108
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7695 |
PNU-282987 S enantiomer free base
|
AChR | Neuroscience |
PNU-282987 S enantiomer free base 是 PNU-282987 的 S 型对映体,是 α7 烟碱乙酰胆碱受体的激动剂。 | |||
T10819 |
Cipropride S enantiomer
|
Others | Others |
Cipropride S enantiomer 是止吐药环普必利的S 对映体。 | |||
T7058 |
Selisistat S-enantiomer
EX-527 S-enantiomer,(1S)-6-氯-2,3,4,9-四氢-1H-咔唑-1-甲酰胺,EX-527 (S-enantiomer) |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Selisistat S-enantiomer (EX-527 S-enantiomer) 是一种选择性的SIRT1抑制剂,IC50值为 98 nM。 | |||
T17102 |
Tipifarnib (S enantiomer)
Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase | Metabolism |
Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体,它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂,IC50=0.6 nM。 | |||
T80678 |
(S)-AK-242
(-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242 |
Others | Others |
(S)-AK-242 ((S)-Resatorvid) 是一种细胞因子抑制剂,可用于治疗心脏病、自身免疫性疾病、炎症性疾病。 | |||
T6156 |
Ruxolitinib (S enantiomer)
S-Ruxolitinib,环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯,Ruxolitinib S enantiomer,INCB018424,INCB18424 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Ruxolitinib S enantiomer (INCB18424) 是 Ruxolitinib 的 S 型对映体,是一种JAK 抑制剂。 | |||
T11335 |
Fulvestrant (S enantiomer)
ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer |
Others | Others |
Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. | |||
T12200 |
Firsocostat S enantiomer
ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer |
Others | Others |
Firsocostat S enantiomer is the less active S enantiomer of Firsocostat. | |||
T11391 |
Gepotidacin S enantiomer
GSK2140944 S enantiomer |
Others | Others |
Gepotidacin S enantiomer is an S enantionmer of gepotidacin. | |||
T11173 |
Elacestrant S enantiomer
RAD1901 S enantiomer |
Others | Others |
Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. | |||
T22401 |
PNU-282987 S enantiomer hydrochloride
(S)-PNU-282987 HCl |
Others | Others |
(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible activity against α1β1γδ and α3β4 nAC | |||
T10465 |
Atuveciclib S-Enantiomer
BAY-1143572 S-Enantiomer |
CDK | Cell Cycle/Checkpoint |
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是 BAY-1143572的 S-对映异构体 ,是一种有效的选择性 CDK9抑制剂,抑制 CDK9/CycT1,IC50为 16 nM。 | |||
T11156 |
Nazartinib S-enantiomer
EGF816 (S-enantiomer) |
Others | Others |
Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib. | |||
T10757 |
Cenobamate S-Enantiomer
|
Others | Others |
Cenobamate S-Enantiomer is a Cenobamate's S-enantiomer. | |||
T11173L |
Elacestrant S enantiomer dihydrochloride
RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride |
Others | Others |
Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride. | |||
T12067 |
MK-7246 S enantiomer
|
Others | Others |
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist. | |||
T11628 |
IACS-8968 S-enantiomer
IDO/TDO Inhibitor (S-enantiomer) |
IDO | Metabolism |
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). | |||
T12203 | Necrostatin 2 S enantiomer | Others | Others |
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 | |||
T11378 |
GDC-0834 S-enantiomer
|
Others | Others |
GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). | |||
