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171

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35664	Tetracosactide acetate	Others	Others
	Tetracosactide acetate 是一种合成的多肽，可刺激肾上腺释放皮质类固醇，如皮质醇。Tetracosactide acetate 在溃疡性结肠炎和克罗恩病、青少年和成人类风湿性关节炎和骨关节病方面有研究的价值。
TP1031	Tetracosactide Tetracosactrin,替可克肽	Others	Others
	Tetracosactide (Tetracosactrin) 是一种肾上腺皮质激素 (ACTH) 的类似物，能够刺激肾上腺皮质激素分泌。
T4507	Chlorphenesin Adermykon,Chlorophenesin,Gecophen,氯苯甘醚	Antibacterial; Antifungal; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Chlorphenesin (Chlorophenesin) 是一种抗原相关免疫抑制剂，可抑制 IgE 介导的组胺释放。它也用作抗真菌剂，用于许多眼保健化妆品中。
T27066	Prostaglandin G/H synthase 1 inhibitor CP74006,CP 74006,2-Amino-N-(4-chlorophenyl)benzamide	Others	Others
	Prostaglandin G/H synthase 1 inhibitor (CP 74006) 是一种选择性D5D 抑制剂，IC(50)值为20nM。
T36045	1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
T37919	Prostaglandin F1α PGF1α,Prostaglandin F1α
	Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]
T37991	15-keto Prostaglandin F2α 15-keto Prostaglandin F2α,15-keto PGF2α	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	15-keto Prostaglandin F2α 是 Prostaglandin F2α 的代谢物，可降低兔眼压。
T36728	9-deoxy-9-methylene Prostaglandin E2 9-deoxy-9-methylene Prostaglandin E2
	9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.
T35944	15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
	Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi...
T37940	17-phenyl trinor Prostaglandin F2α cyclopropyl amide 17-phenyl trinor Prostaglandin F2α cyclopropyl amide
	17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. There are no published reports on the biological activity of 17-phenyl trinor PGF2α cyclopropyl amide.
T37946	17-trifluoromethylphenyl trinor Prostaglandin F2α 17-trifluoromethylphenyl trinor Prostaglandin F2α
	A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists. 17-trifluoromethylphenyl trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trin...
T10046	16,16-Dimethyl prostaglandin E2 16,16-dimethyl PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.
T37839	20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2
	20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE2. 20-hydroxy PGE2 is the putative first intermediate in this chain of chemical transformations.
T36546	Prostaglandin I3 (sodium salt) Prostaglandin I3 (sodium salt)
	PGI3 is synthesized from EPA by COX and PGI synthase. PGI3 has a short in vivo half-life and is hydrolyzed to δ17-6-keto PGF1α. The platelet and vascular activity of PGI3 is equivalent to that of PGI2.
T36165	8-iso-13,14-dihydro-15-keto Prostaglandin F2α 8-iso-13,14-dihydro-15-keto Prostaglandin F2α
	8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-isoprostane is infused into ra...
T36771	11-deoxy Prostaglandin F1α 11-deoxy Prostaglandin F1α
	11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs.
T36770	11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1
	11-deoxy Prostaglandin E1 是前列腺素 E1类似物，具有支气管扩张活性，可抑制组胺诱导的支气管收缩，引起离体豚鼠的气管条松弛。
T36147	13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1
	13,14-dihydro-15-keto Prostaglandin E1 可抑制 ADP 诱导的人离体富血小板血浆中的血小板聚集（IC50=14.8 μg/mL），也是 PGE1 代谢物。
T36040	16,16-dimethyl Prostaglandin A1 16,16-dimethyl Prostaglandin A1
	16,16-dimethyl Prostaglandin A1 是一种前列腺素类似物，可以抑制 Lewis 肺癌和 B 16无黑色素瘤细胞中的 DNA 合成 (DNA synthesis)，以及抑制 HSV 和 HIV-1的病毒复制。
T36829	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimes...
T36155	15(S)-15-methyl Prostaglandin F2α isopropyl ester 15(S)-15-methyl Prostaglandin F2α isopropyl ester
	15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2α isopropyl ester is a lipophilic analog of 15(S)-15-methyl PGF2α methyl ester, which may be hydrolyzed in vivo to the fully active free acid.
T83662	2,3-dinor-8-iso Prostaglandin F1α 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP
	2,3-dinor-8-iso Prostaglandin F1α（2,3-dinor-8-iso PGF1α）是一种异前列腺素和花生四烯酸的活性代谢物，也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩（EC50s分别为12.8和18.5 nM），但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时，它能增加孤立的猪大脑切片中的血栓素B2（TXB2）水平，这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体（nAChR）拮抗剂α-conotoxin来逆转。
T78582	15-keto-Prostaglandin E2 15-keto-PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	15-keto-Prostaglandin E2为内源性代谢产物，通过与STAT3Cys259残基结合，抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体，进而抑制乳腺癌细胞生长与进展，并通过激活PPAR-γ促进真菌生长。
T37326	Prostaglandin F2α 1,11-lactone Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) 是前列腺素 F2α 的脂溶性前药，可用于治疗青光眼的研究。 Prostaglandin F2α 1,11-lactone 作为抗生育剂具有活性，可大大降低血管活性。
T83508	[Arg6]-β-Amyloid (1-42), england mutation
	[Arg6]-β-Amyloid (1-42), england mutation 是具有生物活性的肽类化合物。β-Amyloid (1-42)中的英国 (H6R) 突变被认为与Alzheimer病的常染色体显性遗传形式有关，此突变影响了位点H6的相互作用。
T36166	8-iso-15-keto Prostaglandin F2α 8-iso-15-keto Prostaglandin F2α
	8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the in...
T36157	8-iso Prostaglandin A1 8-iso Prostaglandin A1
	8-iso Prostaglandin A1 (8-iso PGA1) is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.
T37942	17-phenyl trinor Prostaglandin F2α dimethyl amide 17-phenyl trinor Prostaglandin F2α dimethyl amide
	17-phenyl trinor Prostaglandin F2αdimethyl amide is an isomer of 17-phenyl trinor prostaglandin F2αethyl amide . N/A
T36163	8-iso Prostaglandin F1β 8-iso Prostaglandin F1β
	8-iso PGF1β is a potential autoxidation product of DGLA. There are no published reports on its isolation from any biological source or on its biological activity.
T37947	17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophil...
T38342	11-deoxy Prostaglandin E2 11-deoxy Prostaglandin E2
	11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory tract smooth muscle with potencies ranging from 5 to 30 times higher than PGF2α .
T41328	Delta-12-Prostaglandin J2

T37938	17-phenoxy trinor Prostaglandin F2α ethyl amide 17-phenoxy trinor Prostaglandin F2α ethyl amide
	Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable analogs of PGF2α and potent agonists for the FP receptor. 17-phenoxy trinor PGF2α ethyl amide is a lipophilic analog of 17-phenoxy trinor PGF2α . Ethyl amides of PGs serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
T36160	8-iso Prostaglandin E2 8-iso Prostaglandin E2
	8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
T37943	17-phenyl trinor Prostaglandin F2α isopropyl ester 17-phenyl trinor Prostaglandin F2α isopropyl ester
	17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP r...
T36544	Prostaglandin D1 Prostaglandin D1
	Prostaglandin D1 是对离体人动脉具有收缩和舒张作用的一种前列腺素，能抑制 ADP 诱导的血小板聚集（ IC50=320 ng/ml）。Prostaglandin D1 可用于代谢研究。
T37778	19(R)-hydroxy Prostaglandin E1 19(R)-hydroxy Prostaglandin E1
	19(R)-hydroxy Prostaglandin E1 是 EP1 和 EP3 受体亚型的激动剂，并对平滑肌表现出收缩活性，也是灵长类动物精液中的主要前列腺素。
T36455	11β-Prostaglandin F2α 11β-Prostaglandin F2α
	11β-Prostaglandin F2α 是一种由 AKR1C3 催化的生物活性代谢物，可刺激前列腺素 F 受体并诱导乳腺癌中的 slug 表达。11β-Prostaglandin F2α 也是存在于尿液中的内源代谢物。
T36159	8-iso Prostaglandin E1 8-iso Prostaglandin E1
	8-iso Prostaglandin E1 能引起犬肺静脉中的痉挛，还能够起到血管舒张作用。
T38195	Prostaglandin F2α Ethanolamide Prostaglandin F2α Ethanolamide
	Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (...
T37840	20-hydroxy Prostaglandin F2α 20-hydroxy Prostaglandin F2α
	20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.
T38389	Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...
T83773	Prostaglandin E2 Inhibitor 3 PGE2 Inhibitor 3
	Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂，相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH)，在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下，该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中，LPS诱导的IL-6和PGE2生成。同时，它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成，包括白三烯B4 (LTB4) 和5-H(p)ETE（IC50s分别为4.9和5.2 µM）。在体内，10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。
T37264	15(R)-15-methyl Prostaglandin D2 15(R)15methyl PGD2	GPR	Endocrinology/Hormones; GPCR/G Protein
	15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) 是一种 PGD2 合成类似物，也是一种具有选择性和强效性的 CRTH2/DP2 受体激动剂，可调节嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化。
T36167	8-iso-15-keto Prostaglandin F2β 8-iso-15-keto Prostaglandin F2β
	8-iso Prostaglandin F2β (8-iso PGF2β) is an isomer of PGF2α of non-enzymatic origin. It is one of 64 possible isomers of PGF2α which can be produced by free radical peroxidation of arachidonic acid. 8-iso PGF2β exhibits very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood. However, 8-iso PGF2β moderately contracts both the canine and porcine pulmonary vein, although the effect is much weaker than that exhibited by other isoprostanes such as 8...
T36724	6,15-diketo-13,14-dihydro Prostaglandin F1α 6,15-diketo-13,14-dihydro Prostaglandin F1α
	6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.
T37934	15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor Prostaglandin F2α
	Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compo...
T37948	17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
	A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.417-trifluoromethylphenyl-13,14-dihydro trinor PGF2αbears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As a...
T37944	17-phenyl trinor Prostaglandin F2α methyl amide 17-phenyl trinor Prostaglandin F2α methyl amide
	17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The ethyl amide of 17-phenyl trinor PGF2α bimatoprost has been approved for use as an ocular hypotensive drug. 17-phenyl trinor PGF2α methyl amide is an analog of bimatoprost. Its biological and toxicological properties have not been evaluated.
T36041	16,16-dimethyl Prostaglandin A2 16,16-dimethyl Prostaglandin A2
	16,16-dimethyl PGA2 is a metabolism-resistant analog of PGA2 with a prolonged in vivo half-life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-dimethyl PGA2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.

化合物

Tetracosactide acetate

Cat.No: T35664

Target: Others

Cat.No: TP1031

Synonym: Tetracosactrin,替可克肽

Target: Others

Cat.No: T4507

Synonym: Adermykon,Chlorophenesin,Gecophen,氯苯甘醚

Target: Antibacterial, Antifungal, Histamine Receptor

Prostaglandin G/H synthase 1 inhibitor

Cat.No: T27066

Synonym: CP74006,CP 74006,2-Amino-N-(4-chlorophenyl)benzamide

Target: Others

1a,1b-dihomo Prostaglandin E2

Cat.No: T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

Prostaglandin F1α

Cat.No: T37919

Synonym: PGF1α,Prostaglandin F1α

15-keto Prostaglandin F2α

Cat.No: T37991

Synonym: 15-keto Prostaglandin F2α,15-keto PGF2α

Target: Endogenous Metabolite, Prostaglandin Receptor

9-deoxy-9-methylene Prostaglandin E2

Cat.No: T36728

Synonym: 9-deoxy-9-methylene Prostaglandin E2

15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

Cat.No: T35944

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide

17-phenyl trinor Prostaglandin F2α cyclopropyl amide

Cat.No: T37940

Synonym: 17-phenyl trinor Prostaglandin F2α cyclopropyl amide

17-trifluoromethylphenyl trinor Prostaglandin F2α

Cat.No: T37946

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α

16,16-Dimethyl prostaglandin E2

Cat.No: T10046

Synonym: 16,16-dimethyl PGE2

Target: Prostaglandin Receptor

20-hydroxy Prostaglandin E2

Cat.No: T37839

Synonym: 20-hydroxy Prostaglandin E2

Prostaglandin I3 (sodium salt)

Cat.No: T36546

Synonym: Prostaglandin I3 (sodium salt)

8-iso-13,14-dihydro-15-keto Prostaglandin F2α

Cat.No: T36165

Synonym: 8-iso-13,14-dihydro-15-keto Prostaglandin F2α

11-deoxy Prostaglandin F1α

Cat.No: T36771

Synonym: 11-deoxy Prostaglandin F1α

11-deoxy Prostaglandin E1

Cat.No: T36770

Synonym: 11-deoxy Prostaglandin E1

13,14-dihydro-15-keto Prostaglandin E1

Cat.No: T36147

Synonym: 13,14-dihydro-15-keto Prostaglandin E1

16,16-dimethyl Prostaglandin A1

Cat.No: T36040

Synonym: 16,16-dimethyl Prostaglandin A1

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

Cat.No: T36829

Synonym: 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

15(S)-15-methyl Prostaglandin F2α isopropyl ester

Cat.No: T36155

Synonym: 15(S)-15-methyl Prostaglandin F2α isopropyl ester

2,3-dinor-8-iso Prostaglandin F1α

Cat.No: T83662

Synonym: 2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP

15-keto-Prostaglandin E2

Cat.No: T78582

Synonym: 15-keto-PGE2

Target: Prostaglandin Receptor

Prostaglandin F2α 1,11-lactone

Cat.No: T37326

Synonym: Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone

Target: Prostaglandin Receptor

[Arg6]-β-Amyloid (1-42), england mutation

Cat.No: T83508

8-iso-15-keto Prostaglandin F2α

Cat.No: T36166

Synonym: 8-iso-15-keto Prostaglandin F2α

8-iso Prostaglandin A1

Cat.No: T36157

Synonym: 8-iso Prostaglandin A1

17-phenyl trinor Prostaglandin F2α dimethyl amide

Cat.No: T37942

Synonym: 17-phenyl trinor Prostaglandin F2α dimethyl amide

8-iso Prostaglandin F1β

Cat.No: T36163

Synonym: 8-iso Prostaglandin F1β

17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

Cat.No: T37947

Synonym: 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

11-deoxy Prostaglandin E2

Cat.No: T38342

Synonym: 11-deoxy Prostaglandin E2

Delta-12-Prostaglandin J2

Cat.No: T41328

17-phenoxy trinor Prostaglandin F2α ethyl amide

Cat.No: T37938

Synonym: 17-phenoxy trinor Prostaglandin F2α ethyl amide

8-iso Prostaglandin E2

Cat.No: T36160

Synonym: 8-iso Prostaglandin E2

17-phenyl trinor Prostaglandin F2α isopropyl ester

Cat.No: T37943

Synonym: 17-phenyl trinor Prostaglandin F2α isopropyl ester

Prostaglandin D1

Cat.No: T36544

Synonym: Prostaglandin D1

19(R)-hydroxy Prostaglandin E1

Cat.No: T37778

Synonym: 19(R)-hydroxy Prostaglandin E1

11β-Prostaglandin F2α

Cat.No: T36455

Synonym: 11β-Prostaglandin F2α

8-iso Prostaglandin E1

Cat.No: T36159

Synonym: 8-iso Prostaglandin E1

Prostaglandin F2α Ethanolamide

Cat.No: T38195

Synonym: Prostaglandin F2α Ethanolamide

20-hydroxy Prostaglandin F2α

Cat.No: T37840

Synonym: 20-hydroxy Prostaglandin F2α

Prostaglandin D2 Ethanolamide

Cat.No: T38389

Synonym: Prostaglandin D2 Ethanolamide

Prostaglandin E2 Inhibitor 3

Cat.No: T83773

Synonym: PGE2 Inhibitor 3

15(R)-15-methyl Prostaglandin D2

Cat.No: T37264

Synonym: 15(R)15methyl PGD2

Target: GPR

8-iso-15-keto Prostaglandin F2β

Cat.No: T36167

Synonym: 8-iso-15-keto Prostaglandin F2β

6,15-diketo-13,14-dihydro Prostaglandin F1α

Cat.No: T36724

Synonym: 6,15-diketo-13,14-dihydro Prostaglandin F1α

15-keto-17-phenyl trinor Prostaglandin F2α

Cat.No: T37934

Synonym: 15-keto-17-phenyl trinor Prostaglandin F2α

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

Cat.No: T37948

Synonym: 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α

17-phenyl trinor Prostaglandin F2α methyl amide

Cat.No: T37944

Synonym: 17-phenyl trinor Prostaglandin F2α methyl amide

16,16-dimethyl Prostaglandin A2

Cat.No: T36041

Synonym: 16,16-dimethyl Prostaglandin A2

Cat. No.	Product Name	Target	Signaling Pathways
T1221	Acetylcholine chloride ACh chloride,Pilofrin,氯化乙酰胆碱	Calcium Channel; Endogenous Metabolite; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Acetylcholine chloride (Pilofrin) 是一种神经递质，是胆碱能激动剂，通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性，在体外抑制 p53 突变肽的聚集。
T1626	Prostaglandin E1 前列地尔,PGE1,列腺素E1,Alprostadil	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体，对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集，可作为血管扩张剂用于外周血管疾病的研究。
T5014	Prostaglandin E2 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E2 (PGE2) 是一种天然激素，参与人体内的各种生理过程，包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。
T13831	Prostaglandin D2 PGD2	Endogenous Metabolite	Metabolism
	Prostaglandin D2 (PGD2) (PGD2) 是哺乳动物大脑中主要产生的前列腺素之一，为最有效的内源性睡眠促进剂之一，并通过抑制炎症发挥保护作用。
T37164	8-Isoprostaglandin F2α 8-iso Prostaglandin F2α
	8-Isoprostaglandin F2α 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T37164，CAS号为 27415-26-5。
T22473	15-deoxy-Δ-12,14-Prostaglandin J2	Others	Others
	15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.
T20302	Deoxycorticosterone Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite	Metabolism
	Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
T0419	Testosterone propionate	Others; Androgen Receptor; Transferase	Endocrinology/Hormones; Metabolism; Others
	Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.
T2748	Cortodoxone 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortodoxone (11-Desoxycortisol) 是糖皮质类固醇激素，能够氧化为皮质醇。
TN1459	Bufarenogin 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide,伪异沙蟾毒精	ERK; MEK; PI3K	MAPK; PI3K/Akt/mTOR signaling
	Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) 是一种从古巴地方性蟾蜍 Peltophryne fustiger 的腮腺分泌物中分离出来的蟾蜍二烯内酯。 Bufarenogin 显示出抗肿瘤活性。
T1032	Erythromycin 红霉素,E-Mycin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Erythromycin (E-Mycin) 是由放线菌产生的大环内酯类抗生素。它结合细菌的 50S 核糖体亚基，通过阻断转肽和易位反应来抑制 RNA 依赖性蛋白的合成。
T3S0488	Syringaresinol diglucoside Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷	Others	Others
	Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。
T5076	L-Allothreonine L-别苏氨酸,L-allo-Threonine	Others; Endogenous Metabolite	Metabolism; Others
	L-Allothreonine (L-allo-Threonine) 是内源性代谢产物的一种。
T1659	Melatonin Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素	CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
	Melatonin (Melatonine) 是一种由松果体制成的激素，可激活褪黑激素受体。它在睡眠中起作用，有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂，可诱导细胞凋亡。
T13592	Calf thymus DNA DNA from calf thymus, Thymonucleic acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Calf thymus DNA (DNA from calf thymus, Thymonucleic acid) 是一种从牛胸腺中提取出来的高质量双链模板DNA，可广泛应用于DNA 结合抗癌剂和调节DNA 结构和功能的DNA 结合剂的研究。
T1549	Raloxifene hydrochloride LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others
	Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂，用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用，但对乳腺和子宫组织具有完全的雌激素拮抗作用。
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T0864	L-Thyroxine Levothyroxine,NSC 36397,L-甲状腺素,T4	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	L-Thyroxine (NSC 36397) 是一种合成的甲状腺激素，用于甲状腺功能减退症的研究。在 DIO 酶作用下，L-Thyroxine (NSC 36397) 转化成具有生物特性的三碘甲状腺氨酸(T3)。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN1722	Hamamelitannin	Antifection	Microbiology/Virology
	Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚，是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。

天然产物

Acetylcholine chloride

Cat.No: T1221

Synonym: ACh chloride,Pilofrin,氯化乙酰胆碱

Target: Calcium Channel, Endogenous Metabolite, AChR

Prostaglandin E1

Cat.No: T1626

Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil

Target: Endogenous Metabolite, Prostaglandin Receptor

Prostaglandin E2

Cat.No: T5014

Synonym: 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)

Target: Endogenous Metabolite, Prostaglandin Receptor

Prostaglandin D2

Cat.No: T13831

Synonym: PGD2

Target: Endogenous Metabolite

8-Isoprostaglandin F2α

Cat.No: T37164

Synonym: 8-iso Prostaglandin F2α

15-deoxy-Δ-12,14-Prostaglandin J2

Cat.No: T22473

Target: Others

Deoxycorticosterone

Cat.No: T20302

Synonym: Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone

Target: Endogenous Metabolite

Testosterone propionate

Cat.No: T0419

Target: Others, Androgen Receptor, Transferase

Cat.No: T2748

Synonym: 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: TN1459

Synonym: 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide,伪异沙蟾毒精

Target: ERK, MEK, PI3K

Cat.No: T1032

Synonym: 红霉素,E-Mycin

Target: ribosome, Antibacterial, Antibiotic

Syringaresinol diglucoside

Cat.No: T3S0488

Synonym: Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷

Target: Others

L-Allothreonine

Cat.No: T5076

Synonym: L-别苏氨酸,L-allo-Threonine

Target: Others, Endogenous Metabolite

Cat.No: T1659

Synonym: Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素

Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy

Calf thymus DNA

Cat.No: T13592

Synonym: DNA from calf thymus, Thymonucleic acid

Target: DNA/RNA Synthesis

Raloxifene hydrochloride

Cat.No: T1549

Synonym: LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Cat.No: T0864

Synonym: Levothyroxine,NSC 36397,L-甲状腺素,T4

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: TN1722

Target: Antifection

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