269
40
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39868 |
Anticancer agent 11
|
||
Anticancer agent 11 an effective broad-spectrum anticancer agent, exerts its therapeutic potential by suppressing angiogenesis and facilitating the formation of DNA cross-links. | |||
T40330 | Anticancer agent 15 | ||
Anticancer agent 15, an anticancer agent, exerts its efficacy by elevating intracellular levels of reactive oxygen species (ROS) and inducing cell death in melanoma cancer cells through necroptosis. | |||
T40479 |
Anticancer agent 13
|
||
Anticancer agent 13 is an anticancer agent from dicarboxylic acids and amines. | |||
T39501 | Anticancer agent 7 | ||
Anticancer agent 7 (Example 5) is an anti-cancer agent that exhibits potent anticancer activity against H1650 lung cancer cells, with an IC50 value of 5 μM. | |||
T10331 | Anticancer agent 3 | Others | Others |
Anticancer agent 3 (Compound 4) is a anti-cancer agent. | |||
T61046 |
Anticancer agent 43
|
Apoptosis | Apoptosis |
Anticancer agent 43 是一种有效的抗癌剂,通过 caspase 3, PARP1,Bax 蛋白依赖性途径诱导癌细胞凋亡 (apoptosis)。Anticancer agent 43 能够诱导 DNA 损伤,可用于研究大鼠胶质母细胞瘤 。 | |||
T60420 |
Anticancer agent 73
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Anticancer agent 73 是一种抗癌剂,它能有效地靶向反式激活反应(TAR)RNA 结合蛋白2(TRBP),并破坏TRBP-Dicer 的相互作用。Anticancer agent 73 通过调节 HCC 细胞中 miRNA 组和蛋白质组的表达谱,在体外和体内抑制 HCC 的生长和转移。 | |||
T60852 |
Anticancer agent 46
|
||
Anticancer agent 46是一种有效的抗癌剂, 在细胞实验中显示出抗增殖活性,对 MGC803细胞的 IC50为0.986μM。 | |||
T27998 |
MDK-4204
Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I |
||
MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively. | |||
T4434 |
Tirapazamine
Tirazone,Win59075,SR4233,替拉扎明,SR259075 |
Others | Others |
Tirapazamine (Win59075) 是抗癌剂,对实体瘤中的缺氧细胞具有选择性细胞毒性,促使 DNA 中的单链和双链断裂,碱基损伤和细胞死亡。 | |||
T62667 | Anticancer agent 51 | ||
Anticancer agent 51 (compound 3d) 是一种有效的抗癌剂 (Ki: 731.62 nM),具有抗癌活性。Anticancer agent 51 具有潜力进行前列腺癌的研究。 | |||
T64002 | Anticancer agent 61 | ||
Anticancer agent 61 是一种口服具有活力的抗癌剂。Anticancer agent 61 能够抗 HepG2、Bel-7402 和 MCF-7 癌细胞的增殖,他们的 IC50 值分别为 1.12、1.97 和 1.08 μM。Anticancer agent 61 能够抑制肿瘤生长。 | |||
T72502 |
Anticancer agent 92
|
||
Anticancer agent 92 是一种对非癌细胞无毒的抗癌剂。 | |||
T62124 |
Anticancer agent 80
|
||
Anticancer agent 80 (Compound 3c) 是一种抗癌剂。Anticancer agent 80 对 T47-D 表现出明显的暗毒性作用 (IC50: 10.14 μM)。 | |||
T61412 | Anticancer agent 47 | ||
Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1]. | |||
T63982 | Anticancer agent 50 | ||
Anticancer agent 50 (compound 6) 是 ABCB1 外排泵的有效调节剂,具有细胞毒活性和抗增殖活性。Anticancer agent 50 能够减少细胞周期蛋白 D1 的表达,并诱导 p53 表达。Anticancer agent 50 对 T 淋巴瘤表现出研究潜力。 | |||
T60776 | Anticancer agent 68 | ||
Anticancer agent 68 is (Compound 12) 是一种抗癌剂。Anticancer agent 68 将细胞阻滞在 G2/M 期并诱导程序性细胞死亡。Anticancer agent 68 通过激活 p53 和 PTEN 诱导上调肿瘤抑制。 | |||
T64179 | Anticancer agent 65 | ||
Anticancer agent 65 在肿瘤细胞系中显示出良好的效果,尤其是 A549 细胞 (IC50: 1.07 μM)。Anticancer agent 65 能够将 A549 细胞的细胞周期阻滞在 S 期,诱导细胞凋亡,增加 p53、p21 的表达水平,并促使 ROS 生成和 MMP 崩溃。 | |||