T11902 |
LY 344864 S-enantiomer
|
Others | Others |
LY 344864 S-enantiomer, the S-enantiomer of LY344864, serves as a 5-HT1F receptor agonist. | |||
T10517 |
BET-BAY 002 (S enantiomer)
|
Others | Others |
BET-BAY 002 S enantiomer为BET-BAY 002的S型对映异构体,属于BET小分子抑制剂。 | |||
T13294 |
Veledimex (S enantiomer)
RG-115932 S enantiome,INXN-1001 S enantiome |
Others | Others |
Veledimex S enantiomer is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system and CYP3A4/5 inhibitor. | |||
T9848 |
GSK2850163 (S enantiomer)
|
IRE1 | Cell Cycle/Checkpoint |
GSK2850163 (S enantiomer) 是 GSK2850163 的无活性对映体。GSK2850163 是一种新型的肌醇需求酶-1α (IRE1a) 抑制剂。 | |||
T10297 | AMG 487 (S-enantiomer) | Others | Others |
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist. | |||
T0448 |
(S)-(+)-Ibuprofen
左旋布洛芬,Dexibuprofen,(S)-Ibuprofen,(S)-(+)-布洛芬 |
BCL; Thrombin; Cysteine Protease; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome |
(S)-(+)-Ibuprofen (Dexibuprofen) 是 Ibuprofen 的 S(+)-对映异构体,能够有效的抑制COX-1(IC50:2.1 μM)和COX-2(IC50:1.6 μM),。它具有抗癌、退热、止痛,抗炎的效果。 | |||
T6493 |
Escitalopram Oxalate
草酸右旋西酞普兰,依他普仑草酸盐,Cipralex,(S)-(+)Citalopram oxalate |
Others; 5-HT Receptor; Serotonin Transporter | GPCR/G Protein; Neuroscience; Others |
Escitalopram Oxalate ((S)-(+)Citalopram oxalate) 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。 | |||
T75251 | Firsocostat (S enantiomer) | ||
Firsocostat S enantiomer (ND-630 S enantiomer) 是 Firsocostat 的低活性的 S 型异构体。Firsocostat 是乙酰辅酶 A 羧化酶抑制剂。 | |||
T11662 |
INT-777 R-enantiomer
S-EMCA R enantiomer |
Others | Others |
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. | |||
T13869 |
Ribocil B
Ribocil S enantiomer,ent-Ribocil A |
Others | Others |
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN,KD of 6.6 nM). | |||
T10252L |
ADU-S100 enantiomer ammonium salt
MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt |
Others | Others |
ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). | |||
T12814 |
(S)-Tenofovir
(S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF |
Others | Others |
(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体,Tenofovir 是一种核苷酸逆转录酶抑制剂。 | |||
T12632L |
(S)-Mirtazapine
(S)-6-Azamianserin,(S)-Org3770 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
(S)-Mirtazapine ((S)-Org3770) 是 Mirtazapine 的 S(+)-对映体。(S)-Mirtazapine 是一种选择性 5-HT2 受体拮抗剂,具有促痛觉作用,常与Mirtazapine 的 R(-)-对映体混合使用来研究抑郁症。 | |||
T39979 |
(S)-ErSO
|
Others | Others |
(S)-ErSO 是 ErSO 的无活性右旋对映异构体。 | |||
T12809 |
(S)-PF-06873600
|
CDK | Cell Cycle/Checkpoint |
(S)-PF-06873600 是 CDK 抑制剂 PF-06873600 的 S 对映体。 | |||
T22359 |
MDL 100009
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
MDL 100009 是 MDL 100151 的 S-对映体和 MDL 100907 的相反对映体,是 5-HT2A 的选择性拮抗剂。 | |||
T1211 |
Levosulpiride
RV-12309,左旋舒必利,左舒必利,S-(-)-Sulpiride |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Levosulpiride (S-(-)-Sulpiride) 是 Sulpiride 的(S)对映体,是一种多巴胺 D2受体拮抗剂。 | |||
T6566 |
Levobupivacaine hydrochloride
Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) 是有效的钠通道阻滞剂。 | |||
T10003 |
α1 adrenoceptor-MO-1
|
Others | Others |
α1 adrenoceptor-MO-1(S 对映体)对α1肾上腺素受体具有亲和力,具有抗α-肾上腺素能和镇痛作用。α1 adrenoceptor-MO-1比R 对映体更具活性。 | |||
T10012 |
