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72

抑制剂 & 化合物

31

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4304	Azoramide	Apoptosis; PERK	Apoptosis
	Azoramide 是一种小分子调节剂，具有未折叠蛋白反应的抗糖尿病活性。
T8599	Betazole dihydrochloride 盐酸倍他唑,Betazole hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Betazole dihydrochloride (Betazole hydrochloride) 是吡唑类组胺，是一种口服活性 H2受体激动剂，能诱导胃酸分泌，导致胆总管压力立即显著升高。它作为一种诊断剂，用于研究胃酸分泌能力。
T16073	Micronomicin 小诺霉素,Gentamicin C2b,Antibiotic XK-62-2,Sagamicin	Others; Antibacterial	Microbiology/Virology; Others
	Micronomicin (Gentamicin C2b) 是一种具有抗菌和杀菌能力的抗生素。
T14314	Apronal Apronalide,Allylisopropylacetylurea,丙戊酰脲	Others	Others
	Apronal (Apronalide) 具有催眠和镇静作用，可用于神经精神疾病的相关研究。
T21252	DHMB 2,3-Dihydroxy-4-Methoxybenzaldehyde	Others	Others
	DHMB (2,3-Dihydroxy-4-Methoxybenzaldehyde) 对肠上皮细胞发挥保护作用。 DHMB 具有抗炎和抗真菌能力。
T29015	Trithiozine Tresanil,Sulmetozine,Tritiozinum,舒美吗啉,Tritiozine,Tritiozina	Others	Others
	Trithiozine (Tritiozinum) 具有抗分泌和抗溃疡能力。 Trithiozine 可用于治疗消化性溃疡病和高分泌障碍的研究。
T5039	Aminohippurate sodium Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt	Others	Others
	Aminohippurate sodium (Sodium p-aminohippurate) 是能够利用肾血浆流量测量肾脏医学测试的诊断剂。
T20843	Aplodan Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate	Others	Others
	Aplodan (creatinol-O-phosphate) 表现出抗缺血和抗心律失常的能力以及对细胞膜的保护作用。 Aplodan 可用于缺血性心脏病或伴有持续性室性早搏的缺血性心脏病的研究。
T68069	Femoxetine	MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Femoxetine 是一种5-HT 抑制剂，具有抗抑郁活性，可增强吗啡诱导的抗伤害感受，抑制小鼠产生高运动能力所需的MAO-A 和MAO-B。
T68492	AM 374 HDSF,Hexadecanesulfonyl fluoride	FAAH	Metabolism; Neuroscience
	AM 374 (HDSF) 是一种脂肪酸酰胺水解酶(FAAH)抑制剂。AM 374 对氨基酶活性的抑制作用的IC50为 13 nM。AM 374 可用于神经系统疾病的研究。
T36347	Ac-YVAD-CMK Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK	IL Receptor; Caspase; Immunology/Inflammation related; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) 是一种选择性的、不可逆的Caspase-1抑制剂，并能抑制焦亡作用、IL-1β和IL-18。Ac-YVAD-CMK 显示出神经保护和抗炎的能力。
T1386	Phenazopyridine hydrochloride Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶	Sodium Channel	Membrane transporter/Ion channel
	Phenazopyridine hydrochloride (Pyridium) 是一种具有局部止痛作用的化学物质，常被用于缓解手术、损伤尿道及尿路感染引起的疼痛、刺激、不适和尿急。
T1081	Naftidrofuryl oxalate 萘呋胺酯草酸盐,Nafronyl oxalate,Nafronyl oxalate salt	5-HT Receptor	GPCR/G Protein; Neuroscience
	Naftidrofuryl oxalate (Nafronyl oxalate) 是一种用于治疗外周和脑血管疾病的药物，可增加细胞氧化能力，也是一种 5-HT2 受体拮抗剂。
T61338	MS023 dihydrochloride MS023 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 dihydrochloride (MS023 2HCl) 是一种具有选择性、细胞活性和高效性的人I 型蛋白精氨酸甲基转移酶 (PRMTs)抑制剂，具有抗肿瘤活性，抑制 PRMT1，PRMT3，PRMT4，PRMT6和PRMT8，增加离体培养的 MuSC 的增殖能力，可用于研究乳腺癌。
T15410	GNF351	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。
T4341	Betrixaban 贝曲西班,PRT054021	Factor Xa	Metabolism
	Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂，IC50=1.5 nM。
TP2505L	LAH4 acetate KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial	Microbiology/Virology
	LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构，能够与DNA 络合，与细胞表面膜结合后被包裹在核内体中，随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T4980	Betrixaban maleate	Factor Xa	Metabolism
