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309

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T23280 Ruthenium Red

钌红,Ammoniated ruthenium oxychloride

Calcium Channel Membrane transporter/Ion channel; Metabolism
Ruthenium Red (Ammoniated ruthenium oxychloride) 是一种 L 型钙电流 (ICa) 阻断剂,是一种聚阳离子染料,广泛用于电子显微镜 (EM) 下细胞、组织和营养细菌的观察。它能与磷脂和脂肪酸反应强烈,并与酸性粘多糖结合。
T4316 ML365

Potassium Channel Membrane transporter/Ion channel
ML365 是有效的,选择性的双孔结构域钾通道TASK1/KCNK3抑制剂,IC50为 4 nM。它可用于检查 TASK1 通道的特定作用。
T4314 EPZ020411

EPZ020411 2HCl

Histone Methyltransferase Chromatin/Epigenetic
EPZ020411是一种特异性有效的 PRMT6 抑制剂, IC50 为 10 nM,比作用于 PRMT1 和 PRMT8 的选择性高10倍多。
T0582 Fructooligosaccharides

Others Others
Fructooligosaccharides 是一种左旋单糖,是葡萄糖的异构体。
T5981 2,2'-Anhydrouridine

O2,2'-Cyclouridine,2,2'-脱水尿苷,2,2'-Cyclouridine

Antiviral; Reverse Transcriptase Immunology/Inflammation; Microbiology/Virology
2,2'-Anhydrouridine (2,2'-Cyclouridine) 有抗肿瘤和抗病毒活性。
T67772 Phos-tag Acrylamide AAL-107

Phos-tag Acrylamide AAL-107 是一种丙烯酰胺悬垂物,可用作可视化磷酸化蛋白质的工具。
T21221 Meldrum's acid

丙二酸环(亚)异丙酯,Isopropylidene malonate,AI3-39039

Antibacterial Microbiology/Virology
Meldrum's acid (Isopropylidene malonate) 是一种用于除臭剂的抗菌剂。 基于 Meldrum's acid 多组分反应是制备新型聚合物的潜在工具。
T4057 Hoechst 33258 trihydrochloride

Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258

Parasite Microbiology/Virology
Hoechst 33258 trihydrochloride (Bisbenzimide) 是一种能够用于 DNA 染色的荧光染料。
T60020 5'-Fluoro-5'-deoxyadenosine

5'-Fluoro-5'-deoxy-adenosine

Others Others
5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) 常用作研究放线菌卡特链霉菌的工具。
T14994 Coelenterazine h

腔肠素-H,2-Deoxycoelenterazine,CLZN-h

Others Others
Coelenterazine h (CLZN-h) 是一种 Coelenterazine 的衍生物。它对 Ca2+比它的天然复合物更敏感,是一种能够测量 Ca2+浓度的微小变化的有效工具。
T40350 HPK1-IN-4

HPK1-IN-4

MAPK MAPK
HPK1-IN-4是一种HPK1(MAPK41)抑制剂,IC 50为0.061 nM。HPK1-IN-4常被作为临床前免疫治疗工具化合物。
T6515 Go6976

Gö 6976

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
Go6976是蛋白激酶C (PKC)的小分子抑制剂。Go6976作为研究PKC 在各种生理和病理生理过程中的作用的工具,广泛应用于生物医学研究。
T63788 PCLX-001

Others Others
PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2].
T39817 Msr-Ratio

Msr-green,Msr-Ratio

Others Others
Msr-Ratio (Msr-green) (Msr-green) is a ratiometric fluorescent probe specifically designed for the detection of methionine sulfoxide reductase (MSR) activity. It has an excitation wavelength of 375 nm and an emission wavelength of 550 nm. This probe offers the ability to monitor the enzyme activity both in vitro and in live cells, making it a valuable tool for studying MSR function.
T78274 Omburtamab

Omburtamab是一款针对CD276(亦称为B7-H3)的单克隆抗体,后者为在人类实体肿瘤中表达的B7/CD28免疫球蛋白家族成员。此抗体能够结合肿瘤组织,被应用于多种癌症的研究中。
T22180 3F8

3F 8,3F-8

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
3F8 是一种具有选择性的 GSK-3β抑制剂,可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物,可用于研究神经系统疾病和癌症。
T77613 SNX7

