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Cat. No.	Product Name	Target	Signaling Pathways
T4528	Tyrphostin AG 528 Tyrphostin B66,AG 528	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG 528 (Tyrphostin B66) 是一种蛋白酪氨酸激酶抑制剂，对表皮生长因子受体 (EGFR) 的IC50为 4.9 μM，对ErbB2的IC50为 2.1 μM，具有抗癌作用。
T7649	Tyrphostin A1 AG9,(4-甲氧基苄烯)丙二腈,Tyrphostin 1	EGFR; Interleukin	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin A1 (Tyrphostin 1) 对巨噬细胞培养中CD40L 刺激的IL-12产生和抗原诱导的Th1细胞生成具有抑制作用。
T2063	Tyrphostin 23 RG-50810,TX 825,Tyrphostin A23,AG18	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin 23 (AG18) 是一种EGFR 抑制剂，IC50值为35 μM。
T2479	Tyrphostin A9 Malonoben,Tyrphostin 9,SF 6847,AG 17,RG-50872	EGFR; VEGFR; Influenza Virus; PDGFR	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Tyrphostin A9 (SF 6847) 是一种线粒体分裂诱导剂，是 PDGFR 抑制剂，具有抗流感病毒的活性。
T6711	Tyrphostin AG1296 Tyrphostin AG 1296,AG 1296	Apoptosis; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1296 (Tyrphostin AG 1296) 抑制人PDGF α和β受体以及相关干细胞因子受体的信号传导，是一种选择性血小板衍生生长因子受体抑制剂，IC50值为 0.8 μM。
T21622	Tyrphostin A25 AG-82,Tyrphostin AG 82,RG-50875	EGFR; GPR	Angiogenesis; Endocrinology/Hormones; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin A25 (Tyrphostin AG 82)是一种特异性的EGFR 酪氨酸激酶抑制剂和GPR35激动剂，对GPR35的IC50值为 0.94 μM，对GPR35的EC50值为 5.3 μM。
T13238	Tyrphostin AG1433 SU1433,AG1433	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂，IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。
T7101	Tyrphostin AG30 Tyrphostin AG30(AG30),酪氨酸磷酸化抑制剂 AG 30	EGFR; Tyrosine Kinases	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG30 (AG30) 是一种有效的蛋白质酪氨酸激酶 (PTK) 抑制剂，选择性地抑制 c-ErbB 的自我更新诱导，并能抑制原发性红细胞 c-ErbB 激活 STAT5。
T34973	Tyrphostin 8 4-Hydroxybenzylidenemalononitrile	EGFR; GTPase	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂，对 EGFR 激酶有抑制作用， IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM)，增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用，并增加口服胰岛素 - 转铁蛋白的降血糖作用。
T8534	Tyrphostin AG 112	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG 112 是一种EGFR 磷酸化抑制剂。
T6712	Tyrphostin AG 879 AG 879	Apoptosis; EGFR; Trk receptor; HER; PDGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG 879 (AG 879) 是一种抑制TrKA 磷酸化的酪氨酸激酶抑制剂，IC50为 10 μM。它还是一种选择性ErbB2酪氨酸激酶抑制剂，IC50为 1 μM，具有抗癌活性。
T22450	Tyrphostin B44, (+) enantiomer 酪氨酸磷酸化抑制剂AG 835	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin B44, (+) enantiomer 是一种表皮生长因子受体 (EGFR) 激酶抑制剂，IC50 为 0.86 μM，活性低于 (-) 对映体。
T67707	Tyrphostin AG 538 AG 538	IGF-1R	Tyrosine Kinase/Adaptors
	Tyrphostin AG 538 是一种查尔酮化合物，是一种IGF-1受体激酶抑制剂（IC₅0 ：为400 nM），具有有效性、细胞渗透性、可逆性和竞争性。
T11593	I-OMe-Tyrphostin AG 538 I-OMe-AG 538	IGF-1R; PI3K	PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	I-OMe-Tyrphostin AG 538是一种特异性 IGF-1R 抑制剂和 PI5P4Kα的 ATP 竞争性抑制剂（IC50：1 µM）。I-OMe-Tyrphostin AG 538可抑制 IGF-1R 介导的信号传导，并对营养缺乏的 PANC1细胞具有优先细胞毒性。
T4326	AG 555 Tyrphostin B46,Tyrphostin AG 555	EGFR; Reverse Transcriptase	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂，可阻断Cdk2活化。它是一种抗逆转录病毒药。
T2693	AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	AG1024 (Tyrphostin) 是一种可逆的，竞争性和选择性的胰岛素样生长因子-1 受体抑制剂，IC50为 7 μM。它抑制胰岛素受体的磷酸化，IC50值为 57 μM。它诱导细胞凋亡并具有抗癌活性。
T4205	AG-494 Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR; CDK	Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-494 (Tyrphostin B48) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂，IC50为0.7 μM。它阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。它抑制 EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化，IC50为 1.1、39、45 和 6 μM。
T2600	AG490 Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42	EGFR; JAK; STAT; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AG490 (Tyrphostin B42) 是一种 EGFR 抑制剂，IC50为 0.1 μM。它对 EGFR 的选择性比 ErbB2 高 135 倍，还抑制 JAK2。
T3980	Su1498 Tyrphostin SU 1498,AG 1498	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Su1498 (Tyrphostin SU 1498) 是一种选择性的 VEGFR2 抑制剂，能够抑制 Flk-1 (IC50:700 nM)。
