: Beta-Secretase, BACE

4'-Hydroxychalcone

Cat.No: T7917

Synonym: 4-羟基查耳酮,4′-羟基查耳酮,2-Benzal-4-Hydroxyacetophenone

Target: Proteasome

Decursinol angelate

Cat.No: TN1557

Target: ERK, VEGFR, PKC, JNK

Cat.No: T3S2296

Synonym: 羟异栀子苷,栀子苷

Target: Others

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

(E)-3-(4-Methoxyphenyl)acrylic acid

Cat.No: T41095

Synonym: (E)-3-(4-甲氧基苯基)丙烯酸

Target: Glucosidase

Cat.No: T5S2254

Synonym: Bellidifolin-8-O-Glucoside,当药醇苷

Target: Others, HBV, Antibacterial, AChE

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Cat.No: T4749

Synonym: 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene

Target: Reactive Oxygen Species, Endogenous Metabolite, Antifungal

Cat.No: T3822

Synonym: Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮

Target: Others, HIV Protease

Cat.No: T4115

Synonym: 橙皮油内酯,7-geranyloxycoumarin,橙皮油素

Target: MMP, BACE

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

Methylisopelletierine

Cat.No: TN4560

Target: Others

Cat.No: TN5040

Target: Others

1β-Hydroxyeuscaphic acid

Cat.No: TN2543

Synonym: 1beta-Hydroxyeuscaphic acid

Target: Others

Cat.No: T38536

6''-O-Malonylgenistin

Cat.No: TN1322

Synonym: 丙二酰染料木苷,6''-O-丙二酰染料木苷

Target: Others

Anti-inflammatory agent 28

Cat.No: T83062

Cat.No: TN4711

Target: Others

Ganodermanontriol

Cat.No: T11365

Target: Others

Garcinielliptone HD

Cat.No: T82334

Anti-inflammatory agent 29

Cat.No: T83061

5-O-Methylgenistein

Cat.No: TN3133

Target: Others

Anti-inflammatory agent 30

Cat.No: T83060

Cat.No: TN3726

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside

Cat.No: T83353

Cat.No: TN4303

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

1,3,5,6-Tetrahydroxyxanthone

Cat.No: TN2487

Target: Others

Cat.No: TN4388

Target: Antifection

Hautriwaic acid

Cat.No: TN4185

Cat.No: TN3348

Synonym: Acuminatin

Target: PAFR

Cat.No: T4S0083

Target: Others

Homopterocarpin

Cat.No: TN4223

Target: Antifection

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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