	Betrixaban maleate 是一种非维生素 K 口服抗凝剂，其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。
T30025	AMOR 6-O-(4-O-Methyl-β-D-glucuronosyl)-D-galactose,GlcA[4Me]β(1-6)Gal
	AMOR is unique to plant cell walls and enhances plant fertilization efficiency and capacity
T36500	Cyanidin 3-O-arabinoside
	Cyanidin 3-O-arabinoside is an anthocyanin antioxidant that has been found in eggplant. It scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.
T13243	Ubiquinol Ubiquinol-10,CoQH2-10	Others	Others
	Ubiquinol is a reduced form of coenzyme Q10 (CoQ10) and is a potent antioxidant that has the capacity to protect Vitamin E.
T75364	Phototherapeutic agent-1
	Phototherapeutic agent-1是一种具聚集诱导发光性能的多模态光诊疗剂，在光照条件下可生成一定量的活性氧(ROS)，有效杀伤癌细胞与肿瘤组织。
T36037	CBR-470-2
	CBR-470-2, a glycine-substituted analog, exhibits the capacity to activate NRF2 signaling, making it a valuable compound for investigating glycolysis modulation in scientific research [1].
T19616	D-phenylalanine analogue (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid	Others	Others
	(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid, a constrained phenylalanine (Phe) analogue, exhibits the capacity to adopt beta-bend and helical structures, facilitating a preferred side-chain orientation within the peptide.
T25848	Naftidrofuryl
	Naftidrofuryl is used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be spasmolytic.
T69676	LG190155
	LG190155 is a moderately potent VDR agonist. Vitamin D receptor (VDR) agonists are well known for their capacity to control calcium and bone metabolism and to regulate growth and differentiation of many cell types.
T33534	Muzolimine Edrul,Muzolimina,Muzoliminum
	Muzolimine is pyrazole diuretic with long duration and high capacity of action. It was proposed for kidney failure and hypertension but was withdrawn worldwide because of severe neurological effects.
T28878	Sul-121 HCl Sul-121 Hydrochloride
	Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidative stress.
T22104	ML-291
	ML291 is a sufonamidebenzamide compound that induces the unfolded protein response (UPR) and overwhelms the adaptive capacity of UPR, resulting in apoptosis in various solid cancer models. It activates the PERK/eIF2a/CHOP apoptotic pathway of UPR and reduces leukemic cell burden [1].
T78347	Serratia marcescens nuclease
	Serratia marcescens nuclease，为一种非特异性核酸酶，因具备强大消化DNA与RNA活性，应用范围广泛。
T63517	BuChE-IN-4
	BuChE-IN-4 是 BuChE 的有效抑制剂 (IC50: 7.7 nM)，表现出温和的抗氧化能力、无毒、亲脂性和神经保护作用。
T38617	Biotin-TAT (47-57)
	Biotin-TAT (47-57) is a biotin-tagged transactivator of transcription, commonly employed as a protein transduction domain (PTD) in various primary cells. Its transduction capacity is contingent on ATP and temperature, suggesting the participation of endocytosis.
T74719	STING-IN-6
	STING-IN-6 (compound 50) 是一种有效的STING 抑制剂，pIC50为 8.9。STING-IN-6 具有免疫研究的潜力。
T61659	CC214-2
	CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the duration of tuberculosis (TB) [1].
T36910	PF 04449913 maleate
	Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID:24900436 \|Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID:2...
T72315	Caspase-3/7 activator 2
	Caspase-3/7 activator 2 是一种有效的 Caspase-3/7激活剂。Caspase-3/7 activator 2 具有肿瘤选择性、抗增殖活性和高诱导凋亡 (Apoptosis) 能力。
T79722	2-Chlorophenoxazine	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2-Chlorophenoxazine为Akt抑制剂，体外IC50为2-5 μM，能够诱导细胞凋亡(apoptosis)，适用于癌症病理研究。
T72316	Caspase-3/7 activator 3
	Caspase-3/7 activator 3 是一种有效的 Caspase-3/7激活剂。Caspase-3/7 activator 3 具有肿瘤选择性、抗增殖活性和高诱导凋亡 (Apoptosis) 能力。
T75581	Naja Oxiana Venom
	Naja Oxiana Venom (Caspian Cobra Venom) 为从 Naja Oxiana 提取的蛇毒，主要诱导癌细胞凋亡(apoptosis)，对正常细胞影响微弱。其内含细胞毒素CTI与CTII，能破坏细胞膜。
T61385	IDO1/TDO-IN-1
	IDO1/TDO-IN-1 (30) is a highly effective inhibitor that targets both IDO1 and TDO enzymes with uncompetitive (Ki = 0.23 μM) and competitive (Ki = 0.73 μM) mechanisms, respectively. This compound, IDO1/TDO-IN-1 (30), exhibits a significant capacity to induce cell apoptosis via the potential mitochondria-mediated Bcl-2/Bax pathway [1].
T35628	AN-7
	α-Lipoic acid is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form. It is an essential cofactor for decarboxylation reactions of the citric acid cycle and acts as a general antioxidant. AN-7 is a more lipophilic analog of α-lipoic acid with enhanced potency and 1.5-fold increased maximal capacity to stimulate glucose transport into myocytes. This identifies the analogs of lipoic acid as potential new treatments for diabetes.
T40755	Glabrescione B
	Glabrescione B is a novel compound that specifically binds to Gli1, an important modulator of the Hedgehog (Hh) signaling pathway. By disrupting the Gli1-DNA interaction, Glabrescione B effectively impairs the activity of Gli1. Moreover, Glabrescione B demonstrates potent inhibitory effects on the growth of tumor cells that rely on Hedgehog signaling, as well as on the self-renewal capacity and clonogenicity of tumor-derived stem cells.
T29742	AH-9700 free base
	AH-9700 free base 用于治疗急迫性尿失禁和尿毒症。在一项放射性配体结合研究中，AH-9700 free base 对 sigma 受体表现出较高的亲和力，对膀胱功能正常的实验动物的排尿反射(即膀胱容量增加作用)有明显的抑制作用。
T60897	Aldose reductase-IN-5
	Aldose reductase-IN-5 是一种醛糖还原酶（ALR2）抑制剂，可增强抑制性兴奋性和抗氧化能力的组合，从而延缓糖尿病并发症的进程。
T62707	Antimicrobial agent-4
	Antimicrobial agent-4 (compound 6a) 是一种有效的抗微生物剂 (antimicrobial)，对微生物病原体具有极高的活性。Antimicrobial agent-4 具有可靠的毒性，能够杀死细菌和真菌。Antimicrobial agent-4 对靶酶表现出较高的结合能力，为 10.0 kcal/mol。
T61579	BuChE-IN-5
	BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considerable free radical scavenging capacity and antioxidant activity. Given these properties, it holds promise as a valuable tool for Alzheimer's disease research [1].
T81033	TAT-P4-(DATC5)2
	TAT-P4-(DATC5)2 是PICK1 PDZ领域的高亲和性多肽抑制剂，具有 Ki 值为1.7 nM。在大鼠成瘾模型实验中，该化合物展现出抑制作用。
T71033	ZD7114 free base
	ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.
T80453	GLP-1 (1-36) amide (human, rat) Glucagon-like Peptide 1 (1-36) amide (human, rat)
	GLP-1(1-36) amide (human, rat)（人类及大鼠的胰高血糖素样肽1（1-36）酰胺）是GLP-1(7-36)酰胺的一种分子变体。该化合物能激发[14C]氨基吡啶在大鼠胃壁细胞的酶分散体中积累。

