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62

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0026	MDR-1339 DWK-1339	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	MDR-1339 是口服有效Aβ聚集抑制剂，可透过血脑屏障的。MDR-1339可用于阿尔兹海默症的研究。
T22360	MDR-652	TRP/TRPV Channel	Membrane transporter/Ion channel
	MDR-652是瞬时受体电位香草酸亚型 1 的选择性激动剂，对 hTRPV1 和 rTRPV1 的Ki 分别为 11.4 和 23.8 nM，EC50分别为 5.05 和 93 nM。MDR-652在缓解疼痛方面有研究的价值。
T11888	LtaS-IN-1	Others; Antibacterial	Microbiology/Virology; Others
	LtaS-IN-1 是多药耐药粪肠球菌中脂磷壁酸合成的有效抑制剂，可改变细胞壁形态。 LtaS-IN-1 对抗肠球菌属 28 菌株，MIC 值从 0.5 μg/mL 到 64 μg/mL 不等。 LtaS-IN-1 抑制菌株 E1630 和 E1590，MIC 值为 0.5 μg/mL。
T41248	Thiocolchicine	Microtubule Associated	Cytoskeletal Signaling
	Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T6685	Sulbactam sodium 舒巴坦钠,CP-45899-2	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam sodium (CP-45899-2) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂。它具有抗菌活性，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T1631	Sulbactam CP45899,舒巴坦,舒巴坦酸	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T11983	MDRTB-IN-1	Others	Others
	MDRTB-IN-1 (5aα) is an antibiotic which is against Mycobacterium tuberculosis H37Rv(MIC90 :10.5 μM).
T17216	Valspodar PSC 833	P-gp	Membrane transporter/Ion channel; Neuroscience
	Valspodar (PSC 833) 是一种特异性的 P-糖蛋白抑制剂和MDR调节剂，常被用作化学增敏剂，可用于研究晚期上皮卵巢癌。
T16098	Islatravir MK-8591	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Islatravir (MK-8591) 是一种核苷逆转录酶抑制剂，是抗HIV-1药物，对 HIV-1 (WT)，HIV-1 (M184V)，HIV-1 (MDR) 的EC50值分别为 0.068 nM，3.1 nM 和 0.15 nM。
T11071	Dofequidar fumarate MS-209	P-gp	Membrane transporter/Ion channel; Neuroscience
	Dofequidar fumarate (MS-209) 是口服活性的喹啉化合物，通过抑制 ABCB1/P-gp 和 ABCC1/MDR 相关蛋白 1 来克服 MDR。
T67790	Biricodar dicitrate VX 710,VX 710-3	NF-κB; AChR	Neuroscience; NF-κB
	Biricodar dicitrate （VX-710）是一种有效的 MDR 抑制剂没具有抗癌活性，可用于研究前列腺癌。
T9587	CCTA-1523	Others; ABC	Membrane transporter/Ion channel; Others
	CCTA-1523 是 ABCG2 抑制剂的外排功能。它选择性地逆转癌细胞中 ABCG2 介导的 MDR。
T9830	GSK2556286 GSK286	Antibacterial	Microbiology/Virology
	GSK2556286 (GSK286) 是一种具有口服活性的结核分枝杆菌 (M. tuberculosis) 抑制剂。GSK2556286 对人巨噬细胞 (macrophages) 生长具有抑制作用，IC50值为 0.07 μM。GSK2556286对多重耐药 (MDR) 或广泛耐药 (XDR) 和药物敏感 (DS) 结核分枝杆菌均有效。
T15168	DRF-1042	Others	Others
	DRF-1042 acts to inhibit DNA topoisomerase I. DRF-1042 displays perfect anticancer activity against a panel of human cancer cell lines including multi-drug resistance (MDR) phenotype.
T67912	PA3552-IN-1
	PA3552-IN-1 是一种抗生素佐剂，可以降低 PA3552 的表达，恢复 MDR 铜绿假单胞菌 DK2 菌株对 Polymyxin B 的敏感性。
T2657	Elacridar GW0918,依克立达,GW120918,GF120918,GG918	BCRP; P-gp	Membrane transporter/Ion channel; Neuroscience
	Elacridar (GG918) 是一种有效的 P-糖蛋白和BCRP 的抑制剂。
T23801	WCK-4234 sodium WCK-4234,WCK4234,WCK 4234	Antibacterial	Microbiology/Virology
	WCK-4234 sodium (WCK 4234) 是一种 β-内酰胺酶抑制剂，可用于针对 MDR 感染的研究。 WCK-4234 sodium 抑制 A、C 和 D 类 β-内酰胺酶和 OXA 碳青霉烯酶。
T6287	Tariquidar XR9576,他立喹达	P-gp	Membrane transporter/Ion channel; Neuroscience
	Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂，Kd 为 5.1 nM。
T14492	BAL-30072	Others	Others
	BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli
T69317	Dexverapamil
	Dexverapamil is the R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.
TQ0043	Dofequidar MS-209	P-gp	Membrane transporter/Ion channel; Neuroscience
	Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
T29169	XR9051 Hydrochloride
	XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein.
T33754	NSC-57969 NSC57969
	NSC-57969 is a MDR-selective agent, exhibiting a robust Pgp-dependent toxic activity across diverse cancer cell lines.
