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142

抑制剂 & 化合物

51

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1497L	Mast Cell Degranulating Peptide HR-2 acetate Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base)	Others	Others
	Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base) 来自大黄蜂 Vespa orientalis 的肥大细胞脱粒肽，其生物学效应类似于来自蜂毒的肥大细胞脱粒肽。
TP1568	Mast cell degranulating peptide (28-49)
	Mast cell degranulating peptide (28-49) is a bee venom depolarizer that can improve the cGMP content of cerebellum tablets in mice.
TP1497	Mast Cell Degranulating Peptide HR-2
	Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom.
T9689	M4205	c-Kit	Tyrosine Kinase/Adaptors
	M4205 是一种 c-Kit 抑制剂，对外显子 11、13、17 中的 c-Kit 突变具有高活性。
T0118	Mizolastine SL 850324,咪唑司汀,咪唑斯汀	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂，IC50为 47 nM。它用于治疗过敏反应，如花粉热和荨麻疹等。
T6488	Epinastine hydrochloride Alesion,Epinastine HCl,WAL-801CL HCl,依匹斯汀盐酸盐,Elestat	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Epinastine hydrochloride (WAL-801CL HCl) 是抗组胺剂和肥大细胞稳定剂，是一种可口服的选择性组胺 H1 受体拮抗剂，可抑制 IL-8 释放，具有抗过敏作用。
T2648	Pimecrolimus SDZ-ASM 981,ASM 981,吡美莫司	Others	Others
	Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体，能与胞质受体特异性的结合。
T0994	Ketotifen fumarate HC 20511 fumarate,富马酸酮替芬	PDE; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。
T15259	Evatanepag CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Evatanepag (CP-533536 free acid) 是一种 EP2 受体选择性前列腺素 E2 (PGE2) 激动剂，可诱导局部骨形成，EC50 为 0.3 nM。它在大鼠骨折愈合模型中以单剂量局部给药时表现出愈合骨折的能力。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T22256	c-Kit-IN-5-1 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one,AMG-25,3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one	c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-5-1 (AMG-25) 是一种新型的、高效的、选择性的 c-Kit 抑制剂。
T19966	Clemastine HS-592,Mecloprodin,Meclastin,HS592,HS 592	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clemastine (Meclastin) 是 H1 受体的拮抗剂，具有抗炎作用。
T6885	Marimastat BB2516,马立马司他,KB-R8898,TA2516	MMP	Proteases/Proteasome
	Marimastat (BB2516) 是一种血管生成和转移抑制剂，限制血管的生长和生成。它是一种广谱的，具有口服活性的MMPs 抑制剂，有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7，用于癌症的研究。
T2743	Ilomastat Galardin,GM6001,伊洛马司他	MMP	Proteases/Proteasome
	Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂，可抑制 MMP 的活性，IC50值分别为 1.5 nM (MMP-1)，1.1 nM (MMP-2)，1.9 nM (MMP-3)，0.5 nM (MMP-9)，对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。
T6011	Batimastat 巴马司他,BB94	MMP	Proteases/Proteasome
	Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。
T30190	Ataquimast	Others	Others
	Ataquimast 用于治疗晚期受体阳性乳腺癌。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T83168	Aderamastat FP-003,FP-025	MMP	Proteases/Proteasome
	Aderamastat (FP-025) 是一种具有口服活性的基质金属蛋白酶12（MMP-12）抑制剂，适用于过敏性哮喘、COPD与肺纤维化的研究。
T35859	Aldumastat GLPG1972,S201086,G504572	Others	Others
	Aldumastat（GLPG1972）是一种具有高效性、特异性和口服活性的 ADAMTS-5抑制剂。Aldumastat 可用于研究膝骨关节炎。
T68128	Picumast
	Picumast 是一种具有抗过敏活性，可被用于治疗哮喘，可能用于治疗治疗过敏性气道疾病。
TP1386L1	Mastoparan acetate(72093-21-1 free base)	Others	Others
	Mastoparan acetate(72093-21-1 free base) 是一种来自黄蜂毒液的肽毒素。它的化学结构为 Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2。
T0147	Clemastine fumarate HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)	Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺，具有抗胆碱能、镇静和组胺 H1 拮抗作用。
T5449	Bamaquimast L 0042,F 10126	Proton pump	Membrane transporter/Ion channel
	Bamaquimast (L 0042) 是一种 proton pump 抑制剂，可用于研究哮喘类的免疫系统疾病和呼吸系统疾病。
T10461	Batimastat sodium salt BB-94 sodium salt	MMP	Proteases/Proteasome
	Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
T80322	Mastoparan B
	Mastoparan B，源自黄蜂Vespa的抗菌肽，可引起红细胞形态由常规盘形转变为锯齿状。
T76094	Mastoparan X
	Mastoparan X 是一种GTP 结合调节蛋白 (G 蛋白) 激活肽，是一种来自黄蜂毒液的十四肽。Mastoparan X 通过直接激活与磷脂酶 C 偶联的G 蛋白来引起各种细胞的分泌。
T19665	Amastatin hydrochloride 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280
	Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.
T125590	Clemastanin A
	Clemastanin A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125590。
T24817	Otaplimastat J3.046.690J,SP8203,SP-8203,SP 8203
	SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant.
TP1386	Mastoparan
	Mastoparan is a peptide toxin from wasp venom. It has the chemical structure Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2.
T125511	Stigmast-7-en-3-ol
	Stigmast-7-en-3-ol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125511。
T124943	6-Hydroxystigmasta-4,22-dien-3-one
	6-Hydroxystigmasta-4,22-dien-3-one 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124943。
T62090	(Rac)-Tanomastat
	Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂，能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中，Tanomastat 表现出抗侵袭和抗转移作用。
T68012	rebimastat
	Rebimastat 是基于巯基的第二代基质金属蛋白酶(MMP)抑制剂，具有潜在的抗肿瘤活性。利莫司他选择性抑制几种 MMPs (MMP 1、2、8、9和14)，从而诱导细胞外基质降解，抑制血管生成、肿瘤生长、侵袭和转移。
T84308	(24R)-Stigmastane-3β,5α,6α-triol