T61379 | Anticancer agent 30 | ||
Anticancer agent 30 (compound 6f-Z) is a potent anticancer compound. It belongs to the class of 3-arylidene-2-oxindole derivatives and acts as a selective inhibitor of CDK2. Extensive research has demonstrated its significant anticancer activity, making it a promising candidate for cancer treatment [1]. | |||
T83093 |
Anticancer agent 107
|
||
Anticancer agent 107(Compd 11jc) 具有显著的抗肿瘤活性,是研究肺转移性黑色素瘤的潜在抗癌剂。 | |||
T78929 |
Anticancer agent 126
|
Histone Methyltransferase | Chromatin/Epigenetic |
Anticanceragent 126 (compound 12) 作为WDR5抑制剂,能够破坏WDR5-MYC间的相互作用,并降低MYC靶基因的表达,表现出其抗癌活性。 | |||
T79844 |
Anticancer agent 143
|
Phosphatase | Metabolism |
Anticanceragent 143(化合物 369),作为PTPN2/PTP1B双重抑制剂,表现出强效活性,其IC50值均低于2.5 nM。该化合物主要用于癌症研究领域。 | |||
T79482 |
Anticancer agent 137
|
PI3K | PI3K/Akt/mTOR signaling |
Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂,展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡(apoptosis),并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。 | |||
T79202 | Anticancer agent 118 | ||
Anticanceragent 118是一种N-酰化环丙沙星衍生物,展现了针对革兰氏阳性(bacterial)菌株的高度活性,以及对前列腺癌PC3细胞的抗增殖能力,适用于抗肿瘤研究。 | |||
T83078 | Anticancer agent 33 | ||
Anticanceragent 33 (compound 3) 为Squamocin与Bullatacin衍生物,展现出有效的抗癌特性。本化合物对4T1乳腺癌细胞系(包括A549、HeLa、HepG2和MCF-7细胞)的生长抑制作用显著,其IC50范围为1.9-5.4 µM。 | |||
T83087 | Anticancer agent 158 | ||
Anticanceragent 158 (compound 7c) 作为一种有效的抗癌剂,其对HepG-2、MDA-MB-231、HCT-116细胞系的IC50值分别为7.93 μM、9.28 μM、13.28 μM。 | |||
T78780 |
Anticancer agent 139
|
||
Anticanceragent 139(Compound 6h)展现了针对多种癌细胞株的抗癌效能。该化合物能够与Tubulin的Lys352残基发生π-阳离子相互作用。在对SNB-19、OVCAR-8和NCI-H460细胞株的测试中,Anticanceragent 139展现出较高的生长抑制率(PGI),数值分别为86.61、85.26和75.99。同时,该化合物对于HOP-62、SNB-75、ACHN、NCI/ADR-RES、786-O、A549/ATCC、HCT-116以及MDA-MB-231细胞株亦表现出中等的生长抑制作用,其PGI值分别为67.55、65.46、59.09、59.02、57.88、56.88、56.53和56.4、51.88。 | |||
T79301 |
Anticancer agent 140
|
Parasite | Microbiology/Virology |
Anticanceragent 140(Compd 3)是一种化合物,具备潜在的抗癌和抗寄生虫活性。 | |||
T62601 |
Anticancer agent 48
|
||
Anticancer agent 48 (compound 48) 是一种广谱抗癌剂,其表现出抗增殖活性。Anticancer agent 48 对微管蛋白聚合具有抑制作用。Anticancer agent 48 在体内显示抗肿瘤活性。Anticancer agent 48 具有潜力进行实体瘤和血液肿瘤的研究。主语 | |||
T61777 | Anticancer agent 42 | ||
Anticancer agent 42 (compound 10d) is an orally active, potent anticancer agent with demonstrated efficacy against MDA-MB-231 cells, exhibiting an IC50 of 0.07 μM. It exerts its anticancer activity through the activation of apoptotic pathways and p53 expression. Anticancer agent 42 is a valuable tool for investigating metastatic breast cancer [1]. | |||
T63587 | Anticancer agent 45 | ||
Anticancer agent 46 是有效的、选择性的抗癌剂,能够诱导细胞凋亡 (apoptosis)。Anticancer agent 46 在癌细胞中表现出细胞毒效果,对人血的活化淋巴细胞显示出低毒性。 | |||
T63913 |
Anticancer agent 41
|
||
Anticancer agent 41 是一种有效的抗癌剂,对 MDA-MB-231 细胞表现出良好的抗肿瘤效果 (IC50: 3.99 μM)。 | |||
T63917 | Anticancer agent 67 | ||
Anticancer agent 67 是环丙沙星类似物,是一种抗癌剂,在 MCF-7 细胞中能够诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。 | |||
