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67

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1098	Motilin, canine Motilin (canine)
	Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist.
TP1085L	Neuromedin N acetate(92169-45-4 free base) Neuromedin N (rat, mouse, porcine, canine) acetate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Neuromedin N acetate(92169-45-4 free base) 是一种神经肽，其衍生自与神经降压素相同的前体多肽，具有相似但略有不同的表达和作用。Neuromedin N 是多巴胺 D2 受体激动剂与大鼠新纹状体膜结合的有效调节剂。
TP1610	Secretin, canine
	Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
TP1174	Endothelin-2 (49-69), human Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2	Others	Others
	Endothelin-2 (49-69), human (Human endothelin-2) 是一种由 21 个氨基酸组成的血管活性肽。它可与 G 蛋白连接的跨膜受体，ET-RA 和ET-RB 结合。
TP1085	Neuromedin N Neuromedin N (rat, mouse, porcine, canine)
	Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.
TP1016	Aviptadil Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔
	Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction.
TP2143	Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA	Others	Others
	Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.
T16347	NS3623	Potassium Channel	Membrane transporter/Ion channel
	NS3623 是 hERG1 (KV11.1)钾通道激活剂，激活IKr 和Ito 电流，具有抗心律失常作用。NS3623也是 hERG1 通道抑制剂。
T0696	Naftopidil KT-611,萘哌地尔,BM-15275	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil (KT-611) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM 、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T80148	GRP (14-27) (human, porcine, canine)	Bombesin Receptor	GPCR/G Protein
	GRP (14-27) (human, porcine, canine) 表现为铃蟾肽受体配体。其特异性结合受到 GTP 和 GDP 的抑制作用，但 GMP 对此无影响。
T8236	RHC 80267 U-57908	Others; Phospholipase; COX; Acyltransferase; AChR	Immunology/Inflammation; Metabolism; Neuroscience; Others
	RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂，对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解，还抑制胆碱酯酶活性，IC50为 4 μM，增强乙酰胆碱引起的松弛。
T76651	Peptide YY (13-36) (canine, mouse, porcine, rat)
	Peptide YY (13-36) (canine, mouse, porcine, rat) 是 Y2受体的激动剂。
T6600	Naftopidil dihydrochloride KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil dihydrochloride (KT-611 2HCl) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
TP1016L	Aviptadil Acetate 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) 是模拟血管活性肠多肽类似物，具有血管舒张效应。它可诱导肺血管舒张并抑制血管 SMC 的增殖和血小板聚集。它可用于研究 SARS-CoV-2 引起的肺纤维化、肺动脉高压和呼吸衰竭。
T9220	Naftopidil hydrochloride 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naftopidil hydrochloride (BM-15275 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b 和 α1d 亚型肾上腺素受体的亲和力 Ki 分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。
T15209	Elobixibat AZD 7806,A 3309	Others	Others
	Elobixibat (A 3309) 是回肠胆汁酸转运蛋白的抑制剂(小鼠、人和犬 IBAT 的 IC50：0.13 nM、0.53 nM 和 5.8 nM)。 Elobixibat 可用于慢性特发性便秘的研究。
T22893	L-168049 L-168,049	Glucagon Receptor	GPCR/G Protein
	L-168049 是一种选择性和非竞争性人胰高血糖素受体拮抗剂，对人、鼠和犬的 IC50 分别为 3.7 nM、63 nM 和 60 nM。
T0489	Flutamide SCH 13521,氟他胺	Androgen Receptor	Endocrinology/Hormones
	Flutamide (SCH 13521) 是一种抗雄激素化合物，在啮齿动物和犬科动物中的效力与环丙孕酮大致相同。
T28895	T-0509 T 0509,T0509	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	T-0509 是一种选择性 beta 1 受体激动剂，可增加犬心室肌的肌力，选择性下调大鼠心脏 β 1-肾上腺素受体。
T12321	ORM-10103	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ORM-10103 是一种新型有效且具有选择性的 Na+/Ca2+ 交换体 (NCX) 抑制剂。ORM-10103 对 NCX 电流有抑制作用，在 -80 和 20 mV 下的 IC50 的估算值分别为 55 和 67 nM，可减少犬心脏的早期和延迟后去极化。
T17030	Tegoprazan	ATPase; Proton pump	Membrane transporter/Ion channel
	Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，能够控制胃酸分泌和运动，在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。
T17006	TC-I 2014	TRP/TRPV Channel	Membrane transporter/Ion channel
	TC-I 2014 是一种口服有效的、强效的、苯并咪唑类的、 TRPM8 的拮抗剂，其对犬类、人和大鼠通道的 IC50 值分别为 0.8 nM, 3.0 nM 和 4.4 nM。在疼痛动物模型中具有抗痛觉超敏作用。
T20714	Levolansoprazole 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole	Proton pump	Membrane transporter/Ion channel
	Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50：82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。
T71012	Nemazoline Free Base
	Nemazoline Free Base is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal administration to dogs, the compound was devoid of systemic effects up to a concentration 1000 times that needed for local decongestant effect (1.65 micrograms, atomized from a 1 microgram mL-1 solution) suggesting limited mucosal absorption. After nasal administration to rats for 1...
T7339	Angiotensin (1-7) Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO	RAAS; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性，因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮，是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。
T1325	Carprofen 卡洛芬,Ridamyl,Imadyl,Rimadyl	FAAH; COX; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Neuroscience
	Carprofen (Ridamyl) 是多靶点FAAH/COX 抑制剂，能够抑制 COX-2，COX-1 和 FAAH 的活性，IC50值分别为 3.9 μM，22.3 μM 和 78.6 μM。它是一种丙酸衍生物和非甾体抗炎药，具有抗炎、镇痛和解热活性。
T1546	Nitazoxanide NSC 697855,硝唑尼特	Others; Influenza Virus; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Nitazoxanide (NSC-697855) 是一种广谱驱虫剂，对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。它在无菌培养中抑制Giardia lamblia 滋养体增殖，IC50为 2.4 μM。它可研究寄生虫性胃肠炎，具有抗病毒特性。
T15487	HMR 1556	Others	Others
	HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).
T27278	Epsiprantel
	Epsiprantel is an antiparasitic for canine worms.
T76816	Lokivetmab
	Lokivetmab（Anti-Canine IL31 Recombinant Antibody）为针对犬特应性皮炎（AD）研究的抗犬IL-31单克隆抗体。
T70510	CVS-1123
	CVS-1123 is a direct thrombin inhibitor, preventing occlusive arterial and venous thrombosis in a canine model of vascular injury.
T26312	Uredofos Sansalid,RH 32565,RH32565,RH-32565
	Uredofos 是一种广谱驱虫药，它犬绦虫、蛔虫、钩虫和鞭虫都非常有效。
T71421	Bemoradan
	Bemoradan is an inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue
T31030	CP 71362 CP71362
	CP 71362 is a selective pentapeptide renin inhibitor for canine enzymes.
T13340	Win-62005	Others	Others
	Win-62005 is an inhibitor of cyclic AMP phosphodiesterase III (PDE III)(Kis: 25 and 26 nM for rat heart and canine aorta).
T38686	Melarsomine
	Melarsomine, a trivalent arsenical compound, is employed as an adulticide for canine heartworm disease and other helminth infections. It has significant utility in the research of these conditions.
TC0008	Desoxycorticosterone pivalate DOCP	Others	Others
	Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones.
T76932	Blontuvetmab
	Blontuvetmab (AT 004)，犬源化CD20单克隆抗体，主要用于研究犬B细胞淋巴瘤。
T71601	CU-2010
	CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model.
TP2010	Kisspeptin 10 (dog)
	Endogenous ligand for the canine KISS1 receptor (Kisspeptin receptor or GPR54). Stimulates section of luteinizing hormone, follicle stimulating hormone and estradiol in vivo.
T78300	Anivovetmab KIND-030
	Anivovetmab (KIND-030)为针对细小病毒主要衣壳蛋白的IgG2型单克隆抗体，潜在应用于研究犬细小病毒感染。
T41020	Melarsomine dihydrochloride
	Melarsomine dihydrochloride is a trivalent arsenical compound employed as an adulticide in the treatment of canine heartworm disease and other helminth infections. It is also utilized for research purposes in the study of these conditions.
T16906	Sograzepide YM-220,Netazepide,YF 476	Others	Others
	Sograzepide is an effective and highly selective Gastrin/CCK-B antagonist (IC50: 0.1 nM), has an inhibitory effect on Gastrin/CCK-A activity (IC50: 502 nM). Sograzepide replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine, and cloned human Gastrin/CCK-B receptors (Ki: 0.068, 0.62 and 0.19 nM, respectively).
T28884	SUN-C5174 SUNC-5174
	SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06). SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma
T70379	PF-04479745 tartrate
	PF-04479745, also known as PF-4479745, is a potent and selective 5-HT2C agonist (EC50 = 10 nM). PF-4479745 displayed robust pharmacology in a preclinical canine model of stress urinary incontinence (SUI) and no measurable functional agonism at the key selectivity targets 5-HT2A and 5-HT2B in relevant tissue-based assay systems.
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T80990	Thrombostatin cont-1
	Thrombostatin cont-1为缓激肽代谢物，归属于凝血抑制素类似物。该化合物在犬颈动脉球囊成形术损伤模型中，能有效减少血小板活化。
T27038	CL385319 HCl CL-385319,CL385319 hydrochloride,CL 385319,CL385319
	CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.
T72812	(R)-Tegoprazan
	(R)-Tegoprazan (example 3) 是一种苯并咪唑衍生物，是一种有效的胃H+/K+-ATP 酶抑制剂，对犬肾 Na+/K+-ATPase 的IC50为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。
T36561	(3S)-hydroxy Quinidine
	(3S)-hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S)-hydroxy quinidine formation. (3S)-hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-depe...

