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Search Results for " hypolipidemic "

23

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14933	Cetaben	Others	Others
	Cetaben 是不依赖 PPARα 的过氧化物酶体增殖物。它可有效降低胆固醇和甘油三酸酯的浓度，是一种非纤维化降血脂药。
T3941	Choline Fenofibrate Trilipix,ABT-335,非诺贝特胆碱	P450; COX; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	Choline Fenofibrate (Trilipix) 是 Fenofibric acid 的胆碱盐，在胃肠道中释放游离的 Fenofibric acid。Fenofibric acid 是一种合成的苯氧基异丁酸衍生物和具有抗高血脂活性的前药。
T5123	Pirozadil	Others	Others
	Pirozadil 是降血脂药。
T15471	Hepronicate Megrin	Others	Others
	Hepronicate（Megrin）是一种具有降血脂和血管扩张活性的小分子化合物。
T19864	Xenalipin BW 207U	Others	Others
	Xenalipin (BW 207U) 具有降血脂作用。它可以降低大鼠的血液胆固醇和甘油三酯。
T31083	CP-868388 free base CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388	PPAR	DNA Damage/DNA Repair; Metabolism
	CP-868388 free base (CP-868388) 是一种具有口服活性、有效性和选择性的 PPARα 激动剂，具有降血脂和抗炎活性，可用于研究血脂异常。
T30506	BMS-212122 UNII-0Z473OO6GB,BMS212122,BMS 212122	CETP	Metabolism
	BMS-212122 (UNII-0Z473OO6GB) 是一种有效的微粒体甘油三酯转移蛋白(MTP )抑制剂，在动物实验中显示出降血脂作用。BMS-212122 显著减少动脉粥样硬化斑块中的脂质含量和单核细胞衍生(CD68+)细胞。
T27832	Lifibrol U 83860,K-12148,K-12.148,U-83860,K12148	Lipid	Metabolism
	Lifibrol (U-83860) 是一种胆固醇合成抑制剂。Lifibrol 具有抗胆固醇和降血脂的作用，可促进高胆固醇血症和混合型高脂血症患者体内低密度脂蛋白载脂蛋白 B-100 的转化。
T1162	Acipimox Olbemox,K-9321,阿西莫司,阿昔莫司	Others	Others
	Acipimox (K-9321) 是烟酸类似物，能够急性抑制脂解作用，抑制全身游离脂肪水平，改善胰岛素敏感性。
T67974	Berberine ursodeoxycholate HTD1801,BUDCA
	Berberine ursodeoxycholate (HTD1801) 是一种口服有效的降血脂剂，是 Berberine 和 Ursodeoxycholic acid 的一种离子盐。Berberine ursodeoxycholate 具有广泛的代谢活性，可显著降低肝脏脂肪含量。Berberine ursodeoxycholate 可用于研究高脂血症、非酒精性脂肪性肝炎 (NASH) 和糖尿病。
T1415	Gemfibrozil 吉非罗齐,CI-719,Jezil,Decrelip,Lopid	P450; Adrenergic Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Gemfibrozil (CI-719) 是一种PPAR-α激活剂，可作为降脂药。它也是P450非选择性抑制剂，对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。
T34872	Tiadenol LL 1558,NSC66316,LL-1558,LL1558 NSC 66316,NSC-66316
	Tiadenol is a Hypolipidemic Agent.
T13821	Pirinixil BR-931,匹立昔尔	Others	Others
	Pirinixil is a hypolipidemic low toxicity agent.
T30238	Axitirome CGS-26214,CGS 26214,CGS26214
	Axitirome, also known as CGS 26214, is a hypolipidemic agent.
T13909	TA-1801	Others	Others
	TA-1801 is an agent of hypolipidemic.
T34552	SC 33459 SC-33459,SC33459
	SC 33459 is a hypolipidemic agent.
T24223	JTT 130 JTT-130,JTT130
	JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein.
T15256	Etofylline clofibrate	Others	Others
	Etofylline clofibrate has a hypolipidemic and antithrombotic effect and it also has an agonistic interaction with intimal PGI2.
T13972	Y-9738	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-9738 is an agent of hypolipidemic.
T30977	Clofibride
	Clofibrin is a kind of hypolipidemic drug, which can reduce Hypertriglyceride and hypercholesterolemia.
T82853	BM 15766 sulfate
	BM 15766 sulfate是一种7-脱氢胆固醇δ7-还原酶的抑制剂，具有降低血浆胆固醇水平的作用，属于降血脂剂类药物。
T35448	10-Thiastearic Acid
	Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more than 80% at a concentration of 25 μM. This activity is associated with a hypolipidemic effect, making this 10-thiastearic acid a useful tool for evaluating new anti-obesity therapeutics.
T64171	LXR antagonist 2
	LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂，能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂，能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。

化合物

Cat.No: T14933

Target: Others

Choline Fenofibrate

Cat.No: T3941

Synonym: Trilipix,ABT-335,非诺贝特胆碱

Target: P450, COX, PPAR

Cat.No: T5123

Target: Others

Cat.No: T15471

Synonym: Megrin

Target: Others

Cat.No: T19864

Synonym: BW 207U

Target: Others

CP-868388 free base

Cat.No: T31083

Synonym: CP868388,CP 868388,(-)-CP-868388,UNII-999KY5ZIGB,CP-868388

Target: PPAR

Cat.No: T30506

Synonym: UNII-0Z473OO6GB,BMS212122,BMS 212122

Target: CETP

Cat.No: T27832

Synonym: U 83860,K-12148,K-12.148,U-83860,K12148

Target: Lipid

Cat.No: T1162

Synonym: Olbemox,K-9321,阿西莫司,阿昔莫司

Target: Others

Berberine ursodeoxycholate

Cat.No: T67974

Synonym: HTD1801,BUDCA

Cat.No: T1415

Synonym: 吉非罗齐,CI-719,Jezil,Decrelip,Lopid

Target: P450, Adrenergic Receptor, PPAR

Cat.No: T34872

Synonym: LL 1558,NSC66316,LL-1558,LL1558 NSC 66316,NSC-66316

Cat.No: T13821

Synonym: BR-931,匹立昔尔

Target: Others

Cat.No: T30238

Synonym: CGS-26214,CGS 26214,CGS26214

Cat.No: T13909

Target: Others

Cat.No: T34552

Synonym: SC-33459,SC33459

Cat.No: T24223

Synonym: JTT-130,JTT130

Etofylline clofibrate

Cat.No: T15256

Target: Others

Cat.No: T13972

Target: ROCK

Cat.No: T30977

BM 15766 sulfate

Cat.No: T82853

10-Thiastearic Acid

Cat.No: T35448

LXR antagonist 2

Cat.No: T64171

Cat. No.	Product Name	Target	Signaling Pathways
T3S0175	Gardenia yellow alpha-Crocin,Crocin I,Crocine,西红花苷 I,西红花苷I,藏红花	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Gardenia yellow (Crocin I) 是藏红花素家族的一员，作为可口服的抗抑郁剂，能增强 SIRT3的 mRNA 的表达，具有抗动脉粥样硬化和降血脂作用。
T2756	Swertiamarin 獐牙菜苦苷,獐牙菜苦甙,Swertiamaroside	Others	Others
	Swertiamarin (Swertiamaroside) 是一种裂环烯醚萜苷，在 Enicostemma Species 属植物中发现，具有降血糖和降血脂作用。
T5707	3-O-Methylgalangin 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚	Antibacterial	Microbiology/Virology
	3-O-Methylgalangin (GALANGIN-3-METHYLETHER) 是一种来源于高良姜根茎的天然黄酮，具有抗菌活性，抑制胰腺脂肪酶。
T2840	Phloracetophenone 2,4,6-三羟基苯乙酮,2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone	Others; P450; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Others
	Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) 是多叶姜黄中苯乙酮糖苷的糖苷配基部分，具有抗肥胖，降血脂和降低胆固醇作用，能够增强胆固醇 7α-羟化酶的活性。
T5690	7,4'-Di-O-methylapigenin 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE	Amylase	Metabolism
	7,4'-Di-O-methylapigenin (4',7-DIMETHOXY-5-HYDROXYFLAVONE) 可能具有抗真菌c.zeyheri 的作用，是一种潜在的抗真菌药物。它还能抑制药物流出泵(IC50 = 51.64μg /毫升)。
T3884	Neoandrographolide Neoandrographiside,新穿心莲内酯	NOS; COX	Immunology/Inflammation; Neuroscience
	Neoandrographolide (Neoandrographiside) 是一种二萜类化合物，从穿心莲中分离得到。
T0687	Simvastatin 辛伐他汀,MK-0733,MK 733	Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM)，具有口服活性。Simvastatin 具有降血脂活性，可以抑制肝脏产生胆固醇，还可以用于预防心血管疾病。
T5431	[10]-Shogaol 10-姜烯酚,10-Shogaol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	[10]-Shogaol (10-Shogaol) 是一种从生姜中提取的抗氧化剂，用于皮肤细胞增殖和迁移增强剂。它抑制 COX-2，IC50值为 7.5 μM，可能有降血脂和胰岛素增敏作用。
T5311	Crocin (Gardenia Fruits Extract) 藏红花,西红花苷	Others	Others
	Crocin (Gardenia Fruits Extract)（42553-65-1）是藏红花（Crocus sativus L.）的水溶性类胡萝卜素色素。藏红花素具有抗炎、抗氧化、抗凋亡、抗哮喘、抗癌、降血脂等作用。
T8189	Dihydroberberine	Potassium Channel; HSP; HER	Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
	Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用，具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。
T4749	Squalene 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species; Endogenous Metabolite; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Squalene (AddaVax) 是胆固醇合成的中间产物，具有降血脂、保肝、心脏保护、抗氧化和抗毒活性等多种药理特性。它还具有抗真菌活性，可用于毛癣菌治疗的相关研究。
TN1868	Ligupurpuroside A	LDL; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	Ligupurpuroside A has antioxidant,and hypolipidemic effects, it can significantly inhibit lipid accumulation in HepG2 cell at the concentration of 50 μMol/L.
TN4138	Globularin	Others	Others
	Globularin has hypoglycaemic and hypolipidemic activities in normal and streptozotocin-induced diabetic rats.
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮	ERK; MEK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.
T11202	Enniatin complex	Others	Others
	Enniatin complex, a mixture of cyclohexadepsipeptides predominantly derived from various Fusarium species of fungi, exhibits inhibitory effects on enzymes such as acyl-CoA: cholesterol acyl transferase. Furthermore, it has demonstrated the ability to induce apoptosis in multiple cancer cell lines. In addition to these activities, the Enniatin complex possesses ionophoric, antibiotic, and in vitro hypolipidemic properties.
TN6613	Delphinidin-3-O-galactoside chloride
	Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably
TN5431	Icariside E4	Antioxidant; AMPK; Liver X Receptor; Lipid; Fatty Acid Synthase	Chromatin/Epigenetic; Metabolism; oxidation-reduction; PI3K/Akt/mTOR signaling
	Icariside E4是一种从小叶榆中提取得到天然化合物，通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害，抗氧化，抗阿尔茨海默氏症和抗炎作用，抑制了SREBP-1c，肝脏X 受体-α（LXR）和FASN 在HepG2细胞中从头脂肪生成的表达。Icariside E4是治疗脂肪肝疾病的有效候选药物，在HepG1细胞中具有低脂化潜力。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Gardenia yellow

Cat.No: T3S0175

Synonym: alpha-Crocin,Crocin I,Crocine,西红花苷 I,西红花苷I,藏红花

Target: Sirtuin

Cat.No: T2756

Synonym: 獐牙菜苦苷,獐牙菜苦甙,Swertiamaroside

Target: Others

3-O-Methylgalangin

Cat.No: T5707

Synonym: 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚

Target: Antibacterial

Phloracetophenone

Cat.No: T2840

Synonym: 2,4,6-三羟基苯乙酮,2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone

Target: Others, P450, Antibacterial, Antibiotic

7,4'-Di-O-methylapigenin

Cat.No: T5690

Synonym: 芹菜素二甲醚,4',7-DIMETHOXY-5-HYDROXYFLAVONE

Target: Amylase

Neoandrographolide

Cat.No: T3884

Synonym: Neoandrographiside,新穿心莲内酯

Target: NOS, COX

Cat.No: T0687

Synonym: 辛伐他汀,MK-0733,MK 733

Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T5431

Synonym: 10-姜烯酚,10-Shogaol

Target: Antioxidant, COX

Crocin (Gardenia Fruits Extract)

Cat.No: T5311

Synonym: 藏红花,西红花苷

Target: Others

Dihydroberberine

Cat.No: T8189

Target: Potassium Channel, HSP, HER

Cat.No: T4749

Synonym: 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene

Target: Reactive Oxygen Species, Endogenous Metabolite, Antifungal

Ligupurpuroside A

Cat.No: TN1868

Target: LDL, AMPK

Cat.No: TN4138

Target: Others

Cat.No: TN1462

Synonym: 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮

Target: ERK, MEK, Akt

Enniatin complex

Cat.No: T11202

Target: Others

Delphinidin-3-O-galactoside chloride

Cat.No: TN6613

Cat.No: TN5431

Target: Antioxidant, AMPK, Liver X Receptor, Lipid, Fatty Acid Synthase

(E)-Guggulsterone

Cat.No: T36563

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