WAY-323879

CDK Cell Cycle/Checkpoint
SNX7 (WAY-323879) 是细胞周期蛋白依赖性激酶抑制剂 (CDKI) 途径的抑制剂。 SNX7 可用作研究衰老过程和与 CDKI 相关的其他疾病的工具。
T9314 CC214-1

mTOR; Autophagy Autophagy; PI3K/Akt/mTOR signaling
CC214-1 是一种 mTOR 抑制剂,具有潜在的抗癌活性,抑制蛋白翻译,可诱导自噬 (autophagy)。 CC214-1 是探索 mTOR 激酶生物学的体外工具化合物,可用于研究骨髓瘤。
T60219 ELOVL1-IN-3 

Others Others
ELOVL1-IN-3 是一种有效且具有口服活性的超长链脂肪酸 1 (ELOVL1) 酶延长抑制剂。ELOVL1-IN-3 是研究肾上腺脑白质营养不良 (ALD) 的有用工具。
TP1344 Luciferase

Others Others
Luciferase 是一种在生物发光细菌中发现的依赖黄素的单加氧酶。 Luciferase 是识别和表征功能变体的宝贵工具,可用于研究基因表达、细胞内信号传导、转录因子、受体活性和蛋白质折叠。
T21720 GP-82996

Cdk4/6 Inhibitor IV,CINK4

CDK Cell Cycle/Checkpoint
GP-82996 (CINK4) (CINK4) 是 CDK4/6的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡,可用于癌症研究。
T9361 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Others Others
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 是一种合成化合物。它已被用作催化剂以及酶动力学研究中的工具;还被用于酶抑制的研究,以及药物受体相互作用的研究。
T67835 LKM38

LKM38是一种新型的重氮烷基胆固醇探针,是一种有前途的胆固醇模拟物。LKM38既能维持抗胆固醇细胞的生长,又能适当地调节关键的胆固醇平衡途径。LKM38可以作为研究胆固醇蛋白相互作用和贩运的有力工具。
T64355 TDI-10229

cAMP GPCR/G Protein
TDI-10229 是一种口服有效的可溶性腺苷酸环化酶 (sAC, ADCY10) 抑制剂 (IC50 值为 195 nM)。TDI-10229 在生化和细胞分析中都显示出对 sAC 的纳摩尔级抑制,并表现出足以保证其用作体内工具化合物的小鼠药代动力学特性。
T11553 Heptamidine dimethanesulfonate

SBi4211 dimethanesulfonate

Others Others
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) 是一种与喷他脒有关的、强效的钙结合蛋白 S100B 的抑制剂 (Kd=6.9 μM),选择性地杀死表达 S100B 的黑素瘤细胞。它是有效的强直性肌营养不良 (DM) 研究工具。
T13330 WAY-213613 hydrochloride

WAY-213613 hydrochloride (868359-05-1 free base)

transporter Metabolism
WAY-213613 hydrochloride 是一个有效,选择性的,非底物再摄取 GLT-1/EAAT2抑制剂,具有有效的 EAAT2 抑制活性,IC50值为 85 nM,它是阐明 EAAT2 功能的潜在工具,可用于中枢神经系统的研究。
T22891 KL001

KL 001,KL-001

Others Others
KL001 是一流的隐花色素蛋白 (CRY)稳定剂,可与 CRY1 和 CRY2 特异性相互作用。其中CRY 是一种对蓝光敏感的黄素蛋白,参与调节动植物的昼夜节律。KL001能够防止泛素依赖性 CRY 降解,从而延长了昼夜节律周期,具有控制空腹激素诱导的糖异生的潜力。
T37020 Endosidin-2

ES2,Endosidin 2

Endosidin-2是一种囊外囊抑制剂,具有细胞渗透性的亚苄基苯甲酰肼,可与外囊复合体70 kDa(EXO70)亚基的外囊成分结合(Kd = 253 μM,EXO70A1)。Endosidin-2会破坏蛋白质在内质体和质膜之间的转运,从而促进蛋白质转运至液泡降解。它还能抑制 HeLa 细胞中内吞转铁蛋白向质膜的再循环,并能靶向哺乳动物 EXO70的多种异构体,导致外泌失调。Endosidin2 可作为工具分子研究胞吐。
T36466 Chlorin E6