化合物

Motilin, canine

Cat.No: TP1098

Synonym: Motilin (canine)

Neuromedin N acetate(92169-45-4 free base)

Cat.No: TP1085L

Synonym: Neuromedin N (rat, mouse, porcine, canine) acetate

Target: Dopamine Receptor

Secretin, canine

Cat.No: TP1610

Endothelin-2 (49-69), human

Cat.No: TP1174

Synonym: Human endothelin-2,Endothelin-2, human,Endothelin-2 (human, canine),人内皮素2

Target: Others

Cat.No: TP1085

Synonym: Neuromedin N (rat, mouse, porcine, canine)

Cat.No: TP1016

Synonym: Vasoactive Intestinal Peptide (human, rat, mouse, rabbit, canine, porcine),阿肽地尔

Endothelin-2 (49-69), human TFA

Cat.No: TP2143

Synonym: Endothelin-2 (49-69) (human, canine) TFA,Human endothelin-2 TFA

Target: Others

Cat.No: T16347

Target: Potassium Channel

Cat.No: T0696

Synonym: KT-611,萘哌地尔,BM-15275

Target: Adrenergic Receptor

GRP (14-27) (human, porcine, canine)

Cat.No: T80148

Target: Bombesin Receptor

Cat.No: T8236

Synonym: U-57908

Target: Others, Phospholipase, COX, Acyltransferase, AChR

Peptide YY (13-36) (canine, mouse, porcine, rat)

Cat.No: T76651

Naftopidil dihydrochloride

Cat.No: T6600

Synonym: KT-611,KT-611 2HCl,盐酸萘哌地尔,Naftopidil DiHCl

Target: 5-HT Receptor, Adrenergic Receptor

Aviptadil Acetate

Cat.No: TP1016L

Synonym: 醋酸阿肽地尔,阿肽地尔,Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

Naftopidil hydrochloride

Cat.No: T9220

Synonym: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-,萘哌地尔盐酸盐,KT-611 hydrochloride,BM-15275 hydrochloride

Target: Adrenergic Receptor

Cat.No: T15209

Synonym: AZD 7806,A 3309

Target: Others

Cat.No: T22893

Synonym: L-168,049

Target: Glucagon Receptor

Cat.No: T0489

Synonym: SCH 13521,氟他胺

Target: Androgen Receptor

Cat.No: T28895

Synonym: T 0509,T0509

Target: Adrenergic Receptor

Cat.No: T12321

Target: Calcium Channel

Cat.No: T17030

Target: ATPase, Proton pump

Cat.No: T17006

Target: TRP/TRPV Channel

Levolansoprazole

Cat.No: T20714

Synonym: 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Nemazoline Free Base

Cat.No: T71012

Angiotensin (1-7)

Cat.No: T7339

Synonym: Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO

Target: RAAS, Endogenous Metabolite

Cat.No: T1325

Synonym: 卡洛芬,Ridamyl,Imadyl,Rimadyl

Target: FAAH, COX, Autophagy

Cat.No: T1546

Synonym: NSC 697855,硝唑尼特

Target: Others, Influenza Virus, Parasite, Autophagy

Cat.No: T15487

Target: Others

Cat.No: T27278

Cat.No: T76816

Cat.No: T70510

Cat.No: T26312

Synonym: Sansalid,RH 32565,RH32565,RH-32565

Cat.No: T71421

Cat.No: T31030

Synonym: CP71362

Cat.No: T13340

Target: Others

Cat.No: T38686

Desoxycorticosterone pivalate

Cat.No: TC0008

Synonym: DOCP

Target: Others

Cat.No: T76932

Cat.No: T71601

Kisspeptin 10 (dog)

Cat.No: TP2010

Cat.No: T78300

Synonym: KIND-030

Melarsomine dihydrochloride

Cat.No: T41020

Cat.No: T16906

Synonym: YM-220,Netazepide,YF 476

Target: Others

Cat.No: T28884

Synonym: SUNC-5174

PF-04479745 tartrate

Cat.No: T70379

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Thrombostatin cont-1

Cat.No: T80990

Cat.No: T27038

Synonym: CL-385319,CL385319 hydrochloride,CL 385319,CL385319

Cat.No: T72812

(3S)-hydroxy Quinidine

Cat.No: T36561

Cat. No.	Product Name	Target	Signaling Pathways
TN5768	Chiricanine A
	Chiricanine A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5768，CAS号为 350593-30-5。
TN1485	Chicanine	Others; NF-κB; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; NF-κB; Others
	Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
T33817	Orellanine 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one	Others	Others
	Orellanine 是一种从蘑菇 Cortinarius orellanus 中提取的肾毒性化合物。 Orellanine 强烈抑制 Madin-Darby 犬肾细胞和大鼠肝线粒体中大分子（蛋白质、RNA 和 DNA）的合成。
T2S2046	Bruceine A Dihydrobrusatol,鸦胆子素 A,NSC31616	Antibiotic; Parasite	Microbiology/Virology
	Bruceine A (NSC-31616) 是一种从鸦胆子 (L.) 的干果中提取的天然类苦素化合物，有治疗犬巴贝斯虫病的潜力。
T27380	FR-198248
	FR-198248, a new anti-influenza agent, shows antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro.
TN1875	Liriodenine 鹅掌揪碱	BCL; Caspase; p53	Apoptosis; Proteases/Proteasome
	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti

天然产物

Cat.No: TN5768

Cat.No: TN1485

Target: Others, NF-κB, Prostaglandin Receptor

Cat.No: T33817

Synonym: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one

Target: Others

Cat.No: T2S2046

Synonym: Dihydrobrusatol,鸦胆子素 A,NSC31616

Target: Antibiotic, Parasite

Cat.No: T27380

Cat.No: TN1875

Synonym: 鹅掌揪碱

Target: BCL, Caspase, p53

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