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Cat. No. | Product Name | Target | Signaling Pathways |
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T7272 |
2,3,5-TRIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE
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2,3,5-TRIFLUORO-4-(TRIFLUOROMETHYL)PYRIDINE 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T7272,CAS号为 675602-93-4。 | |||
T1360 |
4-Nitro-3-trifluoromethyl aniline
|
Others | Others |
4-Nitro-3-trifluoromethyl aniline 也被称为5-Amino-2-nitrobenzotrifluoride。 | |||
T7783 |
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE
|
Others | Others |
2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 是一种单胺类神经递质,已被研究其调节各种神经递质活性的潜力,包括血清素、多巴胺和去甲肾上腺素,还研究了其作为5-HT2A 受体激动剂的潜力。 | |||
T9323 |
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
4-氨基-6-(三氟甲基)苯-1,3-二磺酰胺,4-Amino-6-(trifluoromethyl)benzene-1,3-d,2,4-Disulfamyl-5-trifluoromethylaniline,2-amino-4-trifluoromethyl-1,5-benzendisulfonamide |
Carbonic Anhydrase | Metabolism |
4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide (4-Amino-6-(trifluoromethyl)benzene-1,3-d) 是一种碳酸酐酶抑制剂,用作潜在的抗肿瘤和抗青光眼药物。 | |||
T50023 |
ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
|
Others | Others |
ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 又称 EAPT,是一种有效的选择性 PDE4抑制剂,调节细胞内环腺苷酸(cAMP)水平。它已被用于多种科研应用,包括 cAMP 介导的信号转导通路的研究,并有潜力作为治疗炎症和免疫相关疾病的药物。 | |||
T60231 |
N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine
|
Others | Others |
N-[2-nitro-4-(trifluoromethyl)phenyl]piperazine 是一种生物活性化合物,属于哌嗪类。它是一种重要的合成中间体,用于制备多种药物、农用化学品和其他化学品。它被认为是参与药物代谢的某些酶的抑制剂,例如细胞色素P450酶,也已被证明具有抗炎和抗肿瘤作用。 | |||
T50071 |
5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile
|
Others | Others |
5-amino-1-[4-(trifluoromethyl)phenyl]-1H-pyrazole-4-carbonitrile 是一种用作分子结构单元的化合物,被认为是 COX-2、5-LOX 等酶的抑制剂,具有多种生化和生理作用,包括抗肿瘤活性、抗炎作用和抗氧化活性。 | |||
T4303 |
4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid
|
Others | Others |
4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid 用作医药中间体。 | |||
T22424 |
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
SC-1 是一种 Sorafenib 的衍生物,可抑制 STAT3磷酸化,通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡,具有抗癌作用。 | |||
T50107 |
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
|
Others | Others |
ethyl 2-[3,5-bis(trifluoromethyl)phenyl]-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 是一种合成化合物,属于姜黄素家族。它通过抑制NF-κB 信号通路参与免疫反应和炎症的调节,通过激活Nrf2信号通路参与抗氧化反应的调节,通过抑制Akt 信号通路参与细胞存活和增殖的调节。 | |||
T39805 |
LDHA-IN-3
PSTMB,1-(phenylseleno)-4-(trifluoromethyl) benzene |
Dehydrogenase | Metabolism |
LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) 是一种有效的非竞争性乳酸脱氢酶(LDHA) 抑制剂,IC50值为 145.2 nM。LDHA-IN-3 是一种硒苯化合物,可用于研究癌症。 | |||
T20713 |
Flonicamid
UNII-9500W2Z53J,N-(cyanomethyl)-4-(trifluoromethyl)nicotinamide |
Others | Others |
Flonicamid (N-(cyanomethyl)-4-(trifluoromethyl)nicotinamide) 是一种吡啶甲酰胺杀虫剂,在食用日本萝卜叶的过程中抑制蚜虫(M.persicae)的唾液分泌和汁液摄入。它对棉蚜、红蚜、巴迪蚜、禾谷蚜和大鼠产生毒性。 | |||
T13925 |
THS-044
N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine,N-Morpholino-2-nitro-4-(trifluoromethyl)aniline |
HIF | Angiogenesis; Chromatin/Epigenetic |
THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) 的结合可稳定 HIF2α PAS-B 折叠状态,kd 为 2 μM,并在内源性和临床环境中调节 HIF2 活性。 | |||
T9818 |
NGD-8243
NGD8243,N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine |
TRP/TRPV Channel | Membrane transporter/Ion channel |
NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) 是一种 TRPV1 抑制剂,可用于预防和治疗心脏肥大的研究。 | |||
T21356 |
4-(Trifluoromethyl)phenylboronic acid
|
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4-(Trifluoromethyl)benzeneboronic acid is used to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones. | |||
T60055 |
Chromeceptin
2-amino-7-(dimethylamino)-4-[3-(trifluoromethyl)phenyl]-4H-chromene-3-carbonitrile |
Akt; IGF-1R; mTOR | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Chromeceptin 是 IGF 信号通路的抑制剂,可减少肿瘤球的数量,并抑制 AKT/mTOR 通路。 | |||
T8562 |
A 425619
1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA |
TRP/TRPV Channel | Membrane transporter/Ion channel |
A 425619 (1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA) 是一种有效的 TRPV1 拮抗剂。 | |||
T117521 |
7-BFC
7-Benzyloxy-4-(trifluoromethyl)coumarin,Y040-0031 |
P450 | Metabolism |
7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) 是一种香豆素类荧光底物,可作为细胞色素 P 450 的生物标记物,可用于研究 CYP 亚型和细胞色素 P 450 代谢。 | |||
T37926 |
7-Ethoxy-4-(trifluoromethyl)coumarin
|
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7-Ethoxy-5-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1Upon O-deethylation by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively. 1.Buters, J.T.M., Schiller, C.D., and Chou, R.C.A highly sensitive tool for the assay of cytochrome P450 enzyme activity in rat, dog and man. Direct fluorescence monitoring of the deethylation o... | |||
T9330 |
MIPS521
{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MIPS521 ({2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone) 是腺苷受体 (A1AR) 的正向变构调节剂,通过调节大鼠脊髓中内源性腺苷水平的升高,在体内表现出减轻疼痛的作用。 | |||
T14775 |
Bragsin2
6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2 |
Others | Others |
Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) 是非竞争性的核苷酸交换因子 BRAG2选择性抑制剂,其 IC50值为 3 μM。它能够结合到 BRAG2 的 PH 结构域和磷脂双分子层的界面处,使 BRAG2 无法激活磷脂化的 Arf GTPase。它能够影响乳腺癌干细胞。 | |||
T9645 |
CU-115
N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide |
TLR | Immunology/Inflammation |
CU-115 是一种有效的,选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中,CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。 | |||
T16806 |
RU-302
[2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone |
TAM Receptor | Tyrosine Kinase/Adaptors |
RU-302 是一种 TAM 受体泛抑制剂,可阻断 TAM Ig1 胞外域和 Gas6 Lg 域之间的界面。 RU-302 有效阻断 Gas6 诱导的 AXL 的激活并抑制肺癌肿瘤的生长。 | |||
T50110 |
CD532
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
CD532 是一种高效的 Aurora A 激酶抑制剂,IC50 值为 45 nM。CD532 可阻断 Aurora A 激酶活性,驱动 MYCN 降解,可以直接与 AURKA 相互作用并诱导整体构象转变。CD532 可用于研究癌症。 | |||
T9199 |
GLPG2938
1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea |
S1P Receptor; LPL Receptor | GPCR/G Protein |
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) 是一种选择性 S1P2拮抗剂,可用于特发性肺纤维化的研究。 | |||
T64340 |
ML267
4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate |
Others | Others |
ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) 是一种有效的细菌磷酸泛酰氨基转移酶抑制剂,可减弱二次代谢并阻碍细菌生长。 | |||
T16688 |
Pyr6
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。 | |||
T8616 |
Fasentin
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide |
transporter | Metabolism |
Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂,可抑制GLUT-1/GLUT-4转运蛋白,优先抑制 GLUT4,IC50为 68 μM。它是死亡受体刺激敏化剂,可敏化细胞对 FAS 诱导的细胞死亡,具有抗血管生成活性。 | |||
T16277 |
NCT-502
N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide |
Dehydrogenase | Metabolism |
NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) 是磷酸甘油酸脱氢酶 (PHGDH) 抑制剂(IC50:3.7 μM),对 PHGDH 依赖性癌细胞具有细胞毒性,能够减少葡萄糖衍生的丝氨酸的产生,。 | |||
T30363 |
Benzenesulfonamide, N-(4-chloro-3-(trifluoromethyl)phenyl)-4-fluoro-
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Benzenesulfonamide, N-(4-chloro-3-(trifluoromethyl)phenyl)-4-fluoro- is a bioactive chemical. | |||
T20789 |
S-23
(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 |
Androgen Receptor | Endocrinology/Hormones |
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活,提高去势大鼠前列腺、精囊和肛提肌重量。 | |||
T72022 |
11β-HSD1 inibitor 19
|
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11β-HSD1 inibitor 19 对 hHSD1 和 mHSD1 显示抑制活性,IC50 为 16 nM 和 10 nM。 | |||
T30362 |
Benzenesulfonamide, N-(2-chloro-5-(trifluoromethyl)phenyl)-4-fluoro-
|
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Benzenesulfonamide, N-(2-chloro-5-(trifluoromethyl)phenyl)-4-fluoro- is a bioactive chemical. | |||
T24833 |
ZINC69391
ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base) |
Apoptosis; Rho | Apoptosis; Cell Cycle/Checkpoint |
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) 是 Rac1 的选择性抑制剂,具有抗增殖和抗转移作用。 ZINC69391 干扰 Rac1 与 Dock180 的相互作用,降低 Rac1-GTP 水平并诱导细胞凋亡。 | |||
T9658 |
DCZ3301
NPS ALX Compound 4a hydrochloride(1:1)(299433-10-6 Free base) |
Others | Others |
DCZ3301是一种新的芳基胍抑制剂。 | |||
T2265 |
Bimiralisib
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 |