T69301	Picumast dihydrochloride
	Picumast dihydrochloride is a prophylactically active anti-allergic compound which combines inhibition of mediator release and action. The activity profile of PDH differs clearly from that of known prophylactic anti-allergic drugs such as DSCG and ketotifen.
T12539	Prinomastat hydrochloride KB-R9896 hydrochloride,AG3340 hydrochloride	MMP	Proteases/Proteasome
	Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.
T33215	Masticadienediol
	Masticadienediol is a tetracyclic triterpene.
T124674	3β,5α-Dihydroxystigmastan-6-one
	3β,5α-Dihydroxystigmastan-6-one 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124674。
T124266	6α-Hydroxystigmast-4-en-3-one
	6α-Hydroxystigmast-4-en-3-one 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124266。
T81850	MASTL-IN-2
	MASTL-IN-2为MASTL（microtubule-associated Ser/Thr kinase-like）抑制剂，能够抑制人上皮MIA PaCa癌细胞的增殖，其IC50值为2.8 nM。
T10817	Cipemastat Ro 32-3555	Others	Others
	Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).
T16986	Tanomastat BAY 12-9566	MMP	Proteases/Proteasome
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
T31794	FireMaster 695 1,2-Bis(pentabromophenoxy)ethane,Decabromo diphenyl ethyl,Ethylene bis(pentabromophenoxide),Decabromodiphenoxyethane
	FireMaster 695 is a biochemical.
T30164	Asobamast
	Asobamast is a biochemical.
T22255	Amastatin	Others	Others
	Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM .
T131480	Masticadienonic acid
	Masticadienonic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131480。
T71488	Cremastranone
	Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
T81851	MASTL-IN-1
	MASTL-IN-1是一款针对MASTL(微管相关丝氨酸/苏氨酸样激酶)的抑制剂，起到调控细胞增殖、迁移及侵袭的作用。它显示出在癌症研究中的应用潜力。
T12539L	Prinomastat KB-R9896,普啉司他,AG3340	MMP	Proteases/Proteasome
	Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor (

化合物

Mast Cell Degranulating Peptide HR-2 acetate

Cat.No: TP1497L

Synonym: Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base)

Target: Others

Mast cell degranulating peptide (28-49)

Cat.No: TP1568

Mast Cell Degranulating Peptide HR-2

Cat.No: TP1497

Cat.No: T9689

Target: c-Kit

Cat.No: T0118

Synonym: SL 850324,咪唑司汀,咪唑斯汀

Target: Histamine Receptor

Epinastine hydrochloride

Cat.No: T6488

Synonym: Alesion,Epinastine HCl,WAL-801CL HCl,依匹斯汀盐酸盐,Elestat

Target: 5-HT Receptor, Histamine Receptor

Cat.No: T2648

Synonym: SDZ-ASM 981,ASM 981,吡美莫司

Target: Others

Ketotifen fumarate

Cat.No: T0994

Synonym: HC 20511 fumarate,富马酸酮替芬

Target: PDE, Histamine Receptor

Cat.No: T15259

Synonym: CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸

Target: Prostaglandin Receptor

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T22256

Synonym: 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one,AMG-25,3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one

Target: c-Kit

Cat.No: T19966

Synonym: HS-592,Mecloprodin,Meclastin,HS592,HS 592

Target: Histamine Receptor

Cat.No: T6885

Synonym: BB2516,马立马司他,KB-R8898,TA2516

Target: MMP

Cat.No: T2743

Synonym: Galardin,GM6001,伊洛马司他

Target: MMP

Cat.No: T6011

Synonym: 巴马司他,BB94

Target: MMP

Cat.No: T30190

Target: Others

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T83168

Synonym: FP-003,FP-025

Target: MMP

Cat.No: T35859

Synonym: GLPG1972,S201086,G504572

Target: Others

Cat.No: T68128

Mastoparan acetate(72093-21-1 free base)

Cat.No: TP1386L1

Target: Others

Clemastine fumarate

Cat.No: T0147

Synonym: HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)

Target: Autophagy, Histamine Receptor

Cat.No: T5449

Synonym: L 0042,F 10126

Target: Proton pump

Batimastat sodium salt

Cat.No: T10461

Synonym: BB-94 sodium salt

Target: MMP

Cat.No: T80322

Cat.No: T76094

Amastatin hydrochloride

Cat.No: T19665

Synonym: 氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280

Cat.No: T125590

Cat.No: T24817

Synonym: J3.046.690J,SP8203,SP-8203,SP 8203

Cat.No: TP1386

Stigmast-7-en-3-ol

Cat.No: T125511

6-Hydroxystigmasta-4,22-dien-3-one

Cat.No: T124943

(Rac)-Tanomastat

Cat.No: T62090

Cat.No: T68012

(24R)-Stigmastane-3β,5α,6α-triol

Cat.No: T84308

Picumast dihydrochloride

Cat.No: T69301

Prinomastat hydrochloride

Cat.No: T12539

Synonym: KB-R9896 hydrochloride,AG3340 hydrochloride

Target: MMP

Masticadienediol

Cat.No: T33215

3β,5α-Dihydroxystigmastan-6-one

Cat.No: T124674

6α-Hydroxystigmast-4-en-3-one

Cat.No: T124266

Cat.No: T81850

Cat.No: T10817

Synonym: Ro 32-3555

Target: Others

Cat.No: T16986

Synonym: BAY 12-9566

Target: MMP

Cat.No: T31794

Synonym: 1,2-Bis(pentabromophenoxy)ethane,Decabromo diphenyl ethyl,Ethylene bis(pentabromophenoxide),Decabromodiphenoxyethane

Cat.No: T30164

Cat.No: T22255

Target: Others

Masticadienonic acid

Cat.No: T131480

Cat.No: T71488

Cat.No: T81851

Cat.No: T12539L

Synonym: KB-R9896,普啉司他,AG3340

Target: MMP

Cat. No.	Product Name	Target	Signaling Pathways
TN6737	(25R)-Spirost-4-ene-3,12-dione	Others	Others
	(25R)-Spirost-4-ene-3,12-dione 是一种天然产物。
T16943	Stigmastanol	Endogenous Metabolite	Metabolism
	Stigmastanol 是分离自Hypericum riparium 的 6-氨基衍生物。Hypericum riparium 是属于杜仲科的药用植物。
T2967	Stigmasterol Stigmasterin,beta-Stigmasterol,豆甾醇	MMP; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Stigmasterol (Stigmasterin) 是一种植物性甾醇，具有抑制胆固醇的特性，此外在风湿性疾病的研究中被评价为抗硬化因子。
T83259	6β-Hydroxystigmasta-4,22-dien-3-one
	6β-Hydroxystigmasta-4,22-dien-3-one为一类固醇化合物，可从Hedychium coronarium中提取。
TN5067	Stigmastane-3,5,6-triol	Antifection	Microbiology/Virology
	Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine.
TN5064	Stigmasta-4,22-dien-3-one	Others	Others
	Stigmasta-4,22-dien-3-one has antioxidant activity.
TN2908	3,7,16-Trihydroxystigmast-5-ene	Others	Others
	3,7,16-Trihydroxystigmast-5-ene 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2908，CAS号为 289056-24-2。
TN5069	(5α)-Stigmastane-3,6-dione Stigmastane-3,6-dione,豆甾烷-3,6-二酮
	Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils.
T81085	Stigmasta-3,5-dien-7-one
	Stigmasta-3,5-dien-7-one为源自Harrisonia abyssinica之甾体化合物。
TN5068	Stigmastane-3,6-diol	Others	Others
	Stigmastane-3 beta, 6 alpha-diol and stigmastane-3 beta, 6 beta-diol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose is 0.5--1.0 mg/ear.
TN5065	Stigmasta-4,25-dien-3-one	Others	Others
	Stigmasta-4,25-dien-3-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5065，CAS号为 848669-08-9。
T81086	Stigmast-5-ene-3,7-dione
	Stigmast-5-ene-3,7-dione（Compound 10）是一种从Penianthus longifolius的根、叶与细枝中分离得到的化学物质。
TN1327	7,22,25-Stigmastatrienol	Others	Others
	7,22,25-Stigmastatrienol is a natural product
TN5066	Stigmasta-5,8-dien-3-ol	Others	Others
	Stigmasta-5,8-dien-3-ol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5066，CAS号为 570-72-9。
TN3172	6beta-Hydroxystigmast-4-en-3-one	Others	Others
	6beta-Hydroxystigmast-4-en-3-one 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3172，CAS号为 36450-02-9。
TN2238	Stigmasterol glucoside 豆甾醇葡萄糖苷	Others	Others
	Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent.
T83543	(E)-Masticadienonic acid
	(E)-Masticadienonic acid为三萜类化合物，可从Vallesia glabra中提取。
TN5294	Stigmasta-4,22-diene-3β,6β-diol
	Stigmasta-4,22-diene-3β,6β-diol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5294，CAS号为 167958-89-6。
T83339	3β-(Acetyloxy)stigmast-5-en-7-one
	3β-(Acetyloxy)stigmast-5-en-7-one 表现出抗补体活性。
TN5062	Stigmast-4-ene-3,6-dione
	Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties.
TN5285	Stigmast-4-ene-3β,6β-diol
	Stigmast-4-ene-3beta,6beta-diol possesses marked inhibitory activity against 12-O- -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
TN5063	Stigmasta-4,22,25-trien-3-one	Others	Others
	Stigmasta-4,22,25-trien-3-one is a natural product from Callicarpa giraldiana.
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac
TN6801	Stigmastadienone
	Stigmastadienone is a natural product.
TN1506	Clemastanin B 直铁线莲宁B,落叶松树脂醇苷B	Influenza Virus	Microbiology/Virology
	Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment.
T75638	Himastatin
	Himastatin 是一种具有抗肿瘤活性的抗生素，由S. hygroscopicus sp 菌株产生。Himastatin 是一种二聚环六肽，含有哌嗪酸和一个独特的芳香族中心。
TN3254	7alpha-Hydroxystigmasterol	Others	Others
	7alpha-Hydroxystigmasterol是一种天然产物，属于菊科苍耳属，其产品编号为 TN3254，CAS号为 64998-19-2。7alpha-Hydroxystigmasterol可用作对照参考。
T4946	(+)-Columbianetin acetate 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE	Others	Others
	(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) 是一种 Columbianetin 异构体。其中Columbianetin 是植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，表现出良好的抗炎及抗真菌活性。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
T6943	Picropodophyllin AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂，IC50为1 nM。
T6926	Palmitoylethanolamide Mackpeart DR 14V,帕米醇,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol	Influenza Virus; Endogenous Metabolite; PPAR	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Palmitoylethanolamide (Impulsin) 是一种内源性脂肪酸酰胺。它有消炎药、降压药、神经保护剂和抗惊厥药的作用。在给药后，Palmitoylethanolamide 可抑制促炎介质从活化肥大细胞的释放。
T5S1286	(+)-Columbianetin 二氢山芹醇,(S)-Columbianetin,Columbianetin	Antifungal	Microbiology/Virology
	(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，具有良好的抗真菌和抗炎作用。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
TN2895	3,5-Dicaffeoyl-epi-quinic acid 金银花	IL Receptor; p38 MAPK; TNF; Caspase; JNK; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
TN3864	Dihydroresveratrol 3-O-glucoside	Others	Others
	Dihydroresveratrol 3-O-glucoside 是一种天然产物，存在于Camellia sinensis var. assamica (J.W. Mast.) Kitam.叶子。
T83329	4,7-Didehydroneophysalin B
	4,7-Didehydroneophysalin B，一种源自Physalis alkekengi L. var. franchetii (Mast.) Makino的黄酮类化合物，展现出胆碱酯酶的抑制作用。
T80998	Thapsigargicin Thapsigargicine
	Thapsigargicin（Thapsigargicine）作为肥大细胞和白细胞的激活剂，能诱导大鼠腹膜肥大细胞及人嗜碱性粒细胞释放组胺，并提升完整人血小板中的细胞质游离钙水平。
TN3062	4'-O-Methylnyasol	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
TN6539	Pd-C-II
	Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by
TN5279	Zeorin	ATPase; Calcium Channel; Antifection; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release.
TN5647	Confluentin
	Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li
T25687	Leukotriene C4 白三烯C4,LTC4,Leukotriene C
	Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contracti
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
TN6667	Spinacetin
	Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t
TN1009	Epimagnolin B	NF-κB; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; NF-κB
	Epimagnolin B 是一种双环氧木质素，分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。
TN4683	Nyasol	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
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天然产物

