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Search Results for " tgf-β1 "

Targets Recommended: TGF-beta/Smad

40

抑制剂 & 化合物

11

天然产物

1

化合物库

16

重组蛋白

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Cat. No.	Product Name
L4100	TGF-β/Smad靶点化合物库		184 compounds
	184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

TGF-β/Smad靶点化合物库

Cat.No: L4100

Compounds: 184

Cat. No.	Product Name	Target	Signaling Pathways
T3636	(E)-SIS3 SIS3,SIS3 盐酸盐,SIS3 HCl	TGF-beta/Smad	Stem Cells
	(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂，能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T0459	Sulindac Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide	COX; Autophagy	Autophagy; Immunology/Inflammation; Neuroscience
	Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂，可抑制COX-2的活性，也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药，具有潜在的抗肿瘤活性。
T61389	TGFβ1-IN-1	TGF-beta/Smad	Stem Cells
	TGFβ1-IN-1 是一种具有口服活性的 TGF-β1 抑制剂，抑制 TGF-β1 诱导的纤维化标志物（α-SMA 和纤连蛋白）的产生，可用于研究癌症和自身免疫疾病。
T73300	AXL-IN-13	FLT; TAM Receptor; PDGFR; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	AXL-IN-13 是一种有效且具有口服活性的 AXL 抑制剂，其IC50值为 1.6 nM，Kd 值为0.26 nM。AXL-IN-13 具有抗癌活性，可逆转 TGF-β1 诱导的上皮间质转化 (EMT)，并抑制癌细胞迁移和侵袭。
T1763	SB 525334 SB525334	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	SB525334是转化生长因子β1受体 (ALK5) 选择性抑制剂，IC50=14.3 nM。
T38752	EW-7195	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	EW-7195 是一种具有选择性和高效性的 ALK5 (TGFβR1) 抑制剂，IC50 值为 4.83 nM。EW-7195 对 ALK5 的亲和力是 p38α 的 300 多倍。EW-7195 对 TGF-β1 诱导的 Smad 信号转导、上皮间质转化 (EMT) 和乳腺癌向肺转移有抑制作用。
T32613	LCB 03-0110 dihydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶（IC50=1.3 nM）和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化，抑制巨噬细胞和成纤维细胞的活化，并抑制伤口愈合模型中的瘢痕形成。
T11052L	Disitertide acetate P144 acetate,Disitertide acetate(272105-42-7 Free base)	TGF-beta/Smad	Stem Cells
	Disitertide acetate (P144 acetate) 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide acetate 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T9953	BT173	Others	Others
	BT173 是一种新型的同源域相互作用蛋白激酶 2 (HIPK2) 抑制剂，通过抑制 TGF-β1/Smad3 通路减轻肾纤维化。
T11793	KY-05009	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂，Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性，并诱导癌细胞凋亡，显示抗癌活性。
T62483	CJJ300	TGF-beta/Smad	Stem Cells
	CJJ300 是一种转化生长因子-β（TGF-β）抑制剂（IC50 : 5.3 μM）。CJJ300 通过破坏 TGF-β-TβR-I-TβR-II 信号传导复合物的形成来抑制 TGF-β 信号传导。CJJ300 可抑制细胞迁移。
T76066	pm26TGF-β1 peptide
	pm26TGF-β1 peptide为模拟人TGF-β1分子的肽，对TGF-β1受体展现高亲和力。该肽显示出有效抗炎特性，无嗜中性粒细胞的趋化性。
T76066L	pm26TGF-β1 peptide TFA
	pm26TGF-β1 peptide TFA 是模拟人类TGF-β1分子的肽，对TGF-β1受体有高亲和力。该化合物具备显著的抗炎性能，不引起嗜中性粒细胞的趋化现象。
T24470	Mitochonic Acid 35 MA35,MA-35,MA 35,Mitochonic Acid-35
	Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation.
T12923	(Rac)-SIS3 free base	TGF-beta/Smad	Stem Cells
	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T80272	Vicatertide SB-01
	Vicatertide为TGF beta-1抑制剂。
T11052	Disitertide P144	Others	Others
	Disitertide (P144) is an inhibitor of TGF-β1.
T76498	H-Leu-Ser-Lys-Leu-OH
	H-Leu-Ser-Lys-Leu-OH 是一种与LATENCY-ASSOCIATED PEPTIDE (LAP) 氨基端相关的延迟肽，能够抑制TGF-β1的激活。当与KRFK结合时，H-Leu-Ser-Lys-Leu-OH 可以阻断TGF-β1的信号转导，进而防止肝损伤和纤维化的发展。
T69517	Bexotegrast HCl
	Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts.
TP2147	LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)	Others	Others
	LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, a latency-associated protein (LAP)-TGFβ derived tetrapeptide, is a competitive antagonist of TGF-β1.
T79789	DT-6	TGF-beta/Smad	Stem Cells
	DT-6为一有效TGF-β1抑制剂，能够抑制M2巨噬细胞诱导的上皮至间质转化(Epithelial-Mesenchymal Transition, EMT)及癌细胞侵袭性迁移，可用于癌症相关疾病研究。
T77189	Sudubrilimab
	Sudubrilimab (HS636) 是一种针对 PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1通路和 TGF-β 生物活性。
T3689L	Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate
	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/
T78944	VDR agonist 2
	VDR agonist 2（化合物16i）作为VDR（vitamin D receptor）激动剂，能有效抑制TGF-β1诱导的肝星状细胞（HSC）活化，并在体外和体内展现出显著的抗肝纤维化效果。
T74432	Mongersen
	Mongersen (GED-0301)为特异性及口服活性SMAD7反义寡核苷酸，通过恢复TGF-β1活性来抑制炎症信号，能有效减轻小鼠克罗恩病样实验性结肠炎。
T72383	3,3-Dimethyl-1-butanol Neohexanol,DMB,DMB ; Neohexanol
	3,3-Dimethyl-1-butanol (DMB)是一种口服有效的三甲胺(TMA)和三甲基胺-N-氧化物(TMAO)抑制剂，能够抑制p65NF-κB和TGF-β1/Smad3信号通路，展示了在心血管疾病(CVD)中的潜在应用。
T74996	FXR agonist 3
	FXR agonist3 是一种抗 NASH 试剂，通过激活 FXR 起作用。FXR agonist3 抑制 COL1A1、TGF-β1、α-SMA 和 TIMP1的表达，具有抗纤维化活性。FXR agonist3 显著减轻肝脏脂肪变性和炎症，改善肝纤维化水平。
T79603	3,7-DMF	TGF-beta/Smad	Stem Cells
	3,7-DMF作为一种口服活性抑制剂，有效抑制了TGF-β1诱导的HSC活化，并通过诱导抗氧化基因及淬灭ROS为研究肝纤维化提供了潜在应用。
T73035	STAT3-IN-15
	STAT3-IN-15是一款有效、具口服活性的STAT3抑制剂，用于对抗特发性肺纤维化（IPF）。该化合物阻止STAT3磷酸化，同时抑制TGF-β1引起的上皮细胞迁移及变形，并防止上皮间质转化（EMT）。
T69990	Ruboxistaurin mesylate monohydrate
	Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T61029	TP0427736 hydrochloride
	TP0427736 hydrochloride 可用于雄激素性脱发 (AGA) 研究。TP0427736 hydrochloride 可抑制由 TGF-β1 诱导的 A549 细胞中 Smad2/3 的磷酸化，IC50值为 8.68 nM。它也是ALK5激酶的有效抑制剂，IC50值为 2.72 nM，比对 ALK3 836 nM 的抑制作用高 300 倍。
T82314	GK444	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GK444（Compound 15a），一种针对HDAC1/2的抑制剂，IC50分别为HDAC1和HDAC2的100 nM与92 nM。其对Caco-2细胞的IC50为4.1μM，并能下调原代正常人肺成纤维细胞中TGF-β1刺激的COL1A1 mRNA水平。此外，GK444还能抑制博来霉素诱发的小鼠肺纤维化。
T60854	ENMD-1068 hydrochloride
	ENMD-1068 hydrochloride 是一种选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。ENMD-1068 hydrochloride 可通过抑制TGF-β1/Smad 信号转导而减少肝星状细胞的活化和胶原蛋白的表达。ENMD-1068 hydrochloride 还能抑制子宫内膜细胞的增殖，并诱导病灶中上皮细胞的凋亡。ENMD-1068 hydrochloride 可用于子宫内膜异位症、肝纤维化的研究。
T21978	p-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T75717	Disitertide diammonium
	Disitertide (P144) diammonium 是转化生长因子TGFβ1的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide diammonium 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T75716	Disitertide TFA
	Disitertide (P144) TFA 是转化生长因子TGFβ1的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide TFA 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not Hep...
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。
T61585	Sulindac sodium
	Sulindac (sodium) (MK-231) 是一种非甾体抗炎剂，具有口服活性。Sulindac (sodium) 用于减轻疼痛，肿胀和关节僵硬的关节炎。Sulindac 还用于脊柱关节炎、痛风性关节炎的研究。Sulindac (sodium) 作为一种免疫调节剂，可通过阻断 NF-κB 信号通路下调 PD-L1，调节 pMMR CRC 对抗 PD-L1 免疫治疗的应答，抑制结直肠癌 CRC 的发生发展。 Sulindac 还可通过下调 SIRT1 抑制 TGF-β1-诱导的 EMT，抑制肺癌细胞的迁移和侵袭。

