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248

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0122L	VCH-916 free acid(1200133-34-1 free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	VCH-916 free acid(1200133-34-1 free base) 是一种新型非核苷 HCV NS5B 聚合酶抑制剂。
T11492	GSK2983559 free acid	Others; RIP kinase	Apoptosis; NF-κB; Others
	GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。
T10293	AM095 free acid [4'-[3-甲基-4-[[[((R)-1-苯基乙基)氧基]羰基]氨基]异恶唑-5-基]联苯-4-基]乙酸	LPA Receptor; LPL Receptor	GPCR/G Protein
	AM095 free acid 是LPA1受体拮抗剂，对重组人和小鼠 LPA1 的IC50值分别为 0.98 和 0.73 μM。
T16704L	Quilseconazole Formic acid(1340593-70-5 Free base) Quilseconazole Formic acid(1340593-70-5 Free base)	Antifungal	Microbiology/Virology
	Quilseconazole Formic acid 是真菌 Cyp51 的选择性抑制剂，对新型隐球菌和格特隐球菌具有有效活性。
TP2500	Cholecystokinin (26-33) free acid CCK (26-33) free acid	cholecystokinin	GPCR/G Protein
	Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分，是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体，可诱导大鼠轻度味觉厌恶条件反射。
T7768	RGX-104 RGX-104 free Acid	Liver X Receptor	Metabolism
	RGX-104 (RGX-104 free Acid) 是一种口服具有活力的肝X 核激素受体激动剂，通过 ApoE 基因的转录激活调节先天免疫。
T12527L	Mavodelpar free acid hydrochloride Mavodelpar free acid hydrochloride(942594-93-6 Free base),Pparδ agonist HCl,HPP593 free acid HCl,REN001 free acid HCl	PPAR	DNA Damage/DNA Repair; Metabolism
	Mavodelpar free acid hydrochloride (Pparδ agonist HCl) 是一种有效的 PPARδ激动剂。
T3627	IQ-1S free acid IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB; JNK	MAPK; NF-κB
	IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力。
T4998L	Cefpodoxime (free acid)	Others	Others
	Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外，它对大多数革兰氏阳性和革兰氏阴性微生物均有效。
T7407	Thyrotropin-Releasing Hormone (TRH), Free Acid TRH-OH	Others	Others
	Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) 是一种促甲状腺激素释放激素的生理代谢产物。
T18954L	CY7-SE Triethylamine (477908-53-5(free acid) )	Others	Others
	CY7-SE Triethylamine (477908-53-5(free acid) ) 是一种荧光标记剂（Ex=700-770 nm，Em=790 nm），用于标记蛋白质、肽、抗体和寡核苷酸。
T40528	Oxytocin free acid 9-Deamidooxytocin
	Oxytocin free acid, also known as 9-Deamidooxytocin, is an analog of oxytocin where the glycinamide residue at position 9 has been substituted with a glycine residue. Oxytocin, a pleiotropic peptide hormone, has wide-ranging implications for general health, adaptation, development, reproduction, and social behavior.
T39926	SR-717 free acid
	SR-717 free acid is a stable cGAMP mimetic and a non-nucleotide STING agonist. It exhibits antitumor activity with EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
T69424	Zomepirac free acid
	Zomepirac is a prostaglandin synthetase inhibitor. Zomepirac is an orally effective nonsteroidal anti-inflammatory drug (NSAID) that has antipyretic actions.
T41369	(S)-Butaprost free acid
	(S)-Butaprost (free acid) 是有效的、选择性的EP2受体激动剂。
T37933	15-keto Latanoprost (free acid)
	15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto Latanoprost is al...
T37214	5-trans Latanoprost (free acid)
	Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from ci...
T69566	MSX-3 free acid
	MSX-3 free acid is an A2A adenosine receptor antagonist and a prodrug of MSX-2.
T69266	Cefcanel free acid
	Cefcanel is a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel is active against the species E. coli, K. aerogenes and Proteus mirabilis; H. influenzae and M. catarrhalis has reasonable susceptibility. Cefcanel inhibits 90% of S. aureus strains at 2 µg/ml, irrespective of the presence of a β-lactamase. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the te...
T71113	Minnelide free acid
	Minnelide is an effective therapy against pancreatic cancer. Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants. Minnelide reduced tumor volume in multiple models of pancreatic cancer. Minnelide was a more effective drug against pancreatic cancer models. It effectively reduced tumor burden and tumor related morbidity in different unique but complementary mouse models. It reduced metastat...
T70335	Cangrelor free acid
	Cangrelor is a P2Y12 inhibitor, and was approved in June 2015 as an antiplatelet drug for intravenous application. Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. It does not require metabolic conversion to an active metabolite. This allows cangrelor’s immediate effect after infusion, and the therapeutic effects can be maintained with...
T7652	AM211 AM211 free acid	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	AM211 (AM211 free acid) 是可口服的选择性前列腺素受体拮抗剂，对人、小鼠、豚鼠和大鼠的 DP2 的IC50值分别为 4.9、7.8、4.9 和 10.4 nM。
T36370	4-Methylumbelliferyl-α-L-Iduronide (free acid)
