首页 工具
登录
购物车
Angiotensin (1-7)

Angiotensin (1-7)

产品编号 T7339   CAS 51833-78-4
别名: Ang-(1-7), Angiotensin 1-7, ASP-ARG-VAL-TYR-ILE-HIS-PRO

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性,因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮,是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大,并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
Angiotensin (1-7) Chemical Structure
Angiotensin (1-7), CAS 51833-78-4
规格 价格/CNY 货期 数量
2 mg ¥ 243 现货
5 mg ¥ 428 现货
10 mg ¥ 672 现货
25 mg ¥ 1,490 现货
50 mg ¥ 2,370 现货
100 mg ¥ 3,490 现货
其他形式的 Angiotensin (1-7):
产品目录号及名称: Angiotensin (1-7) (T7339)
点击图片重新获取验证码
选择批次  
纯度: 100%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activities.
靶点活性 ACE:0.65 μM (IC50)
体外活性 ANG-(1-7) significantly attenuated ANG II-induced cardiac hypertrophy and perivascular fibrosis in these rats. These effects of ANG-(1-7) were confirmed in cultured cardiomyocytes, in which ANG-(1-7) significantly attenuated ANG II-induced increases in cell size[1].
体内活性 Ang-(1-7) treatment attenuated the shortening of the atrial effective refractory period and the increase in the atrial fibrillation inducibility level. Immunohistochemistry and Western blotting showed sympathetic nerve hyperinnervation in the pacing group, while Ang-(1-7) attenuated sympathetic nerve proliferation. Ang-(1-7) alleviated the pacing-induced increases in tyrosine hydroxylase and nerve growth factor mRNA expression levels[2].
细胞实验 Cultured cardiomyocytes were treated with PBS (control), ANG II (100 nM), ANG-(1–7) (100 nM), ANG II + ANG-(1–7), ANG II + ANG-(1–7) + A779 (10 μM), ANG II + ANG-(1–7) + Sirt3 short hairpin (sh)RNA, lentiviral particles (1 × 10^6 TU) containing a Sirt3 shRNA viral vector, or ANG II + Mito-TEMPO (0.1 μM) for 24 h. Each treatment was performed in triplicate wells. Monoclonal anti-α-sarcomeric actin antibody was used for identification and measurement of cardiomyocytes via immunofluorescence staining. Cells were fixed in methanol at ?10°C and washed with fresh washing solution (0.1% Triton X-100 in PBS) three times. After preincubation with 3% BSA for 20 min, cells were incubated with primary antibody, which was diluted to 1:100 with PBS containing 3% BSA, overnight at 4°C. After three washings with the washing solution, cells were incubated with fluorescence-conjugated anti-mouse IgG (1:500 diluted in PBS) for 1 h at room temperature. Photographic images of cardiomyocytes were taken with a fluorescence microscope. Image-analysis software was used to measure the cell surface area of cardiomyocytes that were positively stained for sarcomeric actin. Variations in cell size were expressed as relative cell surface area versus the control. At least 50 cells in each dish were randomly selected for surface area analysis[1].
动物实验 Eighteen dogs were randomly assigned to sham group, pacing group and Ang-(1-7) group. Rapid atrial pacing was maintained for 14 days in the pacing and Ang-(1-7) groups. Ang-(1-7) was administered intravenously in the Ang-(1-7) group. The atrial effective refractory period and atrial fibrillation inducibility level were measured at baseline and under sympathetic nerve stimulation after 14 days of measurement. The atrial sympathetic nerves labeled with tyrosine hydroxylase were detected using immunohistochemistry and Western blotting, and tyrosine hydroxylase and nerve growth factor mRNA levels were measured by reverse transcription polymerase chain reaction[2].
别名 Ang-(1-7), Angiotensin 1-7, ASP-ARG-VAL-TYR-ILE-HIS-PRO
分子量 899
分子式 C41H62N12O11
CAS No. 51833-78-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 8.99 mg/ml (10 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1123 mL 5.5617 mL 11.1235 mL 27.8087 mL
5 mM 0.2225 mL 1.1123 mL 2.2247 mL 5.5617 mL
10 mM 0.1112 mL 0.5562 mL 1.1123 mL 2.7809 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
=
X
X
X
=
X
=
/
g/mol

输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Guo L , Yin A , Zhang Q , et al. Angiotensin (1-7) Attenuates Angiotensin II-induced Cardiac Hypertrophy via a Sirt3-Dependent Mechanism[J]. American Journal of Physiology - Heart and Circulatory Physiology, 2017:ajpheart.00768.2016. 2. Shangguan W , Shi W , Li G , et al. Angiotensin-(1–7) attenuates atrial tachycardia-induced sympathetic nerve remodeling[J]. Journal of the Renin-Angiotensin-Aldosterone System, 2017, 18(3):147032031772928.
DX600 TFA Fosinopril sodium Candesartan N-Acetyl-Ser-Asp-Lys-Pro Pratosartan Leucosceptoside A Angiotensin I/II (1-5) TRV-120027 acetate (1234510-46-3 free base)

相关化合物库

该产品包含在如下化合物库中:
多肽分子库 人代谢物化合物库 临床前化合物库 抗COVID-19化合物库 抗高血压化合物库 免疫/炎症分子化合物库 内分泌激素分子库 抑制剂库 代谢化合物库 NO PAINS 化合物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Angiotensin (1-7) 51833-78-4 Endocrinology/Hormones Metabolism RAAS Endogenous Metabolite Angiotensin Receptor Angiotensin (17) Ang Inhibitor Ang-(1-7) inhibit Angiotensin 1-7 Angiotensin ASP-ARG-VAL-TYR-ILE-HIS-PRO Angiotensin (1 7) Angiotensin-converting Enzyme (ACE) inhibitor

 

陶术
生物
TargetMol®中国区唯一合作伙伴
点击进入陶术生物官网陶术生物
联系我们
400-820-0310

上海市静安区江场三路238号8楼