T63159 | Anticancer agent 28 | ||
Anticancer agent 28 在体内 H22 同种异体移植小鼠中具有良好的抗肿瘤作用。Anticancer agent 28 对 K562 细胞的作用是 Oridonin 的50倍,其 IC50 值为 0.09 μM。 | |||
T63671 |
Anticancer agent 60
|
||
Anticancer agent 60 对人 HepG2 细胞具有抗增殖效果,其 IC50 值为 4.13 μM。在人 HepG2 异种移植小鼠模型中,Anticancer agent 60 表现出抗肿瘤活性。 | |||
T61750 |
Anticancer agent 72
|
||
Anticancer agent 72 (compound 8c) effectively inhibits the K+ channel, displaying significant potential as an anticancer treatment. Additionally, it induces apoptosis, a programmed cell death process [1]. | |||
T63354 | Anticancer agent 17 | ||
Anticancer agent 17 对 HeLa 细胞 (IC50: 0.19 μM) 和 A2780 细胞 (IC50: 0.09 μM) 具有有效抗癌作用。 | |||
T61673 |
Anticancer agent 56
|
||
Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat... | |||
T79204 |
Anticancer agent 122
|
||
Anticanceragent 122,作为一种hLDHA抑制剂,表现出显著的抗癌活性,主要应用于抗肿瘤研究。 | |||
T83080 | Anticancer agent 171 | ||
Anticanceragent 171(Compound 6a)是一款肟类似物,对HCT116细胞表现出显著的抗癌活性,IC50值为3.43 μM,主要用于癌症研究领域。 | |||
T83084 |
Anticancer agent 162
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||
Anticanceragent 162 (compound 1d)作为一种抗癌药物,显示出亲脂性和针对性细胞毒性,能够特异性诱导Hela细胞系的癌细胞死亡。 | |||
T83075 | Anticancer agent 94 | ||
Anticanceragent 94, 一种4-羟基香豆素衍生物,能抑制肺癌细胞的侵袭和迁移,其机制为调节(EMT)效应子表达。 | |||
T83076 |
Anticancer agent 93
|
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Anticanceragent 93, 一种4-羟基香豆素衍生物,能够抑制肺癌细胞的侵袭与迁移,其机制为调节上皮间质转化(EMT)效应子的表达。 | |||
T78957 |
Anticancer agent 105
|
Apoptosis | Apoptosis |
Anticanceragent 105 是基于噻吩嘧啶支架的抗癌化合物,显示出高度的安全性与抗肿瘤活性。该化合物对黑色素瘤细胞表现出选择性毒性,并能诱导细胞凋亡(apoptosis)。在肺转移性黑色素瘤小鼠模型中,Anticanceragent 105 能够显著地抑制转移性结节的形成。 | |||
T79359 | Anticancer agent 147 | Ferroptosis | Apoptosis |
Anticanceragent 147(化合物6j),作为槐定碱的衍生物,功能为铁死亡(Ferroptosis)诱导剂。该化合物能促进Fe2+、活性氧(ROS)及丙二醛(MDA)在细胞内的积累,并通过增加内质网(ER)应激和上调转录因子ATF3的表达发挥作用。在体外及体内实验中,Anticanceragent 147展现了出色的抗肝癌活性。 | |||
T79388 |
Anticancer agent 154
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Anticanceragent 154 (Compound 8h) 增加活性氧水平、导致线粒体损伤,并诱导细胞凋亡和 DNA 损伤。此外,该化合物通过降低 GSH 和 GPX4 水平,增加脂质过氧化,进而诱导铁死亡。Anticanceragent 154 对多种癌细胞株(HT29、H1975、A549 及 MCF-7)显示抑制作用,IC50 值在 1.0-1.9 μM 范围。 | |||
T62602 |
Anticancer agent 49
|
||
Anticancer agent 49 (compound 69) 是一种广谱抗癌剂,其表现出抗增殖活性。Anticancer agent 49 对微管蛋白聚合具有抑制作用。Anticancer agent 49 在体内显示抗肿瘤活性。Anticancer agent 49 具有潜力进行实体瘤和血液肿瘤的研究。 | |||
T62427 | Anticancer agent 32 | ||
Anticancer agent 32 (compound 2g) 是一种抗癌剂。Anticancer agent 32 能够影响细胞周期并诱导细胞凋亡,表现出抗癌效果。Anticancer agent 32 能够用于研究癌症。 | |||
T60314 |
Anticancer agent 38
|
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Anticancer agent 38 (compound 19) 是芳基脲化合物,是一种有效的抗癌剂。Anticancer agent 38 抑制 A431 细胞生长的 IC50为 5.2 μg/mL。 | |||
T74767 | Anticancer agent 102 | ||
Anticancer agent 102 是丁卡因的衍生物。Anticancer agent 102 具有抗癌活性. Anticancer agent 102 诱导细胞凋亡。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T83089 |
Anticancer agent 149
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Anticanceragent 149 (compound 3) 是一种从薯蓣 (DM) 根茎中分离出的抗癌剂,其对MCF-7 细胞呈现选择性细胞毒活性,特有IC50值为31.41 μM。 | |||