	4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an...
T13003	SSR128129E free acid SSR free acid	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
T12166	Nacubactam OP0595 free acid,那库巴坦	Antibacterial	Microbiology/Virology
	Nacubactam (OP0595 free acid) 是一种非 β-内酰胺-β-内酰胺酶抑制剂，对 A 类和 C 类 β-内酰胺酶具有活性。它作为青霉素结合蛋白 2 活性抗菌剂，并赋予 β-内酰胺酶非依赖性增强作用以靶向其他 PBP。
T10422	Avibactam free acid NXL-104 free acid	Antibacterial	Microbiology/Virology
	Avibactam (NXL-104) free acid is a covalent and reversible inhibitor of non-β-lactam β-lactamase (IC50s: 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15).
T34887	Tiron free acid
	Tiron free acid is a bioactive chemical.
T30531L	BMS-561392 Formic acid BMS-561392 Formic acid(611227-74-8 Free base)	MMP	Proteases/Proteasome
	BMS-561392 Formic acid 是 TACE 的选择性抑制剂，可降低 TNFalpha 水平。
T29940	AM-643 Free Acid AM643 Free Acid
	AM-643 Free Acid is a bio-active chemical.
T29605	Acid Red 186 free acid J2.886.590B
	Acid Red 186 free acid is a dye.
T23657L	AFP-07 free acid
	AFP 07 free acid is a 7,7-difluoroprostacyclin derivative. It also acts as a selective and highly potent agonist for the IP receptor.
T22239	AMI-1, free acid
	AMI-1 free acid 是一种有效的，具有细胞渗透性和可逆的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂，对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 μM 和 3.0 μM。AMI-1 free acid 通过阻断肽-底物结合发挥 PRMTs 抑制作用。
T30852L	CGP-75254A Free Acid CGP-75254A
	CGP-75254A Free Acid is a novel oral iron chelator.
TP1788	Substance P, Free Acid
	Substance P, Free Acid is a synthetic analog of native Substance P, however, it lacks the biological activity exhibited by Substance P.
T28814	SM19712 free acid SM 19712,SM-19712,SM19712
	SM19712 free acid is an inhibitor of nonpeptide endothelin converting enzyme.
T68019L	Ursulcholic acid trisodium salt Ursodeoxycholic acid disulfate trisodium salt,Ursulcholic acid trisodium salt(88426-32-8 Free base)	Others	Others
	Ursulcholic acid trisodium salt (Ursodeoxycholic acid disulfate trisodium salt) 是 ursodeoxycholic acid 的可溶形式，ursodeoxycholic acid 具有抗高血脂和利胆活性活性。
T29928	AM-103 Free Acid UNII-B1Z78DJ75Y
	AM-103 Free Acid is a bio-active chemical.
T30927	CI-959 free acid UNII-Y8M8A93SU8
	CI-959 Free Acid is an orally effective inhibitor of cell activation in vitro and in animal models and also has anti-allergic/anti-inflammatory properties.
T31749	Fast Green free acid J247.014D
	Fast Green free acid is a dye that resists acid once applied.
T27325	FK-739 free acid FK-739,FK 739,FK739
	FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebel
T7482	3-chloro-5-hydroxybenzoic Acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	3-Chloro-5-hydroxybenzoic acid 是一种口服具有活力的乳酸受体GPR81选择性激动剂，对人 GPR81 的EC50为 16 μM。肥胖小鼠模型中，它表现出良好的体内脂肪分解作用。
T34777	Talaporfin free acid Monoaspartyl chlorin,NPe6,Talaporfin,Aspartyl chlorin
	Talaporfin, an effective tumor localizer, can produce the selective degradation of tumor tissue following light exposure.
T27228	E-3030 free acid E-3030,E3030,E 3030
	E-3030 free acid is a peroxisome proliferator-activated receptor (PPAR) agonist. E-3030 decreased blood glucose, triglyceride, non-esterified fatty acids, and insulin levels and increased blood adiponectin levels. Triglyceride- and non-high-density lipopr
T24085	Gastrazole free acid JB 95008,JB95008,JB-95008,Gastrazole
	Gastrazole is a CCK2 receptor antagonist potentially. It also used for the treatment of pancreatic cancer.
T36624L	α-Hydroxyglutaric Acid Lithium α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)	Decarboxylase; Endogenous Metabolite; mTOR	Metabolism; Others; PI3K/Akt/mTOR signaling
	α-Hydroxyglutaric Acid Lithium 在微生物和动物体内有谷氨酸转化而来，是 α-酮戊二酸依赖性双加氧酶和 5-甲基胞嘧啶羟化酶抑制剂，对 ATP 合酶和 mTOR 信号传导有抑制作用。
T27743	KRH-594 free acid WK14922K,WK-1492,WK-14922K,WK1492
	KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm ra
T27347	Fonsartan free acid HR720,HOE720,HR-720,HOE-720
	Fonsartan is an angiotensin receptor antagonist. Fonsartan inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.
T25358	EC-17 free acid EC17,EC 17,EC-17,FTIC-Folate,Folate-FTIC
	EC17 is a FITC conjugated folic acid, also known as Folate-FITC. It also acts as an FRα-targeting agent that fluoresces at 500nm. EC17 is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic acti
TP1766L	D-γ-Glutamyl-D-glutamic acid acetate D-γ-Glutamyl-D-glutamic acid acetate(4553-17-7 free base)	Others	Others
	D-γ-Glutamyl-D-glutamic acid acetate(4553-17-7 free base) 是一种聚（γ-谷氨酸），由线性链中的 D-和 D-谷氨酸重复单元簇组成。
T24572	OSI-7904L free acid OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904
	OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.

化合物

VCH-916 free acid(1200133-34-1 free base)

Cat.No: TQ0122L

Target: HCV Protease

GSK2983559 free acid

Cat.No: T11492

Target: Others, RIP kinase

AM095 free acid

Cat.No: T10293

Synonym: [4'-[3-甲基-4-[[[((R)-1-苯基乙基)氧基]羰基]氨基]异恶唑-5-基]联苯-4-基]乙酸

Target: LPA Receptor, LPL Receptor

Quilseconazole Formic acid(1340593-70-5 Free base)

Cat.No: T16704L

Synonym: Quilseconazole Formic acid(1340593-70-5 Free base)

Target: Antifungal

Cholecystokinin (26-33) free acid

Cat.No: TP2500

Synonym: CCK (26-33) free acid

Target: cholecystokinin

Cat.No: T7768

Synonym: RGX-104 free Acid

Target: Liver X Receptor

Mavodelpar free acid hydrochloride

Cat.No: T12527L

Synonym: Mavodelpar free acid hydrochloride(942594-93-6 Free base),Pparδ agonist HCl,HPP593 free acid HCl,REN001 free acid HCl

Target: PPAR

IQ-1S free acid

Cat.No: T3627

Synonym: IQ-1,IQ-1S,IQ-1S (free acid)

Target: NF-κB, JNK

Cefpodoxime (free acid)

Cat.No: T4998L

Target: Others

Thyrotropin-Releasing Hormone (TRH), Free Acid

Cat.No: T7407

Synonym: TRH-OH

Target: Others

CY7-SE Triethylamine (477908-53-5(free acid) )

Cat.No: T18954L

Target: Others

Oxytocin free acid

Cat.No: T40528

Synonym: 9-Deamidooxytocin

SR-717 free acid

Cat.No: T39926

Zomepirac free acid

Cat.No: T69424

(S)-Butaprost free acid

Cat.No: T41369

15-keto Latanoprost (free acid)

Cat.No: T37933

5-trans Latanoprost (free acid)

Cat.No: T37214

MSX-3 free acid

Cat.No: T69566

Cefcanel free acid

Cat.No: T69266

Minnelide free acid

Cat.No: T71113

Cangrelor free acid

Cat.No: T70335

Cat.No: T7652

Synonym: AM211 free acid

Target: Prostaglandin Receptor

4-Methylumbelliferyl-α-L-Iduronide (free acid)

Cat.No: T36370

SSR128129E free acid

Cat.No: T13003

Synonym: SSR free acid

Target: FGFR

Cat.No: T12166

Synonym: OP0595 free acid,那库巴坦

Target: Antibacterial

Avibactam free acid

Cat.No: T10422

Synonym: NXL-104 free acid

Target: Antibacterial

Tiron free acid

Cat.No: T34887

BMS-561392 Formic acid

Cat.No: T30531L

Synonym: BMS-561392 Formic acid(611227-74-8 Free base)

Target: MMP

AM-643 Free Acid

Cat.No: T29940

Synonym: AM643 Free Acid

Acid Red 186 free acid

Cat.No: T29605

Synonym: J2.886.590B

AFP-07 free acid

Cat.No: T23657L

AMI-1, free acid

Cat.No: T22239

CGP-75254A Free Acid

Cat.No: T30852L

Synonym: CGP-75254A

Substance P, Free Acid

Cat.No: TP1788

SM19712 free acid

Cat.No: T28814

Synonym: SM 19712,SM-19712,SM19712

Ursulcholic acid trisodium salt

Cat.No: T68019L

Synonym: Ursodeoxycholic acid disulfate trisodium salt,Ursulcholic acid trisodium salt(88426-32-8 Free base)

Target: Others

AM-103 Free Acid

Cat.No: T29928

Synonym: UNII-B1Z78DJ75Y

CI-959 free acid

Cat.No: T30927

Synonym: UNII-Y8M8A93SU8

Fast Green free acid

Cat.No: T31749

Synonym: J247.014D

FK-739 free acid

Cat.No: T27325

Synonym: FK-739,FK 739,FK739

3-chloro-5-hydroxybenzoic Acid

Cat.No: T7482

Target: GPR

Talaporfin free acid

Cat.No: T34777

Synonym: Monoaspartyl chlorin,NPe6,Talaporfin,Aspartyl chlorin

E-3030 free acid

Cat.No: T27228

Synonym: E-3030,E3030,E 3030

Gastrazole free acid

Cat.No: T24085

Synonym: JB 95008,JB95008,JB-95008,Gastrazole

α-Hydroxyglutaric Acid Lithium

Cat.No: T36624L

Synonym: α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)

Target: Decarboxylase, Endogenous Metabolite, mTOR

KRH-594 free acid

Cat.No: T27743

Synonym: WK14922K,WK-1492,WK-14922K,WK1492

Fonsartan free acid

Cat.No: T27347

Synonym: HR720,HOE720,HR-720,HOE-720

EC-17 free acid

Cat.No: T25358

Synonym: EC17,EC 17,EC-17,FTIC-Folate,Folate-FTIC

D-γ-Glutamyl-D-glutamic acid acetate

Cat.No: TP1766L

Synonym: D-γ-Glutamyl-D-glutamic acid acetate(4553-17-7 free base)

Target: Others

OSI-7904L free acid

Cat.No: T24572

Synonym: OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904

Cat. No.	Product Name	Target	Signaling Pathways
T8504	Dianemycin Nanchangmycin (free acid)	Antibacterial; Antibiotic	Microbiology/Virology
	Dianemycin (Nanchangmycin (free acid)) 由Streptomyces nanchangensis 产生的一种聚醚抗生素，抑制革兰氏阳性菌。它也是一种针对 Zika 病毒的广谱抗病毒药物。
TN5845	Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester,Methyl 3-caffeoylquinate,GIP (1-39) acetate(725474-97-5 Free base),Methyl neochlorogenate,新绿原酸甲酯	Antioxidant; HBV	Microbiology/Virology; oxidation-reduction
	Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) 来源于毛蒿和黑色苦莓(Aronia melanocarpa)果实。Neochlorogenic acid methyl ester 显示出抗 HBV 活性、抗氧化活性和醌还原酶活性，CD 为 6.7 μM。
T3919	Ginsenoside Rb2 Ginsenoside C,人参皂苷 Rb2,人参皂苷Rb2	GPR; Others; Influenza Virus; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Others
	Ginsenoside Rb2 (Ginsenoside C) 是人参提取物中的一种主要生物活性成分，具有抗病毒活性，可上调 GPR120 基因表达。
T1286	Vincamine Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱，可作为外周血管扩张剂，对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态，对 2 型糖尿病具有研究潜力。它是GPR40激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。
T4931	Dihydroxyfumaric acid hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Dihydroxyfumaric acid hydrate 是内源性代谢产物的一种。
TN1558	N-Vanillyldecanamide 癸酸香草酰胺,Decylic acid vanillylamide	Others	Others
	N-Vanillyldecanamide (Decylic acid vanillylamide) 分离自辣椒果实，以剂量依赖的方式显著减小紫花苜蓿幼苗的自由基长度。
T0562	Protocatechuic acid 3, 4-Dihydroxybenzoic acid,3,4-二羟基苯甲酸,Protocatechuate,原儿茶酸,3,4-Dihydroxybenzoic acid	Others	Others
	Protocatechuic acid (3, 4-Dihydroxybenzoic acid) 是天然的多酚类物质，具有神经保护活性。
T4943	Monoolein 1-Oleoyl-rac-glycerol,甘油单油酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Monoolein (1-Oleoyl-rac-glycerol) 是内源性代谢产物的一种。
T0926	Azelaic acid Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。
TJS2190	Nordihydroguaiaretic acid 去甲二氢愈创木酸,NDGA,Dihydronorguaiaretic Acid	Antioxidant; Ferroptosis; Lipoxygenase; Autophagy	Apoptosis; Autophagy; Metabolism; oxidation-reduction
	Nordihydroguaiaretic acid (NDGA) 是从极叉开拉瑞阿提取出的一种天然产物，是脂氧合酶抑制剂，具有抗氧化和清除自由基的特性。
T4S1312	Gypsogenin-3-O-glucuronide 丝石竹皂苷元3-O-Β-D-葡萄糖醛酸甲酯,Methyl gypsogenin 3-O-beta-D-glucuronopy,丝石竹皂苷元-3-O-β-D-葡萄糖醛酸甲酯	Others	Others
	Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) 是一种皂角苷前体，普遍存在于满天星属植物中。
T75319	Taurodeoxycholic acid Taurodeoxychloic acid	Apoptosis; Calcium Channel; Caspase	Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。
TN6908	Polyporusterone A (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one
	Polyporusterone A 是一种从 P. umbellatus 的子实体中提取出来的三萜羧酸。Polyporusterone A 抑制自由基诱导的红细胞裂解 (溶血) ，可用于研究头发再生和牛皮癣。
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine	PI3K	PI3K/Akt/mTOR signaling
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
TN6909	Polyporusterone B 猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) 是一种三萜羧酸，从Polyporus umbellatusFries 中分离得到。它对自由基诱导的红细胞裂解 (溶血) 具有抑制作用。
T19880	Friedelinol Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol
	Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.
T4131	Arjunic acid	COX; Antifection	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Arjunic acid is a strong antioxidant and a free radical scavenger. Arjunic acid shows activity against Gram-positive and Gram-negative bacteria with MIC values ranging between 1.9 and 15.6 microg/mL.
T70891	Pyridoxatin
	Pyridoxatin is a fungal metabolite that inhibits production of thiobarbituric acid reactive substance (TBARS). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH and is active against C. albicans.
TN2749	(2-Aminoethyl)phosphinic acid	Others	Others
	The specific growth rates of C. raciborskii cells in media treated with β-glycerol phosphate, d-glucose-6-phosphate, and (2-aminoethyl)phosphinic acid are significantly higher than those of cells grown in phosphorus free media.
TN5250	Vomifoliol	VEGFR; NF-κB; HIF	Angiogenesis; Chromatin/Epigenetic; NF-κB; Tyrosine Kinase/Adaptors
	Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major metabolise, and a cell-free extract exhibits vomifoliol dehydrogenase activity. Vomifoliol and
TN4605	Myriceric acid B	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val
T39605	β-D-Glucopyranosyl abscisate ABA-GE,β-D-Glucopyranosyl abscisate,(S)-cis,trans-Abscisicacidglucosylester
	β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA), which predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate enables a swift release of free ABA in response to abiotic stress factors like dehydration and salt stress. β-D-Glucopyranosyl abscisate plays a crucial role in maintaining ABA homeostasis.
T37972	12-OxoETE
	12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.
T83876	L-Ascorbic Acid 6-stearate L-Ascorbyl-6-stearate,6-O-Stearoyl-L-Ascorbic Acid
	L-抗坏血酸6硬脂酸酯是L-抗坏血酸与硬脂酸的衍生物，在K. coccinea中发现，具有抗氧化和抗癌作用。在细胞外试验中清除DPPH（IC50 = 3.31 µg/ml）。包裹L-抗坏血酸6硬脂酸酯的脂质纳米颗粒（LNPs）在190 µM浓度下诱导HL-60前髓母细胞凋亡。含有L-抗坏血酸6硬脂酸酯的配方已用于化妆品和个人护理产品中。
T82284	Glycyrrhizin-6′′-methylester
	Glycyrrhizin-6′′-methylester (compound 22) 是从甘草根中分离的一种甘草皂苷，能参与葡萄糖醛酸甲酯的生成，赋予其甜味和甘草特有风味，但不具苦味。该化合物的研究强调了糖苷锥结合葡萄糖醛酸的游离羧基在形成天然甜味和甘草味觉中的关键作用。
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。

天然产物

Cat.No: T8504

Synonym: Nanchangmycin (free acid)

Target: Antibacterial, Antibiotic

Neochlorogenic acid methyl ester

Cat.No: TN5845

Synonym: 5-O-Caffeoylquinic acid methyl ester,Methyl 3-caffeoylquinate,GIP (1-39) acetate(725474-97-5 Free base),Methyl neochlorogenate,新绿原酸甲酯

Target: Antioxidant, HBV

Ginsenoside Rb2

Cat.No: T3919

Synonym: Ginsenoside C,人参皂苷 Rb2,人参皂苷Rb2

Target: GPR, Others, Influenza Virus, Endogenous Metabolite

Cat.No: T1286

Synonym: Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval

Target: GPR, Others

Dihydroxyfumaric acid hydrate

Cat.No: T4931

Target: Others, Endogenous Metabolite

N-Vanillyldecanamide

Cat.No: TN1558

Synonym: 癸酸香草酰胺,Decylic acid vanillylamide

Target: Others

Protocatechuic acid

Cat.No: T0562

Synonym: 3, 4-Dihydroxybenzoic acid,3,4-二羟基苯甲酸,Protocatechuate,原儿茶酸,3,4-Dihydroxybenzoic acid

Target: Others

Cat.No: T4943

Synonym: 1-Oleoyl-rac-glycerol,甘油单油酸酯

Target: Others, Endogenous Metabolite

Cat.No: T0926

Synonym: Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Nordihydroguaiaretic acid

Cat.No: TJS2190

Synonym: 去甲二氢愈创木酸,NDGA,Dihydronorguaiaretic Acid

Target: Antioxidant, Ferroptosis, Lipoxygenase, Autophagy

Gypsogenin-3-O-glucuronide

Cat.No: T4S1312

Synonym: 丝石竹皂苷元3-O-Β-D-葡萄糖醛酸甲酯,Methyl gypsogenin 3-O-beta-D-glucuronopy,丝石竹皂苷元-3-O-β-D-葡萄糖醛酸甲酯

Target: Others

Taurodeoxycholic acid

Cat.No: T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

Polyporusterone A

Cat.No: TN6908

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

(2S,3R,4S)-4-Hydroxyisoleucine

Cat.No: T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine

Target: PI3K

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Sinapinic Acid

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Polyporusterone B

Cat.No: TN6909

Synonym: 猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: Others

Cat.No: T19880

Synonym: Friedelan-3alpha-ol,Friedelan-3-ol,NSC 407041,epi-Friedelinol,Epifriedelanol

Cat.No: T4131

Target: COX, Antifection

Cat.No: T70891

(2-Aminoethyl)phosphinic acid

Cat.No: TN2749

Target: Others

Cat.No: TN5250

Target: VEGFR, NF-κB, HIF

Myriceric acid B

Cat.No: TN4605

Target: HIV Protease

β-D-Glucopyranosyl abscisate

Cat.No: T39605

Synonym: ABA-GE,β-D-Glucopyranosyl abscisate,(S)-cis,trans-Abscisicacidglucosylester

Cat.No: T37972

L-Ascorbic Acid 6-stearate

Cat.No: T83876

Synonym: L-Ascorbyl-6-stearate,6-O-Stearoyl-L-Ascorbic Acid

Glycyrrhizin-6′′-methylester

Cat.No: T82284

Norbixin hydrate

Cat.No: T83915

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