化合物

Cat.No: T3636

Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl

Target: TGF-beta/Smad

Cat.No: T0459

Synonym: Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

Cat.No: T61389

Target: TGF-beta/Smad

Cat.No: T73300

Target: FLT, TAM Receptor, PDGFR, TGF-beta/Smad

Cat.No: T1763

Synonym: SB525334

Target: ALK, TGF-beta/Smad

Cat.No: T38752

Target: ALK, TGF-beta/Smad

LCB 03-0110 dihydrochloride

Cat.No: T32613

Target: Src

Disitertide acetate

Cat.No: T11052L

Synonym: P144 acetate,Disitertide acetate(272105-42-7 Free base)

Target: TGF-beta/Smad

Cat.No: T9953

Target: Others

Cat.No: T11793

Target: Wnt/beta-catenin

Cat.No: T62483

Target: TGF-beta/Smad

pm26TGF-β1 peptide

Cat.No: T76066

pm26TGF-β1 peptide TFA

Cat.No: T76066L

Mitochonic Acid 35

Cat.No: T24470

Synonym: MA35,MA-35,MA 35,Mitochonic Acid-35

(Rac)-SIS3 free base

Cat.No: T12923

Target: TGF-beta/Smad

Cat.No: T80272

Synonym: SB-01

Cat.No: T11052

Synonym: P144

Target: Others

H-Leu-Ser-Lys-Leu-OH

Cat.No: T76498

Bexotegrast HCl

Cat.No: T69517

LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)

Cat.No: TP2147

Target: Others

Cat.No: T79789

Target: TGF-beta/Smad

Cat.No: T77189

Ruboxistaurin mesylate

Cat.No: T3689L

Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Cat.No: T78944

Cat.No: T74432

3,3-Dimethyl-1-butanol

Cat.No: T72383

Synonym: Neohexanol,DMB,DMB ; Neohexanol

Cat.No: T74996

Cat.No: T79603

Target: TGF-beta/Smad

Cat.No: T73035

Ruboxistaurin mesylate monohydrate

Cat.No: T69990

TP0427736 hydrochloride

Cat.No: T61029

Cat.No: T82314

Target: HDAC

ENMD-1068 hydrochloride

Cat.No: T60854

p-nitro-Pifithrin-α

Cat.No: T21978

Disitertide diammonium

Cat.No: T75717

Disitertide TFA

Cat.No: T75716

Cat.No: T63776

ß-Carboline-1-carboxylic acid

Cat.No: T71884

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Sulindac sodium

Cat.No: T61585

Cat. No.	Product Name	Target	Signaling Pathways
T13741	Isoviolanthin 异佛莱心苷,异佛来心苷	Others	Others
	Isoviolanthin 是一种黄酮类苷类化合物，提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力，对正常细胞没有毒性影响，对转移性肝癌晚期具有潜在的研究价值。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
T0518	Methacycline hydrochloride Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Methacycline hydrochloride (Rondomycin) 是四环素抗生素，可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT，体内抑制纤维发生，不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂，有潜力研究肺纤维化。
TN1471	Cassiaside C 决明子苷C,Toralactone 9-O-β-D-gentiobioside	Others; Endogenous Metabolite	Metabolism; Others
	Cassiaside C (Toralactone 9-O-β-D-gentiobioside) 是一种萘酚类化合物，从决明子种子中分离得到，对晚期糖基化终产物 (AGE) 的形成具有抑制作用。
T3876	Loureirin B 龙血素B,龙血素 B	PAI-1; ERK; Potassium Channel; JNK	MAPK; Membrane transporter/Ion channel; Metabolism
	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
T5688	Micheliolide	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Micheliolide 是一种倍半萜内酯，能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化，IκBα的降解，和MCP-1，TGF-β1，FN 在鼠系膜细胞的表达。
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T4938	Potassium 1H-indol-3-yl sulfate 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂，Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚，吲哚被吸收到血液中，然后在肝脏中进一步代谢为硫酸吲哚，通常通过尿液排出体外。在肾功能受损的慢性肾病患者中，Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累，诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化，促进大鼠近端小管细胞TGF-β1和Smad3的表达，与促纤维化活性相关。
T72798	Ganodermaones B
	Ganodermaones B 是一种肾纤维化抑制剂，抑制 TGF-β1诱导的 collagen I 和 fibronectin 的表达。
TMA1743	Ergosterol peroxide	ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to

天然产物

Cat.No: T13741

Synonym: 异佛莱心苷,异佛来心苷

Target: Others

Cat.No: TN1644

Target: Others

Methacycline hydrochloride

Cat.No: T0518

Synonym: Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

Cat.No: TN1471

Synonym: 决明子苷C,Toralactone 9-O-β-D-gentiobioside

Target: Others, Endogenous Metabolite

Cat.No: T3876

Synonym: 龙血素B,龙血素 B

Target: PAI-1, ERK, Potassium Channel, JNK

Cat.No: T5688

Target: NOS, NF-κB, COX

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Potassium 1H-indol-3-yl sulfate