T24912	Tyrphostin AG 568 Tyrphostin AG-568,Tyrphostin AG568
	Tyrphostin AG 568 promotes Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity. It also induces K562 to differentiate.
T3545	RG13022 RG 13022,Tyrphostin RG13022	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	RG13022 (Tyrphostin RG13022) 是一种酪氨酸激酶抑制剂，抑制EGF 受体自身磷酸化的IC50值为4 μM。
T24909	Tyrphostin 51 Tyrphostin A51,Tyrphostin A-51,Tyrphostin A 51
	Tyrphostin 51 is an effective inhibitor of EGFR kinase.
T5155	(E)-AG 99 (E)-Tyrphostin AG 99,(E)-Tyrphostin 46,AG 99,Tyrphostin 46	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(E)-AG 99 ((E)-Tyrphostin AG 99) 是一种 EGFR 抑制剂。
T14138	AG-825 Tyrphostin AG-825	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-825（Tyrphostin C15）是一种具有选择性和竞争性且抑制酪氨酸磷酸化的 ErbB2 抑制剂，其 IC50 值为 0.35 μM。AG-825（Tyrphostin C15）对 HER2 具有抑制作用，在小鼠乳腺癌异种模型中显示出抗癌活性。AG-825（Tyrphostin C15）是一种潜在的克服锰诱导的神经毒性或阿尔茨海默病发展的活性分子，能促进人中性粒细胞的凋亡，可用于研究乳腺癌。
T24910	Tyrphostin A46 Tyrphostin A-46,Tyrphostin A 46
	Tyrphostin A46 is an antagonist of the epidermal growth factor-urogastrone receptor.
T3554	RG14620 Tyrphostin RG14620,RG 14620	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	RG14620 (Tyrphostin RG14620)是一种EGFR 抑制剂，IC50值为3 μM。
T4092	AG126 Tyrphostin AG126,AG 126	ERK; COX	Immunology/Inflammation; MAPK; Neuroscience
	AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。
T24911	Tyrphostin AG 1112 Tyrphostin AG-1112,Tyrphostin AG1112
	Tyrphostin AG 1112 is a Bcr-Abl kinase blocker. It can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.
T2047	AG-1478 AG1478,NSC 693255,Tyrphostin AG-1478	EGFR; HCV Protease; Influenza Virus; HER; PDGFR	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	AG-1478 (NSC-693255) 是一种选择性 EGFR 酪氨酸激酶抑制剂，IC50为 3 nM。它对 HCV 和脑心肌炎病毒有抗病毒作用。
T68822	Tyrphostin AG17
	Tyrphostin AG17 is a biochemical that promotes adipocyte apoptosis in vivo and is an effective modulator of adipocyte differentiation and WAT hypertrophy in vitro and in vivo. It is thought to possibly be useful as a pharmacological obesity treatment. It is a tyrosine kinase antagonist that has also been found to inhibit tumor cell growth.
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T70392	Tyrphostin AG-808
	Tyrphostin AG-808 is a 15-human lipoxygenase inhibitor.
T24908	Tyrphostin 47 AG213,AG-213 AG 213
	Tyrphostin 47 inhibits the protein-tyrosine kinase activity of EGF-R.
T1761	PD153035 hydrochloride ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD153035 hydrochloride (ZM 252868) 是有效地EGFR 抑制剂，Ki 和IC50值分别为6和25 pM。
T23660	AG1433 Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433
	AG1433 is a tyrosine kinases inhibitor that acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.
T20199	AG-1478 hydrochloride AG1478 HCl,AG-1478 HCl,Tyrphostin,AG1478 Hydrochloride,AG 1478 HCl
	AG1478 HCl is an epidermal growth factor receptor protein inhibitor.
T70391	AMG151 HCl
	ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse...
T21853	(E)-AG 556	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(E)-AG 556 是有效的、选择性 EGFR 抑制剂。(E)-AG 556阻断 LPS 诱导的促炎因子 TNF-α 的产生。
T4605	NT157	IGF-1R; STAT	JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	NT157 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。
T21783	AG-183
	(Z)-Tyrphostin A51 是 Lanoconazole A51 的 Z 构型形式。Tyrphostin A51 是一种有效的蛋白酪氨酸激酶 (PTK)抑制剂，以剂量依赖性方式抑制原代星形胶质细胞培养物中 [3H]牛磺酸的体积敏感释放。Tyrphostin A51 显着降低细胞酪氨酰磷酸化水平。Tyrphostin A51 抑制基础和 EGF 诱导的人骨细胞增殖。
T60624	(E/Z)-AG490
	(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) 是异构体 (E)-AG490 和 (Z)-AG490 的外消旋体。(E)-AG490 是一种可抑制EGFR，Stat-3和JAK2/3的酪氨酸激酶抑制剂。
T71815	TX-1918
	TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells.
T21784	AG-370
	AG 370 是一种吲哚 tyrphostin，是一种有效的PDGF 诱导的有丝分裂抑制剂，IC50值为 20 μM。AG 370 对 EGF 受体的抑制作用较弱。

化合物

Tyrphostin AG 528

Cat.No: T4528

Synonym: Tyrphostin B66,AG 528

Target: EGFR

Tyrphostin A1

Cat.No: T7649

Synonym: AG9,(4-甲氧基苄烯)丙二腈,Tyrphostin 1

Target: EGFR, Interleukin

Tyrphostin 23

Cat.No: T2063

Synonym: RG-50810,TX 825,Tyrphostin A23,AG18

Target: EGFR

Tyrphostin A9

Cat.No: T2479

Synonym: Malonoben,Tyrphostin 9,SF 6847,AG 17,RG-50872

Target: EGFR, VEGFR, Influenza Virus, PDGFR

Tyrphostin AG1296

Cat.No: T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Tyrphostin A25

Cat.No: T21622

Synonym: AG-82,Tyrphostin AG 82,RG-50875

Target: EGFR, GPR

Tyrphostin AG1433

Cat.No: T13238

Synonym: SU1433,AG1433

Target: VEGFR, PDGFR

Tyrphostin AG30

Cat.No: T7101

Synonym: Tyrphostin AG30(AG30),酪氨酸磷酸化抑制剂 AG 30

Target: EGFR, Tyrosine Kinases

Cat.No: T34973

Synonym: 4-Hydroxybenzylidenemalononitrile

Target: EGFR, GTPase

Tyrphostin AG 112

Cat.No: T8534

Target: EGFR

Tyrphostin AG 879

Cat.No: T6712

Synonym: AG 879

Target: Apoptosis, EGFR, Trk receptor, HER, PDGFR

Tyrphostin B44, (+) enantiomer

Cat.No: T22450

Synonym: 酪氨酸磷酸化抑制剂AG 835

Target: EGFR

Tyrphostin AG 538

Cat.No: T67707

Synonym: AG 538

Target: IGF-1R

I-OMe-Tyrphostin AG 538

Cat.No: T11593

Synonym: I-OMe-AG 538

Target: IGF-1R, PI3K

Cat.No: T4326

Synonym: Tyrphostin B46,Tyrphostin AG 555

Target: EGFR, Reverse Transcriptase

Cat.No: T2693

Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200

Target: Apoptosis, IGF-1R

Cat.No: T4205

Synonym: Tyrphostin AG-494,AG 494,Tyrphostin B48

Target: EGFR, CDK

Cat.No: T2600

Synonym: Zinc02557947,Tyrphostin AG 490,AG 490,AG-490,Tyrphostin B42

Target: EGFR, JAK, STAT, Autophagy

Cat.No: T3980

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Tyrphostin AG 568

Cat.No: T24912

Synonym: Tyrphostin AG-568,Tyrphostin AG568

Cat.No: T3545

Synonym: RG 13022,Tyrphostin RG13022

Target: EGFR

Tyrphostin 51

Cat.No: T24909

Synonym: Tyrphostin A51,Tyrphostin A-51,Tyrphostin A 51

Cat.No: T5155

Synonym: (E)-Tyrphostin AG 99,(E)-Tyrphostin 46,AG 99,Tyrphostin 46

Target: EGFR

Cat.No: T14138

Synonym: Tyrphostin AG-825

Target: Apoptosis, EGFR

Tyrphostin A46

Cat.No: T24910

Synonym: Tyrphostin A-46,Tyrphostin A 46

Cat.No: T3554

Synonym: Tyrphostin RG14620,RG 14620

Target: EGFR, HER

Cat.No: T4092

Synonym: Tyrphostin AG126,AG 126

Target: ERK, COX

Tyrphostin AG 1112

Cat.No: T24911

Synonym: Tyrphostin AG-1112,Tyrphostin AG1112

Cat.No: T2047

Synonym: AG1478,NSC 693255,Tyrphostin AG-1478

Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR

Tyrphostin AG17

Cat.No: T68822

Cat.No: T21785

Target: Bcr-Abl

Tyrphostin AG-808

Cat.No: T70392

Tyrphostin 47

Cat.No: T24908

Synonym: AG213,AG-213 AG 213

PD153035 hydrochloride

Cat.No: T1761

Synonym: ZM 252868 HCl,AG 1517,Tyrphostin AG 1517,SU 5271,PD153035 HCl,ZM 252868

Target: EGFR

Cat.No: T23660

Synonym: Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433

AG-1478 hydrochloride

Cat.No: T20199

Synonym: AG1478 HCl,AG-1478 HCl,Tyrphostin,AG1478 Hydrochloride,AG 1478 HCl

Cat.No: T70391

Cat.No: T21853

Target: EGFR

Cat.No: T4605

Target: IGF-1R, STAT

Cat.No: T21783

Cat.No: T60624

Cat.No: T71815

Cat.No: T21784

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