30
9
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6777 |
Bay K 8644
(±)-BAY-K-8644,SQ 28,873 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Bay K 8644 (SQ 28,873)是一种二氢吡啶化合物,是一种选择性的 L 型 Ca2+ 通道激活剂,IC50 为 17.3 nM。它通过增加通道的开放时间来增加通过肌膜 Ca2+通道的 Ca2+流入。 | |||
T0370 |
Pheniramine maleate
Daneral,Inhiston,Trimetose,马来酸非尼拉敏 |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Pheniramine maleate (Trimetose) 是一种具有抗组胺和血管扩张特性的烷基胺衍生物,可与组胺 H1 受体结合,从而抑制磷脂酶 A2 和内皮源性松弛因子一氧化氮的产生。 | |||
T12234 |
NMDA-IN-1
|
NMDAR | Neuroscience |
NMDA-IN-1是一种 NR2B 选择性 NMDA 拮抗剂,对NMDA 的Ki 值为 0.85 nM,对NR2B Ca2+ influx 的IC50值为 9.7 nM。 | |||
T16687 |
Pyr3
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr3 是一种选择性瞬时受体电位经典通道 3 抑制剂。 Pyr3 以剂量依赖性方式抑制 TRPC3 介导的 Ca2+ 内流 (IC50 = 700 nM)。 | |||
TNU0864 |
HUP30
|
Potassium Channel; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
HUP30是一种强效的血管舒张剂。HUP30可以刺激可溶性鸟苷酸环化酶,激活 K+离子通道,阻断细胞外 Ca2+的内流。 | |||
T16688 |
Pyr6
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。 | |||
T11102 |
DS16570511
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
DS16570511 是一种细胞渗透性的线粒体钙单核转运蛋白(mitochondrial calcium uniporter)小分子抑制剂,阻断了依赖于 MCU 或 MICU1 的 Ca2+流入增加。 | |||
T16686 |
Pyr10
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
T10782 |
CGP52411
DAPH |
EGFR; Beta Amyloid | Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors |
CGP52411 是一种具有口服活性的 ATP 竞争性 EGFR 抑制剂(IC50:0.3 μM)。 CGP52411 阻止 Ca2+ 离子有毒流入神经元细胞,并显着抑制和逆转 β-淀粉样蛋白 Aβ42 原纤维聚集体的形成。 CGP52411 可用于阿尔茨海默病的研究。 | |||
TP1910L1 |
CALP1 acetate
CALP1 acetate(145224-99-3 free base) |
CaMK | Neuroscience |
CALP1 acetate 是一种钙调蛋白 (CaM) 激动剂(Kd 为 88 µM),可与 CaM EF-hand/Ca2+ 结合位点结合。 CALP1 通过抑制钙通道的开放来阻断钙流入和细胞凋亡(IC50 为 44.78 µM)。 CALP1 阻断谷氨酸受体通道并阻断储存操作的非选择性阳离子通道。 CALP1 激活依赖于 CaM 的磷酸二酯酶活性。 | |||
T4996 |
Atosiban
阿托西班,RWJ22164,RW22164 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T2711 |
Chembridge-5861528
TCS 5861528 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。 | |||
T5148 |
Atosiban acetate
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban acetate (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T6530 |
HC-030031
2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺,HC030031,TOSLAB 829227 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
HC-030031 (TOSLAB 829227) 是一种有效的TRPA1选择性抑制剂,拮抗福尔马林和AITC 诱发的钙流入,IC50分别为5.3±0.2和6.2±0.2μM。 | |||
T27639 |
ITH-12575
|
||
ITH-12575 is an inhibitor of Mitochondrial Na+/Ca2+ exchange (mNCX). ITH12575 reduces Ca(2+) influx through CALHM1 at low micromolar concentrations. | |||
T11480 | GSK205 | Others | Others |
GSK205 is a selective TRPV4 antagonist (IC50: 4.19 μM) for inhibiting TRPV4-mediated Ca2+ influx. | |||
T68361 |
Asocainol hydrochloride
|
||
Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also interferes with the fast inward Na+ current. | |||
T14829 |
Bromoenol lactone
(6E)-Bromoenol lactone |
Phospholipase | Metabolism |
Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. | |||
T37475 |
Cyclic ADP-Ribose (ammonium salt)
cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) |
||
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i... | |||
