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Search Results for " osteoblast "

20

抑制剂 & 化合物

23

天然产物

1

化合物库

23

重组蛋白

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Cat. No.	Product Name
L7900	成骨分子库		317 compounds
	317 种成骨相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

成骨分子库

Cat.No: L7900

Compounds: 317

Cat. No.	Product Name	Target	Signaling Pathways
T81593	Osteoblast-Adhesive Peptide
	Osteoblast-Adhesive Peptide是一种促进成骨细胞黏附的多肽，用于生物材料的化学修饰，具有牙科和骨科领域的潜在应用价值。
T39508	KY-02327	Others	Others
	KY-02327 是 KY-02061的一种类似物，具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径，从而促进成骨细胞分化。
T7844	4-IPP 4-Iodo-6-phenylpyrimidine	Others	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物，也是 MIF 的不可逆抑制剂。
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T8550	NDMC101	Others; NF-κB; Proteasome	NF-κB; Others; Proteases/Proteasome; Ubiquitination
	NDMC101 是有效的破骨细胞形成抑制剂，通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似，通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究，如类风湿关节炎、滑膜炎等。
T1810	Purmorphamine Shh Signaling Antagonist VI	Hedgehog/Smoothened; Smo; Autophagy	Autophagy; GPCR/G Protein; Stem Cells
	Purmorphamine (Shh Signaling Antagonist VI) 是平滑受体激动剂，EC50为 1 μM。它阻止 BODIPY-cyclopamine 与 Smo 结合。它也是成骨细胞分化的诱导剂。
TP1345	Kisspeptin-10, human (TFA)(374675-21-5,FREE)	GPR; Kisspeptin	Endocrinology/Hormones; GPCR/G Protein
	Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10，人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化
T11048L	DIPQUO hydrochloride DIPQUO hydrochloride(1269365-82-3 Free base)	Phosphorylase	Metabolism
	DIPQUO hydrochloride 是一种骨标记碱性磷酸酶 (ALP) 激活剂，在 C2C12 细胞中作用的 EC50 值为 6.27 μM。DIPQUO hydrochloride 通过激活 p38 MAPK-β 促进小鼠和人类的成骨细胞分化。
T22767	ER 50891	Retinoid Receptor	Metabolism
	ER-50891是一种强效的视黄酸受体α（RARα）拮抗剂。ER-50891能减少全价视黄酸的抑制作用并恢复骨形态生成蛋白2诱导的成骨细胞分化。
T60554	Schnurri-3 inhibitor-1	Others	Others
	Schnurri-3 inhibitor-1 是有效的 schnurri-3 抑制剂，schnurri-3是成人骨形成的重要调节因子。在成骨细胞系 Shn3FFL 中，Schnurri-3 inhibitor-1 通过 EF1alpha 启动子抑制 Shn3 蛋白表达 (AC50= 2.09 μM)。Schnurri-3 inhibitor-1 可用于骨质疏松症相关的研究。
T72008	E09241
	E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.
T27999	MDK-4624 AMPKα1 activator C13,C13, Compound 13
	MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation
T71904	Chlormadinone (free base)
	Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
T75745	Kisspeptin-10, human TFA
	Kisspeptin-10, human TFA为一种有效的血管收缩剂及血管生成抑制剂，通过其受体GPR54抑制肿瘤转移。Kisspeptin-10-GPR54系统对胚胎肾脏发展具有关键影响，而Kisspeptin-10/GPR54信号则通过NFATc4介导的BMP2表达促进成骨细胞分化。
T69656	E197
	E197 is a DOCK5 inhibitor. E197 can inhibit both mouse and human osteoclast activity. In particular, E197 prevented pathological bone loss in mice. Most interestingly, treatment with E197 did not affect osteoclast and osteoblast numbers and hence did not impair bone formation. E197 could represent a lead molecule to develop new antiosteoporotic drugs targeting the mechanism of osteoclast adhesion onto the bone.
T62436	KY-02327 acetate
	KY-02327 acetate 是一种有效的 Dishevelled (Dvl)-CXXC5相互作用抑制剂，是一种代谢稳定的 KY-02061 类似物。KY-02327 acetate 能够激活 Wnt/β-catenin 途径，进而促进成骨细胞分化。
T36080	Rivenprost ONO-4819
	Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively). It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.[1][2][3][4][5] Rivenprost has also been used to support wound healing.[6]
T71284	Glimepiride urethane
	Glimepiride urethane is a third generation sulfonylurea compound, which increases the release of insulin from pancreatic beta cells. In addition, glimepiride increases the activity of intracellular insulin receptors. Glimepiride increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases prote...
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。

化合物

Osteoblast-Adhesive Peptide

Cat.No: T81593

Cat.No: T39508

Target: Others

Cat.No: T7844

Synonym: 4-Iodo-6-phenylpyrimidine

Target: Others

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

Cat.No: T8550

Target: Others, NF-κB, Proteasome

Cat.No: T1810

Synonym: Shh Signaling Antagonist VI

Target: Hedgehog/Smoothened, Smo, Autophagy

Kisspeptin-10, human (TFA)(374675-21-5,FREE)

Cat.No: TP1345

Target: GPR, Kisspeptin

DIPQUO hydrochloride

Cat.No: T11048L

Synonym: DIPQUO hydrochloride(1269365-82-3 Free base)

Target: Phosphorylase

Cat.No: T22767

Target: Retinoid Receptor

Schnurri-3 inhibitor-1

Cat.No: T60554

Target: Others

Cat.No: T72008

Cat.No: T27999

Synonym: AMPKα1 activator C13,C13, Compound 13

Chlormadinone (free base)

Cat.No: T71904

Kisspeptin-10, human TFA

Cat.No: T75745

Cat.No: T69656

KY-02327 acetate

Cat.No: T62436

Cat.No: T36080

Synonym: ONO-4819

Glimepiride urethane

Cat.No: T71284

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Cat.No: T83848

Cat. No.	Product Name	Target	Signaling Pathways
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
T2771	Orcinol glucoside Sakakin,苔黑酚葡萄糖苷	Antioxidant	oxidation-reduction
	Orcinol glucoside (Sakakin) 是一种提取自莪术中的活性成分，具有抗抑郁活性。它能诱导 MSC 转化为成骨细胞，并通过 Wnt/β-catenin 信号通路阻断脂肪形成。
T3925	Astragaloside I 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化，可用于成骨活性研究。
TN5086	Syringetin	Others	Others
	Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物，可促进 B16F10 细胞的黑色素生成，抑制人肺腺癌中成骨细胞介导的破骨细胞生成。
T13768	(+)-Medicarpin	Estrogen/progestogen Receptor	Endocrinology/Hormones
	(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β.
T3488	Tectorigenin 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素	Apoptosis	Apoptosis
	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) 是一种从葛根汤干燥的花中分离出来的植物异黄酮。
T2848	Osthole Osthol,NSC 31868,蛇床子素,Ostol	Apoptosis; HBV; Parasite; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Osthole (Osthol) 是一种天然抗组胺药替代试剂，可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性，还可抑制细胞培养物中 HBV 的分泌。
T6S1559	Aurantio-obtusin	Others	Others
	Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物，具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应，具有研究过敏相关疾病的潜力。在大鼠中，它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉，是潜在的新型血管扩张剂。
T4915	β-Glycerophosphate disodium salt hydrate	Phosphatase; Endogenous Metabolite	Metabolism
	β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂，是内源性代谢产物的一种。
TN1918	Medicarpin 美迪紫檀素	Apoptosis; BCL; ROS; JNK	Apoptosis; Immunology/Inflammation; MAPK
	Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流，诱导白血病 P388 细胞凋亡并克服多药耐药性。
T10109	3-Carene Delta-3-Carene	COX; Antifungal	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	3-Carene（Delta-3-Carene）是西部落叶松和花旗松中提取的双环单萜烯，可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用，能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
TN6926	Paeonoside	Others	Others
	Paeonoside 发现与P. suffruticosa 中，具有生物活性，可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性，可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用，以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶（ALP）染色及其活性。
TMA0132	Dihydrophaseic acid	Others	Others
	Dihydrophaseic acid 3'-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis.
TN3552	Byzantionoside B	Others	Others
	Byzantionoside B shows stimulatory activity on human osteoblast cells, it may have the potential to stimulate bone formation and regeneration.
TN1265	3'-O-Methylorobol 3'-O-METHYLOROBOL,3'-O-甲基香豌豆苷元	Others	Others
	3'-O-Methylorobol exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, it also exerts potential analgesic properties. 3'-O-Methylorobol can increase osteoblast differentiation.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
TN2830	26-Nor-8-oxo-alpha-onocerin	Others	Others
	26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
TN4594	Murraol	Antifection	Microbiology/Virology
	Murraol shows the significant proliferative activities on osteoblast-like UMR106 cells lines at the concentration of 1 × 10-10 mol/L. It and auraptenol show 63 ug/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372.
T81987	Kanzonol D
	Kanzonol D为一种存在于Glycyrrhiza glabra的毛状根培养物中的类黄酮化合物。
TN4394	Kobophenol A	MMP; BCL; p38 MAPK; NF-κB; ROS; DNA/RNA Synthesis; CDK; JNK	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome
	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell death. Kobophenol A inhibits AChE activity in a dose-dependent manner, and the IC50 value is
TN1778	Isoformononetin 异刺芒柄花素,黄豆苷元杂质	IL Receptor; Antifection	Immunology/Inflammation; Microbiology/Virology
	Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.

