65
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2121 |
SW033291
|
Dehydrogenase | Metabolism |
SW033291 是有效的15-PGDH 抑制剂,与15-PGDH 亲和力高,Ki 为 0.1 nM。它增加骨髓和其他组织中前列腺素 PGE2 的水平。它还可促进组织再生。 | |||
T8645 |
PF-06446846
|
Others | Others |
PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome,选择性地直接抑制 PCSK9 的翻译。 | |||
T8550 |
NDMC101
|
Others; NF-κB; Proteasome | NF-κB; Others; Proteases/Proteasome; Ubiquitination |
NDMC101 是有效的破骨细胞形成抑制剂,通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似,通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究,如类风湿关节炎、滑膜炎等。 | |||
T9026 |
MEISi-2
Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide |
Others | Others |
MEISi-2 是 MEIS(造血干细胞自我更新的关键调控因子)选择性抑制剂。它可用于心脏损伤、造血问题、骨髓移植和癌症的研究。 | |||
T9603 |
MNITMT
|
||
MNITMT 是一种有效的免疫抑制剂 (immunosuppressive agent),没有骨髓毒性。 | |||
T8400 |
Pamidronic acid
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Pamidronic acid 可用于各种骨吸收类疾病的研究。 | |||
T25705 |
Imupedone
LF1695,LF-1695,LF 1695 |
Others | Others |
Imupedone (LF 1695) 是一种合成免疫调节剂,可调节 T 淋巴细胞和巨噬细胞,诱导骨髓前体细胞的 T 细胞分化,增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。 | |||
T9089 |
FTO-IN-1
UUN44923 |
Others | Others |
UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。 | |||
T1199 |
Mitotane
Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦 |
Apoptosis; AChR | Apoptosis; Neuroscience |
Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物,可作用于肾上腺皮质癌,有抗癌活性。 | |||
T1776L |
Plerixafor octahydrochloride
盐酸普乐沙福,JM3100 octahydrochloride,Plerixafor 8HCl (AMD3100 8HCl),Plerixafor 8HCl,SID791 octahydrochloride,AMD 3100 octahydrochloride,JM 3100 8HCl |
Virus Protease; HIV Protease; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂,IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。 | |||
T14692 |
BMX-IN-1
BMX kinase inhibitor |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
BMX-IN-1 (BMX kinase inhibitor) 是 X 染色体上的骨髓酪氨酸激酶 (BMX, IC50 = 8 nM) 和相关的布鲁顿酪氨酸激酶 (BTK, IC50 = 10.4 nM) 的特异性抑制剂,但 BMX-IN-1 对 Blk、JAK3、EGFR、Itk 或 Tec 活性的效力要低 47-656 倍以上。 | |||
TP1828 |
N-Acetyl-Ser-Asp-Lys-Pro
|
RAAS | Endocrinology/Hormones |
N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。 它抑制多能造血干细胞进入细胞周期的 S 期,并防止小鼠中的 Ara-C 致死性。 | |||
T76699 |
Sabatolimab
MBG453,NVP-MBG453 |
Others | Others |
Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体,是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性,可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。 | |||
TP1820L |
Osteogenic Growth Peptide, OGP acetate
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) |
Others | Others |
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽,存在于血清中,浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。 | |||
T4570 |
Pipobroman
Vercyte,A-8103,Amedel,哌泊溴烷 |
Others; DNA Alkylator/Crosslinker | DNA Damage/DNA Repair; Others |
Pipobroman (Vercyte) 是一种烷基化剂,是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性,可用于癌症研究。 | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T25299 |
Degranol
NSC 9698,NSC-9698,NSC9698 |
||
Degranol is a nitrogen mustard derivative alkylating agent utilized as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant. | |||
TP2339 |
Goralatide
|
||
Goralatide, isolated from fetal calf bone marrow, exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells. | |||
T31124 |
CW 008
CW-008,CW008 |
||
CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice. | |||
T71422 |
S6821
|
||
S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo. | |||
T25319 |
Diacetylsplenopentin HCl
Diacetylsplenopentin hydrochloride |
||
Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the immune system. This effect is specific | |||
T25816 |
Mitolactol
NSC 104800,NSC-104800,NSC104800 |
||
Mitolactol is an alkylating antineoplastic toxic to bone marrow; utilized in breast cancer, also in combination with other drugs. Mitolactol is able to cross bloodbrain barrier, consequently could control certain brain tumors. | |||
T71904 |
Chlormadinone (free base)
|
||
Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells. | |||
T15135 |
Direct Black 38
C.I. 30235,Chlorazol Black E |
Others | Others |
Direct Black 38 is an azo dye.It induces unscheduled DNA synthesis in liver and micronucleus in bone marrow of rats in vivo[1]. | |||
TP1371 |
N-Acetyl-Ser-Asp-Lys-Pro TFA
|
||
N-Acetyl-Ser-Asp-Lys-Pro (TFA) is an endogenous tetrapeptide that is naturally produced in the bone marrow. It serves as a specific substrate for the N-terminal site of ACE, the enzyme responsible for angiotensin converting activity. | |||
TP2340 |
Hemoregulatory peptide 5b
hp 5B,Pglu-glu-asp-cys-lys-OH,Peedck,Glp-glu-asp-cys-lys-OH,SP1 Pentapeptide |
||
Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone which initially identified in extracts of rodent bone marrow and human leukocytes. Monomer inhibits both formations of GM-CFC colonies and cytotoxic drug-induced recruitment of murine | |||
T32009 |
GSK321
GSK 321,GSK-321 |
||
GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia blasts and more stem cells. | |||
T40908 |
KLD-12
|
||
KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondral defects in their original location, leading to improved cartilage repair. | |||
T36260 | NR 7h | ||
Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo. | |||
T27367 |
FR 900490
BMY 28700,FR-900490,FR900490 |
||
FR 900490 is an immunoactive substance produced by a fungus Discosia sp. F-11809. In vitro FR-900490 restores the colony forming units in culture (cfu-c) in bone marrow cells, which were suppressed by immunosuppressive factor obtained from the serum of sa | |||
T61417 | PPARγ agonist 7 | ||
PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1]. | |||
T78459 |
Leishman's stain
|
||
Leishman's stain为外周血和骨髓涂片染色的关键试剂,染色结果呈淡蓝灰色至深蓝色(在油镜下观察)。 | |||
T14374 |
AZD2906
|
||
AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow. | |||
T37907 | DL 175 | ||
Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis. | |||
T69288 |
CEP-7055
|
||
CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cel... | |||
T61554 | CSF1R-IN-13 | ||
CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1]. | |||
TP1820 |
Osteogenic Growth Peptide, OGP
|
||
Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury | |||
T82851 |
BMP2-derived peptide
|
||
BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序,具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。 | |||
T80932 |
Tritrpticin
|
||
Tritrpticin是一种来源于猪骨髓的抗菌肽,对Aspergillus fumigatus和Candida albicans表现出抗菌活性,其最小抑菌浓度(MIC)分别为250和1000 μg/ml。 | |||
TP1978 |
11R-VIVIT
NFAT inhibitor, Cell Permeable |
||
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse | |||
TP2193 |
Myelopeptide-2 (MP-2)
|
Others | Others |
Myelopeptide-2 (MP-2) with the sequence Leu-Val-Val-Tyr-Pro-Trp is originally isolated from the supernatant of porcine bone marrow cell culture and is able to restore the mitogen responsiveness of human T lymphocytes inhibited by conditioned medium from H | |||
T60731 |
Mitobronitol
|
||
Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物。Mitobronitol 是被归类为烷化剂的抗癌剂。Mitobronitol 具有骨髓抑制作用,可显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险。 | |||
T9655 |
NBC 6
|
||
NLRP3-IN-NBC6 是一种有效的选择性 NLRP3炎性小体抑制剂 ,IC50为574 nM,其作用独立于 Ca2+。NLRP3-IN-NBC6 抑制 Nigericin 诱导的 THP-1 细胞炎症反应和 Imiquimod 诱导的 LPS-primed 的骨髓源性巨噬细胞 (BMDMs) 释放 IL-1β。 | |||
T69205 |
GGTI-2166
|
||
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. | |||
T9134 | UNC5293 | ||
UNC5293 是一种有效的、口服的、高度 MERTK 选择性的抑制剂 (Ki=190 pM)。UNC5293 抑制 MERTK (IC50=0.9 nM),对 Axl、Tyro3 和 Flt3 更具选择性。UNC5293 表现出优异的小鼠药代动力学特性,并可以被用于骨髓白血病研究。 | |||
T78305 |
Briquilimab
JSP-191 |
||
Briquilimab (JSP-191) 是针对 CD117 (c-Kit) 的无毒人源化单克隆抗体,用于消耗造血干细胞 (HSC)。它被应用于重度联合免疫缺陷 (SCID) 治疗中,以清空宿主骨髓生态位,为供体造血干细胞移植及免疫重建创造条件。 | |||
T81171 | SH491 | ||
SH491(Compound 33)是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞(BMM)分化为破骨细胞(IC50: 11.8 nM)。同时,SH491降低了破骨细胞形成的相关标记基因(TRAP、CTSK、MMP-9和ATPase v0d2)以及相应蛋白(TRAP、CTSK、MMP-9)的表达。 | |||
T35587 |
Ganglioside GD1a mixture (sodium salt)
Ganglioside B1 |
||
Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T... | |||
T62494 |
Cathepsin C-IN-5
|
||
CathepsinC-IN-5 (compound SF38) 为一高效、选择性、口服活性的组织蛋白酶 C (Cat C) 抑制剂,其针对Cat C、Cat L、Cat S、Cat B、Cat K 的IC50s 分别为 59.9 nM、4.26 µM、>5 µM、>5 µM、>5 µM。该化合物能够抑制骨髓和血液中的Cat C活性,降低中性粒细胞丝氨酸蛋白酶(NSP)的激活,并展现抗炎活性。 | |||
T68480 |
4SC-207
|
||
4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome a... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5751 |
Tigogenin
|
Others | Others |
Tigogenin 是甾体皂甙元,普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化,促使成骨细胞的分化。 | |||
T9171 |
Methenolone enanthate
|
Others | Others |
Methenolone enanthate 是一种雄激素和合成代谢类固醇 (AAS) 药物,主要用于治疗由于骨髓衰竭引起的贫血。 | |||
T3004 |
Batilol
鲨肝醇,Batilolum,Stearyl monoglyceride,Batyl alcohol,1-O-Octadecylglycerol |
Others; Endogenous Metabolite | Metabolism; Others |
Batilol (Stearyl monoglyceride) 是内源性代谢产物的一种。 | |||
T8117 |
Metenolone acetate
Methenolone acetate,美替诺龙醋酸酯 |
Others; Androgen Receptor | Endocrinology/Hormones; Others |
Metenolone acetate (Methenolone acetate) 是一种合成代谢类固醇(AAS) 药物,是一种雄激素,主要用于治疗由于骨髓衰竭引起的贫血。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
T2820 |
Glycitin
黄豆黄苷,Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside |
Others; Influenza Virus; Antibacterial | Microbiology/Virology; Others |
Glycitin (Glycitein 7-O-β-glucoside) 是一种从豆类中分离出来的天然异黄酮,有抗菌,抗病毒和雌激素作用,还有促进骨髓基质细胞和成骨细胞的增殖和抑制骨转换的生物学功能。 | |||
T3674 |
Hydroxysafflor yellow A
藏红花,羟基红花黄色素A,HSYA,Safflomin A |
TGF-beta/Smad | Stem Cells |
Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物,从中药红花中分离得到,具有抗癌作用。 | |||
TN2143 |
3,7,4'-Trihydroxyflavone
Resokaempferol,5-Deoxykampferol |
DNA | DNA Damage/DNA Repair |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物,可抑制 NF-κB 配体 (RANKL) 受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
TL0008 |
Gigantol
|
Wnt/beta-catenin; Glucosidase | Cytoskeletal Signaling; Metabolism; Stem Cells |
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。 | |||
TN1484 |
Cheilanthifoline
|
NF-κB; Antifection | Microbiology/Virology; NF-κB |
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. | |||
TN1009 |
Epimagnolin B
|
NF-κB; NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; NF-κB |
Epimagnolin B 是一种双环氧木质素,分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。 | |||
TN2533 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone | 5-HT Receptor | GPCR/G Protein; Neuroscience |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel | |||
TN2534 |
1-Hydroxy-2,3,5-trimethoxyxanthone
|
IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c... |