T83073 |
Anticancer agent 96
|
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Anticanceragent 96 (Compound 4) 对人癌细胞表现出显著的细胞毒性。 | |||
T83086 | Anticancer agent 160 | ||
Anticanceragent 160 (Compound 6),源自Parthenium hysterophorus的天然化合物,对HCT-116细胞表现出细胞毒作用,其半数抑制浓度(IC50)为5.0 μM。 | |||
T83088 | Anticancer agent 156 | ||
Anticanceragent 156(compound 11)是一种基于Miliusanes的强效抗癌剂,有效抑制人源癌细胞生长,并对胃癌细胞展现出显著细胞毒性。 | |||
T5S0620 |
3-Dehydrotrametenolic acid
Dehydrotrametenolic acid,松苓新酸,3-氢化去氢松苓酸 |
Apoptosis; Others; Dehydrogenase | Apoptosis; Metabolism; Others |
3-Dehydrotrametenolic acid 是从茯苓菌核分离的一种乳酸脱氢酶抑制剂,可诱导细胞凋亡,具有抗癌活性。它促进体外脂肪细胞分化,在体内起胰岛素增敏剂的作用。 | |||
TN1727 |
Helichrysetin
4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
T30969 |
Clitocine
|
Apoptosis; BCL | Apoptosis |
Clitocine 是一种来从蘑菇中提取的一种腺苷类似物,是一种有效的转录通读剂,是一种无义突变的抑制剂,具有抗癌活性,可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 通过促进 Mcl-1 降解来增强 TRAIL 介导的人结肠癌细胞凋亡。 | |||
T2830 |
Betulinic acid
白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid |
Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物,是真核细胞拓扑异构酶 I 的抑制剂,IC50值为 5 μM,具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。 | |||
TN1206 |
2,4,6-Trihydroxybenzaldehyde
|
Others | Others |
2,4,6-Trihydroxybenzaldehyde 是一种天然产物。 2,4,6-三羟基苯甲醛是一种潜在的抗肥胖治疗药物,可抑制 C57BL/6 小鼠的 3T3-L1 细胞中的脂肪细胞分化和高脂饮食诱导的脂肪积累。它也是一种有效的抗糖尿病药物。 2,4,6-三羟基苯甲醛具有潜在的抗癌活性。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T2S1865 |
Octyl gallate
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯 |
Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN2238 |
Stigmasterol glucoside
豆甾醇葡萄糖苷 |
Others | Others |
Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent. | |||
TN4932 |
Sageone
|
PARP; Akt; Caspase; Antifection | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity. | |||
T40578 | β-Bisabolene | ||
β-Bisabolene is a sesquiterpene isolated from opoponax ( Commiphora guidotti ). β-Bisabolene, an anti-cancer agent , can be used for the study of breast cancer. | |||
TN4341 |
IVHD-valtrate
|
Mdm2; BCL; PARP; Caspase; p53 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a basis for development of the compound as a novel chemotherapeutic agent. | |||
T83134 |
Alterbrassicene B
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Alterbrassicene B,一种从甘蓝链格孢菌(Alternaria brassicicola)分离得到的抗癌化合物。 | |||
T1033L |
Monensin
Elancoban,Rumensin,莫能菌素 |
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Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling. | |||
T21523 |
β-Tocotrienol
Beta-Tocotrienol |
Caspase | Apoptosis; Proteases/Proteasome |
Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. | |||
TN2567 |
10-Hydroxycanthin-6-one
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Antifection | Microbiology/Virology |
10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent. | |||
T72795 |
(S)-Erypoegin K
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(S)-Erypoegin K,一种显示对HL-60细胞具有有效抗增殖活性的抗癌剂,能诱导细胞凋亡(apoptosis)。 | |||
T81995 | Kadsuphilin J | ||
Kadsuphilin J,一种木脂素,从长柄山竹根部分离得到。 | |||
T81690 | Neocucurbitacin A | STAT | JAK/STAT signaling; Stem Cells |
Neocucurbitacin A (compound 7)是一种从沉香果皮提取的STAT3抑制剂,常用于抗癌研究。 | |||
T83282 |
5β-Hydroxybufotalin
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5β-Hydroxybufotalin (化合物 6) 是一种来源于中药蟾酥的天然产物,具有有效的抗癌作用,能够抑制癌细胞的生长活性。 | |||
T73067 |
Isodispar B
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Isodispar B,一种抗癌剂,能够抑制鼻咽癌和乳腺癌细胞的增殖,并诱导(apoptosis)。它对多种癌细胞系展示出了细胞毒性作用。 | |||
TN1543 |
Cynaropicrin
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IL Receptor; Others; TNF | Apoptosis; Immunology/Inflammation; Others |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro- | |||
T60581 |
Alkannin
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Alkannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂,不抑制 PKM1 和丙酮酸激酶-L (PKL)。Alkannin 是一种潜在的抗癌剂。 | |||
TN1783 |
Isolicoflavonol
异甘草黄酮醇 |
Lipid | Metabolism |
Isolicoflavonol 以可逆和混合的方式抑制人羧酸酯酶2介导的荧光素二乙酸酯水解, Ki 小于1.0 μM。 | |||
T82046 |
Irisquinone
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Irisquinone,一种具有抗癌活性的天然产物,同时作为癌症放射增敏剂。该化合物通过降低GSH水平并抑制DNA单链断裂修复,展现其药理作用。 | |||
T20749 |
Bisabolene
Bisabolene (natural),红没药烯,FEMA 3331,Limene |
Others | Others |
Bisabolene (FEMA 3331) 是从牛至和其他芳香植物中提取的倍半萜。它是一种潜在的抗癌剂,研究表明它可以诱导 A549 癌细胞系凋亡。 | |||
T75569 | Xerophilusin B | ||
Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂,对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用,可诱导 G2/M 细胞周期停滞,介导细胞凋亡 apoptosis。 | |||
T73069 |
Kurzipene D
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Kurzipene D是一种有效的抗癌剂(anticanceragent),通过诱导HepG2细胞凋亡(apoptosis)并使其在S期阻滞,显示出明显的抗肿瘤作用。通过体内斑马鱼模型,Kurzipene D展现了其抑制肿瘤增殖和迁移的特性。 | |||
T19978 |
Puromycin
NSC 3055,NSC3055,Puromycine,嘌呤霉素,NSC-3055 |
Antibiotic | Microbiology/Virology |
Puromycin (NSC-3055) 是一种抗生素蛋白质合成抑制剂。它通过与 RNA 结合来抑制蛋白质合成。它还通过 Akt 磷酸化抑制食道癌细胞的生长和转移而用作抗癌药物。它是一种抗肿瘤剂和抗锥虫剂,在研究中用作蛋白质合成的抑制剂。 | |||
T73403 |
Aviculin
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Aviculin 是一种木聚糖苷,是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下,IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。 | |||
T82031 | Isoguaiacin | ||
Isoguaiacin为一种天然产物,具有复杂的多环化合物结构,广泛应用于生物医药研究领域。 | |||
T83323 |
4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside
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化合物3(4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside)是一种从Lilium regale提取的抗癌天然产物,具有显著抑制肺癌A549细胞增殖的活性,显示出其研究癌症治疗潜力。 | |||
TN5639 |
Rocaglaol
Ferrugin,Aglaiastatin A |
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Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis | |||
TN4291 | Isofuranodiene | IL Receptor; NOS | Immunology/Inflammation |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo | |||
T79941 |
Antimycin A2c
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Apoptosis | Apoptosis |
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。 |