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Search Results for " platelets "

98

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13769	TA-316 Megakaryocytes/platelets inducing agent	Others	Others
	Megakaryocytes/platelets inducing agent being useful in treating diseases involving thrombopenia. Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells.
T5519	Bivalirudin BG-8967,比伐卢定,Hirulog-1	Thrombin	Proteases/Proteasome
	Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂，是一种肽类抗凝剂，可在侵入性心脏病，特别是在经皮冠状动脉介入中用于抗凝。
T1986	Atopaxar E5555,ER-172594-00	Protease-activated Receptor	GPCR/G Protein
	Atopaxar (E5555) 是一种高效、可口服的，选择性的，可逆的凝血酶受体蛋白酶激活受体-1 (PAR-1) 拮抗剂。它是一种抗血小板剂，能干扰血小板信号，可用于动脉粥样硬化血栓性疾病的研究。
T12870	SCH79797 dihydrochloride	Apoptosis; Others; Protease-activated Receptor	Apoptosis; GPCR/G Protein; Others
	SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂，IC50 为 70 nM，Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。
T7625	TRAP-6 PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)	Protease-activated Receptor	GPCR/G Protein
	TRAP-6 (Thrombin Receptor Activator Peptide 6) 是一种多肽片段，是选择性的蛋白酶激活受体 1 (PAR1) 激动剂，通过凝血酶受体激活人血小板。
T1986L	Atopaxar Hydrobromide	Protease-activated Receptor	GPCR/G Protein
	Atopaxar hydrobromide 是可口服的，高效选择性的可逆凝血酶受体蛋白酶激活受体-1 拮抗剂。它是一种抗血小板剂，能干扰血小板信号，用于动脉粥样硬化血栓性疾病的研究。
T8236	RHC 80267 U-57908	Others; Phospholipase; COX; Acyltransferase; AChR	Immunology/Inflammation; Metabolism; Neuroscience; Others
	RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂，对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解，还抑制胆碱酯酶活性，IC50为 4 μM，增强乙酰胆碱引起的松弛。
TP1736L	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)	Others	Others
	Fibrinogen-Binding Peptide 137235-80-4(fb-acetate) 是纤维蛋白原受体上玻连蛋白结合位点的推定肽模拟物。它结合纤维蛋白原并抑制血小板与纤维蛋白原的粘附和血小板聚集，还抑制血小板与玻连蛋白的粘附
T21996	Zoniporide hydrochloride CP-597396 hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Zoniporide hydrochloride 是一种特异性的 NHE-1 抑制剂，IC50 为 14 nM，是其他 NHE 同工型的 >150 倍特异性。 Zoniporide hydrochloride 对人血小板的 NHE-1 依赖性肿胀的 IC50 为 59 nM。
T6243	U-73122 U73122	Phospholipase; Ferroptosis; Lipoxygenase	Apoptosis; Metabolism
	U-73122 (U73122) 是一种磷脂酶 C 和 5-脂氧合酶抑制剂，对磷脂酶 C 的 IC50值约为 1-2.1 µM。它是一种 PLC 抑制剂，可减少激动剂诱导的血小板和 PMN 中的 Ca2+ 增加。
T2238	Cariporide 卡立泊来德,HOE-642	Sodium Channel	Membrane transporter/Ion channel
	Cariporide (HOE-642) 是一种选择性的Na+/H+交换抑制剂。
T15338	Foropafant SR27417,福罗帕泛	Others; Platelet aggregation	Others
	Foropafant (SR27417) 是一种高效和特异性的血小板活化因子 (PAF) 受体拮抗剂 (Ki: 57 pM)。 Foropafant 有效抑制 PAF 诱导的兔和人血小板聚集。
TP1458L	Arg-Gly-Glu-Ser acetate(93674-97-6 free base)	Others	Others
	Arg-Gly-Glu-Ser acetate(93674-97-6 free base) 是一种 RGD 相关肽，可控制纤维蛋白原与活化血小板结合的 RGDS 活性。
T17284	Zardaverine BY 290,B 84290	PDE	Metabolism
	Zardaverine (BY 290) 是一种可口服且具有选择性和有效性的 PDE3/4 抑制剂，具有支气管扩张活性和抗肝癌活性。Zardaverine 在血小板中的作用是通过PDE III同工酶介导，可用于研究急性肾衰竭呵呵慢性气流阻塞。
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
T0182L	Clopidogrel hydrogen sulfate 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷	P450; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) 是一种抗血小板药物，可防止血栓形成。它抑制 CYP2B6和 CYP2C19，IC50分别为 18.2 和 524 nM。它是一种选择性的高亲和力 P2Y12 受体拮抗剂，可抑制纤维蛋白原与血小板的结合以及血小板的粘附和聚集。
T1893	Parmodulin 2 ML 161	Protease-activated Receptor	GPCR/G Protein
	Parmodulin 2 (ML 161) 是一种蛋白酶激活受体 1(PAR1) 变构抑制剂，IC50为 0.26 μM。它是蛋白酶激活受体 1 (PAR1) 介导的血小板活化的抑制剂，可以抑制体外血小板聚集和体内血小板血栓形成。
T11824LL	Lanraplenib GS-9876	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib (GS-9876) 是高效的、选择性的、口服具有活力的 SYK 抑制剂 (IC50=9.5 nM) ，能够用于炎症性疾病的研究。它通过糖蛋白 VI (GPVI) 受体抑制血小板中的 SYK 活性，而不会延长猴子或人类的出血时间 (BT)。
TP1530L	YRGDS Fibronectin Fragment acetate YRGDS Fibronectin Fragment acetate(134282-68-1 free base)	Others	Others
	YRGDS Fibronectin Fragment acetate (YRGDS Fibronectin Fragment acetate (134282-68-1 free base))(134282-68-1 free base) 是一种纤连蛋白片段乙酸酯，是一种粘附肽，对凝血酶刺激的血小板具有很强的结合亲和力。它是由序列组成的 RGD。
T13623	Compound 48/80 trihydrochloride C48/80 trihydrochloride	Phospholipase	Metabolism
	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。
T6040	Aloxistatin E64d,Loxistatin,阿洛司他丁,E64c ethyl ester	SARS-CoV; Cysteine Protease	Microbiology/Virology; Proteases/Proteasome
	Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂，能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂，具有血小板聚集抑制活性。
T12913	Siguazodan SKF 94836	PDE	Metabolism
	Siguazodan (SKF 94836) 是选择性的，口服有效的磷酸二酯酶 III 抑制剂，IC50为 117 nM。它可增加完整血小板中 cAMP 的积累，EC50为 18.88 μM。它也抑制苯肾上腺素诱导的 5-HT 释放，IC50为 4.2 μM。
T19686	SCH-37370 乙酰地氯雷他定	Platelet aggregation	Others
	SCH-37370 是一种有效且具有口服活性的血小板活化因子和组胺双重拮抗剂。 Sch 37370 阻断 [3H]pyrilamine 与大鼠脑膜中组胺-H1 受体的结合。 Sch 37370 选择性地抑制 PAF 诱导的人血小板聚集（IC50：0.6 mM），并且还与 PAF 竞争与人肺膜制剂中特定位点的结合（IC50：1.2 mM）。
T3616	Carbazochrome AC-17,Adrenostazin,Cromadrenal,Adona,Adchnon,卡巴克络,Adedolon	Others; Phospholipase	Metabolism; Others
	Carbazochrome (Adchnon) 是毛细管稳定剂，是抗出血剂，用于研究出血。
T0680	Lamotrigine LTG,BW430C,拉莫三嗪	5-HT Receptor; Sodium Channel; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Lamotrigine (BW430C) 是一种抗癫痫剂和情绪稳定剂，可研究癫痫、局灶性癫痫等。。它选择性地阻断电压门控钠离子通道，稳定突触前神经元膜，抑制谷氨酸释放。
T13160	Timegadine 替美加定,SR1368	COX	Immunology/Inflammation; Neuroscience
	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
T29074	UR-3216
	UR-3216, a prodrug, is a selective and orally active platelet surface glycoprotein (GPIIb/IIIa) receptor antagonist. UR-3216 is the very tight binding of its active metabolite to platelets (Ki for resting platelets is < 1 nM). UR-2992, the active form of
T31421	Diazodiiodoarsanilic acid Dadiaa
	Diazodiiodoarsenic acid was used to isolate plasma membrane proteins from platelets by means of affinity chromatography.
T71489	SC 42619
	SC 42619 is a tripeptide analogue that inhibits aggregation of, and secretion from, human platelets.
T29270	1,2-Didecanoylglycerol 1,2-Dicaprin
	1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.
T28100	MRS2298 MRS-2298,MRS 2298
	MRS2298, a potent antagonists of the P2Y 1 receptor, has antiaggregatory activity in human platelets.
TP2450	Argipressin, des-glynh2(9)- 9-Deglycinamide-argipressin,(Arg8,de-Gly9)-vasopressin,DEAVP,DGAVP,9-Des-glynh2-argipressin
	Argipressin, des-glynh2(9)-, can effect on aggregation of blood platelets.
T27408	Gea 3162 Gea3162,Gea-3162