Others; PI3K; S6 Kinase; mTOR | MAPK; Others; PI3K/Akt/mTOR signaling |
Bimiralisib (PI3K-IN-2) 是一种有效的,可渗透脑的 mTOR/PI3K 抑制剂,是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR,IC50分别为 33 nM,451 nM,661 nM,708 nM 和 89 nM。 | |||
T8746L |
I-49 free base
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-,I-49 |
Raf | MAPK |
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) 是一种新型苄氨基取代的吡啶并嘧啶酮,可作为 SOS1 抑制剂。 | |||
T8929 |
BC1618
2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- |
Mitophagy; Others; E1/E2/E3 Enzyme; AMPK | Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination |
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂,可刺激 Ampk 依赖性信号传导。它促进线粒体分裂,促进自噬并提高肝脏胰岛素敏感性。 | |||
T77702 |
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
|
Others | Others |
4-Chloro-3-(trifluoromethyl)phenyl isocyanate 是一种生化试剂,可被邻氯三氟甲苯与醋酐通过一系列反应生成。 | |||
T66972 |
4-(Trifluoromethyl)phenol
|
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4-(Trifluoromethyl)phenol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66972,CAS号为 402-45-9。 | |||
T70070 |
Cisapride tartrate
|
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Cisapride tartrate is chemically related to metoclopramide, but unlike metoclopramide, it does not cross the blood-brain barrier or have antidopaminergic effects. Cisapride is a serotonin-4 (5-HT4) receptor agonist. Cisapride was indicated for the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease. The Food and Drug Administration (FDA) in America stopped the marketing of cisapride as of 14th July 2000. They had received at least 341 reports o... | |||
T8721 |
I-37
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]- |
Raf | MAPK |
I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) 是一种新型苄氨基取代的吡啶并嘧啶酮,可作为 SOS1 抑制剂。 | |||
TNU0515 |
2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine
|
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2'-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a Nucleoside Derivative - Halo-nucleoside;2-Modified purine nucleoside; 6-Modified purine nucleoside;. | |||
T67196 |
4-(Trifluoromethyl)-D-phenylalanine
|
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4-(Trifluoromethyl)-D-phenylalanine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67196,CAS号为 114872-99-0。 | |||
T67405 | 4-(Trifluoromethyl)cinnamic acid | ||
4-(Trifluoromethyl)cinnamic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T67405。 | |||
T65695 |
4-(Trifluoromethyl)-L-phenylalanine
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4-(Trifluoromethyl)-L-phenylalanine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T65695。 | |||
T69085 |
Mabuterol, (S)-
|
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Mabuterol, (S)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors. | |||
T64898 | 4-Bromo-3-(trifluoromethyl)aniline | ||
4-Bromo-3-(trifluoromethyl)aniline 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64898,CAS号为 393-36-2。 | |||
T60124 |
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
|
TNF | Apoptosis |
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物,可以诱导细胞分泌 TNF-α。 | |||
T60186 |
(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
|
Discoidin Domain Receptor (DDR) | Tyrosine Kinase/Adaptors |
MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂,IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TJS0341 |
7-Amino-4-(trifluoromethyl)coumarin
香豆素151,Coumarin 151,AFC,7-氨基-4-(三氟甲基)香豆素 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
7-Amino-4-(trifluoromethyl)coumarin (Coumarin 151) 是一种荧光标记物,其激发和发射波长分别为400和500 nm,可用来灵敏的检测蛋白酶。 | |||
T4643 |
TFAP
N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide |
COX; Endogenous Metabolite | Immunology/Inflammation; Metabolism; Neuroscience |
TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) 是环氧酶 1 的一种选择性抑制剂,IC50值为 0.8 μM。 | |||
TN6663 |
trans-4-(Trifluoromethyl)cinnamic acid
|
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trans-4-(Trifluoromethyl)cinnamic acid 是一种光敏化合物。它被用作合成各种化合物的试剂,如杂环化合物和药物。它也被用作有机反应的催化剂,例如赫克反应和铃木-宫浦反应。它还被用作生物学研究中的荧光探针,以检测和监测各种生物分子。 |