71
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38361 |
GSK717
|
IL Receptor; NOD | Immunology/Inflammation; NF-κB |
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。 | |||
T7123 |
AMG-47a
|
VEGFR; p38 MAPK; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
T4686 |
Simeprevir
TMC435,西咪匹韦,TMC-435350,Olysio |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂,抑制 HCV 复制,EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T77761 |
BMS-502
|
Others | Others |
BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂, 诱导人和小鼠T细胞的免疫反应,阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应,可用于研究与免疫相关的疾病。 | |||
T21608L |
β-Interleukin I (163-171), human Acetate
β-Interleukin I (163-171), human Acetate(106021-96-9 Free base) |
Others | Others |
β-Interleukin I (163-171), human Acetate 是一种参与调节免疫反应、炎症反应和造血的肽。 | |||
T76699 |
Sabatolimab
MBG453,NVP-MBG453 |
Others | Others |
Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体,是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性,可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。 | |||
T14513 |
BBIQ
|
TLR | Immunology/Inflammation |
BBIQ 是一种有效且选择性的 toll 样受体 7 (TLR7) 激动剂,对人 TLR7 的 EC50 为 59.1 nM。BBIQ 还是一种功能强大的疫苗佐剂,可增强机体的先天免疫应答。 | |||
T50068 |
2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide
|
Others | Others |
2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide 是一种用作分子结构单元的化合物,为环状二肽。它可以诱导细胞凋亡、抑制细胞增殖和调节免疫反应,具有广泛的生物活性,包括抗肿瘤、抗真菌、抗细菌、抗病毒和免疫条件活性等。 | |||
T6964 |
Resiquimod
R848,雷西莫特,S28463 |
HCV Protease; TLR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂,可诱导细胞因子上调。 | |||
T3614 |
Inosine pranobex
Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun |
IL Receptor; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Inosine pranobex (Delimmun) 是一种免疫增强剂,它是一种广谱抗病毒剂,用于 HIV 感染。 | |||
T78362 |
Transglutaminase
TG |
||
Transglutaminase (TG) 是一种硫醇酶,促使蛋白质分子间交联,通过催化谷氨酰胺残基的γ-羧酰胺基团与其他化合物的一级ε-胺基团形成异肽键。该酶在包括凝血、抗菌免疫反应和光合作用在内的多种生理过程中发挥作用。 | |||
T10865 |
Cot inhibitor-1
|
TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生,其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路,特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性,可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。 | |||
T28708 |
Sch 24937
|
||
Sch 24937 is a potent immunosuppressant on B lymphocyte mediated immune responses. | |||
T61110 | UC-1V150 | ||
UC-1V150 is a distinct TLR7 agonist, which activates cellular immune responses and exhibits anti-tumor effects. It also serves as a precursor for the synthesis of ISAC molecules, known as immune-stimulating antibody conjugates [1] [2]. | |||
T25319 |
Diacetylsplenopentin HCl
Diacetylsplenopentin hydrochloride |
||
Diacetylsplenopentin HCl is used as a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the immune system. This effect is specific | |||
T27099 |
CU-3
CU 3,CU3 |
||
CU-3 is a potent and selective inhibitor of diacylglycerol kinase alpha (DGKalpha). CU-3 attenuates cancer cell proliferation and simultaneously enhances immune responses including anti-cancer immunity. | |||
T34026 |
Phevamine A
PHVA |
Others | Others |
Phevamine A (PHVA) 是植物免疫反应的抑制剂。 | |||
T38614 |
TLR7 agonist 3
|
||
TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development. | |||
T40452 |
N-Acetylpsychosine
N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0) |
||
N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (DCs). | |||
T73990 | Lipid M | ||
Lipid M (pKa: 6.75) 可用于递送 mRNA 疫苗,引发强大的免疫反应并提高耐受性。 | |||
T74872 | ODN 105870 | ||
ODN 105870 是一种 G 修饰的抑制性寡核苷酸 (INH-ODN),是一种选择性 TLR7抑制剂。ODN 105870 可用于炎症免疫反应研究。 | |||
T80131 |
C5a Anaphylatoxin (human)
|
Complement System | Immunology/Inflammation |
C5a Anaphylatoxin (human)为促炎多肽及白细胞化学引诱剂,主要应用于炎症与免疫领域研究,例如过敏性哮喘。 | |||
T39292 |
NS2 (114-121), Influenza
NS2 (114-121), Influenza |
||
NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses. | |||
T14035 |
3M-011
|
TLR | Immunology/Inflammation |
3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3]. | |||
T40216 |
PTPN22-IN-1
PTPN22-IN-1 |
||
PTPN22-IN-1 is a potent PTPN22 inhibitor ( IC 50 =1.4 μM; K i =0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses. From WO2021007491A1 compound L-1. | |||
T13667 |
Dusquetide TFA (931395-42-5 free base)
SGX942 TFA,Dusquetide TFA |
Others | Others |
Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune responses to PAMPs and DAMPs in combinat | |||
T82142 |
Hymenistatin I
|
||
Hymenistatin I,一种环八肽[c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-ile-Ile-)],具有免疫抑制活性,影响体液和细胞免疫应答。 | |||
T69834 |
Tivumecirnon
FLX475 |
||
Tivumecirnon (FLX475) 是一种有效的 CCR4拮抗剂,可以阻断干扰有效抗肿瘤免疫反应的调节性 T 细胞,具有抗肿瘤活性。 | |||
T77775 |
TP-1454
|
||
TP-1454是一种针对PKM2的激活剂,其生化测定的AC50为10 Nm。它可通过作用于T调节细胞来调控肿瘤的免疫反应。 | |||
T76748 | Foralumab | ||
Foralumab(NI-0401)为口服有效的人源化单克隆抗体,针对CD3进行靶向。其能够调控NSG小鼠体内,由人类造血干细胞重建的人类细胞的免疫反应。 | |||
T79927 |
Pectate Lyase
|
||
Pectate Lyase为植物病原菌分泌的关键酶,主要功能包括在果胶降解和真菌毒力形成中发挥作用。此外,Pectate Lyase还能诱导植物的免疫反应并参与其毒力过程。 | |||
T74873 | ODN 105871 | ||
ODN 105871,一种G修饰的抑制性寡核苷酸(INH-ODN),作为选择性TLR7抑制剂,适用于炎症免疫反应的研究。 | |||
T74584 |
5-Methylcytidine 5′-triphosphate
|
||
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) 为修饰核苷三磷酸,用以替代未修饰 mRNA,以增强翻译性能与稳定性,显著降低人类及其他哺乳动物细胞的先天免疫反应。 | |||
T81022 |
Tegoprubart
|
||
Tegoprubart为针对CD40配体(CD40L)的单克隆抗体,该配体为共刺激介质的核心。通过抑制CD40L,可减弱细胞与抗体介导的免疫反应,促进免疫环境趋向耐受性。在移植动物模型中,Tegoprubart已展现出体内活性。 | |||
T27638 |
Israpafant
Y-24180,Y 24180,Y24180 |
||
Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and consequently delays the development o | |||
T82858 |
Bleselumab
ASKP 1240,Anti-Human CD40 Recombinant Antibody |
||
Bleselumab (ASKP 1240)为人源化抗-CD40单克隆抗体,通过高亲和力(Kd: 0.24 nM)与CD40结合,阻断CD40与CD40L配体的相互作用,从而抑制免疫反应,用于预防器官移植排斥。 | |||
T73659 |
HLF1-11
|
||
HLF1-11,一种人乳铁蛋白衍生肽,是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使GM-CSF 驱动的单核细胞向巨噬细胞分化,并增强其免疫反应。 | |||
T76241 |
Trichomide A
|
||
Trichomide A 是一种有效的 SHP2激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A 具有研究免疫相关皮肤病的潜力。 | |||
T74268 |
STING agonist-13
|
||
STINGagonist-13 是一种STING 激动剂,通过STING 介导的免疫激活进行癌症免疫。STINGagonist-13 可刺激STING 下游信号传导并促进 I 型干扰素免疫反应。STINGagonist-13 能显著降低肿瘤体积并具有免疫记忆衍生的癌症抑制活性。 | |||
T79320 |
Antitumor agent-114
|
STING | Immunology/Inflammation |
Antitumor agent-114为一种强效STING激动剂,具有激活免疫功能并在乳腺癌小鼠模型中缩减肿瘤体积的作用,适用于免疫与癌症疾病研究之用。 | |||
T74706 | Vidutolimod | ||
Vidutolimod 是一种CpG-A 类寡核苷酸,是TLR9的激动剂。Vidutolimod 激活浆细胞样树突状细胞(pDCs)并触发IFNα的释放,导致抗肿瘤免疫作用。 | |||
T68383 |
BIIB028
|
||
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o... | |||
T79488 |
RNase L-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RNase L-IN-1(compound 17a)为RNase L的特异性抑制剂,能有效地防止该酶降解RNA,从而抑制病毒复制,并对先天性免疫反应及炎症过程具调控作用。 | |||
T74585 | 5-Methylcytidine 5′-triphosphate trisodium | ||
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium 为一种修饰核苷三磷酸,可用以替换原生mRNA,进而提升翻译效率与稳定性,同时在人类及其他哺乳动物细胞中显著降低先天免疫反应。 | |||
T82793 |
Caerin 1.1 TFA
|
Apoptosis | Apoptosis |
Caerin 1.1 TFA 是澳大利亚树蛙Litoria腺体分泌物中分离出的宿主防御肽,具有抑制 HeLa 细胞增殖及介导细胞凋亡 (apoptosis) 的能力,并可能促进适应性 T 细胞免疫反应。 | |||
T76786 | Cabiralizumab | ||
Cabiralizumab (FPA 008) 是一种抗 CSF1R 单克隆抗体 (MAb)。Cabiralizumab 可增强 T 细胞浸润和抗肿瘤 T 细胞免疫反应。Cabiralizumab 抑制破骨细胞的活化并阻止骨质破坏,可用于类风湿性关节炎 (RA) 的研究。Cabiralizumab 可与 Nivolumab 结合用于肺癌研究。 | |||
T74910 | ODN 24888 | ||
ODN 24888 是一种鸟嘌呤修饰的抑制性寡核苷酸 (INH-ODN),对TLR7/TLR9介导的信号通路表现出强烈的抑制作用。ODN 24888 损害 IFN-α 水平和NF-κB 激活,抑制IL-6的释放。ODN 24888 参与免疫和炎症应答,可作为疫苗佐剂使用。 | |||
T74905 |
ODN 2007
|
||
ODN 2007是一种B类CpG ODN(寡脱氧核苷酸),兼具Toll样受体(TLR)配体功能。作为免疫调节剂和疫苗佐剂,它能够增强哺乳动物、鱼类及人类的免疫反应。其序列为5'-TCGTCGTTGTCGTTTTGTCGTT-3'。 | |||
T80761 |
XQ2B
|
||
XQ2B为cGAS抑制剂,针对蛋白质-DNA相互作用及其相分离。该化合物可阻止单纯疱疹病毒1(HSV-1)触发的抗病毒免疫响应,在体外与体内都能增强HSV-1的感染效果。 | |||
T74693 |
CDN-A
|
||
CDN-A为一种环二核苷酸,主要用于抗体-活性分子偶联物(ADC)的合成。作为先天免疫及适应性免疫反应的关键激活剂,环状二核苷酸能由内源性外来DNA或侵入性细菌病原体生成,在人体内通过促进干扰素基因表达激活先天免疫系统。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13502 |
3-Oxo-5β-cholanoic acid
3-氧代-5β-胆烷酸,Dehydrolithocholic acid |
ROR | Metabolism |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。 | |||
TN2088 |
Platycodin D2
桔梗皂苷D2 |
IL Receptor; HBV | Immunology/Inflammation; Microbiology/Virology |
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。 | |||
T0948L |
Corticosterone
皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants) |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇,有盐皮质激素和糖皮质激素的活性,具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。 | |||
T5S0993 |
Kurarinone
苦参酮,苦参黄素 |
BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells |
Kurarinone 是从灌木苦参中提取的黄酮类化合物,具有抗肿瘤、雌激素和抗炎活性,对免疫反应也有很强的抑制作用。 | |||
T67710 |
3-Indoleacrylic acid
|
Endogenous Metabolite | Metabolism |
3-Indoleacrylic acid 是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid 对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。 | |||
T5731 |
1-Kestose
蔗果三糖,1-蔗果三糖 |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
1-Kestose 是低聚果糖成分,有效刺激了 Faecalibacterium prausnitzii 和 Bifidobacteria。它有抗羟基自由基的潜力。它可促进肠道内乳酸菌数量,影响微生物以及肠道和全身免疫反应。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T1614 |
Hydrocortisone
氢化可的松,Cortisol |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Hydrocortisone (Cortisol) 是一种糖皮质激素,由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体,可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄,并抑制免疫和炎症反应。 | |||
T5S1895 |
Norisoboldine
Laurelliptine,去甲异波尔定,(+)-Laurelliptine |
MAPK; Adenosine Receptor | GPCR/G Protein; MAPK; Neuroscience |
Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂,是乌药中主要的异喹啉类生物碱,可用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T3386 |
Kaempferitrin
Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷 |
cell cycle arrest; Glucokinase; IGF-1R | Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。 | |||
TN4804 |
Platycoside A
|
Antifection | Microbiology/Virology |
Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice. | |||
TN2181 | Sarmentosin | Others | Others |
Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum glutamate-pyruvate transaminase. | |||
T38838 |
QS-21
Stimulon,QS-21 |
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QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. |