	Gea 3162 is a potent inhibitor of ADP-induced platelet aggregation in platelet rich plasma (PRP). GEA 3162 stimulates cGMP production in granulocytes, platelets, and polymorphonuclear leukocytes.
T69088	Oxagrelate
	Oxagrelate is a specific inhibitor of cyclic AMP phosphodiesterase, produced in vitro a concentration-dependent inhibition of platelet aggregation induced by collagen and ADP in human platelets.
T36774	13,14-dehydro-15-cyclohexyl Carbaprostacyclin
	13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is comparable to the potency of carbaprostacyclin.
T37657	Mitochondrial respiration-IN-1 hydrobromide
	Mitochondrial respiration-IN-1 hydrobromide (compound 49) is a potent mitochondrial inhibitor (IC50=8.8 mg/mL). Mitochondrial respiration-IN-1 hydrobromide significantly reduces mitochondrial respiration in platelets[1].
T81530	Pegacaristim
	Pegacaristim是一种单克隆抗体，具有促进血小板生成的活性。
T33431	MK-287 L680573,L 680573,L-680573
	MK-287 (L-680573) is a platelet activator (PAF) antagonist that effectively inhibates the binding of [3H]C18-PAF to human platelets, polynucleated white blood cells (PMN), and pulmonary membranes. May be used to treat asthma,
T23629	Adam I-123 Adam I 123,Adam I123
	Adam I-123 is a radiopharmaceutical containing the serotonin transporter (SERT) ligand, with SERT-binding and radioisotope activities. SERT is a monoamine transporter protein found in the membranes of neurons and platelets.
TP2342	Krds peptide Lys-arg-asp-ser
	Krds peptide is a synthetic tetrapeptide derived from lactotransferrin (residues 39 to 42) that suppresses binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-Stimulated platelets and megakaryocytes.
T37047	12(S)-HETE
	12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. [1] It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1μM181M.[2][3]
T10260	Aglafoline Rocaglamide U,Aglafolin,(-)-Methyl rocaglate	Others	Others
	Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
T37225	(±)7(8)-DiHDPA
	(±)7(8)-DiHDPA is a major metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases. Epoxygenase metabolites of DHA, including (±)7(8)-DiHDPA, suppress aggregation and thromboxane synthesis in isolated platelets.
TP1458	Arg-Gly-Glu-Ser
	Arg-Gly-Glu-Ser is a RGD related peptide that is a control for the RGDS activity of fibrinogen binding to activated platelets.
T27374	FR-181877 FR181877,FR 181877
	FR-181877, a nonprostanoid PGI2 agonist, inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.
T41088	Diadenosine pentaphosphate pentalithium
	Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes.
T37556	CAY10502
	Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits ...
TP1530	YRGDS Fibronectin Fragment
	This is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets. It is RGD consisting of sequence.
T28281	OXSI-2 OXSI 2,Syk Inhibitor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	OXSI-2 (Syk Inhibitor) 是 Syk 的抑制剂，EC50 为 313 nM，IC50 为 14 nM。 OXSI-2 完全抑制适配器蛋白 LAT Y191 磷酸化和 Syk 介导的血小板聚集。
T16709	R 59-022 Diacylglycerol kinase inhibitor I,DKGI-I	Others	Others
	R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu

化合物

Cat.No: T13769

Synonym: Megakaryocytes/platelets inducing agent

Target: Others

Cat.No: T5519

Synonym: BG-8967,比伐卢定,Hirulog-1

Target: Thrombin

Cat.No: T1986

Synonym: E5555,ER-172594-00

Target: Protease-activated Receptor

SCH79797 dihydrochloride

Cat.No: T12870

Target: Apoptosis, Others, Protease-activated Receptor

Cat.No: T7625

Synonym: PAR-1 agonist peptide,Thrombin Receptor Activator Peptide 6,TRAP-6(2TFA)

Target: Protease-activated Receptor

Atopaxar Hydrobromide

Cat.No: T1986L

Target: Protease-activated Receptor

Cat.No: T8236

Synonym: U-57908

Target: Others, Phospholipase, COX, Acyltransferase, AChR

Fibrinogen-Binding Peptide 137235-80-4(fb-acetate)

Cat.No: TP1736L

Target: Others

Zoniporide hydrochloride

Cat.No: T21996

Synonym: CP-597396 hydrochloride

Target: Sodium Channel

Cat.No: T6243

Synonym: U73122

Target: Phospholipase, Ferroptosis, Lipoxygenase

Cat.No: T2238

Synonym: 卡立泊来德,HOE-642

Target: Sodium Channel

Cat.No: T15338

Synonym: SR27417,福罗帕泛

Target: Others, Platelet aggregation

Arg-Gly-Glu-Ser acetate(93674-97-6 free base)

Cat.No: TP1458L

Target: Others

Cat.No: T17284

Synonym: BY 290,B 84290

Target: PDE

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Clopidogrel hydrogen sulfate

Cat.No: T0182L

Synonym: 硫酸氢氯吡格雷,(S)-(+)-Clopidogrel hydrogen sulfate,(S)-(+)-Clopidogrel bisulfate,SR-25990C,Clopidogrel,硫酸氯吡格雷

Target: P450, P2Y Receptor

Cat.No: T1893

Synonym: ML 161

Target: Protease-activated Receptor

Cat.No: T11824LL

Synonym: GS-9876

Target: Syk

YRGDS Fibronectin Fragment acetate

Cat.No: TP1530L

Synonym: YRGDS Fibronectin Fragment acetate(134282-68-1 free base)

Target: Others

Compound 48/80 trihydrochloride

Cat.No: T13623

Synonym: C48/80 trihydrochloride

Target: Phospholipase

Cat.No: T6040

Synonym: E64d,Loxistatin,阿洛司他丁,E64c ethyl ester

Target: SARS-CoV, Cysteine Protease

Cat.No: T12913

Synonym: SKF 94836

Target: PDE

Cat.No: T19686

Synonym: 乙酰地氯雷他定

Target: Platelet aggregation

Cat.No: T3616

Synonym: AC-17,Adrenostazin,Cromadrenal,Adona,Adchnon,卡巴克络,Adedolon

Target: Others, Phospholipase

Cat.No: T0680

Synonym: LTG,BW430C,拉莫三嗪

Target: 5-HT Receptor, Sodium Channel, Autophagy

Cat.No: T13160

Synonym: 替美加定,SR1368

Target: COX

Cat.No: T29074

Diazodiiodoarsanilic acid

Cat.No: T31421

Synonym: Dadiaa

Cat.No: T71489

1,2-Didecanoylglycerol

Cat.No: T29270

Synonym: 1,2-Dicaprin

Cat.No: T28100

Synonym: MRS-2298,MRS 2298

Argipressin, des-glynh2(9)-

Cat.No: TP2450

Synonym: 9-Deglycinamide-argipressin,(Arg8,de-Gly9)-vasopressin,DEAVP,DGAVP,9-Des-glynh2-argipressin

Cat.No: T27408

Synonym: Gea3162,Gea-3162

Cat.No: T69088

13,14-dehydro-15-cyclohexyl Carbaprostacyclin

Cat.No: T36774

Mitochondrial respiration-IN-1 hydrobromide

Cat.No: T37657

Cat.No: T81530

Cat.No: T33431

Synonym: L680573,L 680573,L-680573

Cat.No: T23629

Synonym: Adam I 123,Adam I123

Cat.No: TP2342

Synonym: Lys-arg-asp-ser

Cat.No: T37047

Cat.No: T10260

Synonym: Rocaglamide U,Aglafolin,(-)-Methyl rocaglate

Target: Others

(±)7(8)-DiHDPA

Cat.No: T37225

Arg-Gly-Glu-Ser

Cat.No: TP1458

Cat.No: T27374

Synonym: FR181877,FR 181877

Diadenosine pentaphosphate pentalithium

Cat.No: T41088

Cat.No: T37556

YRGDS Fibronectin Fragment

Cat.No: TP1530

Cat.No: T28281

Synonym: OXSI 2,Syk Inhibitor

Target: Syk

Cat.No: T16709

Synonym: Diacylglycerol kinase inhibitor I,DKGI-I

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3839	Cycloolivil Isoolivil,环橄榄树脂素	Free radical scavengers; Others; Platelet aggregation	Others; oxidation-reduction
	Cycloolivil (Isoolivil) 是一种天然多酚化合物，在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性，它可以预防与血小板过度聚集相关的血栓并发症，是开发抗聚集治疗策略的基础。
T25253	Cinnamtannin B-1 Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Cinnamtannin B-1 (LDN 0022358) 是一种 A 型原花青素，包含在多种植物中，如越桔、桂树、泽兰肉桂和猪苓。它是一种有效的抗氧化剂和保护剂，可对抗人类血小板的氧化应激和凋亡。它是一种 Cox-2抑制剂。
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
TN5939	Glutinone 赤杨酮,5-Glutinen-3-one
	Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets.
TN4794	Pinusolidic acid	PAFR	GPCR/G Protein
	Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml).
T36532	SCH 38519
	SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μg/ml, respectively). It inhibits the growth of various Gram-negative and Gram-positive bacteria (mean MICs = 122.1 and 0.92 μg/ml, respectively).
T37972	12-OxoETE
	12-OxoETE is synthesized by human platelets and Aplysia nervous tissue after incubation with arachidonic acid. Microsomal fractions of various tissues will reduce 12-oxoETE to 12(S)-HETE or a mixture of 12(S)- and 12(R)-HETE. 12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence.
TN2799	20-Deoxyingenol 3-angelate	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets,
TN3568	Calceolarioside A	Calcium Channel; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi
T80998	Thapsigargicin Thapsigargicine
	Thapsigargicin（Thapsigargicine）作为肥大细胞和白细胞的激活剂，能诱导大鼠腹膜肥大细胞及人嗜碱性粒细胞释放组胺，并提升完整人血小板中的细胞质游离钙水平。
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T3839

Synonym: Isoolivil,环橄榄树脂素

Target: Free radical scavengers, Others, Platelet aggregation

Cinnamtannin B-1

Cat.No: T25253

Synonym: Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1

Target: Antioxidant, COX

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

Cat.No: TN5939

Synonym: 赤杨酮,5-Glutinen-3-one

Pinusolidic acid

Cat.No: TN4794

Target: PAFR

Cat.No: T36532

Cat.No: T37972

20-Deoxyingenol 3-angelate

Cat.No: TN2799

Target: PKC

Calceolarioside A

Cat.No: TN3568

Target: Calcium Channel, Antifection

Cat.No: T80998

Synonym: Thapsigargicine

Cat.No: T38330

Cat.No: T35624

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