天然产物

Cat.No: TN5888

Target: Others

Orcinol glucoside

Cat.No: T2771

Synonym: Sakakin,苔黑酚葡萄糖苷

Target: Antioxidant

Astragaloside I

Cat.No: T3925

Synonym: 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV

Target: Wnt/beta-catenin

Cat.No: TN5086

Target: Others

Cat.No: T13768

Target: Estrogen/progestogen Receptor

Cat.No: T3488

Synonym: 4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine,鸢尾黄酮,鸢尾黄素

Target: Apoptosis

Cat.No: T2848

Synonym: Osthol,NSC 31868,蛇床子素,Ostol

Target: Apoptosis, HBV, Parasite, Histamine Receptor

Aurantio-obtusin

Cat.No: T6S1559

Target: Others

β-Glycerophosphate disodium salt hydrate

Cat.No: T4915

Target: Phosphatase, Endogenous Metabolite

Cat.No: TN1918

Synonym: 美迪紫檀素

Target: Apoptosis, BCL, ROS, JNK

Cat.No: T10109

Synonym: Delta-3-Carene

Target: COX, Antifungal

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Cat.No: TN6926

Target: Others

Dihydrophaseic acid

Cat.No: TMA0132

Target: Others

Byzantionoside B

Cat.No: TN3552

Target: Others

3'-O-Methylorobol

Cat.No: TN1265

Synonym: 3'-O-METHYLOROBOL,3'-O-甲基香豌豆苷元

Target: Others

Cat.No: T14368

Target: Others

26-Nor-8-oxo-alpha-onocerin

Cat.No: TN2830

Target: Others

Cat.No: TN4594

Target: Antifection

Cat.No: T81987

Cat.No: TN4394

Target: MMP, BCL, p38 MAPK, NF-κB, ROS, DNA/RNA Synthesis, CDK, JNK

Isoformononetin

Cat.No: TN1778

Synonym: 异刺芒柄花素,黄豆苷元杂质

Target: IL Receptor, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His) PN,OSF-2,OSF2,periostin,periostin, osteoblast speci...	Human	HEK293 Cells
	Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His) A630052E07Rik,OSF-2,Osf2,PLF,AI747096,peri,PN,periostin,	Mouse	HEK293 Cells
	Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2.
TMPJ-01266	CDH11 Protein, Human, Recombinant (hFc & His) OSF-4,Osteoblast cadherin,CDH11,Cadherin-11	Human	HEK293 Cells
	Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular doma...
TMPJ-01267	CDH11 Protein, Human, Recombinant (His) Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform...	Human	HEK293 Cells
	Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, and thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in the brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and...
TMPK-00587	CDH11 Protein, Human, Recombinant (aa 54-617, His) CDH11,Osteoblast cadherin,OSF-4,CAD11OSF-4,OB,Cadhe...	Human	HEK293 Cells
	CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was positively correlated with liver fibrosis in patients with cirrhosis, and could therefore be a prognostic factor in patients with liver fibrosis.
TMPJ-01051	Pleiotrophin/PTN Protein, Mouse, Recombinant (His) HBGF-8,OSF-1,PTN,HBBM,Pleiotrophin,Heparin-binding brain mit...	Mouse	HEK293 Cells
	Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or greater. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates it...
TMPH-02569	WISP2/CCN5 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC...	Human	HEK293 Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF...
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr...	Human	Baculovirus Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Receptor activator of nuclear factor kappa-B ligand,Receptor...	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPH-02128	SMOC1 Protein, Human, Recombinant (GST & His)	Human	E. coli
	Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
TMPY-02010	DMP1 Protein, Human, Recombinant (His) ARHR,dentin matrix acidic phosphoprotein 1,ARHP,DMP-1	Human	HEK293 Cells
	Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. DMP1 contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nu...
TMPK-00657	SPARC Protein, Cynomolgus, Recombinant (His) BM-40,EGM_15571,SPARC,ON	Cynomolgus	HEK293 Cells
	Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues.The capacity of SPARC to influence pathways involved in extracellular matrix assembly such as procollagen processing and collagen fibril formation as well as the capacity to influence osteoblast differentiation and osteoclast activity will be addressed.
TMPH-02570	WISP2/CCN5 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.
TMPH-01016	GDF-10 Protein, Human, Recombinant (His)	Human	E. coli
	Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. GDF-10 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is P55107.
TMPY-01783	SMOC1 Protein, Human, Recombinant (His) OAS,SPARC related modular calcium binding 1	Human	HEK293 Cells