化合物

Cat.No: T4304

Target: Apoptosis, PERK

Betazole dihydrochloride

Cat.No: T8599

Synonym: 盐酸倍他唑,Betazole hydrochloride

Target: Histamine Receptor

Cat.No: T16073

Synonym: 小诺霉素,Gentamicin C2b,Antibiotic XK-62-2,Sagamicin

Target: Others, Antibacterial

Cat.No: T14314

Synonym: Apronalide,Allylisopropylacetylurea,丙戊酰脲

Target: Others

Cat.No: T21252

Synonym: 2,3-Dihydroxy-4-Methoxybenzaldehyde

Target: Others

Cat.No: T29015

Synonym: Tresanil,Sulmetozine,Tritiozinum,舒美吗啉,Tritiozine,Tritiozina

Target: Others

Aminohippurate sodium

Cat.No: T5039

Synonym: Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt

Target: Others

Cat.No: T20843

Synonym: Nergize,Creatinolfosfate,磷酸肌肉醇,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate

Target: Others

Cat.No: T68069

Target: MAO, 5-HT Receptor

Cat.No: T68492

Synonym: HDSF,Hexadecanesulfonyl fluoride

Target: FAAH

Cat.No: T36347

Synonym: Caspase-1 Inhibitor II,Ac-Tyr-Val-Ala-Asp-chloromethylketone,Ac-Tyr-Val-Ala-Asp-CMK

Target: IL Receptor, Caspase, Immunology/Inflammation related, Pyroptosis

Phenazopyridine hydrochloride

Cat.No: T1386

Synonym: Urodine,Pyridium,Phenazopyridine HCl,盐酸非那吡啶

Target: Sodium Channel

Naftidrofuryl oxalate

Cat.No: T1081

Synonym: 萘呋胺酯草酸盐,Nafronyl oxalate,Nafronyl oxalate salt

Target: 5-HT Receptor

MS023 dihydrochloride

Cat.No: T61338

Synonym: MS023 2HCl

Target: Histone Methyltransferase

Cat.No: T15410

Target: Aryl Hydrocarbon Receptor

Cat.No: T4341

Synonym: 贝曲西班,PRT054021

Target: Factor Xa

Cat.No: TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Betrixaban maleate

Cat.No: T4980

Target: Factor Xa

Cat.No: T30025

Synonym: 6-O-(4-O-Methyl-β-D-glucuronosyl)-D-galactose,GlcA[4Me]β(1-6)Gal

Cyanidin 3-O-arabinoside

Cat.No: T36500

Cat.No: T13243

Synonym: Ubiquinol-10,CoQH2-10

Target: Others

Phototherapeutic agent-1

Cat.No: T75364

Cat.No: T36037

D-phenylalanine analogue

Cat.No: T19616

Synonym: (R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid

Target: Others

Cat.No: T25848

Cat.No: T69676

Cat.No: T33534

Synonym: Edrul,Muzolimina,Muzoliminum

Cat.No: T28878

Synonym: Sul-121 Hydrochloride

Cat.No: T22104

Serratia marcescens nuclease

Cat.No: T78347

Cat.No: T63517

Biotin-TAT (47-57)

Cat.No: T38617

Cat.No: T74719

Cat.No: T61659

PF 04449913 maleate

Cat.No: T36910

Caspase-3/7 activator 2

Cat.No: T72315

2-Chlorophenoxazine

Cat.No: T79722

Target: Akt

Caspase-3/7 activator 3

Cat.No: T72316

Naja Oxiana Venom

Cat.No: T75581

Cat.No: T61385

Cat.No: T35628

Cat.No: T40755

AH-9700 free base

Cat.No: T29742

Aldose reductase-IN-5

Cat.No: T60897

Antimicrobial agent-4

Cat.No: T62707

Cat.No: T61579

TAT-P4-(DATC5)2

Cat.No: T81033

ZD7114 free base

Cat.No: T71033

GLP-1 (1-36) amide (human, rat)

Cat.No: T80453

Synonym: Glucagon-like Peptide 1 (1-36) amide (human, rat)

Cat. No.	Product Name	Target	Signaling Pathways
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T8213	Isolinderalactone	NOS; STAT	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Isolinderalactone 具有抗炎和抗癌能力，具有中等的 iNOS 抑制活性，IC50 值为 0.30 uM。
T1436	4-Aminohippuric Acid p-Aminohippuric acid,对氨基马尿酸	Amino Acids and Derivatives; Endogenous Metabolite	Metabolism
	4-Aminohippuric Acid 是诊断剂，能够用于肾脏检测，在肾血浆流量的测定中使用。
T2S0850	Malic acid E 296,苹果酸,2-Hydroxysuccinic acid,Hydroxybutanedioic acid,FDA 2018,Deoxytetraric acid,Pomalus acid	Others; Endogenous Metabolite	Metabolism; Others
	Malic acid (Pomalus acid) 是一种天然存在于水果中的二羧酸，如苹果和梨。Malic acid 在许多酸味或酸味食物中起作用。
TN1420	Bacopaside I	Others	Others
	Bacopaside I 是一种皂苷，分离自 Bacopa monniera 中，具有抗氧化活性和清除自由基的功能，有抗抑郁作用。
T3S1641	Esculentoside H	TNF; NF-κB; JNK	Apoptosis; MAPK; NF-κB
	Esculentoside H 是一种皂苷，分离自多年生植物 Phytolacca esculent 的根提取物中，具有抗肿瘤作用。它的机制与 TNF 释放能力有关。它能够阻断 JNK1/2和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达，抑制结肠癌细胞迁移。
T8733	Antrodin A (2-氯苯基)二苯基甲醇,camphorataanhydride A	Others	Others
	Antrodin A (camphorataanhydride A) 是固体发酵樟脑菌菌丝体的一种主要活性成分。它能够增强肝脏的抗炎及抗氧化能力，维持肠道菌群的稳定，避免酒精对肝脏的损伤。
TN6989	Isotoosendanin 异川楝素,(1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate	Others	Others
	Isotoosendanin ((1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate) 是一种从楝树 Melia toosendan 果实中分离出的柠檬苦素类天然产物，具有抗炎和镇痛作用。
T3674	Hydroxysafflor yellow A 藏红花,羟基红花黄色素A,HSYA,Safflomin A	TGF-beta/Smad	Stem Cells
	Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物，从中药红花中分离得到，具有抗癌作用。
T40080	(±)-Taxifolin (±)-Dihydroquercetin	Antioxidant; Tyrosinase	oxidation-reduction; Proteases/Proteasome
	(±)-Taxifolin ((±)-Dihydroquercetin) 是 Taxifolin 的外消旋体。Taxifolin 是一种常见于洋葱，水飞蓟，法国海洋松树皮和道格拉斯冷杉树皮中的类黄酮，具有抗酪氨酸酶和抗纤维化活性。Taxifolin 对胶原酶具有抑制作用，IC 50 值为 193.3 μM。Taxifolin是一种具有抗氧化能力的自由基清除剂。
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。
TN6456	N-trans-caffeoyloctopamine
	N-trans-Caffeoyltyramine has both arginase inhibitory property and antioxidant capacity.
TN1541	Cyanidin 3-sophoroside chloride	Others	Others
	Cyanidin-3-sophoroside has antioxidant capacity.
T82364	Fumonisin B4
	Fumonisin B4，作为一种伏马菌素衍生物，展现出较低的白蛋白结合能力。
TN4247	Ikshusterol 3-O-glucoside	Phospholipase	Metabolism
	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T40584	Corymbiferin
	Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of histopathology in both the liver and pancreatic β cells.
TN1867	Licoricidin	MMP; VEGFR; ROS	Angiogenesis; Immunology/Inflammation; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
TN6651	Picrasidine Q
	Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
TN2287	Turkesterone	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group, also is an analogue of the insect steroid hormone 20-hydroxyecdysone. It has immunomodulating and antistress activity, can increase the adaptation capacity of mice under immobilization-induced stress conditions.
T38497	(-)-Taxifolin (-)-二氢槲皮素,(-)-Dihydroquercetin
	(-)-Taxifolin is the less active enantiomer of Taxifolin, demonstrating vital anti-tyrosinase activity and notable inhibition against collagenase (IC50 = 193.3 μM). It is valued as an essential natural compound showing antifibrotic potential, while also acting as a capable free radical scavenger and possessing antioxidant capacity.
T72965	Inuviscolide
	Inuviscolide，一种诱导细胞凋亡(apoptosis)的化合物，能够引起人黑素瘤细胞系在G2/M期的停滞，并展现出抗肿瘤和抗炎活性。
TN1242	3,3'-Di-O-methylellagic acid 3,8-Di-O-methylellagic acid,3,3'-O-二甲基鞣花酸	Others; TNF; Antifection	Apoptosis; Microbiology/Virology; Others
	3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a lower capacity of stimulating murine peritoneal macrophages to release nitric oxide and tumoural-alpha necrose factor
TN4041	Eupatoriopicrin	Others	Others
	Eupatoriopicrin shows anti-trypanosomal activity and cytotoxicity against Trypanosoma brucei rhodesiense. Eupatoriopicrin-induced DNA damage may play a role in the observed cytotoxicity, it shows a weak sensitizing capacity in guinea pigs.
T83254	7,4'-Dihydroxyhomoisoflavane
	7,4'-Dihydroxyhomoisoflavane 是一种具有抗氧化能力的天然化合物，能有效清除 ABTS 自由基，其半抑制浓度 (IC50) 为 0.22 mg/mL。
T80690	β-Maaliene
	β-Maaliene 是从也是密花荆鲜叶中提取的主要成分，其在特定剂量下能显著抑制小鼠的运动活性。
TN4431	Leucosceptoside A	RAAS; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones
	Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidase. Leucosceptoside A has antihypertensive effect, it shows angiotensin converting enzyme (ACE)
T83407	2',3'-Dihydroxy-4',6'-dimethoxychalcone
	2',3'-Dihydroxy-4',6'-dimethoxychalcone 能够抑制β淀粉样蛋白(Aβ42)的纤维化与聚集，并具有口服活性，在大脑中可进行检测。
TWS0787	Oroxin A 木蝴蝶苷A,Baicalin-7-glucoside	PPAR; Glucosidase	DNA Damage/DNA Repair; Metabolism
	Oroxin A (Baicalin-7-glucoside) 是一种部分 PPARγ 激动剂，可在体外和体内激活 PPARγ 转录激活。 Oroxin A 还表现出对 α-葡萄糖苷酶的抑制活性和抗氧化能力。
TN4062	Flavidin	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Flavidin shows very good antioxidant capacity. Flavidin can enhance fluorescent imaging, allowing more sensitive and specific cell labeling in tissues, it should have wide application in molecular detection, providing a general insight into how to optimiz
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。
TN4471	Lysicamine	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini

天然产物

Cat.No: T9352

Target: Others

Isolinderalactone

Cat.No: T8213

Target: NOS, STAT

4-Aminohippuric Acid

Cat.No: T1436

Synonym: p-Aminohippuric acid,对氨基马尿酸

Target: Amino Acids and Derivatives, Endogenous Metabolite

Cat.No: T2S0850

Synonym: E 296,苹果酸,2-Hydroxysuccinic acid,Hydroxybutanedioic acid,FDA 2018,Deoxytetraric acid,Pomalus acid

Target: Others, Endogenous Metabolite

Cat.No: TN1420

Target: Others

Esculentoside H

Cat.No: T3S1641

Target: TNF, NF-κB, JNK

Cat.No: T8733

Synonym: (2-氯苯基)二苯基甲醇,camphorataanhydride A

Target: Others

Cat.No: TN6989

Synonym: 异川楝素,(1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate

Target: Others

Hydroxysafflor yellow A

Cat.No: T3674

Synonym: 藏红花,羟基红花黄色素A,HSYA,Safflomin A

Target: TGF-beta/Smad

Cat.No: T40080

Synonym: (±)-Dihydroquercetin

Target: Antioxidant, Tyrosinase

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

N-trans-caffeoyloctopamine

Cat.No: TN6456

Cyanidin 3-sophoroside chloride

Cat.No: TN1541

Target: Others

Cat.No: T82364

Ikshusterol 3-O-glucoside

Cat.No: TN4247

Target: Phospholipase

Cat.No: T40584

Cat.No: TN1867

Target: MMP, VEGFR, ROS

Cat.No: TN6651

Cat.No: TN2287

Target: Calcium Channel

Cat.No: T38497

Synonym: (-)-二氢槲皮素,(-)-Dihydroquercetin

Cat.No: T72965

3,3'-Di-O-methylellagic acid

Cat.No: TN1242

Synonym: 3,8-Di-O-methylellagic acid,3,3'-O-二甲基鞣花酸

Target: Others, TNF, Antifection

Eupatoriopicrin

Cat.No: TN4041

Target: Others

7,4'-Dihydroxyhomoisoflavane

Cat.No: T83254

Cat.No: T80690

Leucosceptoside A

Cat.No: TN4431

Target: RAAS, PKC

2',3'-Dihydroxy-4',6'-dimethoxychalcone

Cat.No: T83407

Cat.No: TWS0787

Synonym: 木蝴蝶苷A,Baicalin-7-glucoside

Target: PPAR, Glucosidase

Cat.No: TN4062

Target: COX, Prostaglandin Receptor

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

Cat.No: TN4471

Target: IL Receptor, Antifection

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