首页工具

登录

搜索结果

Search Results for " hl-60 "

36

抑制剂 & 化合物

79

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T2099	ABT-737	Mitophagy; BCL; Autophagy	Apoptosis; Autophagy
	ABT737 是 BH3 模拟物，是Bcl-2、Bcl-xL 和Bcl-w 抑制剂，EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬，有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。
T9975	GPR183 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) 是一种趋化受体，在 B 细胞中具有成熟作用，其内源性配体是氧甾醇 7α,25-二羟基胆固醇 (7α,25-OHC)。 GPR183 可用于炎症性肠病 (IBD) 的研究。
T6019	Volasertib BI 6727,伏拉塞替	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3，IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物，有抗肿瘤活性，可诱导有丝分裂停滞和细胞凋亡。
T67899	Topoisomerase II inhibitor 13	Topoisomerase	DNA Damage/DNA Repair
	Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II)，对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。
T14982	Clofilium tosylate	Potassium Channel	Membrane transporter/Ion channel
	Clofilium tosylate 是一种钾通道阻滞剂，可诱导人早幼粒细胞白血病细胞凋亡，具有抗心律失常作用。
T41231	GP 1a	Cannabinoid Receptor; PERK; Arrestin	Apoptosis; GPCR/G Protein
	GP 1a 是cannabinoid receptor 2（CB2）的强效激动剂（EC50=7.1),是在cAMP、GTPγS 和β-arrestin 招募试验中显示的。GP 1a 对CB2受体的选择性约为CB1受体的30倍，且在体外增加HL-60细胞的P-ERK1/2表达。GP 1a 对皮肤伤口愈合有益。GP 1a 可抑制炎症和纤维生成，同时促进上皮的重新形成。
T73588	8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY
	8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY 是一种新型的 BODIPY 荧光染料，可用于治疗细胞毒性研究。
T34694	Spicamycin
	Spicamycin can be used as a potent inducer of differentiation of human myeloid leukemia cells (HL-60) and murine myeloid leukemia cells (M1).
T41133	Ursonic acid methyl ester
	Ursonic acid methyl ester, an esterified derivative of Ursolic acid, exhibits growth inhibitory activity against four tumor cell lines: HL-60, BGC, Bel-7402, and Hela, and the ED50 values for inhibition are >100 μg/ml.
T36693	FD-211
	FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). \|1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char...
T78978	Antitrypanosomal agent 13	Parasite	Microbiology/Virology
	Antitrypanosomal agent 13 (compound 4b) 是一种高效的抗锥虫剂，具备显著的杀锥虫活性和细胞毒性。针对 T. brucei 和 HL-60，Antitrypanosomal agent 13 的 GI50 值分别为 0.18 μM 和 8.4 μM。
T82774	Caspase-3 activator 3	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis，表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM，对K562细胞的IC50值为33.61 μM。
T13643	Demethoxydeacetoxypseudolaric acid B analog 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物	Others	Others
	Demethoxydeacetoxypseudolaric acid B analog 是由 Pseudolaric acid B 半合成得到，能够有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞，且 IC50值范围为 0.136-1.162 μM。
T36399	PAO-Nap
	PAO-Nap is a chemically modified version of PAO, in which a naphthalimide fluorophore is attached to the compound using a linker called aminocaproic acid. This modified compound, PAO-Nap, exhibits a selective targeting of thioredoxin reductase, leading to the induction of apoptosis in HL-60 cells through oxidative stress mechanisms[1].
T36894	5-Bromouridine
	5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions....
T69066	Forphenicine
	Forphenicine is a bacterial metabolite that has been found in S. fulvoviridis and an inhibitor of alkaline phosphatase (IC50 = 0.036 µg/ml for the chicken intestine enzyme). It inhibits the growth of HL-60 leukemia cells when used at a concentration of 10 µM. Forphenicine (50 and 500 µg/animal) increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE).
T36418	O-Desmethyl-N-deschlorobenzoyl Indomethacin
	O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism ...
T78815	MOZ-IN-3	Histone Acetyltransferase	Chromatin/Epigenetic
	MOZ-IN-3 (Compound 6j) 是KAT6A (MOZ) 乙酰转移酶的抑制剂，IC50值为30 nM。该化合物在四种髓系白血病细胞系（HL-60、U937、SKNO-1、K562）上展现了抗肿瘤活性，并且显示出良好的代谢稳定性及药代动力学特性。
T61828	DNA-PK-IN-8
	DNA-PK-IN-8（化合物DK1）是一种高效、选择性且口服活性的DNA依赖蛋白激酶 (DNA-PK) 抑制剂，其IC50值为0.8 nM。与Doxorubicin联合应用时，该化合物能在多种癌细胞中展现出协同的抗增殖效应，并能显著地抑制HL-60肿瘤生长。
T82775	Caspase-3 activator 2	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂，适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性，IC50 值分别为 33.52 μM 和 76.90 μM。
T36593	TEI-9648
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...
T19228	Calcitriol Impurities D 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3	Antiviral	Immunology/Inflammation
	Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式，可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性，抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。
T77629	FD274 FD 274,FD-274	PI3K; mTOR	PI3K/Akt/mTOR signaling
	FD274 是一种高效的 PI3K/mTOR 双重抑制剂，对 PI3Kα/β/γ/δ 和 mTOR 具有抑制作用， IC50 分别为 0.65 nM、1.57 nM、0.65 nM、0.42 nM 和 2.03 nM。 FD274 在 AML 细胞系抗增殖实验中显示出显着的抗增殖活性。 FD274 在 HL-60 异种移植模型中表现出剂量依赖性的坑肿瘤生长活性。 FD274具有用于急性髓系白血病研究的潜力。
T37068	NR-160
	NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
T76379	Myelopeptide-2
	Myelopeptide-2 分离于猪骨髓细胞培养上清，能够恢复 HL-60 白血病细胞或麻疹病毒条件抑制下人 T 淋巴细胞的丝裂原反应活性、白细胞介素-2 (IL-2) 合成水平和白细胞介素-2受体 (IL-2R) 表达水平。Myelopeptide-2 参与免疫稳态调节，在抗肿瘤和抗病毒研究中具有广阔的应用前景。
T83724	TPP-1 hydrochloride Targeting PD-L1 Peptide
	TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时，以4 mg/kg的剂量给药，可减少小鼠异种移植模型中的肿瘤体积。
T69629	M‑89 MLL inhibitor
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
T36035	CAY10784
	CAY10784 is a STAT3 inhibitor (IC50= 0.74 μM in a reporter assay) and a derivative of WP1066 .1It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 μM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 μM for both). CAY10784 is also active againstH. pyloriandC. jejuni(MICs = 1.6 and 4.7 μM, respectively).2 1.Lü, Z., Li, X., Li, K., et al.Structure-activity study of nitazoxanide derivatives as novel STAT3 pathway i...
TP2193	Myelopeptide-2 (MP-2)	Others	Others
	Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from H
T37056	D-erythro-MAPP
	D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 μM; IC50 = 1-5 μM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 μM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 μM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner.
T35927	C2 L-threo Ceramide (d18:1/2:0) C2 L-threo Ceramide (d18:1/2:0)
	C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1...
T38377	ADTL-EI1712 ADTL-EI1712
	ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do...
T35772	Emestrin
	Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestr...
T4057	Hoechst 33258 trihydrochloride Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258	Parasite	Microbiology/Virology
	Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。
T35536	Tpl2 Kinase Inhibitor (hydrochloride)
	Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50= 0.05 μM).1It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by calcitriol in HL-60 and U937 leukemia cells when used at a concentration of 5 μM.2Tpl2 kinase inhibitor (5...
T36199	AZD 1152 (hydrochloride)
	AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...

化合物

Cat.No: T2099

Target: Mitophagy, BCL, Autophagy

Cat.No: T9975

Synonym: 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide

Target: Others

Cat.No: T6019

Synonym: BI 6727,伏拉塞替

Target: Apoptosis, PLK

Topoisomerase II inhibitor 13

Cat.No: T67899

Target: Topoisomerase

Clofilium tosylate

Cat.No: T14982

Target: Potassium Channel

Cat.No: T41231

Target: Cannabinoid Receptor, PERK, Arrestin

8-(4-iodophenyl)-1,3,5,7-tetramethyl BODIPY

Cat.No: T73588

Cat.No: T34694

Ursonic acid methyl ester

Cat.No: T41133

Cat.No: T36693

Antitrypanosomal agent 13

Cat.No: T78978

Target: Parasite

Caspase-3 activator 3

Cat.No: T82774

Target: Caspase

Demethoxydeacetoxypseudolaric acid B analog

Cat.No: T13643

Synonym: 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物

Target: Others

Cat.No: T36399

Cat.No: T36894

Cat.No: T69066

O-Desmethyl-N-deschlorobenzoyl Indomethacin

Cat.No: T36418

Cat.No: T78815

Target: Histone Acetyltransferase

Cat.No: T61828

Caspase-3 activator 2

Cat.No: T82775

Target: Caspase

Cat.No: T36593

Calcitriol Impurities D

Cat.No: T19228

Synonym: 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3

Target: Antiviral

Cat.No: T77629

Synonym: FD 274,FD-274

Target: PI3K, mTOR

Cat.No: T37068

Cat.No: T76379

TPP-1 hydrochloride

Cat.No: T83724

Synonym: Targeting PD-L1 Peptide

M‑89 MLL inhibitor

Cat.No: T69629

Cat.No: T36035

Myelopeptide-2 (MP-2)

Cat.No: TP2193

Target: Others

Cat.No: T37056

C2 L-threo Ceramide (d18:1/2:0)

Cat.No: T35927

Synonym: C2 L-threo Ceramide (d18:1/2:0)

Cat.No: T38377

Synonym: ADTL-EI1712

Cat.No: T35772

Hoechst 33258 trihydrochloride

Cat.No: T4057

Synonym: Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258

Target: Parasite

Tpl2 Kinase Inhibitor (hydrochloride)

Cat.No: T35536

AZD 1152 (hydrochloride)

Cat.No: T36199

Cat. No.	Product Name	Target	Signaling Pathways
TN1121	Evocarpine	Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial	Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱，有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。
TN1684	Ginsenoside F5 人参皂苷 F5,人参皂苷F5	Apoptosis	Apoptosis
	Ginsenoside F5 是从人参中提取的一种天然产物，通过凋亡途径显着抑制 HL-60 细胞的生长。
TJS0328	Nordalbergin 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素	Others	Others
	Nordalbergin 是一种香豆素，分离自Dalbergia sissoo 的木皮中。它能够显著性的诱导 HL-60 细胞的分化。
T1882	Meisoindigo N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛	Apoptosis	Apoptosis
	Meisoindigo (Natura-α) 是 Indirubin 的衍生物，可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞，并诱导凋亡，具有高抗肿瘤活性。
TQ0309	Glaucocalyxin B 蓝萼乙素 B,蓝萼乙素	Autophagy	Autophagy
	Glaucocalyxin B 是从碎米桠中分离出来的二萜类天然产物，可降低 HL-60 细胞的生长，IC50为 5.86 μM，具有抗癌和抗肿瘤活性。
T1166	Ellipticine 玫瑰树碱,NSC 71795,Elliptisine	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
TN7043	Neolancerin	Others	Others
	Neolancerin 是一种对 HL-60 细胞具有弱细胞毒作用的天然产物。
T67922	Lepidiline C	Others	Others
	Lepidiline C 是一种从十字花科Lepidium meenii Walpers 根中提取的新型的咪唑类生物碱，对HL-60细胞表现出细胞毒活性（IC50为：27.7 μM）。
T10390	Asperphenamate	Others; Antifungal	Microbiology/Virology; Others
	Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。
T5S1000	Sophoraflavanone G Kushenol F,槐黄烷酮 G,Vexibinol	Apoptosis	Apoptosis
	Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物，通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡，具有抗肿瘤和抗炎特性。
TJS0487	(-)-Syringaresinol DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素	Others	Others
	(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
TN4375	Kamebanin	Antifection	Microbiology/Virology
	Kamebanin 是一种天然二萜类化合物，具有抗菌活性。它对 HeLa 和 HL-60 细胞显示出有效的细胞毒活性。
T25664	Lepidiline A Macaline A	Others	Others
	Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性，IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分，可改善小鼠内源性性激素的平衡，提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性，提高性激素的生物转化效率，提高生殖能力。Lepidiline A 具有抗癌活性。
TN1369	Alloimperatorin Prangenidin,别欧前胡素	Others	Others
	Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物，具有抗肿瘤作用。
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
TN1215	(2S)-2'-Methoxykurarinone 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt; Antifection	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物，具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号，抑制破骨细胞形成和骨吸收。
T36528	Illudin M	Apoptosis; DNA Alkylator/Crosslinker	Apoptosis; DNA Damage/DNA Repair
	Illudin M是真菌O. illudens中的一种细胞毒性倍半萜，能使DNA烷基化。它对 HL-60 人类白血病细胞的细胞毒性为 6-100 nM。Illudin M 具有抗癌活性，是抗癌化合物的前药，可用于合成抗癌化合物。
T3864	Erianin	BCL; Antibacterial	Apoptosis; Microbiology/Virology
	Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成，可用作退烧药和止疼剂。
TN1258	3-Acetyl-beta-boswellic acid 3-O-Acetyl-beta-boswellic acid,3-乙酰基-BETA-乳香酸	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	3-Acetyl-beta-boswellic acid 是一种乳香酸，分离自乳香锯缘胶树脂。
T3405	[6]-Gingerol 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质，具有抗癌，抗炎和抗氧化活性。
T4601	9-Methoxycanthin-6-one	Others	Others
	9-Methoxycanthin-6-one 是存在于完整植株和不同外植体的愈伤组织中的 Canthin-6-one 生物碱，具有抗肿瘤作用。
T6S2238	Eupalinolide B	Others	Others
	Eupalinolide B 是一种胚芽倍半萜，分离自Eupatorium lindleyanum 中。它对BGC-823、A-549 和 HL-60 等肿瘤细胞具有细胞毒性。
T3S2325	Ardisiacrispin A 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin	HSV	Microbiology/Virology
	Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷，来自于紫金牛属物种。它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性，如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。
TN4245	Icariside D2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC50 value of 9.0 ± 1.0 uM, it induces apoptosis via alteration of expression of apoptosis-related proteins and decreased phosphorylation of AKT in HL-60 cells.
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas
TN5373	Ustusolate A
	1. Ustusolate A shows weak cytotoxicity against HL-60 and A549 cells with IC50 values of 20.6 and 30.0 microM, respectively.
T19960	Hinesol (-)-Hinesol
	Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells.
TN4373	Kaempferol tetraacetate	Antifection	Microbiology/Virology
	Kaempferol tetraacetate is a potent antiplatelet agent. It exhibits significant cytotoxicity in vitro against three human cell lines HL-60, U937 and SK-MEL-1.
TN5676	Musellarin B
	Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
TN2318	Yadanziolide C	Others	Others
	Yadanziolide C induces differentiation with cultured HL-60 promyelocytic leukemia cells.
T61955	Aspochalasin M
	Aspochalasin M 对 HL-60 细胞表现出适度的活性（IC50= 20.0 μM）。Aspochalasin M 在白血病疾病中具有研究的潜力。
T72795	(S)-Erypoegin K
	(S)-Erypoegin K，一种显示对HL-60细胞具有有效抗增殖活性的抗癌剂，能诱导细胞凋亡(apoptosis)。
TN1572	Desacetylcinobufotalin	Others	Others
	Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines.
TN5211	Ustusolate E	Others	Others
	Ustusolate E exhibits moderate cytotoxicity against A549 and HL-60 cells with the IC50 value of 9.0 microM.
TN3371	Albatrelin G	Others	Others
	Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.
TN4087	Furowanin A	Caspase	Apoptosis; Proteases/Proteasome
	Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
TN2184	Schisanlactone E 五内脂	Others	Others
	Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.
TN3250	7-Prenyljacareubin	Others	Others
	7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.
TN3477	Baccatin VIII	Others	Others
	Baccatin VIII exhibits inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 uM, respectively.
TN3992	Erysubin A	Others	Others
	Erysubin A , wighteone, and lupalbigenin show promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM).
TN2837	29-Nor-20-oxolupeol	Others	Others
	29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.
T81529	Peganumine A
	Peganumine A，一种天然产物，源自Peganum harmala，具备对HL-60、MCF-7、PC-3、HepG2细胞线显示出细胞毒性作用，其IC50值依次为5.8、38.5、40.2、55.4 µM[1]< /sup>。
TN6054	Norglaucine hydrochloride
	(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc
TN5210	Ustusolate C	Others	Others
	Ustusolate C and ustusolate E exhibit moderate cytotoxicity against A549 and HL-60 cells with IC50 values of 10.5 and 9.0 microM, respectively.
TN4799	Piptocarphin F	Others	Others
	Piptocarphin F shows strong cytotoxic activities against mouse lymphoid tumor cell line P388. It also shows cytotoxic activity (IC50 3.87-12.5 umol/L) against the human leukemic cell line HL-60.
TN5212	Uvedalin	Others	Others
	Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines.
TN3561	Cabraleone	Others	Others
	The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line.
TN3838	Desmethylrocaglamide	Others	Others
	Desmethylrocaglamide is a novel inducer of cellular differentiation using HL-60 promyelocytic cells, it may be a drug for the prevention and therapy of cancer. It also has insecticidal activity.
TN3799	Dehydrocrebanine	Antifection	Microbiology/Virology
	Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
T81937	Lewis a trisaccharide Lewis a
	Lewis a trisaccharide 是精子聚糖结构和 HL-60 细胞表面聚糖结构的主要组分。
------------------------ 更多 ------------------------

天然产物

Cat.No: TN1121

Target: Apoptosis, cAMP, Anti-infection, Calcium Channel, Antibacterial

Cat.No: TN1684

Synonym: 人参皂苷 F5,人参皂苷F5

Target: Apoptosis

Cat.No: TJS0328

Synonym: 6,7-dihydroxy-4-phenylcoumarin,6,7-Dihydroxy-4-Phenylchromen-2-One,6,7-二羟基-4苯基香豆素

Target: Others

Cat.No: T1882

Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛

Target: Apoptosis

Glaucocalyxin B

Cat.No: TQ0309

Synonym: 蓝萼乙素 B,蓝萼乙素

Target: Autophagy

Cat.No: T1166

Synonym: 玫瑰树碱,NSC 71795,Elliptisine

Target: Topoisomerase

Cat.No: TN7043

Target: Others

Cat.No: T67922

Target: Others

Cat.No: T10390

Target: Others, Antifungal

Sophoraflavanone G

Cat.No: T5S1000

Synonym: Kushenol F,槐黄烷酮 G,Vexibinol

Target: Apoptosis

(-)-Syringaresinol

Cat.No: TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素

Target: Others

Cat.No: TN4375

Target: Antifection

Cat.No: T25664

Synonym: Macaline A

Target: Others

Alloimperatorin

Cat.No: TN1369

Synonym: Prangenidin,别欧前胡素

Target: Others

Cat.No: T5826

Target: HSP

(2S)-2'-Methoxykurarinone

Cat.No: TN1215

Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Cat.No: T36528

Target: Apoptosis, DNA Alkylator/Crosslinker

Cat.No: T3864

Target: BCL, Antibacterial

3-Acetyl-beta-boswellic acid

Cat.No: TN1258

Synonym: 3-O-Acetyl-beta-boswellic acid,3-乙酰基-BETA-乳香酸

Target: DNA/RNA Synthesis

Cat.No: T3405

Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚

Target: Apoptosis, AMPK

9-Methoxycanthin-6-one

Cat.No: T4601

Target: Others

Cat.No: T6S2238

Target: Others

Ardisiacrispin A

Cat.No: T3S2325

Synonym: 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin

Target: HSV

Cat.No: TN4245

Target: Akt

Isoerysenegalensein E

Cat.No: TN5456

Cat.No: TN5373

Cat.No: T19960

Synonym: (-)-Hinesol

Kaempferol tetraacetate

Cat.No: TN4373

Target: Antifection

Cat.No: TN5676

Cat.No: TN2318

Target: Others

Cat.No: T61955

(S)-Erypoegin K

Cat.No: T72795

Desacetylcinobufotalin

Cat.No: TN1572

Target: Others

Cat.No: TN5211

Target: Others

Cat.No: TN3371

Target: Others

Cat.No: TN4087

Target: Caspase

Schisanlactone E

Cat.No: TN2184

Synonym: 五内脂

Target: Others

7-Prenyljacareubin

Cat.No: TN3250

Target: Others

Cat.No: TN3477

Target: Others

Cat.No: TN3992

Target: Others

29-Nor-20-oxolupeol

Cat.No: TN2837

Target: Others

Cat.No: T81529

Norglaucine hydrochloride

Cat.No: TN6054

Cat.No: TN5210

Target: Others

Cat.No: TN4799

Target: Others

Cat.No: TN5212

Target: Others

Cat.No: TN3561

Target: Others

Desmethylrocaglamide

Cat.No: TN3838

Target: Others

Dehydrocrebanine

Cat.No: TN3799

Target: Antifection

Lewis a trisaccharide

Cat.No: T81937

Synonym: Lewis a

--------- 更多 ---------

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