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72

抑制剂 & 化合物

14

天然产物

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Cat. No. Product Name Target Signaling Pathways
T69665 Zelasudil

RXC007

ROCK Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
Zelasudil (RXC007) 是一种 Rho 相关 (ROCK) 激酶 抑制剂,可用于研究特发性肺纤维化和炎症。
T83759 MMP-3 Fluorogenic Substrate TFA

Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate

MMP-3 fluorogenic substrate 是一种针对基质金属蛋白酶-3(MMP-3)的荧光底物。当被MMP-3切割后,7-甲氧基香豆素-4-乙酰基(Mca)会释放并且其荧光可用于量化MMP-3活性。Mca的激发/发射峰值分别为328/420 nm。
T2009 SB-3CT

MMP Proteases/Proteasome
SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂,Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。
T14322 ARP-100

MMP-2 Inhibitor III

MMP Proteases/Proteasome
ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1'口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T7459 Abametapir

5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183

MMP; Others; Parasite Microbiology/Virology; Others; Proteases/Proteasome
Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂,能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
T67827 Urease Inhibitor 07

Others Others
Urease Inhibitor 07 是一种异取代金属蛋白酶抑制剂 , 对结核分枝杆菌H37Rv 菌株的潜在活性。
T37048 MMP-3 Inhibitor

MMP Proteases/Proteasome
MMP-3 Inhibitor 是一种多肽基质金属蛋白酶-3(MMP-3)抑制剂,Ki 值为 95 nM。MMP-3 inhibitor 具有抗癌抗肿瘤活性。
T5361 T-26c

MMP Proteases/Proteasome
T-26c 是高效的、选择性的基质金属蛋白酶-13 抑制剂,IC50=6.75 pM。
T28394 PG-116800

PG-530742,PGE-7113313,PGE 7113313,PG 530742

MMP Proteases/Proteasome
PG-116800 (PG-530742) 是一种基质金属蛋白酶 (MMP) 抑制剂。 PG-116800 可用于骨关节炎治疗的研究。
T8310 MMP-9-IN-1

MMP Proteases/Proteasome
MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂,选择性靶向 MMP-9 的血红素域,对其他 MMP 无影响。
T83168 Aderamastat

FP-025

MMP Proteases/Proteasome
Aderamastat (FP-025) 为口服活性MMP-12抑制剂,适用于哮喘、COPD与肺纤维化研究。
T15574 Incyclinide

COL-3,CMT-3

MMP Proteases/Proteasome
Incyclinide (COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂,能够诱导细胞外基质降解,抑制血管生成,肿瘤生长和侵袭以及转移。
T12414 PF-00356231 hydrochloride

MMP Proteases/Proteasome
PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂,IC50 为 1.4 μM。
T72069 MMP-9-IN-7

MMP-9-IN-7抑制前基质金属蛋白酶活化,可用于预防、治疗或改善 MMP9和/或 MMP13介导的综合征。
T70470 CM-352

MMP Proteases/Proteasome
CM-352是一种金属蛋白酶抑制剂,可减少脑损伤并改善脑出血大鼠模型的功能恢复。
T4282 S-methyl-KE-298

MMP; Drug Metabolite Metabolism; Proteases/Proteasome
S-methyl-KE-298 是 KE-298 的活性代谢物。KE-298 抑制类风湿关节炎滑膜细胞产生基质金属蛋白酶。
T76856 Andecaliximab

GS-5745

MMP; Virus Protease Microbiology/Virology; Proteases/Proteasome
Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。
T12511 PNU-248686A

MMP Proteases/Proteasome
PNU-248686A is an inhibitor of matrix metalloproteinase (MMP).
T68816 Zincov

Zincov is a matrix metalloproteinase inhibitor and chelating agent.
T25765 LY52

LY-52,LY 52

LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis.
T70385 CGS-27023A HCl

CGS-27023A is a novel matrix metalloproteinase inhibitor.
T69631 DDA-tetracycline

DDA-tetracycline, also known CMT-1 and 4-Des-dimethylaminotetracycline, is a Matrix Metalloproteinase Inhibitor.
T12762 Ro 31-9790

GI4747

MMP Proteases/Proteasome
Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP).
T68574 Tigapotide Free Base

Tigapotide Free Base is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.
T27382 FR-217840

FR-217840, a novel matrix metalloproteinase inhibitor, successfully suppresses joint destruction and suggest that FR217840 may have potential as a novel anti-rheumatic drug.
T12539 Prinomastat hydrochloride

KB-R9896 hydrochloride,AG3340 hydrochloride

MMP Proteases/Proteasome
Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.
T71022 GI-129471

GI-129471 is a metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo.
T70051 MMI-166

MMI-166 is a selective matrix metalloproteinase (MMP) inhibitor that prevents tumor invasion and metastasis by downregulating the activity of MMP-2 and MMP-9.
T69666 MMP-8 Inhibitor I

MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.
T30215 AUY-954 free base

AUY 954,NVP-AUY954,AUY-954,AUY954

AUY-954 is an effective selective S1P(1) modulator. It can significantly reduce the local expression of EAN rat sciatic nerve T cells, B cells, macrophage infiltration, inflammatory demyelination, interleukin-17 and matrix metalloproteinase-9.
T31063 CP-544439

UNII-516DO4KL5R

CP-544439 is an inhibitor of matrix metalloproteinase-13, which has an effect on adipose tissue development.
T25925 p-DDAP

pDDAP,p-Dodecylaminophenol

p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9).
T26304 U 27391

U-27391,U27391

U 27391 is a metalloproteinase inhibitor. It acts by inhibits the action of human recombinant interleukin-1beta and glycosaminoglycan synthesis.
T27507 GW-3333

GW 3333,GW3333

GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar
T68573 Tigapotide triflutate

Tigapotide triflutate is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.
T69716 Solimastat

Solimastat is a novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha.
T36363 Dnp-RPLALWRS (trifluoroacetate salt)

Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
TQ0129 TNF Protease Inhibitor 2

TAPI-2

MMP Proteases/Proteasome
TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
T69477 F81-1144b

F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose.
T16291 NF157

COX Immunology/Inflammation; Neuroscience
NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 µM, 170 µM for P2Y
T37025 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
T76009 Thermolysin

Thermolysin 是由革兰氏阳性菌 Bacillus thermoproteolyticus 分泌的耐热的中性金属蛋白酶。Thermolysin 可催化含有疏水残基的肽键水解。
T38378 Dnp-PLAYWAR (trifluoroacetate salt)

Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26. The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T36962 MMP Inhibitor I (trifluoroacetate salt)

MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase at concentrations up to 4 mM.
T71995 Decanoyl chloride

Decanoyl Chloride is used in the synthesis of an effective metalloproteinase inhibitor. Also acts as a reagent in the synthesis of reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analgesics.
T36360 Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9. Upon cleavage by MMP-1 or MMP-9, N-methylanthranilic acid (Nma) is unquenched and its fluorescence can be used to quantify MMP activity. Nma displays excitation/emission spectra of 340/440 nm, respectively.
T12539L Prinomastat

KB-R9896,普啉司他,AG3340

MMP Proteases/Proteasome
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor (
T28251 ONO-8809

ONO8809

ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area i
T75998 cyclo(RLsKDK) TFA

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) 是一种特异性的金属蛋白酶 ADAM8抑制剂,IC50值为 182 nM。cyclo(RLsKDK) (TFA) 在炎性疾病和癌症中有潜在应用。
T36361 Dnp-PLALWAR (trifluoroacetate salt)

Dnp-PLALWAR is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-8. The activity of MMP-1 and MMP-8 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.

化合物

Zelasudil
Cat.No: T69665
Synonym: RXC007
Target: ROCK
MMP-3 Fluorogenic Substrate TFA
Cat.No: T83759
Synonym: Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate
Target:
SB-3CT
Cat.No: T2009
Synonym:
Target: MMP
ARP-100
Cat.No: T14322
Synonym: MMP-2 Inhibitor III
Target: MMP
Abametapir
Cat.No: T7459
Synonym: 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183
Target: MMP, Others, Parasite
Urease Inhibitor 07
Cat.No: T67827
Synonym:
Target: Others
MMP-3 Inhibitor
Cat.No: T37048
Synonym:
Target: MMP
T-26c
Cat.No: T5361
Synonym:
Target: MMP
PG-116800
Cat.No: T28394
Synonym: PG-530742,PGE-7113313,PGE 7113313,PG 530742
Target: MMP
MMP-9-IN-1
Cat.No: T8310
Synonym:
Target: MMP
Aderamastat
Cat.No: T83168
Synonym: FP-025
Target: MMP
Incyclinide
Cat.No: T15574
Synonym: COL-3,CMT-3
Target: MMP
PF-00356231 hydrochloride
Cat.No: T12414
Synonym:
Target: MMP
MMP-9-IN-7
Cat.No: T72069
Synonym:
Target:
CM-352
Cat.No: T70470
Synonym:
Target: MMP
S-methyl-KE-298
Cat.No: T4282
Synonym:
Target: MMP, Drug Metabolite
Andecaliximab
Cat.No: T76856
Synonym: GS-5745
Target: MMP, Virus Protease
PNU-248686A
Cat.No: T12511
Synonym:
Target: MMP
Zincov
Cat.No: T68816
Synonym:
Target:
LY52
Cat.No: T25765
Synonym: LY-52,LY 52
Target:
CGS-27023A HCl
Cat.No: T70385
Synonym:
Target:
DDA-tetracycline
Cat.No: T69631
Synonym:
Target:
Ro 31-9790
Cat.No: T12762
Synonym: GI4747
Target: MMP
Tigapotide Free Base
Cat.No: T68574
Synonym:
Target:
FR-217840
Cat.No: T27382
Synonym:
Target:
Prinomastat hydrochloride
Cat.No: T12539
Synonym: KB-R9896 hydrochloride,AG3340 hydrochloride
Target: MMP
GI-129471
Cat.No: T71022
Synonym:
Target:
MMI-166
Cat.No: T70051
Synonym:
Target:
MMP-8 Inhibitor I
Cat.No: T69666
Synonym:
Target:
AUY-954 free base
Cat.No: T30215
Synonym: AUY 954,NVP-AUY954,AUY-954,AUY954
Target:
CP-544439
Cat.No: T31063
Synonym: UNII-516DO4KL5R
Target:
p-DDAP
Cat.No: T25925
Synonym: pDDAP,p-Dodecylaminophenol
Target:
U 27391
Cat.No: T26304
Synonym: U-27391,U27391
Target:
GW-3333
Cat.No: T27507
Synonym: GW 3333,GW3333
Target:
Tigapotide triflutate
Cat.No: T68573
Synonym:
Target:
Solimastat
Cat.No: T69716
Synonym:
Target:
Dnp-RPLALWRS (trifluoroacetate salt)
Cat.No: T36363
Synonym:
Target:
TNF Protease Inhibitor 2
Cat.No: TQ0129
Synonym: TAPI-2
Target: MMP
F81-1144b
Cat.No: T69477
Synonym:
Target:
NF157
Cat.No: T16291
Synonym:
Target: COX
Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
Cat.No: T37025
Synonym: Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
Target:
Thermolysin
Cat.No: T76009
Synonym:
Target:
Dnp-PLAYWAR (trifluoroacetate salt)
Cat.No: T38378
Synonym:
Target:
MMP Inhibitor I (trifluoroacetate salt)
Cat.No: T36962
Synonym:
Target:
Decanoyl chloride
Cat.No: T71995
Synonym:
Target:
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
Cat.No: T36360
Synonym: Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2
Target:
Prinomastat
Cat.No: T12539L
Synonym: KB-R9896,普啉司他,AG3340
Target: MMP
ONO-8809
Cat.No: T28251
Synonym: ONO8809
Target:
cyclo(RLsKDK) TFA
Cat.No: T75998
Synonym:
Target:
Dnp-PLALWAR (trifluoroacetate salt)
Cat.No: T36361
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T8259 Doxycycline monohydrate

水合强力霉素,强力霉素一水物

MMP; Antibacterial; Antibiotic; Parasite Microbiology/Virology; Proteases/Proteasome
Doxycycline monohydrate 是一种四环素抗生素,是广谱金属蛋白酶抑制剂,具有抗菌活性。
T3813 20(R)-Ginsenoside Rh2

20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2

Apoptosis; MMP; HSV Apoptosis; Microbiology/Virology; Proteases/Proteasome
20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体,具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。
TN6784 ethyl rosmarinate