T80441 |
FS-2
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
FS-2,一种特异性L型CaV通道抑制剂,能够阻断RIN beta 细胞中,高K+或葡萄糖刺激导致的L型Ca2+内流。 | |||
T40101 |
(±)-1,2-Diolein
1,2-Dioleoyl-rac-glycerol,甘油1,2-二油酸酯 |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 是一种PKC 激活剂,可以增加肌小管 Ca2+内流。 | |||
T76203 |
Syringomycin E
|
||
Syringomycin E是一种环状脂肪肽类抗真菌化合物。通过与酿酒酵母的质膜相互作用,Syringomycin E能够抑制其生长,主要机制包括促进K+的外排和Ca2+的内流,引发膜电位的变化,这一过程与通道形成密切相关。 | |||
T26452 |
A 80b
A80b,A-80b |
||
A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-8 | |||
TP1910 |
CALP1
|
||
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibit | |||
T23102 |
OBAA
|
Others | Others |
OBAA 是一种有效的磷脂酶 A2 (PLA2) 抑制剂(IC50= 70 nM),并且在布氏锥虫中阻断 Melittin 诱导的 Ca2+流入(IC50= 0.4 μM)。 | |||
T75793 |
ω-Agatoxin IVA TFA
|
||
ω-Agatoxin IVA TFA 是一种高效的针对P/Q型Ca2+(Cav2.1)通道的选择性阻滞剂,IC50对P型为2 nM,对Q型为90 nM。此化合物能够抑制高钾条件下的谷氨酸释放和钙流入,IC50在30-225 nM范围。同时,ω-Agatoxin IVA TFA阻断高钾诱发的5-羟色胺及去甲肾上腺素释放,但不影响L型或N型Ca2+通道。 | |||
T75791 |
CALP1 TFA
|
||
CALP1 TFA 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM),与 CaMEF-hand/Ca2+结合位点结合。CALP1 TFA 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50为 44.78 µM)。CALP1 TFA 阻止谷氨酸受体 (glutamate receptor channels) 通道,并阻止存储操作的非选择性阳离子通道。CALP1 TFA 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。 | |||
T80930 |
TRPV2-selective blocker 1
|
||
TRPV2-selective blocker 1 (compound IV2-1) 为选择性TRPV2通道阻断剂,具有6.3 μM IC50,不对TRPV1、TRPV3和TRPV4通道产生影响。该化合物能够抑制巨噬细胞中TRPV2介导的Ca2+流入,进而抑制其吞噬功能。 | |||
T73453 |
MRS4719
|
||
MRS4719 是一种有效的P2X4受体拮抗剂,对人 P2X4 受体的IC50为 0.503 μM。MRS4719 可减少脑梗死体积,减少脑萎缩,在缺血性脑中风模型中具有神经保护和神经康复作用。MRS4719 还能减少 ATP 诱导的人单核细胞源性巨噬细胞 [Ca2+]i 内流。MRS4719 可用于研究缺血性脑中风。 | |||
T36805 |
TPC2-A1-N
TPC2-A1-N |
||
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1121 |
Evocarpine
|
Apoptosis; cAMP; Anti-infection; Calcium Channel; Antibacterial | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Evocarpine 是从 Evodiae fructus 分离得到的一种喹诺酮类生物碱,有抗细菌活性。它可通过电压依赖性钙通道抑制 Ca2+内流。 | |||
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
TN1136 |
Procyanidin A1
原花青素 A1,Proanthocyanidin A1,原花色素A1 |
LDL; Calcium Channel; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism |
Procyanidin A1 (Proanthocyanidin A1) 是一种原花青素二聚体,具有抗过敏作用,可抑制蛋白激酶 C 激活下游脱粒或 RBL-213 细胞内部储存的 Ca2+流入。 | |||
TN1065 |
Hirsutine
|
Apoptosis | Apoptosis |
Hirsutine 是一种来自钩藤的吲哚生物碱,可诱导细胞凋亡,是一种登革热病毒抑制剂,且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。 | |||
T5120 |
Rhamnose
6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞,能够作为肠吸收的标志。 | |||
T6S2140 |
β-Anhydroicaritin
Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素 |
MMP; Others; TNF; Interleukin | Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome |
β-Anhydroicaritin 是从乳香提取的一种天然产物,具有重要的生物学和药理学作用,如抗骨质疏松症,雌激素调节和抗肿瘤特性。它改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高,并显著降低 iNOS 蛋白的表达。 | |||
T82753 | Celangulin | ||
Celangulin是一种从Celastrus angulatus中提取的天然杀虫成分,该化合物通过激活细胞质膜上的钙通道来增加细胞内Ca2+浓度,并能激活内质网钙通道。 | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN4624 | Nantenine | Others | Others |
Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca |