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Cat. No. | Product Name | Target | Signaling Pathways |
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T41302 |
Itaconate-alkyne
ITalk |
Others | Others |
Itaconate-alkyne (ITalk) 是一种生物正交探针,用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析,并能够对其直接靶标进行生化评估和蛋白质组学分析。 | |||
T27730 |
KGP94
KGP-94,KGP 94 |
Cysteine Protease | Proteases/Proteasome |
KGP94 是一种有效的、选择性的和竞争性的溶酶体内肽酶抑制剂。 | |||
T1031 |
Cloxacillin sodium monohydrate
Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cloxacillin sodium monohydrate (Cloxacillin Sodium) 有抗菌作用,对Staphylococcus aureus25923 的最小抑菌浓度为256 mg/L。 | |||
TP1938L |
RS09 2TFA (1449566-36-2 free base)
RS09 2TFA 1449566-36-2(free base) |
TLR | Immunology/Inflammation |
RS09 2TFA (1449566-36-2 free base) 是一种 TLR4 激动剂。促进 NF-κB 核转位并在体外诱导 RAW264.7 巨噬细胞分泌炎性细胞因子。它在体内充当佐剂并提高 X-15 特异性抗体血清浓度。 | |||
T82229 |
HD-2a
|
||
HA-2a通过降低RAW264.7细胞内circDcbld2的表达,从而抑制JAK2/STAT3信号传导途径。 | |||
T61157 |
ABAI-30
|
||
ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1]. | |||
T25356 |
E17110
E-17110,E 17110 |
||
E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages. | |||
T83049 | Anti-inflammatory agent 63 | ||
Anti-inflammatory agent 63,在RAW264.7细胞中对脂多糖 (LPS) 诱导的一氧化氮 (NO) 产生显示最佳抑制效果,其半抑制浓度(EC50)为5.33±0.57 μM。 | |||
T79999 |
NF-κB-IN-13
|
NF-κB | NF-κB |
NF-κB-IN-13(compound 12)在RAW264.7巨噬细胞中显著抑制了LPS诱导的NF-κB激活以及NO生成,表现出其抗炎效果。 | |||
T73061 |
Amakusamine
|
||
Amakusamine以IC50值为10.5 μM,抑制NF-κB配体受体激活剂(RANKL)在RAW264.7细胞中诱导的多核破骨细胞形成。 | |||
T79130 | COX-2-IN-32 | NF-κB | NF-κB |
COX-2-IN-32(Compound 2f)为一种抑制iNOS和COX-2的化合物,能够降低NF-κB表达,并抑制LPS诱导的RAW264.7巨噬细胞中NO产生,显示出抗炎活性(IC50: 11.2 μM)。 | |||
T78056 |
HMGB1-IN-1
|
||
HMGB1-IN-1(化合物6)在RAW264.7细胞中具有显著的NO抑制活性,其IC50为15.9 ± 0.6 μM。该化合物能够抑制HMGB1/NF-κB/NLRP3信号通路,并且在肾损伤模型中展现出优异的抗炎及抗脓毒症效果。 | |||
T78750 |
NF-κB-IN-10
|
NF-κB | NF-κB |
NF-κB-IN-10(化合物E1)是一种调节Nrf2/NF-κB信号通路的NF-κB抑制剂,能减少氧化应激与炎症,有助于心力衰竭治疗。它可抑制RAW264.7细胞LPS诱导的NO生成,并降低iNOS和COX-2的表达,适用于心血管疾病研究。 | |||
TP1938 |
RS 09
|
TLR | Immunology/Inflammation |
RS 09 是一种 LPS 肽模拟物,是 TLR4 激动剂佐剂,可在疫苗环境中增加抗体产量。 | |||
T75952 | RS 09 TFA | ||
RS 09 TFA是一种TLR4激动剂,能在体外RAW264.7巨噬细胞中促进NF-κB核易位并诱导炎性细胞因子的分泌。作为体内佐剂,与X-15-KLH联用时,RS 09 TFA能在小鼠中提高X-15特异性抗体的血清浓度。 | |||
T60433 | NF-κB-IN-6 | ||
NF-κB-IN-6 (Compound 3d) 是通过抑制NF-κB 信号通路减少 iNOS 和 COX-2 蛋白的表达的抗炎剂。NF-κB-IN-6 抑制脂多糖诱导的 RAW264.7 细胞中 NO 的生成,IC50值为 23.1 μM。 | |||