Ce6,Chlorin e6,CE6

Parasite Microbiology/Virology
Chlorin E6 (CE6) 是一种第二代光敏剂,在与辐照结合使用时具有抗肿瘤活性。在植入性纤维肉瘤的小鼠模型中,Chlorin E6(2.5-10 毫克/千克,静脉注射,50-200 焦耳/平方厘米的辐照)在不同程度的辐照后会导致肿瘤完全消失。在一项针对支气管源性早期浅表鳞状细胞癌患者的 I 期临床研究中,对包括 Chlorin E6 在内的制剂进行了测试,结果良好(40 毫克/平方米,静脉注射,100 焦耳/平方厘米的激光辐照)。在一项针对早期肺癌患者的二期临床试验中,同样的给药模式使 82.9% 的患者获得了完全应答。Chlorin E6 已被研究为一种纳米技术给药工具。
T33958 PH 1008

PH1008,PH-1008

PH 1008 is a porphyrin photosensitizer that may be useful as a diagnostic tool.
T31156 Cysteine hydrazide

Cysteine,L-hydrazide

Cysteine hydrazide is an enrichment tool for the mass spectrometric characterization of bacterial-free oligosaccharides.
T40648 NOTA

NOTA, a bifunctional chelate, serves as a foundation for PET imaging tool construction, probe design, and signal amplification through the multivalent effect.
T38955 β-Lactamase-IN-4

β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.
T33688 Nitromifene Citrate

Parke davis CI-628,CI-628 citrate,CI 628 citrate,CI628 citrate

Nitromifene Citrate is a nonsteroidal estrogen antagonist most commonly used as a research tool in animal studies.
T37695 NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ

NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ, an ACE2-related peptide, serves as a valuable research tool for comprehending ACE2 functions.
T40957 Adeninobananin

Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase.
T17965 Fmoc-NH-PEG11-CH2CH2COOH

Others Others
Fmoc-NH-PEG11-CH2CH2COOH, a PEG-based PROTAC linker, serves as a valuable tool in PROTAC synthesis[1].
T26343 YK5

YK 5,YK-5

YK5 is an allosteric inhibitor pocket of Hsp70 and represents a previously unknown chemical tool to investigate cellular mechanisms associated with Hsp70.
T82920 Barzuxetan

CHX-A''-DTPA-NCS

Barzuxetan 用于癌症研究。
T39270 2-NP-AMOZ

2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ, which is a metabolite of the antibiotic Furaltadone. This chemical compound specifically serves as a reliable tool for protein bound AMOZ detection.
T30216 AV-105

AV105,AV 105

Av-105 is the precursor of florbetapir (18F). It is a radiopharmaceutical compound scanned by pet, which can be used as a diagnostic tool for Alzheimer's disease.
T39140 SCO-267

SCO-267 is a potent allosteric full agonist of the GPR40 receptor, making it a valuable tool in studying chronic diseases like diabetes.
T69922 EPZ020411 HCl

EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.
T74091 PBFI-AM

PBFI-AM 可用于检测胞内 K+水平。
T39729 HIV Protease Substrate 1

HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect.
T61423 Transthyretin-IN-1

Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T69120 Pempidine tartrate

Pempidine tartrate is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T68992 Pempidine HCl

Pempidine HCl is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T61592 Thalidomide-piperazine hydrochloride

Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant discoveries in the biochemical pathways of limb development [1].
T25914 Pactamycin

Pactamycin is an antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also utilized as a tool in biochemistry because it suppresses certain steps in protein synthesis.

