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48

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T24656	PQ-10 A844337,PQ 10,A-844337,A 844337	PDE	Metabolism
	PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂，其IC50=4.6 nM，ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式，这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。
T7706	LY-404187 N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	LY404187 是一种选择性的、有效的，中枢活性的AMPA 受体的正变构调节剂，作用于GluR1i，GluR2i，GluR2o，GluR3i 和GluR4i 的EC50值分别为 5.65、0.15、1.44、1.66 和 0.21 µM。它用于许多精神疾病和神经退行性疾病的研究潜力。
T28368	PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others	Others
	PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，可透过血脑屏障，抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。
T0024	Primidone Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360	GABA Receptor; Sodium Channel; GluR; AChR	Membrane transporter/Ion channel; Neuroscience
	Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。
T7165	Basmisanil RG1662,RO5186582,巴米沙尼	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Basmisanil (RG1662) 是高度选择性GABAAα5负调节剂，用于治疗与唐氏综合症相关的认知障碍。
T22016	A-582941 dihydrochloride A 582941	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	A-582941 dihydrochloride (A 582941) 是选择性和可透过血脑屏障的 α7 nAChR 的部分激动剂，在大鼠脑膜和人额叶皮层的Ki 值分别为 10.8 和 16.7 nM。它与人5-HT3受体结合，Ki 值为 150 nM，具有与各种神经退行性疾病和精神疾病相关的认知缺陷的研究潜力。
T0678	Amitriptyline hydrochloride Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin	Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。
T83974	OPC18750 HCl	PDE	Metabolism
	OPC18750 HCl 是一种潜在的磷酸二酯酶抑制剂，具有正肌力作用，可用于研究哮喘、癌症、糖尿病和精神疾病。
T20324	Butyrophenone 苯丁酮,NSC8463,NSC 8463,NSC-8463	Others	Others
	Butyrophenone (NSC-8463) 是一种化合物。它的一些衍生物用于治疗各种精神疾病。
T50054	Opromazine hydrochloride	Others	Others
	Opromazine hydrochloride 属于吩噻嗪类抗精神病药物，通过阻断大脑中的多巴胺受体而降低多巴胺能通路的活性，主要用于治疗精神分裂症和精神病等精神疾病。
T31079	CP-810123 CP 810123,UNII-E6G4550EC4,CP810123	AChR	Neuroscience
	CP-810123 是一种新的α 7 nAChR 激动剂，可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。
T50061	[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine	Others	Others
	[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine 是一种哌嗪衍生物，它是血清素和多巴胺受体的部分激动剂，使其成为治疗抑郁症和精神分裂症等精神疾病的候选药物。
T23066	NGD 94-1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	NGD 94-1 是一种选择性的 D4 受体拮抗剂，对D4受体的亲和力为3 nM，而对D1、D2、D3和D5受体的亲和力大于2 pM。NGD 94-1 可用研究认知障碍等精神性疾病。
T5444	CLP290 CLP-290	Potassium Channel	Membrane transporter/Ion channel
	CLP-290 是一种神经特异性 K+-Cl−共转运体 KCC2的口服激活剂，在多种神经和精神疾病方面具有研究潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。
T67811	Tefludazine
	Tefludazine 一种具有苯茚酮结构的新型神经抑制剂，是一种具有良好口服活性且与多巴胺和5-羟色胺受体有拮抗作用的化合物。Tefludazine 在小鼠、大鼠和狗的体外和体内测试模型中表现出强大的多巴胺（DA）拮抗活性。Tefludazine 是一种用来治疗精神类疾病的潜在化合物。
T1292	Tiapride hydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Tiapride 是一种大脑中 D2/3 多巴胺受体的选择性阻滞剂。它用于治疗各种精神和神经系统疾病，包括运动障碍、酒精戒断综合征、精神病的阴性症状以及老年人的攻击和激动。
T77597	SXC 2023 (S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid	Others	Others
	SXC 2023 ((S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid) 是一种可治疗中枢神经疾病和神经认知障碍的N-乙酰-L-半胱氨酸的前药，可用于治疗谷氨酸能功能障碍和氧化应激起关键作用的精神疾病。
T50111	6-Fluorotryptamine hydrochloride	Others	Others
	6-Fluorotryptamine hydrochloride 是一种用作分子结构单元的化合物，是天然色胺生物碱血清素的衍生物。它是5-HT2A 和5-HT2C 血清素受体的激动剂，使其成为开发治疗各种精神和神经疾病的新药的潜在候选者。
T39218	(S)-CVN424 (S)-CVN424
	(S)-CVN424 is a powerful modulator of G-Protein-Coupled Receptor 6 (GPR6), known for its involvement in neurological and psychiatric disorders research, such as Parkinson's disease.
T28085	Moperone Hydrochloride EN1733A,EN 1733A,EN-1733A
	Moperone Hydrochloride, a dopamine D2-receptor antagonist, is used for the treatment of psychiatric disorders.
T12318	Org-10490	Others	Others
	Org-10490 is an dopamine D1 receptor and dopamine D2 receptor antagonist, and treatment for psychiatric disease.
T24766	SBI-0061869 SBI0061869
	SBI-0061869 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders.
T79838	(S)-Bexicaserin	5-HT Receptor	GPCR/G Protein; Neuroscience
	(S)-Bexicaserin (化合物 2)，作为一种5-HT2C受体激动剂，展现了在肥胖和精神相关疾病研究中的应用潜力。
