store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Go6976是蛋白激酶C (PKC)的小分子抑制剂。Go6976作为研究PKC 在各种生理和病理生理过程中的作用的工具,广泛应用于生物医学研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 548 | 现货 | ||
5 mg | ¥ 1,330 | 现货 | ||
10 mg | ¥ 1,990 | 现货 | ||
25 mg | ¥ 3,370 | 现货 | ||
50 mg | ¥ 4,780 | 现货 | ||
100 mg | ¥ 6,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,380 | 现货 |
产品描述 | Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes. |
靶点活性 | PKCα:2.3 nM, PKC:7.9 nM, PKCβ1:6.2 nM, PKC:20 nM |
体外活性 | 30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2] |
别名 | Gö 6976 |
分子量 | 378.43 |
分子式 | C24H18N4O |
CAS No. | 136194-77-9 |
store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6425 mL | 13.2125 mL | 26.425 mL | 66.0624 mL |
5 mM | 0.5285 mL | 2.6425 mL | 5.285 mL | 13.2125 mL | |
10 mM | 0.2642 mL | 1.3212 mL | 2.6425 mL | 6.6062 mL | |
20 mM | 0.1321 mL | 0.6606 mL | 1.3212 mL | 3.3031 mL | |
50 mM | 0.0528 mL | 0.2642 mL | 0.5285 mL | 1.3212 mL | |
100 mM | 0.0264 mL | 0.1321 mL | 0.2642 mL | 0.6606 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Go6976 136194-77-9 Chromatin/Epigenetic Cytoskeletal Signaling PKC Gö 6976 Inhibitor inhibitor inhibit