Cat.No: T4938

Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

Target: AhR, Endogenous Metabolite

Ganodermaones B

Cat.No: T72798

Ergosterol peroxide

Cat.No: TMA1743

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00500	Latent TGF beta 1 Protein, Mouse, Recombinant (His) transforming growth factor, beta 1,TGF β1,...	Mouse	HEK293 Cells
	Latent TGF beta 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202.
TMPY-01133	Latent TGF beta 1 Protein, Human, Recombinant (His) CED,DPD1,transforming growth factor, beta 1,TGF	Human	HEK293 Cells
	Latent TGF beta 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2.
TMPY-00608	TGF beta 1 Protein, Rat/Mouse, Recombinant transforming growth factor, beta 1,transforming growth facto...	Mouse,Rat	HEK293 Cells
	TGF beta 1 Protein, Rat/Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.8 kDa.
TMPY-04211	Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) transforming growth factor, β1,TGF β1<...	Cynomolgus	HEK293 Cells
	Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa.
TMPY-03945	Latent TGF beta 1 Protein, Rat, Recombinant (His) TGF β1,transforming growth factor, β1<...	Rat	HEK293 Cells
	Latent TGF beta 1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P17246.
TMPY-02638	TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant transforming growth factor, beta 1,转化生长因子,transforming growt...	Human,Rhesus,Cynomolgus,Canine	CHO Cells
	TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.8 kDa and the accession number is A0A499FJK2.
TMPJ-00249	TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated TGF-Beta-1,TGFB1,Transforming Growth Facto...	Human	HEK293 Cells
	Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family...
TMPY-06355	Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) 转化生长因子,TGF β1 & GARP Heterotrimer	Human	HEK293 Cells
	Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 108.72 kDa and the accession number is P01137.
TMPY-05521	Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated TGFB,TGF β1,转化生长因子,TGF-b...	Human	HEK293 Cells
	Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.4 kDa and the accession number is A0A499FJK2.
TMPY-05313	Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated transforming growth factor, beta 1,transforming growth facto...	Mouse	HEK293 Cells
	Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.7 kDa and the accession number is P04202.
TMPJ-00771	TGF beta 1 Protein, Mouse/Rat, Recombinant TGFB,TGFbeta,CEDLAP,TGF-beta-1,	Mouse,Rat	HEK293 Cells
	Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)...
TMPY-00229	Latent TGF beta 1 Protein, Canine, Recombinant (His) transforming growth factor, β1,transforming growth ...	Canine	HEK293 Cells
	Latent TGF beta 1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa.
TMPJ-00250	LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated transforming growth factor β1,TGFβ,CED,	Human	HEK293 Cells
	Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with ...
TMPJ-00772	Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated Transforming growth factor β-1,Latent TGF-β1	Mouse	HEK293 Cells
	Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-8xHis-Avi tag. The predicted molecular weight is 13 and 35-45 KDa and the accession number is P04202.
TMPJ-00622	Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) 转化生长因子,Transforming growth factor β-1,Latent TGF-	Cynomolgus	HEK293 Cells
	Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 11 and 35-45 KDa and the accession number is F7HCV5.
TMPJ-00968	NAMPT Protein, Human, Recombinant (His) PBEF,PBEF1,Nicotinamide phosphoribosyltransferase,NAmPRTase,...	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...

重组蛋白

Latent TGF beta 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00500

Species: Mouse

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01133

Species: Human

Expression System: HEK293 Cells

TGF beta 1 Protein, Rat/Mouse, Recombinant

Cat.No: TMPY-00608

Species: Mouse,Rat

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-04211

Species: Cynomolgus

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03945

Species: Rat

Expression System: HEK293 Cells

TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant

Cat.No: TMPY-02638

Species: Human,Rhesus,Cynomolgus,Canine

Expression System: CHO Cells

TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00249

Species: Human

Expression System: HEK293 Cells

Latent TGF beta 1 & GARP Heterotrimer Protein, Human, Recombinant (His)

Cat.No: TMPY-06355

Species: Human

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05521

Species: Human

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05313

Species: Mouse

Expression System: HEK293 Cells

TGF beta 1 Protein, Mouse/Rat, Recombinant

Cat.No: TMPJ-00771

Species: Mouse,Rat

Expression System: HEK293 Cells

Latent TGF beta 1 Protein, Canine, Recombinant (His)

Cat.No: TMPY-00229

Species: Canine

Expression System: HEK293 Cells

LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00250

Species: Human

Expression System: HEK293 Cells

Latent TGF-beta 1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00772

Species: Mouse

Expression System: HEK293 Cells

Latent TGF-beta 1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-00622

Species: Cynomolgus

Expression System: HEK293 Cells

NAMPT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00968

Species: Human

Expression System: E. coli

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