化合物

Ruthenium Red
Cat.No: T23280
Synonym: 钌红,Ammoniated ruthenium oxychloride
Target: Calcium Channel
ML365
Cat.No: T4316
Synonym:
Target: Potassium Channel
EPZ020411
Cat.No: T4314
Synonym: EPZ020411 2HCl
Target: Histone Methyltransferase
Fructooligosaccharides
Cat.No: T0582
Synonym:
Target: Others
2,2'-Anhydrouridine
Cat.No: T5981
Synonym: O2,2'-Cyclouridine,2,2'-脱水尿苷,2,2'-Cyclouridine
Target: Antiviral, Reverse Transcriptase
Phos-tag Acrylamide AAL-107
Cat.No: T67772
Synonym:
Target:
Meldrum's acid
Cat.No: T21221
Synonym: 丙二酸环(亚)异丙酯,Isopropylidene malonate,AI3-39039
Target: Antibacterial
Hoechst 33258 trihydrochloride
Cat.No: T4057
Synonym: Hoechst 33258,Pibenzimol,Bisbenzimide,H 33258 trihydrochloride,bisBenzimide H 33258 trihydrochloride,HOE 33258
Target: Parasite
5'-Fluoro-5'-deoxyadenosine
Cat.No: T60020
Synonym: 5'-Fluoro-5'-deoxy-adenosine
Target: Others
Coelenterazine h
Cat.No: T14994
Synonym: 腔肠素-H,2-Deoxycoelenterazine,CLZN-h
Target: Others
HPK1-IN-4
Cat.No: T40350
Synonym: HPK1-IN-4
Target: MAPK
Go6976
Cat.No: T6515
Synonym: Gö 6976
Target: PKC
PCLX-001
Cat.No: T63788
Synonym:
Target: Others
Msr-Ratio
Cat.No: T39817
Synonym: Msr-green,Msr-Ratio
Target: Others
Omburtamab
Cat.No: T78274
Synonym:
Target:
3F8
Cat.No: T22180
Synonym: 3F 8,3F-8
Target: GSK-3
SNX7
Cat.No: T77613
Synonym: WAY-323879
Target: CDK
CC214-1
Cat.No: T9314
Synonym:
Target: mTOR, Autophagy
ELOVL1-IN-3 
Cat.No: T60219
Synonym:
Target: Others
Luciferase
Cat.No: TP1344
Synonym:
Target: Others
GP-82996
Cat.No: T21720
Synonym: Cdk4/6 Inhibitor IV,CINK4
Target: CDK
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Cat.No: T9361
Synonym: 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Target: Others
LKM38
Cat.No: T67835
Synonym:
Target:
TDI-10229
Cat.No: T64355
Synonym:
Target: cAMP
Heptamidine dimethanesulfonate
Cat.No: T11553
Synonym: SBi4211 dimethanesulfonate
Target: Others
WAY-213613 hydrochloride
Cat.No: T13330
Synonym: WAY-213613 hydrochloride (868359-05-1 free base)
Target: transporter
KL001
Cat.No: T22891
Synonym: KL 001,KL-001
Target: Others
Endosidin-2
Cat.No: T37020
Synonym: ES2,Endosidin 2
Target:
Chlorin E6
Cat.No: T36466
Synonym: Ce6,Chlorin e6,CE6
Target: Parasite
PH 1008
Cat.No: T33958
Synonym: PH1008,PH-1008
Target:
Cysteine hydrazide
Cat.No: T31156
Synonym: Cysteine,L-hydrazide
Target:
NOTA
Cat.No: T40648
Synonym:
Target:
β-Lactamase-IN-4
Cat.No: T38955
Synonym:
Target:
Nitromifene Citrate
Cat.No: T33688
Synonym: Parke davis CI-628,CI-628 citrate,CI 628 citrate,CI628 citrate
Target:
NMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQ
Cat.No: T37695
Synonym:
Target:
Adeninobananin
Cat.No: T40957
Synonym:
Target:
Fmoc-NH-PEG11-CH2CH2COOH
Cat.No: T17965
Synonym:
Target: Others
YK5
Cat.No: T26343
Synonym: YK 5,YK-5
Target:
Barzuxetan
Cat.No: T82920
Synonym: CHX-A''-DTPA-NCS
Target:
2-NP-AMOZ
Cat.No: T39270
Synonym:
Target:
AV-105
Cat.No: T30216
Synonym: AV105,AV 105
Target:
SCO-267
Cat.No: T39140
Synonym:
Target:
EPZ020411 HCl
Cat.No: T69922
Synonym:
Target:
PBFI-AM
Cat.No: T74091
Synonym:
Target:
HIV Protease Substrate 1
Cat.No: T39729
Synonym:
Target:
Transthyretin-IN-1
Cat.No: T61423
Synonym:
Target:
Pempidine tartrate
Cat.No: T69120
Synonym:
Target:
Pempidine HCl
Cat.No: T68992
Synonym:
Target:
Thalidomide-piperazine hydrochloride
Cat.No: T61592
Synonym:
Target:
Pactamycin
Cat.No: T25914
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T3S1251 Neoruscogenin

ROR Metabolism
Neoruscogenin 是甾体 sapogenin 家族的成员,是一种可生物利用且具有高亲和力的核受体RORα (NR1F1)激动剂。
T10662L Calcimycin

Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187

Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal Apoptosis; Autophagy; Microbiology/Virology
Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长,也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。
T0414 D-Mannitol

Mannite,Mannitol,D-甘露糖醇,Osmitrol

Apoptosis; Dehydrogenase; Endogenous Metabolite Apoptosis; Metabolism
D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂,具有较弱的肾脏血管扩张活性。
T0791 Reserpine

利血平,Serpalan,Serpasil,Serpivite

Others; Potassium Channel; MRP; Monoamine Transporter; Autophagy Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others
Reserpine (Serpalan) 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中,导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。
T7285 Ionomycin

Calcium Channel Membrane transporter/Ion channel; Metabolism
Ionomycin 是一种钙离子载体和一种结合钙离子(Ca2+)的抗生素。它是由联合链霉菌(Streptomyces conglobatus)产生的。它在研究中用于提高细胞内钙水平(Ca2+),并作为了解 Ca2+跨生物膜运输的研究工具。Ionomycin 可促进细胞凋亡,诱导蛋白激酶 C (PKC)活化。
T40381 2,8-Dihydroxyadenine

2,8-Dihydroxyadenine, an endogenous metabolite, can induce the generation of urinary crystals and nephrolithiasis. Moreover, 2,8-Dihydroxyadenine serves as a diagnostic tool for detecting adenine phosphoribosyltransferase (APRT) deficiency.
T78505 Ethyl pivaloylacetate

Ethyl pivaloylacetate为β-酮酯,用作酮还原酶工具箱活性及其立体选择性评估的底物。
T6627 Phosphoramidon Disodium

Phosphoramidon Disodium Salt,磷酰胺二钠

RAAS; Neprilysin; Others Endocrinology/Hormones; Metabolism; Others
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ,0.034 和 78 μM。
T39277 D-Hexamannuronic acid

D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4].
T41025 Prunetin 5-O-β-D-glucopyranoside

Prunetin 5-O-β-D-glucopyranoside, an isoflavone obtained from Potentilla astracanica extracts, is a potent uncompetitive inhibitor of α-glucosidase (IC 50 = 56.05 μg/mL). It serves as a valuable tool for type-2 diabetes research.
T40966 D-Heptamannuronic acid

D-Heptamannuronic acid, an alginate oligomer, is derived from marine brown algae and a select group of Gram-negative bacteria. This compound serves as a valuable research tool in the study of pain and vascular dementia[4].
T38954 L-Glyceric acid sodium

L-Glyceric acid sodium is a urinary metabolite predominantly found in individuals with the rare inherited metabolic disorder, L-glyceric aciduria. This compound serves as a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and can be used to differentiate between PH1 and PH2 based on its excretion pattern.
TN3057 4-O-Methylbutein

Autophagy Autophagy
4-O-Methylbutein (2',3,4'-trihydroxy-4-methoxychalcone) may have anti-inflammation activity, it is a potent heme oxygenase-1 (HO-1) inducer, the upregulation of HO-1 has proven to be a useful tool for fighting inflammation.
T73068 Mammea A/BA

Mammea A/BA 对克氏锥虫 (T. cruzi) 显示出有效抗性。通过诱导线粒体功能障碍、产生活性氧 (ROS)、DNA 片段化以及增加酸性液泡数量,Mammea A/BA 触发细胞死亡机制,包括细胞凋亡 (apoptosis)、细胞自噬 (autophagy) 和细胞坏死,对于南美锥虫病的研究具有潜在应用价值。

天然产物

Neoruscogenin
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Synonym:
Target: ROR
Calcimycin
Cat.No: T10662L
Synonym: Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187
Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal
D-Mannitol
Cat.No: T0414
Synonym: Mannite,Mannitol,D-甘露糖醇,Osmitrol
Target: Apoptosis, Dehydrogenase, Endogenous Metabolite
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Cat.No: T0791
Synonym: 利血平,Serpalan,Serpasil,Serpivite
Target: Others, Potassium Channel, MRP, Monoamine Transporter, Autophagy
Ionomycin
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Synonym:
Target: Calcium Channel
2,8-Dihydroxyadenine
Cat.No: T40381
Synonym:
Target:
Ethyl pivaloylacetate
Cat.No: T78505
Synonym:
Target:
Phosphoramidon Disodium
Cat.No: T6627
Synonym: Phosphoramidon Disodium Salt,磷酰胺二钠
Target: RAAS, Neprilysin, Others
D-Hexamannuronic acid
Cat.No: T39277
Synonym:
Target:
Prunetin 5-O-β-D-glucopyranoside
Cat.No: T41025
Synonym:
Target:
D-Heptamannuronic acid
Cat.No: T40966
Synonym:
Target:
L-Glyceric acid sodium
Cat.No: T38954
Synonym:
Target:
4-O-Methylbutein
Cat.No: TN3057
Synonym:
Target: Autophagy
Mammea A/BA
Cat.No: T73068
Synonym:
Target:
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