Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ER-50891是一种强效的视黄酸受体α(RARα)拮抗剂。ER-50891能减少全价视黄酸的抑制作用并恢复骨形态生成蛋白2诱导的成骨细胞分化。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,960 | 现货 | ||
5 mg | ¥ 4,650 | 现货 | ||
10 mg | ¥ 6,320 | 现货 | ||
25 mg | ¥ 9,530 | 现货 | ||
50 mg | ¥ 12,800 | 现货 | ||
100 mg | ¥ 17,300 | 现货 | ||
500 mg | ¥ 34,700 | 现货 |
产品描述 | ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2. |
体外活性 | ER-50891 significantly antagonized the inhibition of ATRA and enhanced the total cell metabolic activity and proliferation of preosteoblasts. Dose-dependent assays show ER-50891 could also rescue ATRA inhibited OCN expression and mineralization with or without the induction of BMP. ER-50891 also suppressed the ALP activity that was synergistically enhanced by BMP and ATRA. Neither ATRA, nor ER-50891 or their combination significantly affected the level of BMP-induced phosphorylated Smad1/5. The antagonist of RARα, ER-50891 could significantly attenuate ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.[3] |
分子量 | 432.51 |
分子式 | C29H24N2O2 |
CAS No. | 187400-85-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.7 mg/mL (90.0 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3121 mL | 11.5604 mL | 23.1209 mL | 57.8021 mL |
5 mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 11.5604 mL | |
10 mM | 0.2312 mL | 1.156 mL | 2.3121 mL | 5.7802 mL | |
20 mM | 0.1156 mL | 0.578 mL | 1.156 mL | 2.8901 mL | |
50 mM | 0.0462 mL | 0.2312 mL | 0.4624 mL | 1.156 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ER 50891 187400-85-7 Metabolism Retinoid Receptor ER50891 ER-50891 Inhibitor inhibitor inhibit