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7

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T21497	9-cis-Retinoic Acid Alitretinoin	Apoptosis	Apoptosis
	9-cis-Retinoic Acid (Alitretinoin) 是一种维生素 A 的衍生物，是一种 RAR/RXR 激动剂，具有抗癌、抗肿瘤活性、抗炎和神经保护活性，可诱导细胞凋亡 (apoptosis)，调节细胞周期，可用于研究晚期肿瘤。
T78157	PARP-1-IN-3	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-3 是一种高效的 PARP-1 抑制剂，对 PARP-1 和 PARP-2 具有抑制作用， IC50 值分别为 0.25 nM 和 2.34 nM。PARP-1-IN-3 具有潜在的抗炎活性，促使细胞凋亡并使细胞周期停滞在 G2/M 期。PARP-1-IN-3 可用于研究与癌症相关的疾病。
T61187	BRD4 Inhibitor-17
	BRD4 Inhibitor-17 (Compound 5i) is a highly potent inhibitor of BRD4, exhibiting an impressive IC50 value of 0.33 μM. It fulfills a crucial regulatory function in transcription by effectively modulating the expression of inflammatory, proliferation, and cell cycle genes. Moreover, BRD4 Inhibitor-17 shows promise as a potential remedy for arsenical-induced toxicity, thus highlighting its potential as an antidote in such cases [1].
T71176	Atiprimod (free base)
	Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription 3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1, thereby inhibiting cell proliferation, ind...
T72436	cis,trans-Germacrone
	cis,trans-Germacrone 是 Germacrone 的异构体。Germacrone 具有广泛的抗肿瘤、抗氧化和抗炎作用。Germacrone 抑制肺癌细胞增殖并改变 Akt/MDM2/p53。Germacrone 还能在 G1/S 期阻滞细胞周期。
T41240	Verrucarin A
	Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂，来源于Myrothecium verrucaria，可抑制白血病细胞系生长，并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化，降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。

化合物

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

9-cis-Retinoic Acid

Cat.No: T21497

Synonym: Alitretinoin

Target: Apoptosis

Cat.No: T78157

Target: Apoptosis, PARP

BRD4 Inhibitor-17

Cat.No: T61187

Atiprimod (free base)

Cat.No: T71176

cis,trans-Germacrone

Cat.No: T72436

Cat.No: T41240

Cat. No.	Product Name	Target	Signaling Pathways
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
T4S1540	Myrislignan	Apoptosis; NF-κB	Apoptosis; NF-κB
	Myrislignan 是一种木酚素，从Myristica fragransHoutt 分离得到，具有抗炎作用。它通过抑制NF-kB 信号通路的激活，减轻LPS 诱导的小鼠巨噬细胞炎症反应。
TN1222	26-Deoxyactein 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭	NOS; CDK; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation
	23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分，能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR，CYP1A1 和 ERK 的水平升高具有抑制作用。
T3426	Bacoside A	MMP; Others; TNF; Dopamine Receptor; NOS; ROS	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidative stress by an increase in the concentration of antioxidant enzymes and sustain membrane integrity which leads to restoring the damage caused by tBHP. Bacoside A can able to inhibit the progression of Experimental Autoimmune Encephalomyelitis (EAE) may be by the inhibition of i...
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
TN3655	Cimiside E	ERK; TNF; ROS; Akt; PI3K; PKC; PPAR	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
TN2641	15-Methoxypinusolidic acid	ERK; IL Receptor; p38 MAPK; Calcium Channel; NOS; NF-κB; COX; JNK; NMDAR; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dep
T8199	(±)-α-Bisabolol Bisabolol	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	(±)-α-Bisabolol (Bisabolol) 是一种从洋甘菊、念珠菌树等植物精油中提取的倍半萜烯醇，是一种天然防腐剂，具有舒缓、抗刺激、抗炎、抗氧化和抗癌活性。(±)-α-Bisabolol 通过诱导细胞周期停滞、线粒体死亡和抑制 PI3K/Akt 信号通路来发挥作用，对 A549 NSC-LC 细胞产生抗癌作用 (IC50 = 15 μM)。(±)-α-Bisabolol 能强效诱导胶质瘤细胞凋亡。

天然产物

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cat.No: T4S1540

Target: Apoptosis, NF-κB

Cat.No: TN1222

Synonym: 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭

Target: NOS, CDK, NO Synthase

Cat.No: T3426

Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: TN4132

Cat.No: TN3655

Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

15-Methoxypinusolidic acid

Cat.No: TN2641

Target: ERK, IL Receptor, p38 MAPK, Calcium Channel, NOS, NF-κB, COX, JNK, NMDAR, PPAR

(±)-α-Bisabolol

Cat.No: T8199

Synonym: Bisabolol

Target: Apoptosis, Antioxidant

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