P7C3-OMe
|
Others | Others |
P7C3-OMe 是促神经原性化合物,其 R-对映体活性远高于 S-对映体。可以用于研究神经精神疾病和神经退行性疾病。 | |||
T22148 |
(S)-Lisofylline
|
Others | Others |
(S)-Lisofylline 是抗炎剂 (R)-lisofylline 的非活性光学对映异构体。 (S)-Lisofylline 在人肝微粒体中专门转化为己酮可可碱。 | |||
T6038 |
(-)-Blebbistatin
(S)-(-)-Blebbistatin |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
(-)-Blebbistatin ((S)-(-)-Blebbistatin) 是 blebbistatin 的 S 对映异构体。它是一种有效的选择性肌球蛋白 II 抑制剂,IC50 范围为 0.5 至 5 μM。 | |||
T4295 |
(R)-GNE-140
GNE-140 |
Dehydrogenase | Metabolism |
(R)-GNE-140 (GNE-140) 是 LDHA 抑制剂,能够作用于 LDHA (IC50:3 nM) 和 LDHB (IC50:3 nM)。它的活性是 S 型异构体的 18 倍。 | |||
T22354 |
Levocetirizine Dihydrochloride
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria. | |||
T6357 |
(S)-crizotinib
ent-crizotinib |
Apoptosis; DNA/RNA Synthesis; MTH1 | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
(S)-crizotinib (ent-crizotinib) 是一种选择性MTH1(mutT 同源物)抑制剂,IC50为 330 nM。它通过抑制 MTH1 破坏核苷酸库的稳态,诱导 DNA 单链断裂的增加,激活人结肠癌细胞的 DNA 修复,在动物模型中抑制肿瘤生长。 | |||
T9828 | N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide | PAD | Chromatin/Epigenetic |
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide 是Cl-amidine (S 构型)的消旋形式。Cl-amidine 口服有效的 PAD 抑制剂。 | |||
T6649 |
(S)-(+)-Rolipram
(S)-Rolipram,(+)-Rolipram,盐酸环胞苷,S- (+)-Rolipram |
Apoptosis; PDE | Apoptosis; Metabolism |
(S)-(+)-Rolipram ((+)-Rolipram) 是一种 cAMP 依赖性磷酸二酯酶 4 (PDE4) 抑制剂,IC50=1100 nM。它能够抑制人单核细胞产生的肿瘤坏死因子 α (TNFα)。 | |||
T1545 |
Levamlodipine
左旋氨氯地平,(S)-Amlodipine,S-amlodipine |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levamlodipine (S-amlodipine) 是一种二氢吡啶钙通道阻滞剂,具有舒张血管的作用,可用于高血压和心绞痛的研究。 | |||
T4284 |
Levamlodipine besylate
左旋氨氯地平,(S)-Amlodipine Besylate (103129-82-4(free base)) |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levamlodipine besylate ((S)-Amlodipine Besylate(103129-82-4(free base))) 是一种二氢吡啶钙通道阻滞剂,具有舒张血管的作用,可用于高血压和心绞痛的研究。 | |||
T20828 |
Citalopram
Cipram,Lu 10-171,Lu-10-171 Lu10-171 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Citalopram (Lu 10-171) 是一种具有口服活性的、选择性的血清素再摄取抑制剂 (SSRI),是一种选择性5-羟色胺再摄取抑制剂,是一种 S(+)-对映体 (Escitalopram) 和 R(-)-对映体的外消旋混合物。Citalopram 具有抗抑郁活性,可增强血清素能神经传递,可用于研究老年痴呆。 | |||
T1787 |
Levobupivacaine
|
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0185 |
Escitalopram
Seroplex,依他普仑,S-(+)-Citalopram,艾司西酞普兰,(S)-Citalopram |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Escitalopram (Seroplex) 是一种外消旋 Citalopram 的 S-对映体,是一种选择性 5-羟色胺再摄取抑制剂,Ki=0.89 nM,比 R(-)-enantiomer 结合亲和力高 30 倍。它对多巴胺转运体和去甲肾上腺素转运体均有选择性,是一种研究抑郁症的抗抑郁药。 | |||
T12796 |
S-Dihydrodaidzein
S-二氢大豆苷元,(3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one |
Others | Others |
S-Dihydrodaidzein ((3S)-7-hydroxy-3-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one) 是一种 dihydrodaidzein 的 (S) 型对映体。其中 dihydrodaidzein 是一种可食用性植物雌激素。 | |||
T4000 |
(±)-Equol
Equol,(±)-雌马酚,(R,S)-Equol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Drug Metabolite | Endocrinology/Hormones; Metabolism |
(±)-Equol ((R,S)-Equol) 是 equol 的外消旋体。它对 ERα 和 ERβ 的 EC50s of 分别为 200 和 74 nM。Equol 是大豆异黄酮黄豆苷和大豆黄素的代谢产物。 | |||
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
T40576 |
(S)-Salsolidine
|
||
(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form. |