Methyl rosmarinate,迷迭香酸乙酯

MMP; Tyrosinase; Glucosidase Metabolism; Proteases/Proteasome
ethyl rosmarinate (Methyl rosmarinate) 抑制酪氨酸酶、α-葡萄糖苷酶和基质金属蛋白酶-1 (MMP-1) 的活性。
T1687L Doxycycline (hyclate)

Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate

MMP; ribosome; Antibacterial; Antibiotic Microbiology/Virology; Proteases/Proteasome
Doxycycline hyclate (WC2031) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。
TN1928 Methyl rosmarinate

MMP; Anti-infection; Tyrosinase Microbiology/Virology; Proteases/Proteasome
Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂,从 Rabdosia serra 中分离得到的,对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM,也能抑制a-glucosidase。
T1687 Doxycycline

Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素

MMP; ribosome; Antibacterial; Antibiotic; Parasite Microbiology/Virology; Proteases/Proteasome
Doxycycline (Doxiciclina) 属于四环素类抗生素,是一种广谱的金属蛋白酶 (MMP) 抑制剂,具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。
T7044 Norepinephrine

去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol

MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome
Norepinephrine (Levophed) 是β1选择性的肾上腺素能受体激动剂,EC50值为 5.37 μM。它可上调鼻咽癌肿瘤细胞中血管内皮生长因子、基质金属蛋白酶MMP-2和MMP-9的表达。
TN1299 Desmethylglycitein

4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

PI3K; CDK; PKC Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。
T4S21320 ISOGINKGETIN

异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

MMP; Others Others; Proteases/Proteasome
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。
T3524 Halofuginone hydrobromide

卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T4S0878 Prunetin

樱黄素,Prunusetin

ERK; Dehydrogenase; NF-κB MAPK; Metabolism; NF-κB
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
TN5050 Sprengerinin C

NADPH-oxidase; VEGFR; p38 MAPK; ROS; Akt; PI3K; mTOR; p53 Angiogenesis; Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can strongly suppress tumor angiogenesis in human umbilical vein endothelial cells, it blocks vascul
TN1832 Kanzonol C

Others; NF-κB; Tyrosinase NF-κB; Others; Proteases/Proteasome
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells.
TN2075 Pimaric acid

MMP; p38 MAPK; NF-κB MAPK; NF-κB; Proteases/Proteasome
Pimaric acid has potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α±-induced human aortic smooth muscle cells.

天然产物

Doxycycline monohydrate
Cat.No: T8259
Synonym: 水合强力霉素,强力霉素一水物
Target: MMP, Antibacterial, Antibiotic, Parasite
20(R)-Ginsenoside Rh2
Cat.No: T3813
Synonym: 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2
Target: Apoptosis, MMP, HSV
ethyl rosmarinate
Cat.No: TN6784
Synonym: Methyl rosmarinate,迷迭香酸乙酯
Target: MMP, Tyrosinase, Glucosidase
Doxycycline (hyclate)
Cat.No: T1687L
Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate
Target: MMP, ribosome, Antibacterial, Antibiotic
Methyl rosmarinate
Cat.No: TN1928
Synonym:
Target: MMP, Anti-infection, Tyrosinase
Doxycycline
Cat.No: T1687
Synonym: Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素
Target: MMP, ribosome, Antibacterial, Antibiotic, Parasite
Norepinephrine
Cat.No: T7044
Synonym: 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol
Target: MMP, Endogenous Metabolite, Adrenergic Receptor, Autophagy
Desmethylglycitein
Cat.No: TN1299
Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone
Target: PI3K, CDK, PKC
ISOGINKGETIN
Cat.No: T4S21320
Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮
Target: MMP, Others
Halofuginone hydrobromide
Cat.No: T3524
Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Prunetin
Cat.No: T4S0878
Synonym: 樱黄素,Prunusetin
Target: ERK, Dehydrogenase, NF-κB
Sprengerinin C
Cat.No: TN5050
Synonym:
Target: NADPH-oxidase, VEGFR, p38 MAPK, ROS, Akt, PI3K, mTOR, p53
Kanzonol C
Cat.No: TN1832
Synonym:
Target: Others, NF-κB, Tyrosinase
Pimaric acid
Cat.No: TN2075
Synonym:
Target: MMP, p38 MAPK, NF-κB
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