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Search Results for " methylation "

67

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36631	BAY-6035	MEK; Histone Methyltransferase	Chromatin/Epigenetic; MAPK
	BAY-6035 是 SET 和 MYND 结构域蛋白 3 (SMYD3) 的抑制剂。 BAY-6035 的选择性比其他组蛋白甲基转移酶高 100 倍以上。
T6879	LLY-507 LLY507,LLY 507	Histone Methyltransferase	Chromatin/Epigenetic
	LLY-507 是一种有效的、细胞活性的、特异性的蛋白质赖氨酸甲基转移酶 SMYD2 抑制剂。它是一种化学探针，用于解析 SMYD2 在癌症和其他生物过程中的功能。它有抑制 SMYD2 甲基化 p53 肽的能力，IC50小于 15 nM。
T1923	BRD4770	Histone Methyltransferase	Chromatin/Epigenetic
	BRD4770 是组蛋白甲基转移酶G9a 抑制剂，可激活共济失调毛细血管扩张突变途径并诱导细胞衰老。它可抑制H3K9的二甲基和三甲基化，EC50为 5 µM。
T13748	L-2-Hydroxyglutaric acid disodium S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase; Mitochondrial Metabolism	Chromatin/Epigenetic; Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子，是肾癌中的表观遗传修饰剂和推定的癌代谢物，可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶，从而促进组蛋白甲基化。
T17212	VAL-083 1,2:5,6-二脱水半乳糖醇,Dianhydrogalactitol,去水卫矛醇,Dianhydrodulcitol	DNA Alkylator/Crosslinker; DNA Alkylation	DNA Damage/DNA Repair
	VAL-083 (Dianhydrogalactitol) 是一种烷化剂，具有抗肿瘤活性，可在 DNA 上产生 N7 甲基化。
T9626	Cycloleucine	NMDAR	Neuroscience
	Cycloleucine 是 NMDA 受体相关甘氨酸受体的拮抗剂，Ki 为 600 μM。Cycloleucine 也是 S-腺苷甲硫氨酸介导的甲基化的竞争性抑制剂，具有抗焦虑和细胞抑制作用。
T23284	Ryuvidine	Histone Demethylase; Histone Methyltransferase; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Ryuvidine 是一种 KDM5A 和 SETD8 双重抑制剂，是一种 DNA 损伤反应的诱导剂，具有潜在的抗癌活性，抑制 H4K20 甲基化，抑制 CDK4，可用于研究乳腺癌和红斑病。
T16886	Sinefungin Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP	Others; Histone Methyltransferase; Antibiotic; Antifungal	Chromatin/Epigenetic; Microbiology/Virology; Others
	Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9，通过抑制H3K4甲基化来改善肾纤维化。
T28996	TP-064 TP 064	Histone Methyltransferase	Chromatin/Epigenetic
	TP-064 是选择性蛋白精氨酸甲基转移酶 4 抑制剂，IC50小于10 nM，具有抗癌活性。它抑制 BAF155 和 MED12 的二甲基化，IC50为 340 和 43 nM。它对于 PRMT6 的 IC50为 1.3 μM。
T9573	GSK3685032	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3685032 是一种非时间依赖、非共价、选择性的、可逆的DNMT1抑制剂，IC50=0.036 μM。它诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。
T6163	Salirasib 沙利雷塞,法尼基硫代水杨酸,Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS	Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Salirasib (Farnesyl Thiosalicylic Acid) 是一种有效的竞争性异戊二烯化蛋白甲基转移酶抑制剂，抑制 Ras 甲基化并具有潜在的抗肿瘤活性。
T2169	Zebularine NSC309132,4-Deoxyuridine	DNA Methyltransferase; Autophagy	Autophagy; Chromatin/Epigenetic
	Zebularine (4-Deoxyuridine) 是一种 DNA 甲基化抑制剂，还抑制胞苷脱氨酶。它通过以共价水合物的形式与活性大小结合，充当胞苷脱氨酶的过渡态类似物抑制剂。
T27453	GSK1733953A DG70	Antibacterial	Microbiology/Virology
	GSK1733953A 可作为一种小分子结核分枝杆菌呼吸抑制剂，对 MenG 活性有抑制作用，IC50 值为 2.6 ± 0.6 μM。GSK1733953A 是一种具有选择性的联苯苯甲酰胺，对结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化有抑制作用，对结核分枝杆菌H4Rv的MIC为8.37 μg/ml，对耐药菌株的MIC为1.2至9.6 μg/ml。GSK1733953A 是治疗结核病的候选化合物。
T1488	Procarbazine hydrochloride NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl	DNA Alkylator/Crosslinker; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂，是甲基肼衍生物的盐酸盐，具有抗肿瘤和诱变活性。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
T22297	Clindamycin hydrochloride monohydrate Clindamycin alcoholate	Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride monohydrate（Clindamycin alcoholate）是一种口服蛋白质合成抑制剂，具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基（23S rRNA）的抗生素结合位点通过酶促甲基化。此外，Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素（PVL）、毒性休克-葡萄球菌毒素（TSST-1）或α-溶血素（Hla）的产生。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T69703	BAY-6035-R-isomer
	BAY-6035 is an inhibitor of the methylation of MEKK2 peptide.
T82088	ICMT-IN-54
	ICMT-IN-54 (compound 7c) 为一adamantyl类似物，具有ICMT抑制活性（IC50=12.4 μM），能够有效抑制ICMT的甲基转移作用。此化合物可在表达ICMT的酿酒酵母样本中阻断BFC甲基化，展现出间接抑制ICMT甲基化的能力。
T40713	Dihydro-5-azacytidine DHAC,NSC264880,Dihydro-5-azacytidine
	Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.
T15169	DS-437	Others	Others
	DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
T78565	Dihydro-5-azacytidine acetate DHAC acetate,NSC 264880 acetate	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Dihydro-5-azacytidine acetate (DHAC)，作为一种核苷类似物，能够参与 DNA 合成并抑制 DNA 甲基化 (DNA methylation)，从而展现出抗肿瘤活性。
T69333	LX-5
	LX-5 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-5 de-represses a subset of endogenous genes repressed by DNA methylation.
T41098	Tetrachloroveratrole
	Tetrachloroveratrole, a byproduct of bacterial O-methylation, arises from the biodegradation of Tri- and Tetra chloroguaiacols. These chloroguaiacols emerge as a result of the wood pulp bleaching process within the paper manufacturing industry.
T21097	Decamethyltetrasiloxane Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780
	Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to other organic compounds.
T39580	Histone H3 (23-34) Histone H3 (23-34)
	Histone H3 (23-34) is a peptide consisting of amino acid residues 23 to 34 of the histone H3 protein. This peptide specifically includes lysine residues at positions 23 and 27, which can undergo methylation and acetylation modifications.
T80632	Methyl 3,4-dimethoxycinnamate
	Methyl 3,4-dimethoxycinnamate 组成中展现出对黑孢子萌发的抑制作用，并且在 Hep3B 细胞中抑制整体 DNA 甲基化。
T37693	N-acetyl-S-geranylgeranyl-L-Cysteine
	N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate for the methyltransferase, it effectively functions as an inhibitor of methylation of endogenous isoprenylated proteins.
T69922	EPZ020411 HCl
	EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.
T69937	INCB059872 tosylate
	INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD...
T69321	LX-3
	LX-3 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway, which de-represses a subset of endogenous genes repressed by DNA methylation.
T39144	3,4,5-Trichloroveratrole
	3,4,5-Trichloroveratrole is a chemical compound that is produced through bacterial O-methylation of Tri- and Tetra chloroguaiacols. These chloroguaiacols are generated during bleaching wood pulp in the paper manufacturing industry.
T36576	Histone H3 (21-44)-GK-biotin (trifluoroacetate salt) Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)
	Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.1 and 3.2 sequences and is biotinylated via a C-terminal GK linker. Histone H3 (21-44) contains a lysine residue at position 23 that is subject to acetylation, an arginine at position 26 subject to methylation, and a serine at position 28 subject to phosphorylation, as well as lysine residues at positions 27 and 36 that are subject to methylation and acetylation....
T69412	LX-4
	LX-4 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-4 de-represses a subset of endogenous genes repressed by DNA methylation.
T29651	Ademetionine, (S)-
	Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA.
T63783	AZ506
	AZ506 是一种 SMYD2 的有效抑制剂 (IC50: 17 nM)。AZ506 能够抑制细胞中 SMYD2 甲基转移酶的活性，减少 SMYD2 介导的甲基化信号。
T40776	Diguanosine 5′-triphosphate Diguanosine 5′-triphosphate,Gp3G
	Diguanosine 5′-triphosphate (Gp3G) is a kind of homodinucleotide from by GTP:GTP guanylyltransferase. Diguanosine 5′-triphosphate is a virus-specific oligonucleotide, can be used to prime reovirus transcription and inhibit RNA methylation.
T35764	S-Farnesyl Thioacetic Acid
	S-Farnesyl thioacetic acid is an analog of S-farnesyl cysteine which behaves as a competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). It can also inhibit methylation of both farnesylated and geranylgeranylated substrates.
T38785	Histone H3 (21-44) Histone H3 (21-44)
	Histone H3 (21-44), derived from a sequence of 21-44 amino acids of histone H3, is commonly employed as a substrate, particularly for protein arginine methyltransferase assays, where methylation activity is being examined.
T11750L	KDOAM-25 trihydrochloride (2230731-99-2 free base) KDOAM-25 trihydrochloride	Others	Others
	KDOAM-25 trihydrochloride increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 trihydrochloride is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor
T39648	(R)-GSK-3685032
	(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC 50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation and inhibition of cancer cell growth.
T11751	KDOAM-25	Antibacterial	Microbiology/Virology
	KDOAM-25, a potent and highly selective inhibitor of histone lysine demethylases 5 (KDM5) with IC50 values of 71 nM for KDM5A, 19 nM for KDM5B, 69 nM for KDM5C, and 69 nM for KDM5D, enhances global H3K4 methylation at transcriptional start sites and reduces proliferation in multiple myeloma MM1S cells.
T37373	4-hydroxy-3-Methoxyphenylglycol (piperazine salt)
	4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity.
T75239	c-Myc inhibitor 10
	c-Myc inhibitor10 (compound 17) 是 c-myc 的抑制剂，表现出一定的的细胞效力，与甲基化的 morpholine 氮的通透性增加一致。
T39800	S2116
	S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing reciprocal H3K27 deacetylation at super-enhancer regions. In TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells, S2116 triggers apoptosis by repressing the transcription of NOTCH3 and TAL1 genes. Furthermore, S2116 demonstrates significant growth retardation of T-ALL cells...
T69624	TC-5115
	TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or MLL leukemia.
T35543	Methyl Diethyldithiocarbamate
	Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and...
T21756	Bizine
	Bizine 是一种 Phenelzine 类似物，是一种有效和选择性的LSD1抑制剂，Ki 值为 59 nM。Bizine 可以调节癌细胞中的组蛋白甲基化。Bizine 具有神经保护作用。
T39799	S2157 S2157
	S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound triggers apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by inhibiting NOTCH3 and TAL1 gene expression. Moreover, S2157 is capable of crossing the blood-brain barrier, effectively eliminating central nervous system (CNS) leukemia in mice models implanted...
T70008	Bomedemstat ditosylate
	Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antago...

化合物

Cat.No: T36631

Target: MEK, Histone Methyltransferase

Cat.No: T6879

Synonym: LLY507,LLY 507

Target: Histone Methyltransferase

Cat.No: T1923

Target: Histone Methyltransferase

L-2-Hydroxyglutaric acid disodium

Cat.No: T13748

Synonym: S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

Cat.No: T17212

Synonym: 1,2:5,6-二脱水半乳糖醇,Dianhydrogalactitol,去水卫矛醇,Dianhydrodulcitol

Target: DNA Alkylator/Crosslinker, DNA Alkylation

Cat.No: T9626

Target: NMDAR

Cat.No: T23284

Target: Histone Demethylase, Histone Methyltransferase, CDK

Cat.No: T16886

Synonym: Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP

Target: Others, Histone Methyltransferase, Antibiotic, Antifungal

Cat.No: T28996

Synonym: TP 064

Target: Histone Methyltransferase

Cat.No: T9573

Target: DNA Methyltransferase

Cat.No: T6163

Synonym: 沙利雷塞,法尼基硫代水杨酸,Farnesyl Thiosalicylic Acid,S-Farnesylthiosalicylic acid,FTS

Target: Autophagy, Ras

Cat.No: T2169

Synonym: NSC309132,4-Deoxyuridine

Target: DNA Methyltransferase, Autophagy

Cat.No: T27453

Synonym: DG70

Target: Antibacterial

Procarbazine hydrochloride

Cat.No: T1488

Synonym: NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl

Target: DNA Alkylator/Crosslinker, DNA/RNA Synthesis

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Clindamycin hydrochloride monohydrate

Cat.No: T22297

Synonym: Clindamycin alcoholate

Target: Antibiotic

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

BAY-6035-R-isomer

Cat.No: T69703

Cat.No: T82088

Dihydro-5-azacytidine

Cat.No: T40713

Synonym: DHAC,NSC264880,Dihydro-5-azacytidine

Cat.No: T15169

Target: Others

Dihydro-5-azacytidine acetate

Cat.No: T78565

Synonym: DHAC acetate,NSC 264880 acetate

Target: Nucleoside Antimetabolite/Analog

Cat.No: T69333

Tetrachloroveratrole

Cat.No: T41098

Decamethyltetrasiloxane

Cat.No: T21097

Synonym: Tetrasiloxane, decamethyl-,decamethyl-tetrasiloxan,D3780

Histone H3 (23-34)

Cat.No: T39580

Synonym: Histone H3 (23-34)

Methyl 3,4-dimethoxycinnamate

Cat.No: T80632

N-acetyl-S-geranylgeranyl-L-Cysteine

Cat.No: T37693

Cat.No: T69922

INCB059872 tosylate

Cat.No: T69937

Cat.No: T69321

3,4,5-Trichloroveratrole

Cat.No: T39144

Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Cat.No: T36576

Synonym: Histone H3 (21-44)-GK-biotin (trifluoroacetate salt)

Cat.No: T69412

Ademetionine, (S)-

Cat.No: T29651

Cat.No: T63783

Diguanosine 5′-triphosphate

Cat.No: T40776

Synonym: Diguanosine 5′-triphosphate,Gp3G

S-Farnesyl Thioacetic Acid

Cat.No: T35764

Histone H3 (21-44)

Cat.No: T38785

Synonym: Histone H3 (21-44)

KDOAM-25 trihydrochloride (2230731-99-2 free base)

Cat.No: T11750L

Synonym: KDOAM-25 trihydrochloride

Target: Others

(R)-GSK-3685032

Cat.No: T39648

Cat.No: T11751

Target: Antibacterial

4-hydroxy-3-Methoxyphenylglycol (piperazine salt)

Cat.No: T37373

c-Myc inhibitor 10

Cat.No: T75239

Cat.No: T39800

Cat.No: T69624

Methyl Diethyldithiocarbamate

Cat.No: T35543

Cat.No: T21756

Cat.No: T39799

Synonym: S2157

Bomedemstat ditosylate

Cat.No: T70008

Cat. No.	Product Name	Target	Signaling Pathways
T1339	5-Azacytidine 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC	Nucleoside Antimetabolite/Analog; DNA Methyltransferase; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	5-Azacytidine (Ladakamycin) 是一种胞苷核苷类似物，一种 DNA 甲基化抑制剂，具有特异性。5-Azacytidine 通过降低 DNA 甲基化水平调节基因表达。5-Azacytidine 可以诱导细胞自噬，具有抗肿瘤活性。
T5270	5-Methylcytosine	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	5-Methylcytosine 是一种存在于真核 DNA 中的甲基化核苷酸碱基。它是由 DNA 甲基转移酶作用形成的表观遗传修饰。
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T0069	Uracil	Others; Endogenous Metabolite	Metabolism; Others
	Uracil 是普遍存在的天然嘧啶衍生物，是 RNA 核酸中的四个碱基之一。
T5233	N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。
TWO2759	Thymine 胸腺嘧啶,5-methyluracil	Others; Endogenous Metabolite	Metabolism; Others
	Thymine (5-methyluracil) 是 DNA 的四个碱基之一，在动物癌症模型中，能够作为5-氟尿嘧啶的靶标，其 Km=2.3 μM。
T1507	Streptozocin STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889	DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Streptozocin (NSC-85998) 是一种抗生素，可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性，常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定，建议现配现用。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T9455	4-hydroxyestrone-4-methyl ether 4-Methoxy Estrone,4-甲氧基雌酮	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	4-hydroxyestrone-4-methyl ether (4-Methoxy Estrone) 是由COMT 催化的4-OHE1的甲基化反应。
T9456	4-Methoxy 17β-Estradiol	Others	Others
	4-Methoxy 17β-Estradiol 是雌激素代谢物之一，也是 4-羟基雌二醇的甲基化代谢物。
T13749	L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Others	Others
	L-2-Hydroxyglutaric acid, an epigenetic modifier and potential oncometabolite in renal cancer, impedes mitochondrial creatine kinase (Mi-CK) activity, exhibiting Km and Ki values of 2.52 mM and 11.13 mM, respectively. Additionally, it obstructs histone demethylases, thereby encouraging histone methylation.
T10194	7-Methylguanine	Others	Others
	7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method.

天然产物

Cat.No: T1339

Synonym: 阿托胞苷,Azacitidine,NSC 102816,Mylosar,Ladakamycin,5-氮杂胞苷,5-AzaC

Target: Nucleoside Antimetabolite/Analog, DNA Methyltransferase, Antibacterial, Antibiotic, Autophagy

5-Methylcytosine

Cat.No: T5270

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Cat.No: T0069

Target: Others, Endogenous Metabolite

N-Methylnicotinamide

Cat.No: T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺

Target: Others, Endogenous Metabolite

Cat.No: TWO2759

Synonym: 胸腺嘧啶,5-methyluracil

Target: Others, Endogenous Metabolite

Cat.No: T1507

Synonym: STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

Cat.No: T4877

Target: Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

4-hydroxyestrone-4-methyl ether

Cat.No: T9455

Synonym: 4-Methoxy Estrone,4-甲氧基雌酮

Target: Estrogen Receptor/ERR, Endogenous Metabolite

4-Methoxy 17β-Estradiol

Cat.No: T9456

Target: Others

L-2-Hydroxyglutaric acid

Cat.No: T13749

Synonym: (S)-2-Hydroxyglutaric acid

Target: Others

7-Methylguanine

Cat.No: T10194

Target: Others

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