T24767	SBI-0069332
	SBI-0069332 is a potentiator of metabotropic glutamate receptors. It was used against neurological and psychiatric disorders.
T61578	BRD3731
	BRD3731 is a selective inhibitor of GSK3β, demonstrating an IC50 value of 15 nM for GSK3β and 215 nM for GSK3α. Due to its inhibitory properties, BRD3731 holds promise for investigating various medical conditions, including post-traumatic stress disorder (PTSD), psychiatric disorders, diabetes, and neurodegenerative disorders [1].
T61207	5-HT6/5-HT2A receptor ligand-1
	5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1].
T39940	Plazinemdor
	Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system.
T7352L	Pridopidine hydrochloride ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride
	Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor activity in a state-dependent way t
T82891	Bexicaserin
	Bexicaserin (Compound 3)为5-HT2C受体激动剂，可研究治疗肥胖及精神疾病。
T60923	Zelquistinel
	Zelquistinel 用于研究抑郁、焦虑和其他相关精神疾病的研究。它是一种 N-甲基-D-天冬氨酸(NMDA)受体的部分激动剂。
T60913	Aceprometazine
	Aceprometazine (1664CB) 是具有口服活性的抗精神病剂。Aceprometazine 可用于精神类疾病研究，例如抑郁症。
T38828	Mesdopetam IRL790
	Mesdopetam (IRL790) is a dopamine D3 receptor antagonist with a Ki of 90 nM and an IC50 of 9.8 μM for the human recombinant D3 receptor. It exhibits psychomotor stabilizing properties and is utilized in the study of motor and psychiatric complications associated with Parkinson's disease.
T80971	TNIK-IN-6
	TNIK-IN-6 (Compound 9) 是一种Traf2和Nck相互作用激酶（TNIK）的抑制剂，具有0.93 nM的IC50，对神经与精神疾病具有重要影响。
T62975	Haloperidol lactate
	Haloperidol lactate 是一种有效的抗精神病药。Haloperidol lactate 具有潜力进行精神障碍的研究。Haloperidol lactate 能够用于急性和慢性精神分裂症和多发性秽语综合征。
T16507	PF-5006739	Casein Kinase	Metabolism; Stem Cells
	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selecti
T78920	HDAC-IN-58	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-58为HDAC抑制剂，特异性针对HDAC6，其IC50值达2.06 nM。适用于慢性疾病，如神经退行性和精神疾病的研究。
T60611	Talaglumetad hydrochloride
	Talaglumetad (hydrochloride) 是Eglumegad 的前药，Eglumegad 是II 型代谢型谷氨酸受体(mGluR2/3)有效选择性的激动剂，用于治疗焦虑等精神疾病。
T72246	Bicuculline methobromide (+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide
	Bicuculline methobromide 是选择性GABAA 受体拮抗剂，具IC50值为3 μM。该化合物可引起哺乳类动物阵挛性强直性惊厥，且能阻断Ca2+激活的钾通道，用于癫痫等精神疾病研究。
T60578	Procyclidine
	Procyclidine (Tricyclamol; (±)-Procyclidine) 是一种抗胆碱能剂。它是一种毒蕈碱受体 (muscarinic receptor) 拮抗剂，也是 N-甲基-D-天冬氨酸 (NMDA) 拮抗剂。Procyclidine 可用于帕金森症和相关精神疾病的研究，如Soman 诱发的癫痫。
T70787	AZD1446 tosylate
	AZD1446, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease.
T70196	AZD1446 HCl
	AZD1446, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer's disease.
T62202	mGluR2 modulator 1
	mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。
T74668	Zicronapine fumarate
	Zicronapine (Lu 31-130) fumarate 是抗精神病药，主要通过拮抗多巴胺D1/D2受体和5-HT2A受体发挥作用，在动物模型中显示出显著的前认知效果，展现出治疗多种神经和精神疾病的可能性。
T74112	Bicuculline methochloride
	Bicuculline ((+)-Bicuculline; d-Bicuculline) 甲基氯化物是一种惊厥生物碱，是选择性GABAA 受体 (GABAA receptor) 的拮抗剂，IC50为 3 μM。Bicuculline 甲基氯化物在哺乳动物中可以诱导阵挛性强直性惊厥，还可用于阻断 Ca2+激活的钾通道。Bicuculline 甲基氯化物可用于癫痫等相关精神疾病的研究。
T63115	Perphenazine dihydrochloride
	Perphenazine dihydrochloride 是一种口服具有活力的多巴胺受体 (dopamine receptor) 和组胺-1 受体 (histamine-1 receptor) 拮抗剂，作用于 D2 (Ki: 0.56 nM)、D3 (Ki: 0.43 nM)、5-HT2A (Ki: 0.6 nM)。Perphenazine dihydrochloride 也能够结合 Alpha-1A 肾上腺素受体。Perphenazine dihydrochloride 能够诱导细胞凋亡，并抑制癌细胞增殖。Perphenazine dihydrochloride 能够用于研究精神疾病、癌症、炎症。
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。
T38131	(E)-10-Hydroxynortriptyline
	(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline . Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1]. [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8. [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology ...
T73677	SR 142948 dihydrochloride
	SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂，其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中，该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成，IC50为3.9 nM。此外，SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为，且具有良好的血脑屏障通透性，适用于精神疾病研究。

化合物

Cat.No: T24656

Synonym: A844337,PQ 10,A-844337,A 844337

Target: PDE

Cat.No: T7706

Synonym: N-[2-(4'-氰基联苯-4-基)丙基]-2-丙烷磺酰胺

Target: GluR, iGluR

PF-04859989 HCl

Cat.No: T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Cat.No: T0024

Synonym: Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360

Target: GABA Receptor, Sodium Channel, GluR, AChR

Cat.No: T7165

Synonym: RG1662,RO5186582,巴米沙尼

Target: GABA Receptor

A-582941 dihydrochloride

Cat.No: T22016

Synonym: A 582941

Target: 5-HT Receptor, AChR

Amitriptyline hydrochloride

Cat.No: T0678

Synonym: Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin

Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Cat.No: T83974

Target: PDE

Cat.No: T20324

Synonym: 苯丁酮,NSC8463,NSC 8463,NSC-8463

Target: Others

Opromazine hydrochloride

Cat.No: T50054

Target: Others

Cat.No: T31079

Synonym: CP 810123,UNII-E6G4550EC4,CP810123

Target: AChR

[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methanamine

Cat.No: T50061

Target: Others

Cat.No: T23066

Target: Dopamine Receptor

Cat.No: T5444

Synonym: CLP-290

Target: Potassium Channel

Cat.No: T67811

Tiapride hydrochloride

Cat.No: T1292

Target: Dopamine Receptor

Cat.No: T77597

Synonym: (S)-2-acetamido-3-(4-methylbenzoylthio)propanoic acid

Target: Others

6-Fluorotryptamine hydrochloride

Cat.No: T50111

Target: Others

Cat.No: T39218

Synonym: (S)-CVN424

Moperone Hydrochloride

Cat.No: T28085

Synonym: EN1733A,EN 1733A,EN-1733A

Cat.No: T12318

Target: Others

Cat.No: T24766

Synonym: SBI0061869

(S)-Bexicaserin

Cat.No: T79838

Target: 5-HT Receptor

Cat.No: T24767

Cat.No: T61578

5-HT6/5-HT2A receptor ligand-1

Cat.No: T61207

Cat.No: T39940

Pridopidine hydrochloride

Cat.No: T7352L

Synonym: ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride

Cat.No: T82891

Cat.No: T60923

Cat.No: T60913

Cat.No: T38828

Synonym: IRL790

Cat.No: T80971

Haloperidol lactate

Cat.No: T62975

Cat.No: T16507

Target: Casein Kinase

Cat.No: T78920

Target: HDAC

Talaglumetad hydrochloride

Cat.No: T60611

Bicuculline methobromide

Cat.No: T72246

Synonym: (+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide

Cat.No: T60578

AZD1446 tosylate

Cat.No: T70787

Cat.No: T70196

mGluR2 modulator 1

Cat.No: T62202

Zicronapine fumarate

Cat.No: T74668

Bicuculline methochloride

Cat.No: T74112

Perphenazine dihydrochloride

Cat.No: T63115

Cat.No: T72034

Target: Others

(E)-10-Hydroxynortriptyline

Cat.No: T38131

SR 142948 dihydrochloride

Cat.No: T73677

Cat. No.	Product Name	Target	Signaling Pathways
T3158	Harmane Loturine,Harman,Aribine,哈尔满碱	Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂，具有致突变作用，对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。

天然产物

Cat.No: T3158

Synonym: Loturine,Harman,Aribine,哈尔满碱

Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

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