173
22
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T26834 |
BL-1020 Mesylate
CYP-1020 Mesylate |
Dopamine Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
BL-1020 Mesylate (CYP-1020 Mesylate) 是一种可口服的 GABA A 受体激动剂和 D2 拮抗剂,可降低多巴胺活性并增强GABAA活性。BL-1020 Mesylate 可用于研究神经分裂、阿尔茨海默症和双向认知障碍。 | |||
T10923 |
CYP17-IN-1
|
P450 | Metabolism |
CYP17-IN-1 是一种有效的 CYP17 口服抑制剂,可抑制大鼠和人类的 CYP17,IC50 分别为 15.8 和 20.1 nM。 | |||
T10922 |
CYP11B2-IN-1
|
P450 | Metabolism |
CYP11B2-IN-1 是一种有效的选择性 CYP11B2 抑制剂,对 CYP11B2 和 CYP11B1 的 IC50 分别为 2.3 nM 和 142 nM。 | |||
T67916 |
CYP4A11/CYP4F2-IN-2
|
P450 | Metabolism |
CYP4A11/CYP4F2-IN-2 是一种有效的和具有口服活性的细胞色素 P450 (CYP) 4A11 和 CYP4F2 的双重抑制剂,IC50 值分别为 140 nM 和 40 nM。CYP4A11/CYP4F2-IN-2可从肝脏和肾脏中提取, 具有治疗肾脏疾病的潜力。 | |||
T72501 |
CYP4A11/CYP4F2-IN-1
|
P450 | Metabolism |
CYP4A11/CYP4F2-IN-1 是一种高效的小分子细胞色素 P450 (CYP) 4A11 和 CYP4F2 抑制剂,对P450 (CYP) 4A11 的 IC50 值为 19 nM,对 CYP4F2 的 IC50 值为 17 nM。CYP4A11/CYP4F2-IN-1 可用于研究肾脏疾病和心脑血管疾病。 | |||
T73040 |
CYP1B1-IN-4
|
P450 | Metabolism |
CYP1B1-IN-4为选择性CYP1B1抑制剂(IC50=0.2 nM),属2,4-二芳基噻唑类化合物。其对细胞的毒性低,且在人类及大鼠肝微粒体中表现出稳定性。 | |||
T73042 |
CYP1B1-IN-5
|
P450 | Metabolism |
CYP1B1-IN-5 是一种具有选择性和高效性的细胞色素 P450 1B1 (CYP1B1) 抑制剂,IC50 为 4.7 nM。CYP1B1-IN-5 可用于研究与代谢相关的疾病。 | |||
T27109 |
CYP1A1 inhibitor 8a
|
||
CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxicity. | |||
T63496 | CYP2C9/CYP2C19-IN-1 | ||
CYP2C9/CYP2C19-IN-1 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T63495 | CYP2C1/CYP2C19-IN-2 | ||
CYP2C1/CYP2C19-IN-2 是无肝脏毒性和遗传毒性的CYP2C9/CYP2C19强效抑制剂,能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T6420 |
BMS-707035
N-[(4-氟苯基)甲基1,6-二氢-5-羟基-1-甲基-6-氧代-2-(四氢-1,1-二氧-2H-1,2-噻嗪-2-基)-4-嘧啶甲酰胺 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
BMS707035是一种 HIV-1 整合酶抑制剂,IC50为15 nM。 | |||
T63954 |
CYP3A4-IN-1
|
||
CYP3A4-IN-1 是细胞色素 P450 3A4 (CYP3A4) 的有效抑制剂 (IC50: 0.085 μM)。 | |||
T73039 |
CYP1B1-IN-3
|
||
CYP1B1-IN-3为选择性CYP1B1抑制剂,其IC50值分别针对CYP1B1、CYP1A1、CYP1A2为6.6, 347.3, >10000 nM。该化合物能够抑制细胞迁移与侵袭,并作用于P-gp、AKT/ERK、FAK/SRC及EMT信号通路。 | |||
T64249 | CYP11B1-IN-2 | ||
CYP11B1-IN-2 (compound 7aa) 是一种选择性的、口服具有活力的 CYP11B1 抑制剂,能够作用于 human CYP11B1 (IC50: 9 nM) 和 rat CYP11B1 (IC50: 25 nM)。CYP11B1-IN-2 能够用于研究皮质醇过量所致疾病。 | |||
T63337 | CYP2C19-IN-1 | ||
CYP2C19-IN-1 是强效的,无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM),能够用于研究寨卡病毒 (ZIKV) 感染。 | |||
T61287 | CYP121A1-IN-1 | ||
CYP121A1-IN-1 是一种有效的CYP121A1抑制剂,对抗结核分枝杆菌具有良好的活性 (H37RvMIC90~6.25 μM, ~2.2 μg/mL)。CYP121A1-IN-1 通过抑制 CYP121A1 介导的环(l-酪氨酸-l-酪氨酸)转化为真菌环素,可显著减少真菌环素的产生。 | |||
T64032 |
CYP3A4-IN-3
|
||
CYP3A4-IN-3 是特异性的、高度亲和力的细胞色素 P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) 抑制剂 (IC50: 0.075 μM)。CYP3A4-IN-3 是利托那韦类似物,结构更加简单,且抑制效果是利托那韦的两倍。CYP3A4-IN-3 能够用做抗病毒剂和免疫抑制剂。 | |||
T64037 |
CYP3A4-IN-2
|
||
CYP3A4-IN-2 是细胞色素 P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) 的特异性抑制剂 (IC50: 0.055 μM)。CYP3A4-IN-2 是利托那韦类似物,与利托那韦相比,其 R2 侧基的疏水性更高,抑制作用更强。CYP3A4-IN-2 能够作为免疫抑制剂及抗病毒剂。 | |||
T78204 |
CYP11A1-IN-1
|
||
CYP11A1-IN-1(化合物30)是一种针对CYP11A1的抑制剂,其IC50为201-2000 nM。该化合物主要应用于类固醇受体研究,尤其适用于雄激素受体依赖性疾病,例如前列腺癌的研究。 | |||
T64154 |
CYP51/HDAC-IN-1
|
||
CYP51/HDAC-IN-1 是一种口服具有活力的、有效的、双重 CYP51/HDAC 抑制剂。CYP51/HDAC-IN-1 能够抑制重要的毒力因子,可下调相关耐药基因的表达。CYP51/HDAC-IN-1 对热带念珠菌病和隐球菌性脑膜炎都表现出有效的治疗作用。 | |||
T79739 |
CYP51/PD-L1-IN-2
|
||
CYP51/PD-L1-IN-2(compound L20)是一种具有抗真菌活性的喹唑啉化合物。它作为CYP51(IC50:0.263 μM)和PD-L1(IC50:0.017 μM)的双重抑制剂,能够在细胞周期的早期引发真菌细胞凋亡。CYP51/PD-L1-IN-2进一步显著降低IL-2、NLRP3、NF-κBp65等蛋白水平,触发线粒体损伤及ROS积累,终致真菌细胞裂解和死亡。 | |||
T61082 | CYP1B1-IN-2 | ||
CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1]. | |||
T60723 | CYP1B1-IN-1 | ||
CYP1B1-IN-1 (Compound 9e) 是细胞色素 P450 1B1 (CYP1B1) 的选择性抑制剂 (IC 50 = 0.49 nM)。 | |||
T79738 |
CYP51/PD-L1-IN-1
|
||
CYP51/PD-L1-IN-1(compound L11)是一种具有抗真菌活性的喹唑啉化合物,作为CYP51(IC50: 0.884 μM)和PD-L1(IC50: 0.083 μM)的双重抑制剂,能够在细胞周期早期引发真菌细胞的凋亡。该化合物还能有效减少IL-2、NLRP3、NF-κBp65等蛋白的细胞内水平,诱导线粒体损伤及ROS积聚,进而导致真菌细胞的破裂和死亡。 | |||
T78902 |
CYP51/PD-L1-IN-4
|
||
CYP51/PD-L1-IN-4(化合物14a-2)是一种高效的双靶点抑制剂,其IC50值针对CYP51为0.17 μM,针对PD-L1为0.021 μM。该化合物在体外展现出卓越的抗真菌和抗耐药真菌能力,适用于真菌感染的研究。 | |||
T79740 |
CYP51/PD-L1-IN-3
|
||
CYP51/PD-L1-IN-3(compound L21)是一种具有抗真菌活性的喹唑啉化合物。作为CYP51(IC50: 0.205 μM) 和PD-L1(IC50: 0.039 μM) 的双重抑制剂,它能够引发真菌细胞在细胞周期早期的凋亡。此外,CYP51/PD-L1-IN-3 还能显著降低IL-2、NLRP3、NF-κBp65 蛋白的细胞内水平,并诱导线粒体损害及ROS 聚集,进而导致真菌细胞的裂解与死亡。 | |||
T74519 |
PROTAC CYP1B1 degrader-1
|
||
PROTACCYP1B1 degrader-1 (Compound 6C) 是一种 α-萘黄酮嵌合衍生物,能够通过靶向 CYP1B1降解消除细胞色素 P450 (CYP)1B1 介导的耐药性,对 CYP1B1 和 CYP1A2 的 IC50分别为 95.1 和 9838.6 nM。PROTACCYP1B1 Degrader-1 可用于研究 CYP1B1过表达的前列腺癌。 | |||
T15033 |
Cyproconazole
|
Antibacterial | Microbiology/Virology |
Cyproconazole 是一种三唑类杀菌剂,在农业上用于保护作物免受多种真菌病原体的侵害。 | |||
T7942 |
Tranylcypromine hemisulfate
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate),反苯环丙胺半硫酸盐 |
Histone Demethylase; MAO; Monoamine Oxidase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) 是单胺氧化酶(MAO) 和赖氨酸特异性去甲基化酶 1 (LSD1) 的抑制剂,可用于研究抑郁症和子宫内膜异位症。 | |||
T77698 |
hCYP3A4 Fluorogenic substrate 1
|
Others | Others |
hCYP3A4 Fluorogenic substrate 1 是邻苯二甲酰亚胺衍生物,对 COX 表现出低活性。 | |||
T0168 |
Estradiol (cypionate)
Depofemin,环戊丙酸雌二醇,Estradiol cypionate |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estradiol cypionate (Depofemin) 是一种 Estradiol 的 17β-环戊丙酸酯,能够作用于雌激素受体。抑制ET-1的合成。 | |||
T1167 |
Cyproterone acetate
Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮 |
Androgen Receptor | Endocrinology/Hormones |
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。 | |||
T19213 | Boldenone Cypionate | Others; Androgen Receptor | Endocrinology/Hormones; Others |
Boldenone Cypionate 是一种雄激素合成代谢类固醇,常被休闲健美运动员和普通健身房成员使用。 | |||
T6814 |
Cyproheptadine hydrochloride
Periactin hydrochloride,Anarexol,盐酸赛庚啶,Cyproheptadine HCl,Nuran |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cyproheptadine hydrochloride (Periactin hydrochloride) 是一种 5-HT2A 受体拮抗剂,具有抗抑郁和抗血清素作用。它具有抗血小板活性,可用于血栓栓塞性疾病的研究。 | |||
T1025 |
Tranylcypromine (2-PCPA) hydrochloride
反苯环丙胺盐酸盐,Tranylcypromine (2-PCPA) HCl,SKF-385 HCl |
Histone Demethylase; MAO | Chromatin/Epigenetic; Metabolism; Neuroscience |
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl) 是一种单胺氧化酶抑制剂,对治疗重度抑郁症、心境恶劣障碍和非典型抑郁症有效。 | |||
T20968 |
CyPPA
|
Potassium Channel; Dopamine Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
CyPPA 是hSK2和hSK3的阳性调节剂,其EC50值分别为 5.6 μM 和14 μM。它对 hSK1 和 hIK 通道无活性。 | |||
T64779 | Cypate | ||
3-(2-(7-(3-(2-Carboxyethyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)propanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64779。 | |||
T72977 |
Cyprodenate
Actebral |
||
Cyprodenate (Actebral) 是一种强心性脑兴奋剂,具有口服活性。Cyprodenate 可用于代谢研究。 | |||
T41331 |
Cyprodinil
|
||
Cyprodinil 是一种苯胺嘧啶广谱杀菌剂,可抑制植物病原真菌蛋氨酸的生物合成。Cyprodinil 抑制B. cinerea,P. herpotrichoides,H. oryzae 的菌丝体细胞在无氨基酸的培养基上生长,IC50s 分别为 0.44,4.8,0.03 μM。在没有 AR 激动剂 DHT 的情况下,Cyprodinil 充当雄激素受体 (AR) 激动剂 (EC50=1.91 μM),并抑制 DHT 的雄激素作用 (IC50=15.1 μM)。 | |||
T21016 |
Cyproterone
BAY 94-8367,Ciproterone,Androcur,SH 80881 |
||
Cyproterone, an anti-androgen, is used in combination with estrogen for the therapy of hirsutism and severe acne in females and as a palliative in prostatic carcinoma. | |||
T27110 |
CypD inhibitor C-9
CypD inhibitor C 9 |
||
CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress. | |||
T71997 | CypD-IN-29 | ||
CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction. | |||
T19358 | Hydrocortisone cypionate | Others | Others |
Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid. | |||
T71826 |
(1S,2R)-Tranylcypromine hydrochloride
(1S,2R)-SKF 385 hydrochloride |
||
(1S,2R)-Tranylcypromine ((1S,2R)-SKF 385) hydrochloride 是一种有效的抗抑郁 (antidepressant) 剂。(1S,2R)-Tranylcypromine hydrochloride 对 MAO 和 LSD1有抑制作用。 | |||
T73099 |
Etbicyphat
Trimethylopropane phosphate |
||
Etbicyphat (Trimethylopropane phosphate)作为一种GABA(A)受体竞争性拮抗剂展现出显著效果。通过诱发海马体CA1神经元的类似癫痫的活动并与GABA(A)-benzodiazepine受体结合,Etbicyphat的作用机制得到了阐述。 | |||
T79283 |
hCYP1B1-IN-1
|
||
hCYP1B1-IN-1 (compound B18)为高效的hCYP1B1抑制剂(IC50=3.6 nM),同时亦为芳香烃受体拮抗剂。该化合物展现优秀的代谢稳定性与细胞膜渗透性,能有效抑制MCF-7细胞迁移。 | |||
T79343 |
hCYP3A4-IN-1
|
||
hCYP3A4-IN-1(化合物C6)是一种经口服时具有活性的hCYP3A4抑制剂,其对hCYP3A4的IC50值在人肝微粒体(HLM)为43.93 nM,在CHO-3A4稳定转染细胞系中为153.00 nM。hCYP3A4-IN-1通过竞争性抑制机制,有效抑制CYP3A4催化的N-乙基-1,8-萘二甲酰亚胺(NEN)羟基化反应,其Ki值为30.00 nM。 | |||
T79914 |
Tranylcypromine
SKF 385 |
Monoamine Oxidase | Neuroscience |
Tranylcypromine (SKF 385)为一种高效的单胺氧化酶抑制剂。 | |||
T26117 |
Rolicyprine
RMI 83027,RMI-83027,RMI83,027,RMI 83,027,RMI-83,027 |
||
Rolicyprine is an antidepressant. | |||
T27263 |
Encyprate
NSC43799,NSC 43799,NSC-43799 |
||
Encyprate is an antidepressant. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5786 |
TETRAHYDROPIPERINE
四氢胡椒碱,Cosmoperine |
P450; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Tetrahydropiperine (Cosmoperine) 是胡椒碱的环己基类似物,也是一种天然芳基戊酰胺,从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH;IC50=23 µM)具有抑制作用。 | |||
T1011 |
Itraconazole
伊曲康唑,R51211 |
P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells |
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
T5709 |
Cyperotundone
|
Others | Others |
Cyperotundone 是分离自 Nagarmotha (Cyperus rotundus) 中的一种倍半萜。 | |||
T5S1981 |
alpha-Cyperone
(+)-α-Cyperone,α-香附酮,α-Cyperone |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。 | |||
TN5681 |
Cypellocarpin C
Camaldulenside,桉叶苷 |
||
Cypellocarpin C shows potent in vitro antitumor-promoting activity, it also can suppress an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin. | |||
TN4438 |
Ligucyperonol
|
Others | Others |
Ligucyperonol exhibits significant activities on protecting muscle cells from mild to moderate oxidative stress. | |||
T2761 |
Naringin dihydrochalcone
Naringin DC,柚皮苷二氢查尔酮,柚皮甙二氢查尔酮 |
P450; NF-κB | Metabolism; NF-κB |
Naringin dihydrochalcone (Naringin DC) 是一种新型甜味剂,是来自柚皮苷的一种人工甜味剂。它也是一种CYP enzymes 的抑制剂。 | |||
T0671 |
2-Naphthol
Betanaphthol,β-萘酚,乙萘酚 |
Others; Endogenous Metabolite | Metabolism; Others |
2-Naphthol (Betanaphthol) 是一种 naphthalene 的代谢物,由细胞色素 P450 亚型 (CYP 1A1,CYP 1A2,CYP 2A1,CYP 2E1 和 CYP 2F2) 催化而成。 | |||
T7970 |
7-Ethoxycoumarin
|
Others | Others |
7-Ethoxycoumarin 是细胞色素 P450(CYP) 的底物,现已被应用于多种 CYP 的功能表征。 | |||
T5594 |
Cedrol
|
P450; Antifungal | Metabolism; Microbiology/Virology |
Cedrol 是一种雪松烷倍半萜类叔醇,抑制细胞色素 P450 (CYP) 异构体 CYP2B6 和 CYP3A4,Kis 分别为 0.9 和 3.4 μM,具有抗炎,抗脓毒,抗痉挛,滋补,收敛,利尿,杀虫和抗真菌活性。 | |||
T2876 |
Flavone
2-Phenyl-4-benzopyron,黄酮,2-Phenyl-4-chromone,2-Phenylchromone |
NOS; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Flavone (2-Phenyl-4-chromone) 是内源性代谢产物的一种。 | |||
T5778 |
5,7-DIMETHOXYFLAVONE
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Anti-infection; P450 | Metabolism; Microbiology/Virology |
5,7-Dimethoxyflavone 是一种 Kaempferia parviflora 的主要成分,具有抗肿瘤、抗肥胖及抗炎活性。它对细胞色素 P450 (CYP) 3As 具有抑制作用,也是抗乳腺癌蛋白 (BCRP) 抑制剂。 | |||
T11218 |
ε-Viniferin
epsilon-Viniferin,Epsilon-白藜芦醇脱氢二聚体 |
P450 | Metabolism |
ε-Viniferin (epsilon-Viniferin) 提取自 Vitis vinifera,是 Resveratrol 的二聚体,能够抑制 CYP 家族,其 Ki=0.5~20 μM,具有抗氧化作用。 | |||
T3S0860 |
Gitogenin
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UGT | Metabolism |
Gitogenin 是一种从Tribulus longipetalus 整株中分离出来的天然类固醇,是一种 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂,其IC50分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM,对人类主要细胞色素 P450 亚型的活性无抑制作用。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T13520 | 6-Hydroxymelatonin | Others | Others |
6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by CYP 1A2. | |||
TN4130 | Germacrone 4,5-epoxide | gp120/CD4; IL Receptor; P450 | Immunology/Inflammation; Metabolism |
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP). | |||
T82305 |
Glucoarabin
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Glucoarabin是一种硫代葡萄糖苷,具备生物活性。在Hepa1c1c7细胞内,Glucoarabin的水解产物能够上调NQO1,而对细胞色素P450 (CYP) 1A1的活性无显著作用。 | |||
T40859 |
5-Hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen |
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5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight. | |||
T36472 |
Tetrahydro-11-deoxy Cortisol
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Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA. | |||
T37810 |
6',7'-Epoxybergamottin
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6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo... |