(25R)-Spirost-4-ene-3,12-dione

Cat.No: TN6737

Target: Others

Cat.No: T16943

Target: Endogenous Metabolite

Cat.No: T2967

Synonym: Stigmasterin,beta-Stigmasterol,豆甾醇

Target: MMP, Endogenous Metabolite

6β-Hydroxystigmasta-4,22-dien-3-one

Cat.No: T83259

Stigmastane-3,5,6-triol

Cat.No: TN5067

Target: Antifection

Stigmasta-4,22-dien-3-one

Cat.No: TN5064

Target: Others

3,7,16-Trihydroxystigmast-5-ene

Cat.No: TN2908

Target: Others

(5α)-Stigmastane-3,6-dione

Cat.No: TN5069

Synonym: Stigmastane-3,6-dione,豆甾烷-3,6-二酮

Stigmasta-3,5-dien-7-one

Cat.No: T81085

Stigmastane-3,6-diol

Cat.No: TN5068

Target: Others

Stigmasta-4,25-dien-3-one

Cat.No: TN5065

Target: Others

Stigmast-5-ene-3,7-dione

Cat.No: T81086

7,22,25-Stigmastatrienol

Cat.No: TN1327

Target: Others

Stigmasta-5,8-dien-3-ol

Cat.No: TN5066

Target: Others

6beta-Hydroxystigmast-4-en-3-one

Cat.No: TN3172

Target: Others

Stigmasterol glucoside

Cat.No: TN2238

Synonym: 豆甾醇葡萄糖苷

Target: Others

(E)-Masticadienonic acid

Cat.No: T83543

Stigmasta-4,22-diene-3β,6β-diol

Cat.No: TN5294

3β-(Acetyloxy)stigmast-5-en-7-one

Cat.No: T83339

Stigmast-4-ene-3,6-dione

Cat.No: TN5062

Stigmast-4-ene-3β,6β-diol

Cat.No: TN5285

Stigmasta-4,22,25-trien-3-one

Cat.No: TN5063

Target: Others

Masticadienolic acid

Cat.No: TN4505

Target: Others

Stigmastadienone

Cat.No: TN6801

Cat.No: TN1506

Synonym: 直铁线莲宁B,落叶松树脂醇苷B

Target: Influenza Virus

Cat.No: T75638

7alpha-Hydroxystigmasterol

Cat.No: TN3254

Target: Others

(+)-Columbianetin acetate

Cat.No: T4946

Synonym: 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE

Target: Others

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

Picropodophyllin

Cat.No: T6943

Synonym: AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素

Target: Apoptosis, IGF-1R

Palmitoylethanolamide

Cat.No: T6926

Synonym: Mackpeart DR 14V,帕米醇,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol

Target: Influenza Virus, Endogenous Metabolite, PPAR

(+)-Columbianetin

Cat.No: T5S1286

Synonym: 二氢山芹醇,(S)-Columbianetin,Columbianetin

Target: Antifungal

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

3,5-Dicaffeoyl-epi-quinic acid

Cat.No: TN2895

Synonym: 金银花

Target: IL Receptor, p38 MAPK, TNF, Caspase, JNK, Histamine Receptor

Dihydroresveratrol 3-O-glucoside

Cat.No: TN3864

Target: Others

4,7-Didehydroneophysalin B

Cat.No: T83329

Cat.No: T80998

Synonym: Thapsigargicine

4'-O-Methylnyasol

Cat.No: TN3062

Target: Histamine Receptor

Cat.No: TN6539

Cat.No: TN5279

Target: ATPase, Calcium Channel, Antifection, Histamine Receptor

Cat.No: TN5647

Cat.No: T25687

Synonym: 白三烯C4,LTC4,Leukotriene C

9-O-Feruloyl-5,5'-dimethoxylariciresinol

Cat.No: TN3325

Target: IL Receptor, TNF

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Cat.No: TN6667

Cat.No: TN1009

Target: NF-κB, NO Synthase, Prostaglandin Receptor

Cat.No: TN4683

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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