T79619 | Anti-inflammatory agent 54 | ||
Anti-inflammatory agent 54 (compound 9c),作为薏苡醇 (Coixol) 的衍生物,显示出显著的抗炎效果。它通过抑制NF-κB通路,降低iNOS、TNF-α、IL-6和IL-1β的表达,进而在LPS诱导的RAW264.7巨噬细胞中降低一氧化氮 (NO) 生成(IC50: 2.4 μM)。此外,该化合物在小鼠耳廓水肿模型中表现出了体内抗炎活性。 | |||
T64210 |
ATX inhibitor 13
|
||
ATX inhibitor 13 (compound 10c) 是一种口服具有活力的 ATX 抑制剂 (IC50: 3.4 nM)。ATX inhibitor 13 能够将RAW264.7 细胞的细胞周期阻滞在 G2 期,抑制细胞的增殖和迁移,诱导细胞凋亡。ATX inhibitor 13 对肿瘤细胞集落形成表现出抑制作用。 | |||
T79620 | Anti-inflammatory agent 55 | ||
Anti-inflammatory agent 55 (compound 9j) 作为薏苡醇 (Coixol) 的衍生物,展现出显著的抗炎活性。该化合物通过抑制NF-κB途径,有效下调iNOS、TNF-α、IL-6及IL-1β的表达水平。其中,Anti-inflammatory agent 54 能够在RAW264.7巨噬细胞中通过抑制LPS诱导的NO产生(IC50: 0.8 μM)来发挥其抗炎作用,并在小鼠耳廓水肿模型中证实了其体内抗炎效果。 | |||
T62317 | α7 nAchR-JAK2-STAT3 agonist 1 | ||
α7 nAchR-JAK2-STAT3 agonist 1 是一种 α7 nAchR-JAK2-STAT3 通路的有效抑制剂,能够作用于一氧化氮 (NO) (IC50: 0.32 μM)。α7 nAchR-JAK2-STAT3 agonist 1 在小鼠巨噬细胞 RAW264.7 中对 iNOS、IL-1β 和 IL-6 的表达具有有效的抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 对 LPS 诱导的 NO 释放、NF-κB 激活和细胞因子产生具有抑制作用。α7 nAchR-JAK2-STAT3 agonist 1 能够用于研究败血症。 | |||
T82189 |
HMGB1-IN-2
|
||
HMGB1-IN-2 (compound 15) 是一种针对高度保守的核蛋白 HMGB1 的抑制剂,其在 RAW264.7 细胞中展现出 NO 抑制活性,IC50 为 20.2 μM。 HMGB1-IN-2 (30 μM) 能够减少 IL-1β、TNF-α、caspase-1 p20 的表达,并抑制 NF-κB p65 的磷酸化作用,显示出抗凋亡特性。在脓毒症急性肾损伤模型的小鼠中,HMGB1-IN-2(15 mg/kg;腹腔注射)可有效减轻肾脏伤害。此外,HMGB1-IN-2 对 Huh7 细胞和 A549 细胞的 IC50 分别为 77.0 μM 和 82.0 μM。 | |||
T36486 |
Benpyrine
|
||
Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo... | |||
T37614 |
LDN-0088050
|
||
LDN 0088050 is selectivity adipocyte fatty acid binding protein (AFABP, FABP4) inhibitor with Ki values of 0.29 and 1.3 μM for FABP4 and FABP3, respectively. LDN 0088050 binds to FABP4 with a Kd of 2.05 μM[1]. Ki: 0.29 μM (FABP4), 1.3 μM (FABP3)[1]Kd: 2.05 μM (FABP4)[1] LDN 0088050 significantly inhibits LPS-induced expression of both TNFα and IL-6 in RAW264.7 cells[1]. [1]. Zhou Y, et al. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biolo... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1109 |
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸 |
NOS; NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) 是三萜类化合物。它能够作用于 LPS 刺激的 Raw264.7 细胞,减少NO 产生和 iNOS 表达,具有消炎作用。 | |||
TN6750 |
2-tert-Butyl-1,4-benzoquinone
|
Nrf2 | Immunology/Inflammation |
2-tert-Butyl-1,4-benzoquinone 是丁基化羟基茴香醚 (BHA) 的亲电子代谢物,它在 RAW264.7 细胞中引起 Nrf2 的活化及其负调节剂 Keap1 的 S-芳基化。 | |||
T5727 |
CAFESTOL
咖啡醇,咖啡油醇 |
ERK; NF-κB; COX; PGE Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Cafestol 是咖啡特有的一种二萜,可靶向 AP-1 抑制ERK,有化学预防、抗肿瘤、保肝、抗氧化和抗炎作用。它通过抑制NF-kB 活化途径强烈的抑制 PGE2的产生,还抑制 LGE 激活的 RAW264.7 细胞中的PGE2产生和环氧合酶(COX-2)的 mRNA 表达。 | |||
TN2167 |
Rutaevin
|
Reactive Oxygen Species; NO Synthase | Immunology/Inflammation; Metabolism; NF-κB |
Rutaevin 从Euodia rutaecarpa 中分离。它对 Raw 264.7 巨噬细胞中 LPS 诱导的NO 产生具有抑制作用。 | |||
T5S0581 |
Sec-O-Glucosylhamaudol
亥茅酚苷,Hamaudol 3-glucoside |
Others; Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others |
Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物,能够降低 μ 阿片受体的蛋白水平,可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。 | |||
T6S1543 |
Dehydrodiisoeugenol
去氢二异丁香酚,脱氢二异丁香酚 |
Others; NF-κB; COX; Antibacterial | Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Others |
Dehydrodiisoeugenol 是从Myristica fragrans Houtt 中分离得到的天然产物,具有抗炎和抗菌作用。它抑制 LPS 刺激的小鼠巨噬细胞中NF-κB 活化和环氧合酶 (COX)-2 基因的表达。 | |||
T3927 |
Phellopterin
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Phellopterin 是一种分离自P. trifoliata 中的天然产物。它能够调节 Akt 和 PKC 通路,抑制 TNF-alpha 诱导的 VCAM-1 表达,进而减少单核细胞与内皮细胞的粘附。 | |||
T6S0139 |
Neobavaisoflavone
|
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
TN1712 |
Gossypin
|
NF-κB; S6 Kinase | MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。 | |||
T2S1907 |
Coniferaldehyde
Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,松柏醛,Coniferyl aldehyde,松柏醛;4-羟基-3-甲氧基肉桂醛 |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Coniferaldehyde (Ferulaldehyde) 是一种血红素加氧酶-1 的有效诱导剂,具有抗炎作用。在 RAW264.7 巨噬细胞中,它通过 PKCα/βII/Nrf-2/HO-1 依赖性途径来抑制 LPS 诱导的细胞凋亡。 | |||
T4S1615 |
Sanggenon C
桑根酮C,桑根酮 C,Sanggenone C |
NF-κB | NF-κB |
Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性,抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达,以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 它具有抗氧化和抗炎作用,也有抑制胰脂肪酶作用。 | |||
T38820 |
Methylsyringin
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Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells. | |||
TMA1241 | Apterin | Others | Others |
Apterin has anti-inflammatory activity in vitro, it shows significantly inhibitory activity on nitric oxide production in RAW264.7 cells. | |||
TN4244 |
Icariside B1
淫羊藿次甙B1 |
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells. | |||
T72578 |
Siegesbeckialide I
|
||
Siegesbeckialide I 在 RAW264.7 细胞中通过直接结合IKKα/β有效地抑制 LPS 诱导的 NO 生成。 | |||
TN3241 | 7-O-Acetylbonducellpin C | Others | Others |
7-O-Acetylbonducellpin C may exhibit significant inhibition of nitric oxide production of RAW264.7 macrophages stimulated by lipopolysaccharide (LPS). | |||
TN4633 |
Neocryptotanshinone II
|
NOS; NF-κB | Immunology/Inflammation; NF-κB |
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. | |||
T75615 | Inflexuside B | ||
Inflexuside B为一种冷杉烷二萜,其源自蛇床子地上部分的提取。本化合物在RAW264.7巨噬细胞中,可显著抑制由脂多糖(LPS)激活产生的一氧化氮(NO Synthase)。 | |||
TN4047 | Excisanin B | Others | Others |
Excisanin B shows inhibitory effects on LPS-induced production of nitric oxide in murine macrophage RAW264.7 cells. | |||
TN1638 |
Evodol
|
Others | Others |
Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoe | |||
T79992 |
Sarglaroids F
|
Caspase | Apoptosis; Proteases/Proteasome |
Sarglaroids F(化合物6)为从草珊瑚根部提取的抗炎剂,影响K+外排并降低Caspase-1(P20)水平以抑制LPS/ATP诱导的IL-1β释放,对RAW264.7细胞无细胞毒性。 | |||
T75616 | Inflexuside A | ||
Inflexuside A为一种可从蛇床子地上部分提取的冷杉烷二萜。Inflexuside B在RAW264.7巨噬细胞中强烈抑制由脂多糖(LPS)激活的一氧化氮(NO Synthase)产生。 | |||
TQ0073 |
Andropanolide
|
HIV Protease; NO Synthase; Parasite | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Andropanolide 是一种来自穿心莲的二帖类化合物,具有抗HIV、抗疟和抗癌活性,对 Lipopolysaccharides (LPS) 刺激的 RAW264.7 巨噬细胞中一氧化氮 (NO) 的过量产生有抑制作用。 | |||
T79930 |
Sanggenon A
Sanggenone A |
NF-κB | NF-κB |
Sanggenon A通过调控BV2和RAW264.7细胞中的NF-κB及HO-1/Nrf2信号途径,展现了抗炎效果。该化合物明显抑制了由脂多糖(LPS)引起的一氧化氮产生。 | |||
T75691 | Amaroswerin | ||
Amaroswerin为从獐牙菜提取的硫环烯醚萜苷,显示出抗炎、抗糖尿病、抗病毒、抗胆碱能及免疫调节生物活性。在RAW264.7细胞模型中,Amaroswerin能够抑制NO的释放,其IC50值达到5.42 μg/mL。 | |||
TN4146 | Glutinol acetate | TNF | Apoptosis |
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. | |||
T79970 |
Taxamairin B
|
||
Taxamairin B是有效的抗炎化合物,能显著抑制LPS诱导的RAW264.7细胞中促炎因子(TNF-α, IL-1β和IL-6)表达及NO、ROS生成,并对LPS引起的急性肺损伤模型小鼠具有保护效果。 | |||
TN4635 | Neoechinulin A | NADPH-oxidase; Beta Amyloid; ASK; IκB/IKK; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu | |||
TN4580 |
Morachalcone A
|
Tyrosinase | Proteases/Proteasome |
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai | |||
TN4064 |
Flavoglaucin
|
Phosphatase; IL Receptor; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato | |||
TN4411 |
Lappaol F
|
CDK; P-gp; JNK | Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju |