48
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10395L |
ATM-3507
|
Others | Others |
ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM. | |||
T2685 |
KU-55933
ATM Kinase Inhibitor |
ATM/ATR; DNA-PK; PI3K; mTOR; Autophagy | Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
KU-55933 (ATM Kinase Inhibitor) 是一种 ATM 抑制剂,IC50和 Ki 值分别为 12.9 和 2.2 nM。它对 ATM 的选择性比对 PI3K/PI4K、 DNA-PK、ATR 和 mTOR 高。 | |||
T62684 |
ATM Inhibitor-5
|
||
ATM Inhibitor-5 [formula (1)] 是一种丝氨酸/苏氨酸蛋白激酶 ATM 的有效抑制剂。 | |||
T70113 | ATM-1001 | ||
ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. | |||
T10395 |
ATM-3507 trihydrochloride (1861449-70-8 free base)
ATM-3507 trihydrochloride |
Others | Others |
ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines). | |||
T10396 |
ATM Inhibitor-1
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50, 10.3 μM), PI3Kγ (IC50, 3 μM) and PI3Kδ (IC50, 0.73 μM). | |||
T1821 |
CGK733
CGK 733 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
CGK733 (CGK 733) 是一种有效的选择性 ATM/ATR 抑制剂,用于癌症研究。 | |||
T6261 |
CP-466722
CP 466722,CP466722 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
CP-466722 是一种有效且可逆的 ATM 抑制剂,IC50值为 4.1 μM。它不会抑制细胞中的 ATR 和 PI3K 或 PIKK 家族成员。 | |||
T63714 | ATM-IN-1 | ||
ATM-IN-1 是 ATM 的有效抑制剂。其中 ATM 主要位于细胞核和微粒体中,参与细胞周期进程和细胞周期检查点对 DNA 损伤的反应。ATM-IN-1 对癌症和神经疾病表现出研究潜力。 | |||
T63279 | ATM Inhibitor-2 | ||
ATM Inhibitor -2 是强效的、选择性的 ATM 抑制剂 (IC50<1 nM)。 | |||
T79305 |
ATM Inhibitor-8
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATMInhibitor-8(Compound 10r)为口服型有效且选择性ATM抑制剂,IC50值为1.15 nM,表现出抗肿瘤活性。 | |||
T6770 |
AZD0156
|
Apoptosis; ATM/ATR | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZD0156 是一种口服活性 ATM 选择性抑制剂,IC50为 0.58 nM。它抑制 ATM 介导的信号转导,防止 DNA 损伤检查点激活,破坏 DNA 损伤修复,起抗肿瘤作用。 | |||
T63171 | ATM Inhibitor-3 | ||
ATM Inhibitor -3 是一种强效的、选择性的 ATM 抑制剂 (IC50: 0.71 nM)。ATM Inhibitor -3 能够抑制 PI3K 激酶家族,并表现出良好的代谢稳定性。 | |||
T63317 | ATM Inhibitor-4 | ||
ATM Inhibitor -4 是选择性的、强效的 ATM 抑制剂 (IC50: 0.32 nM),较强的抑制PI3K 激酶家族的活性,并表现出良好的代谢稳定性。ATM Inhibitor-4 在 1 μM 时能完全抑制mTOR。 | |||
T79306 |
ATM Inhibitor-9
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATMInhibitor-9 (Compd 7a)是一种针对癌症研究的ATM抑制剂,其针对ATM激酶的IC50为5 nM,显示出高效抑制活性。 | |||
T72218 | ATM-3507 trihydrochloride | ||
ATM-3507 trihydrochloride 是原肌球蛋白 (tropomyosin)的一个有效抑制剂,其在人类黑色素瘤细胞系中的 IC50值约为 3.83-6.84 μM。 | |||
T5175 |
azd1390
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZD1390 是一种可口服的,可渗透脑的ATM 高度选择性抑制剂,IC50为 0.78 nM。 | |||
T4443 |
AZ32
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZ32 是一种口服生物利用度和血脑屏障穿透性 ATM 抑制剂,对 ATM 酶的 IC50 <6.2 nM,对细胞内 ATM 的 IC50 为 0.31 μM。 | |||
T1958 |
AZ20
|
ATM/ATR; mTOR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZ20 是一种有效且特异性的 ATR 激酶抑制剂,IC50值为 5 nM。它还抑制mTOR 活性,IC50值为 38 nM。 | |||
T7122 |
AZD-7648
|
DNA-PK | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZD-7648 是一种 DNA 依赖性蛋白激酶 (DNA-PK) 抑制剂,在酶试验中 IC50 为 0.63 nM,具有抗肿瘤活性。 | |||
T3338 |
Ceralasertib
AZD6738 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Ceralasertib (AZD6738) 是一种具有口服活性的选择性 ATR 激酶抑制剂,IC50 为 1 nM。 | |||
T2084 |
ETP-46464
|
ATM/ATR; DNA-PK; PI3K; mTOR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ETP-46464 是一种有效且特异性的 ATR 抑制剂,IC50为 25 nM。 | |||
T7318 |
Elimusertib
BAY-1895344 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Elimusertib (BAY-1895344) 是一种可口服的选择性ATR 抑制剂,IC50值为 7 nM。它具有抗肿瘤活性,可研究实体瘤和淋巴瘤。 | |||
T3032 |
VE-821
ATR Inhibitor IV |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
VE-821 (ATR Inhibitor IV) 是一种有效的 ATP 竞争性的ATR 抑制剂,Ki 为 13 nM,IC50为 26 nM。 | |||
T6612 |
NU6027
|
ATM/ATR; DNA-PK; CDK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
NU6027 是一种有效的 ATR/CDK 抑制剂,抑制 CDK1/2、ATR 和 DNA-PK,Ki 为 2.5 μM/1.3 μM、0.4 μM 和 2.2 μM。它以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。 | |||
T5092 |
AIM-100
AIM100 |
ACK | Tyrosine Kinase/Adaptors |
AIM-100 是选择性的 Ack1 抑制剂 (IC50:21.58 nM)。它还抑制 Tyr267磷酸化,但不抑制其他激酶,包括 PI3K 和 AKT 亚家族成员。它具有抗癌活性。 | |||
T1923 |
BRD4770
|
Histone Methyltransferase | Chromatin/Epigenetic |
BRD4770 是组蛋白甲基转移酶G9a 抑制剂,可激活共济失调毛细血管扩张突变途径并诱导细胞衰老。它可抑制H3K9的二甲基和三甲基化,EC50为 5 µM。 | |||
T70112 | GT-2227 | ||
GT-2227 is a histamine H3 receptor antagonist. | |||
T13238 |
Tyrphostin AG1433
SU1433,AG1433 |
VEGFR; PDGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂,IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。 | |||
T19671 |
AZ31
AZ 31,AZ-31 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
AZ31 是一种 ATM 抑制剂,具有有效性、高选择性、和口服活性。AZ31对 ATM 酶、细胞内 ATM 具有抑制作用,IC50 值 分别为<1.2 nM 和 46 nM。AZ31 表现出优异的 ATR 选择性 、PIKK 家族选择性和泛激酶选择性。AZ31 是一种强效的体外放射增敏剂,可用于研究癌症。 | |||
T2474 |
KU60019
KU-60019,KU 60019 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
KU60019 是一种有效的、可逆的 ATM 激酶抑制剂 (IC50: 6.3 nM)。它对一组 229 种其他激酶的效果要差得多或没有效果。 | |||
T6100 |
Torin 2
|
Apoptosis; ATM/ATR; DNA-PK; mTOR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Torin 2 是一种特异性 mTOR 抑制剂,IC50值为0.25 nM,并改善了药代动力学特性。它抑制 ATM/ATR/DNA-PK 的 EC50 分别为 28 nM/35 nM/118 nM。 | |||
T70873 |
M3541
|
Apoptosis; ATM/ATR | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
M3541 是一种具有选择性有效性和口服活性的 ATM 抑制剂,具有潜在抗肿瘤活性。M-3541 通过与 ATM 结合来抑制 ATM 的激酶活性和 ATM 介导的信号传导。M3541 防止 DNA 损伤检查点激活,抑制 DNA 损伤修复,促使肿瘤细胞凋亡,并诱导 ATM 过表达的肿瘤细胞死亡。 | |||
T16773 |
Ro 90-7501
RO-90-7501 |
Apoptosis; Phosphatase; ATM/ATR; Gamma-secretase | Apoptosis; DNA Damage/DNA Repair; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维和 TPR 依赖性 PP5 抑制剂,是一种新型宫颈癌细胞放射增敏剂,可抑制 ATM 磷酸化 ,促进细胞凋亡,诱导细胞周期停滞。Ro 90-7501 具有抗病毒活性和潜在的抗癌活性,抑制 ATM 磷酸化和 DNA 修复,抑制HCMV。 | |||
T63872 |
KU-60019
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
KU-60019 是特异性的 ATM 激酶抑制剂 (IC50: 6.3 nM)。 | |||
T62083 |
Camonsertib
ATR inhibitor 4,RP-3500 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Camonsertib (RP-3500) 是一种选择性的、口服具有活力的 ATR 激酶抑制剂 (ATRi),在生化试验中的 IC50: 1.00 nM,表现出有效的抗肿瘤作用。RP-3500 对 ATR 的选择性是 mTOR 的 30 倍 (IC50: 120 nM),是 ATM、DNA-PK 和 PI3Kα 激酶的 2,000 倍以上。 | |||
T2433 |
NU 7026
NU7026,DNA-PK Inhibitor II,LY293646 |
Apoptosis; ATM/ATR; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
NU 7026 (DNA-PK Inhibitor II) 是一种新型特异性的DNA-PK 抑制剂,IC50为 0.23 μM,也抑制PI3K,IC50为 13 μM。 | |||
T15673 | KU 59403 | ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively). | |||
T78711 |
A011
|
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
A011,作为一种选择性的ataxia-telangiectasia mutated (ATM)抑制剂,其IC50为1.0 nM,能够在与CPT-11联合应用时,诱导Apoptosis及G2/M期细胞周期阻滞,显示出显著的抗肿瘤活性。 | |||
T35942 |
AZ 5704
|
||
Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan in tumor bearing, immunocompromised mice. Orally bioavailable. Degorce et al (2016) Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiecta... | |||
T6283 |
Wortmannin
SL-2052,渥曼青霉素,KY-12420 |
ATM/ATR; DNA-PK; Serine/threonin kinase; PLK; PI3K; Antibiotic; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Wortmannin (SL-2052) 是一种 PI3K 抑制剂 (IC50=3 nM),具有共价性和不可逆性。Wortmannin 也是一种 PlK1 和 PlK3 的抑制剂 (IC50=5.8/48 nM),可以阻断自噬。 | |||
T68845 | Americanin A | ||
Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells. | |||
T39523 |
Antitumor agent-28
|
||
Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and demonstrates significant anti-cancer activity. | |||
T73301 |
ATR-IN-20
|
||
ATR-IN-20是一种高效的ATR(ATM/ATR)抑制剂, IC50值仅为3 nM。该化合物还能抑制mTOR(IC50值为18 nM),并展示出对PI3Kα(100 nM)、ATM(100 nM)和DNA-PK(662 nM)的良好选择性。ATR-IN-20具备优秀的药代动力学属性(F=30%),同时显示了其抗癌潜力。 | |||
T60273 |
Mirin
|
||
Mirin 是一种有效的 Mre11-Rad50-Nbs1 (MRN)复合物抑制剂。Mirin 可在不影响 ATM 蛋白激酶活性的情况下,抑制ATM 的 MRN 依赖性激活(IC50=12 μM),并抑制 Mre11 相关的核酸外切酶活性。与其靶向 MRN 复合物的能力一致,Mirin 可消除哺乳动物细胞中的 G2/M 检查点和同源性依赖性修复。 | |||
T62290 | SKLB-197 | ||
SKLB-197 能够作用于 ATR (IC50: 0.013 μM),但对其他 402 种蛋白激酶的活性极弱或无活性。在体外和体内,SKLB-197 对 ATM 缺陷型肿瘤具有显著的抗肿瘤作用。 | |||
T68870 |
SU-11752
|
||
SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited. | |||
T36701 | Phosphoramide mustard (cyclohexanamine) | ||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1673 |
Garcinone C
伽升沃 C,伽升沃C |
ATM/ATR; CDK; STAT; AChR; Antifection | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物,具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂,对某些癌症具有潜在的细胞毒性作用。 | |||
T7892 |
ATMP
|
Others | Others |
ATMP 是一种具有螯合特性的膦酸。它是一种阻垢剂。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 |