T68737	XR9051
	XR9051 is as a potent modulator of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor of the binding of the cytotoxic to P-glycoprotein (EC50 = 1.4 +/- 0.5 nM). XR9051 reverses the MDR phenotype through direct interaction with P-glycoprotein.
T68404	Azidopine
	Azidopine is a photoactive dihydropyridine channel blocker which may also act as a multidrug resistant (MDR) modulator.
T15383	Glesatinib hydrochloride MGCD265 hydrochloride	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC.
T28120	MTC420 MTC-420,MTC 420
	MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM).
T15384	Glesatinib MGCD265	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multidrug resistance (MDR) in NSCLC.
T70695	CP 100356
	CP 100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells.
T33683	NITD-304 NITD304
	NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates.
T61471	Antitubercular agent-13
	Antitubercular agent-13 (Compound 3d) 是一种抗结核剂，对 MTB H37Rv 和 MDR-MTB 16833 的 MIC 值分别为 0.007 μg/mL 和 1.851 μg/mL。Antitubercular agent-13 表现出代谢不稳定性。
T13222	TTT-28	Others	Others
	TTT-28 is a thiazole-valine peptidomimetic, and is a selective ABCB1 (P-gp/MDR1) inhibitor with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated Multidrug resistance (MDR) by selectively blocki
T61624	Antibacterial agent 106
	Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pathogens, including the eradication of 99.7% of intracellular methicillin-resistant S. aureus (MRSA) harbored within macrophages [1].
T72665	P-gp inhibitor 3
	P-gp inhibitor 3 是一种高效 P 糖蛋白（P-gp）抑制剂，通过激活 P-gp ATP酶抑制其外排功能，具有显著的多重耐药性（MDR）逆转能力，并能增强紫杉醇的抗肿瘤活性。
T68326	Annamycin
	Annamycin is a semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp).
T79514	ABCG2-IN-2	BCRP	Membrane transporter/Ion channel
	ABCG2-IN-2为一有效ABCG2抑制剂，呈现小鼠良好口服药代动力学性质。适用于研究肿瘤多药耐药（MDR）与红细胞生成性原卟啉症（EPP）。
T80535	AMPR-22
	AMPR-22 是一种具有抗菌作用的肽类化合物，能够与细菌膜结合并诱导透化作用，对 MDR 菌株引起的败血症小鼠模型表现出有效的对抗性。
T28480	Q-203 Ditosylate Q203,Q-203,Q 203
	Q-203 Ditosylate, also known as Q-203, is a mycobacterium tuberculosis protein potentially for the treatment of tuberculosis. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in
T80276	Lynronne-3
	Lynronne-3 是一种具有抗革兰氏阳性细菌活性的抗菌肽，涵盖 MDR 菌株（对MRSA菌株的 MIC 为 32-128 μg/mL）。此外，Lynronne-3 亦对 P. aeruginosa 感染显示出效力。
T63655	Antimalarial agent 9
	Antimalarial agent 9 是有效的抗疟药，是一种喹啉-咪唑衍生物化合物。Antimalarial agent 9 在体外对 CQ 敏感株(IC50-0.14 μM)和 MDR 株(IC50-0.41 μM) 均显示出明显的抗疟效果，具有较小的细胞毒性和高度的选择性。
T78883	DprE1-IN-9
	DprE1-IN-9（compound B18）是一款高效的可逆DprE1抑制剂，能够结合至DprE1的受体腔。该化合物对分枝杆菌表现出显著的抗菌活性，作用于非致病性菌株H37Ra（MIC=0.18 µg/mL）及致病性H37Rv菌株，并对多重耐药（MDR）和极度耐药（XDR）的临床分离株同样有效。
T39296	DS86760016
	DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
T39983	SPR206 acetate
	SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301.
T63945	Antitubercular agent-19
	Antitubercular agent-19 是一种抗结核剂。Antitubercular agent-19 对 MTB H37Rv 和 MDR-MTB 表现出良好的抗结核效果 (MIC＜0.016 μg/ml)。Antitubercular agent-19 在 BALB/c 小鼠中表现出较低的细胞毒性和相对较高的急性致死毒性。
T76219L	MDP1 acetate
	MDP1 acetate为一种基于蜂毒肽(melittin)的衍生肽，能够破坏革兰氏阳性及革兰氏阴性细菌的膜完整性，进而通过膜损伤机制杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌及铜绿假单胞菌等耐多药(MDR)与标准菌株表现出显著的抗菌活性。
T78950	HIV-1 protease-IN-8	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1protease-IN-8（compound 34b）是一款高效的HIV-1蛋白酶抑制剂，其IC50为0.32 nM。该化合物对野生型HIV-1（HIV-1NL4-3）及耐药变体（HIV-1MDR）的IC50分别为0.29 μM与1.90 μM，表明其对这两种型别均展现出显著的抗病毒效果。
T76219	MDP1
	MDP1是一种源自蜂毒肽(melittin)的衍生肽，具有破坏革兰氏阳性及阴性细菌膜完整性的能力，能够通过膜损伤方式杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌以及铜绿假单胞菌的耐多药(MDR)和参考菌株显示出高度的抗菌活性。

化合物

Cat.No: TQ0026

Synonym: DWK-1339

Target: Beta Amyloid, Gamma-secretase

Cat.No: T22360

Target: TRP/TRPV Channel

Cat.No: T11888

Target: Others, Antibacterial

Cat.No: T41248

Target: Microtubule Associated

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Sulbactam sodium

Cat.No: T6685

Synonym: 舒巴坦钠,CP-45899-2

Target: Antibacterial, Antibiotic

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Cat.No: T1631

Synonym: CP45899,舒巴坦,舒巴坦酸

Target: Antibacterial, Antibiotic

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Cat.No: T11983

Target: Others

Cat.No: T17216

Synonym: PSC 833

Target: P-gp

Cat.No: T16098

Synonym: MK-8591

Target: HIV Protease, Reverse Transcriptase

Dofequidar fumarate

Cat.No: T11071

Synonym: MS-209

Target: P-gp

Biricodar dicitrate

Cat.No: T67790

Synonym: VX 710,VX 710-3

Target: NF-κB, AChR

Cat.No: T9587

Target: Others, ABC

Cat.No: T9830

Synonym: GSK286

Target: Antibacterial

Cat.No: T15168

Target: Others

Cat.No: T67912

Cat.No: T2657

Synonym: GW0918,依克立达,GW120918,GF120918,GG918

Target: BCRP, P-gp

WCK-4234 sodium

Cat.No: T23801

Synonym: WCK-4234,WCK4234,WCK 4234

Target: Antibacterial

Cat.No: T6287

Synonym: XR9576,他立喹达

Target: P-gp

Cat.No: T14492

Target: Others

Cat.No: T69317

Cat.No: TQ0043

Synonym: MS-209

Target: P-gp

XR9051 Hydrochloride

Cat.No: T29169

Cat.No: T33754

Synonym: NSC57969

Cat.No: T68737

Cat.No: T68404

Glesatinib hydrochloride

Cat.No: T15383

Synonym: MGCD265 hydrochloride

Target: c-Met/HGFR

Cat.No: T28120

Synonym: MTC-420,MTC 420

Cat.No: T15384

Synonym: MGCD265

Target: c-Met/HGFR

Cat.No: T70695

Cat.No: T33683

Synonym: NITD304

Antitubercular agent-13

Cat.No: T61471

Cat.No: T13222

Target: Others

Antibacterial agent 106

Cat.No: T61624

P-gp inhibitor 3

Cat.No: T72665

Cat.No: T68326

Cat.No: T79514

Target: BCRP

Cat.No: T80535

Q-203 Ditosylate

Cat.No: T28480

Synonym: Q203,Q-203,Q 203

Cat.No: T80276

Antimalarial agent 9

Cat.No: T63655

Cat.No: T78883

Cat.No: T39296

Cat.No: T39983

Antitubercular agent-19

Cat.No: T63945

Cat.No: T76219L

HIV-1 protease-IN-8

Cat.No: T78950

Target: HIV Protease

Cat.No: T76219

Cat. No.	Product Name	Target	Signaling Pathways
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
T19768	γ-Tocotrienol gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚	Others	Others
	γ-Tocotrienol (Plastochromanol) 是一种维生素 E 的活性形式。
TN1731	Hernandezine	TNF; ROS; P-gp; AMPK	Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling
	Hernandezine 是 AMPK 激动剂的激动剂，也是癌细胞中 ABCB1 介导的 MDR 的特异性逆转剂。
TN1342	8-Epidiosbulbin E acetate 8-表黄药子素E乙酸酯	Anti-infection; Antibacterial	Microbiology/Virology
	8-Epidiosbulbin E acetate 是从 Dioscorea bulbifera L.中发现的呋喃类化合物，对耐多药细菌具有广谱的质粒治疗活性。
T3924	Astragaloside II 黄芪皂苷 II,Astrasieversianin VIII	TGF-beta/Smad	Stem Cells
	Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。
T6S0095	Genkwanin 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素	Virus Protease	Microbiology/Virology
	Genkwanin (Apigenin 7-methyl ether) 是一种O-甲基化黄酮，有抗炎活性，通过被动扩散和多药耐药蛋白介导的外排机制转运。
T1441	Capreomycin sulfate Capastat sulfate,硫酸卷曲霉素	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Capreomycin sulfate (Capastat sulfate) 是一种多肽类抗生素，与其它抗生素结合用于MDR-肺结核。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 与微管蛋白结合并抑制微管的形成，从而抑制癌细胞的有丝分裂。 Vincristine 可用作微管去稳定剂，用于研究治疗血液系统癌症，如白血病和淋巴瘤以及儿童肉瘤的相关研究。
T24002	Disermolide XAA 296,XAA296,XAA-296
	Disermolide is a polyketide natural product found to stabilize microtubules. Disermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines.
TN4819	(-)-Praeruptorin A	ATPase; IL Receptor; Calcium Channel; P-gp	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
TN5414	Wallichinine
	Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa
TN2726	Jatrophane 5	P-gp	Membrane transporter/Ion channel; Neuroscience
	Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
T72737	Ganoderic acid R
	Ganoderic acid R为一种高效的抗癌化合物，通过促进肿瘤细胞系的凋亡(apoptosis)机制来抑制其生长。它对多药耐药(MDR)肿瘤细胞系(KB-A-1/Dox)及敏感肿瘤细胞系(KB-A-1)展现出显著的细胞毒性效应。
T83055	Anti-inflammatory agent 57
	Anti-inflammatory agent 57（Compound 13），一种天然产自Peucedanum praeruptorum根部的吡喃香豆素，既能逆转多药耐药性（MDR）又具备抗炎效果。
TN3077	5,5'-Dimethoxylariciresinol 4-O-glucoside 5,5'-二甲氧基落叶松脂素4-O-葡萄糖苷	Others	Others
	5,5'-Dimethoxylariciresinol-4'-O-beta-D-glucoside is shown to effectively enhance chemosensitivity of resistant cells, which makes it may be a suitable candidate for potential multidrug resistance (MDR)-reversing agents.
TN4319	Isopimaric acid	Antifection	Microbiology/Virology
	Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
TN1165	(Rac)-Myrislignan 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟	Others	Others
	1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC
TN2727	Jatrophane 2	P-gp; Antifection	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Jatrophane 2 also demonstrates the mo

天然产物

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T19768

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚

Target: Others

Cat.No: TN1731

Target: TNF, ROS, P-gp, AMPK

8-Epidiosbulbin E acetate

Cat.No: TN1342

Synonym: 8-表黄药子素E乙酸酯

Target: Anti-infection, Antibacterial

Astragaloside II

Cat.No: T3924

Synonym: 黄芪皂苷 II,Astrasieversianin VIII

Target: TGF-beta/Smad

Cat.No: T6S0095

Synonym: 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素

Target: Virus Protease

Capreomycin sulfate

Cat.No: T1441

Synonym: Capastat sulfate,硫酸卷曲霉素

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

Cat.No: T24002

Synonym: XAA 296,XAA296,XAA-296

(-)-Praeruptorin A

Cat.No: TN4819

Target: ATPase, IL Receptor, Calcium Channel, P-gp

Cat.No: TN5414

Cat.No: TN2726

Target: P-gp

Ganoderic acid R

Cat.No: T72737

Anti-inflammatory agent 57

Cat.No: T83055

5,5'-Dimethoxylariciresinol 4-O-glucoside

Cat.No: TN3077

Synonym: 5,5'-二甲氧基落叶松脂素4-O-葡萄糖苷

Target: Others

Isopimaric acid

Cat.No: TN4319

Target: Antifection

(Rac)-Myrislignan

Cat.No: TN1165

Synonym: 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟

Target: Others

Cat.No: TN2727

Target: P-gp, Antifection

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