	SPARC-related modular calcium-binding protein 1, also known as secreted modular calcium-binding protein 1 and SMOC1, is a member of the SPARC family. SMOC1 is widely expressed in many tissues with a strongest signal in ovary. It contains two EF-hand domains, one Kazal-like domain and two thyroglobulin type-1 domains. Extracellular matrix proteins have been implicated in the regulation of osteoblast differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) through paracrine or autocri...
TMPH-02864	Wnt1 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.
TMPH-02240	TMEM119 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation.
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His) OIF,OG,osteoglycin,SLRR3A	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epith...
TMPJ-01369	DPT Protein, Mouse, Recombinant (hFc) EQ-1,Early quiescence protein 1,TRAMP,Tyrosine-rich acidic m...	Mouse	HEK293 Cells
	Dermatopontin is a widely expressed noncollagenous protein component of the extracellular matrix. It is a 22 kDa molecule that is tyrosine sulfated but not glycosylated. Dermatopontin is down regulated in fibrotic growths such as leiomyoma and scar tissue, inhibits cell proliferation, accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation, Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization. Dermatopontin s...
TMPJ-01211	EDA2R Protein, Mouse, Recombinant (His) EDA-A2R,Tumor necrosis factor receptor superfamily member XE...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 ...
TMPY-03046	APCDD1 Protein, Human, Recombinant (hFc) HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS...	Human	HEK293 Cells
	Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells...
TMPJ-00521	CHL2 Protein, Mouse, Recombinant (His) CHRDL2,chordin-like 2,chordin-like protein 2,BNF-1	Mouse	HEK293 Cells
	Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites, one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney, partly expressed in the connective ...

重组蛋白

Periostin/OSF-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01020

Species: Human

Expression System: HEK293 Cells

Periostin/OSF-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01613

Species: Mouse

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-01266

Species: Human

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01267

Species: Human

Expression System: HEK293 Cells

CDH11 Protein, Human, Recombinant (aa 54-617, His)

Cat.No: TMPK-00587

Species: Human

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01051

Species: Mouse

Expression System: HEK293 Cells

WISP2/CCN5 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02569

Species: Mouse

Expression System: P. pastoris (Yeast)

Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

Cat.No: TMPJ-01466

Species: Human

Expression System: HEK293 Cells

PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02575

Species: Human

Expression System: Baculovirus Insect Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-00662

Species: Human

Expression System: E. coli

SMOC1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-02128

Species: Human

Expression System: E. coli

DMP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02010

Species: Human

Expression System: HEK293 Cells

SPARC Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00657

Species: Cynomolgus

Expression System: HEK293 Cells

WISP2/CCN5 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02570

Species: Mouse

Expression System: E. coli

GDF-10 Protein, Human, Recombinant (His)

Cat.No: TMPH-01016

Species: Human

Expression System: E. coli

SMOC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01783

Species: Human

Expression System: HEK293 Cells

Wnt1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02864

Species: Mouse

Expression System: E. coli

TMEM119 Protein, Human, Recombinant (hFc)

Cat.No: TMPH-02240

Species: Human

Expression System: HEK293 Cells

OGN/Osteoglycin Protein, Human, Recombinant (His)

Cat.No: TMPY-04899

Species: Human

Expression System: HEK293 Cells

DPT Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01369

Species: Mouse

Expression System: HEK293 Cells

EDA2R Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01211

Species: Mouse

Expression System: HEK293 Cells

APCDD1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03046

Species: Human

Expression System: HEK293 Cells

CHL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00521

Species: Mouse

Expression System: HEK293 Cells

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