48
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9023 |
Atuliflapon
AZD5718 |
FLAP | Immunology/Inflammation |
Atuliflapon (AZD5718) 是可口服的FLAP(5 -脂氧合酶激活蛋白)的抑制剂,IC50值为 2 nM,可用于冠状动脉疾病的研究。 | |||
T6033 |
Zotarolimus
ABT-578,佐他莫司,咗他莫司,A 179578 |
mTOR | PI3K/Akt/mTOR signaling |
Zotarolimus (ABT-578) 是一种免疫抑制剂,是雷帕霉素的衍生物,具有抗增殖活性。它被专门开发作为局部输送支架用于预防冠状动脉再狭窄。 | |||
T0005 |
Aspirin
阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA |
Mitophagy; Virus Protease; COX; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂,具有多种药理活性。它是组蛋白去乙酰化酶抑制剂,可上调细胞周期阻滞蛋白 p21,抑制携带 COX-1 的卵巢 Y 细胞。 它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达,分别减少 PG 的产生和 ERK 和 NF-KB 的下调。 | |||
T0154 |
Nebivolol hydrochloride
R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824 |
Apoptosis; Adrenergic Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂,IC50为0.8 nM。 | |||
T19345 |
GP2-114
|
Others | Others |
GP2-114 是一种儿茶酚胺运动模拟剂 ,可用于研究冠状动脉疾病 (CAD)。 | |||
T8687 |
diaminohydroxypropanetetraacetic acid
|
Others | Others |
diaminohydroxypropanetetraacetic acid 已被研究用于治疗血管疾病、冠状动脉疾病、心肌缺血、冠状动脉再狭窄和冠状动脉疾病等。 | |||
T24873 |
TGX-115
TGX 115 |
PI3K | PI3K/Akt/mTOR signaling |
TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM),是一种调节血小板粘附过程的酶,可抑制磷酸肌苷(PI)3-激酶,可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病 。 | |||
T1986 |
Atopaxar
E5555,ER-172594-00 |
Protease-activated Receptor | GPCR/G Protein |
Atopaxar (E5555) 是一种高效、可口服的,选择性的,可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,可用于动脉粥样硬化血栓性疾病的研究。 | |||
T22787 |
FPL 55712
|
LTR | Immunology/Inflammation |
FPL 55712 是白三烯受体和 SRS-A 拮抗剂,抑制支气管收缩,可用于研究哮喘和冠状动脉血栓。 | |||
T32155 |
Indecainide
Ricainide,Ricainid,Decabid,Indecainidum,Indecainida |
Others | Others |
Indecainide (Ricainid) 是一种新型抗心律失常化合物,具有致癌性,可用于研究继发于冠状动脉疾病或心肌病的慢性稳定型室性心律失常。 | |||
T4179 |
Probucol disuccinate
|
LDL | Metabolism |
Probucol disucinate 是一种 Probucol 的衍生物。其中 Probucol 是脂质调节的化合物,它能降低 LDL-cholesterol 水平。 | |||
T2480 |
Apabetalone
RVX-208,RVX000222,阿帕他隆 |
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
Apabetalone (RVX000222) 是一种 BET 溴结构域抑制剂,用于研究治疗糖尿病、动脉粥样硬化和冠状动脉疾病。 | |||
T61028 |
Mitiperstat
AZD4831 |
Glutathione Peroxidase | Metabolism |
Mitiperstat 是一种强效的骨髓过氧化物酶(MPO)抑制剂。Mitiperstat 对预防如心力衰竭和冠状动脉疾病类的心血管疾病有很好的效果。 | |||
T10595 |
BQ-788
BQ788 |
Endothelin Receptor | GPCR/G Protein |
BQ-788 是一种具有选择性和有效性的 ETB 受体拮抗剂,具有潜在的高血压活性,抑制 ET-1 与 ETB 受体结合,抑制外源性 ET-1 诱导的冠状动脉灌注压升高。 | |||
T4287 |
Succinobucol
Probucol monosuccinate,AGI-1067 |
Antioxidant; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Succinobucol (Probucol monosuccinate) 是酚类抗氧化剂,具有抗炎、抗血小板聚集活性。 | |||
T10364 |
Arbutamine
GP 21213 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Arbutamine (GP 21213) 是一种新型非选择性β-肾上腺素受体激动剂,具有α-1-拟交感神经活性。Arbutamine 促进心脏应激,增加心率、心脏收缩力。Arbutamine 可用于研究心脏应激和冠状动脉疾病。 | |||
T0182L2 |
(±) Clopidogrel hydrogen sulfate
硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover |
P2Y Receptor | GPCR/G Protein; Neuroscience |
(±) Clopidogrel hydrogen sulfate (Iscover) 是一种在药理学和结构上类似于ticlopidine 的抗血小板药物,用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。 | |||
T31992 |
Granotapide
|
CETP | Metabolism |
Granotapide 是一种微粒体甘油三酯转移蛋白(MTP)抑制剂,治疗和而预防动脉硬化,冠状动脉疾病,代谢综合征,肥胖,糖尿病,糖尿病前期和高血压。 | |||
T5856 |
Barnidipine hydrochloride
盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride) |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Barnidipine hydrochloride (YM-09730-5 hydrochloride) 是一种二氢吡啶类钙通道阻滞剂,对 CaA 受体具有选择性作用。它是一种抗高血压药物,通过减少其血管扩张作用继发的外周血管阻力起作用。 | |||
T4567 |
Sulfaphenazole
Plisulfan,Raziosulfa,Depocid,磺胺苯吡唑,Depotsulfonamide |
P450; Antibacterial | Metabolism; Microbiology/Virology |
Sulfaphenazole (Plisulfan) 是一种 CYP2C9的特异性抑制剂,抑制 CYP2C9介导的亚油酸动脉粥样硬化和促炎症效应,增加 AP-1的氧化应激和激活。 | |||
T73695 |
Canakinumab
ACZ 885,Ilaris |
IL Receptor | Immunology/Inflammation |
Canakinumab (ACZ885) 是一种重组人靶向 IL-1β 单克隆抗体。Canakinumab 显示出对人类和绒猴 IL-1β 具有抑制作用, IC50 值为分别为 43.6 和 40.8 pM。Canakinumab 具有抗炎活性,通过中和 IL-1β 信号来抑制与自身免疫性疾病相关的炎症。Canakinumab 可用于治疗痛风和冠状动脉疾病。 | |||
T14390L | (2R,3S)-Azelaprag | Apelin receptor | GPCR/G Protein |
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide 是一种Apelin 受体激动剂,对Apelin 受体的EC50为0.012 µM。(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide 可用于治疗心力衰竭、动脉粥样硬化、肥胖、糖尿病、肌萎缩侧索硬化、冠心病、高血压、中风和心肌梗塞等疾病。 | |||
T30255 |
AZD2716
AZD 2716,AZD-2716 |
||
AZD2716 is an effective selective phospholipase A2 inhibitor for the treatment of coronary artery and cardiovascular disease. | |||
T27351 |
Fostedil
KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546 |
||
Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial corona | |||
T26739 |
Batifiban
|
||
Batifiban, a glycoprotein IIb/IIIa antagonist, is used potentially for the treatment of coronary artery disease. | |||
T69970 |
AZD5718
|
||
AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Preclinical toxicology studies in rat and dog did not show any serious adverse events of clinical significance. Currently, AZD5718 is evaluated in a phase 2a study for treatment of coronary artery disease. | |||
T41029 | Streptokinase | ||
Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary artery occlusion. | |||
T1986L |
Atopaxar Hydrobromide
|
Protease-activated Receptor | GPCR/G Protein |
Atopaxar hydrobromide 是可口服的,高效选择性的可逆凝血酶受体蛋白酶激活受体-1 拮抗剂。它是一种抗血小板剂,能干扰血小板信号,用于动脉粥样硬化血栓性疾病的研究。 | |||
T68639 |
Ciprostene (free base)
|
||
Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-induced platelet aggregation. Ciprostene was evaluated in clinical trials in patients with peripheral vascular disease. It was found to reduce restenosis in patients with coronary artery disease undergoing therapeutic percutaneous transluminal coronary angioplasty. | |||
T71402 |
Nicorandil-d4
|
||
Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =... | |||
TP2119 |
Sarafotoxin S6a
|
||
Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo. | |||
T79239 |
PCSK9-IN-19
|
||
PCSK9-IN-19 (Compound 1)作为一种PCSK9抑制剂,用于研究高LDL胆固醇水平及预防冠状动脉疾病。 | |||
T76302 |
[Lys4] Sarafotoxin S6c
|
||
[Lys4] Sarafotoxin S6c 是一种 sarafotoxin 类似物,是一种有效的内皮素受体 (endothelin receptor) 的部分激动剂。[Lys4] Sarafotoxin S6c 可诱导猪冠状动脉收缩,其 EC50为 1.5 nM。 | |||
T75807 |
Sarafotoxin S6a TFA
|
||
Sarafotoxin S6a TFA 是一种 Sarafotoxin 类似物,是一种内皮素受体 (endothelin receptor) 激动剂,具有与 Endothelin-3 相似的 ETA/ETB 选择性。Sarafotoxin S6a TFA 诱导猪冠状动脉的 EC50值为 7.5 nM。 | |||
T24690 |
Pyrromecaine HCl
Bumecaine hydrochloride,Pyrromecaine |
||
Pyrromecaine is a local anesthetic used for surface anesthesia. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favorable effect on the contractility of the left ventricle, and on the myocardial blood flow following the ligation of the | |||
T35463 |
(±)14(15)-EET
(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET |
||
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o... | |||
T60901 | S(-)-Bisoprolol | ||
S(-)-Bisoprolol 是 Bisoprolol 的 S(-)-对映异构体。Bisoprolol 在高血压,冠状动脉疾病和稳定的心室功能不全的研究方面具有潜力。Bisoprolol 是一种有效的选择性的,口服活性的 β1 肾上腺素受体阻滞剂,对 β2 受体几乎没有活性。 | |||
T36547 |
Quazinone
|
||
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smoot... | |||
T68297 | Dilmapimod tosylate | ||
Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and... | |||
T74156 |
S(-)-Bisoprolol fumarate
|
||
S(-)-Bisoprolol fumarate 是 Bisoprolol fumarate 的 S(-)-对映异构体,这种化合物是一种有效的、选择性的,并具有口服活性的 β1 肾上腺素受体 (β1-adrenergic receptor) 阻滞剂,对 β2 受体的活性较低。它主要用于研究高血压、冠状动脉疾病和稳定的心室功能障碍。 | |||
T73083 |
Nipradolol
KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351 |
||
Nipradolol (KT-210; K-351) 是一种有效的 α-1-肾上腺素能受体的阻滞剂。Nipradolol 还抑制白化兔模型中 Phenylephrine 诱导的眼压升高 (IOP)。Nipradolol 抑制去甲肾上腺素 (NA) 引起的肌肉收缩,对犬冠状动脉也有血管扩张剂活性。 | |||
T63035 |
Izilendustat hydrochloride
|
||
Izilendustat (hydrochloride) 是一种脯氨酰羟化酶 (prolyl hydroxylase) 的有效抑制剂,能够稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有潜力进行 HIF-1α 相关疾病的研究(包括外周血管疾病(PVD)、心力衰竭、冠状动脉疾病(CAD)、缺血、贫血、结肠炎和其他炎症性肠病)。 | |||
T21485 |
Perindopril
|
||
Perindopril (S-9490) 是一种长效血管紧张素转换酶(ACE)抑制剂,用于治疗高血压、心力衰竭或稳定性冠状动脉疾病。 | |||
T17231 |
Vicagrel
|
Others | Others |
Vicagrel 是一种有效的、具有口服活性抗血小板化合物,通过不可逆地抑制 P2Y12 受体,降低代谢失活,增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。 | |||
T81451 |
PKCd (8-17)
|
||
PKCd (8-17) 是源自蛋白激酶 C (PKC)d V1 结构域的生物活性肽。它能抑制由佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (PMA) 诱导的 PKCd 易位和激活。此外,PKCd (8-17) 在降低心脏和脑细胞缺血损伤、促进成纤维细胞增殖、以及抑制小鼠移植冠状动脉疾病方面具有潜在应用。 | |||
T36221 |
2-chloro Palmitic Acid
|
||
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot... | |||
T35598 |
Neuromedin U-25 (human) (trifluoroacetate salt)
|
||
Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.1Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated rolesin vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.2,2NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery ... | |||
T83769 |
TC 14012 hydrochloride
H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 |
||
TC 14012是一种化学肽模拟的拮抗剂,针对趋化因子(C-X-C motif)受体4(CXCR4;IC50 = 2.9 nM)和CXCR7激动剂。它能在表达CXCR7的HEK293T细胞中诱导β-arrestin招募(EC50 = 350 nM)。TC 14012可减少HIV在MT-4细胞中的细胞病理效应(EC50 = 0.4 nM),并以CXCR4依赖的方式抑制HIV在体外进入(IC50 = 19.3 nM)。它还能抑制由趋化因子(C-X-C motif)配体12(CXCL12)在MDA-MB-231乳腺癌细胞和人脐静脉内皮细胞(HUVECs)中诱导的迁移,当使用浓度范围从10到1,000 nM时。在通过左前降(LAD)冠状动脉结扎诱导的急性心肌梗死小鼠模型中,TC 14012(10 mg/kg)能减少梗死面积。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6715 |
7-Ketocholesterol
|
Others | Others |
7-Ketocholesterol 是胆固醇的代谢物。 | |||
S00015 |
Tea polyphenol
|
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Tea polyphenol 也称为绿茶提取物,是茶中天然存在的酚类化合物,具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
TN2533 | 1-Hydroxy-2,3,4,7-tetramethoxyxanthone | 5-HT Receptor | GPCR/G Protein; Neuroscience |
1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel |