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9

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1031	Cloxacillin sodium monohydrate Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) 有抗菌作用，对Staphylococcus aureus25923 的最小抑菌浓度为256 mg/L。
T2036	6-OAU GTPL5846	GPR	Endocrinology/Hormones; GPCR/G Protein
	6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。
T39823L	Apelin-12 acetate Apelin-12 acetate (229961-08-4 Free base)	Apelin receptor; p38 MAPK; JNK	GPCR/G Protein; MAPK
	Apelin-12 acetate 对 APJ 受体具有高亲和力。 Apelin-12 acetate 抑制凋亡相关 MAPKs 家族的 JNK 和 p38 MAPK 信号通路，从而为神经元提供保护。
T4133	CCT196969	Raf; Src	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	CCT196969 是泛-Raf 抑制剂，抑制B-Raf、BRafV600E 和CRAF，IC50分别为 0.1、0.04、和 0.01 μM。
T12871	Talmapimod 他匹莫德,SCIO-469	p38 MAPK	MAPK
	Talmapimod (SCIO-469) 是选择性的，具有口服活性的，ATP 竞争性的 p38α抑制剂，对 p38α和 p38β的 IC50 值分别是 9 nM 和90 nM。Talmapimod 在 20 个其他激酶 (包括其他 MAPKs) 上显示出至少 2000 倍的选择性。
T12871L	Talmapimod hydrochloride SCIO-469 hydrochloride	p38 MAPK	MAPK
	Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
T10901	Curcumin-d6 Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6	Others	Others
	Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a
T73058	Cloxacillin 氯唑西林
	Cloxacillin 是一种口服有效的抗菌剂和β-lactamase 抑制剂，其IC50值为 0.04 µM。Cloxacillin 可通过抑制MAPKs、NF-кB 和NLRP3相关蛋白的激活从而抑制金黄色葡萄球菌所引起的炎症反应。
TP2177	Amyloid Precursor C-Terminal Peptide	Others	Others
	Amyloid precursor c-terminal peptide has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. APP is best known as the precursor molecule whose proteolysis generates beta-amyloid (Aβ), a 37 to 49 amino acid peptide whose am

化合物

Cloxacillin sodium monohydrate

Cat.No: T1031

Synonym: Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物

Target: Antibacterial, Antibiotic

Cat.No: T2036

Synonym: GTPL5846

Target: GPR

Apelin-12 acetate

Cat.No: T39823L

Synonym: Apelin-12 acetate (229961-08-4 Free base)

Target: Apelin receptor, p38 MAPK, JNK

Cat.No: T4133

Target: Raf, Src

Cat.No: T12871

Synonym: 他匹莫德,SCIO-469

Target: p38 MAPK

Talmapimod hydrochloride

Cat.No: T12871L

Synonym: SCIO-469 hydrochloride

Target: p38 MAPK

Cat.No: T10901

Synonym: Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6

Target: Others

Cat.No: T73058

Synonym: 氯唑西林

Amyloid Precursor C-Terminal Peptide

Cat.No: TP2177

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0107	Peimine 贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素	Others	Others
	Peimine (Wanpeinine A) 是一种天然化合物，具有很好抗炎症活性。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
TN1879	Lucideric acid A Lucidenic acid A,赤芝酸A	MMP; p38 MAPK; JNK	MAPK; Proteases/Proteasome
	Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物，可抑制 PMA 诱导的MMP-9活性，具有抵抗肝癌细胞侵袭的作用。
T3908	10-Gingerol 10-姜酚	Apoptosis	Apoptosis
	10-Gingerol 是一种姜根脂的主要刺激性成分，具有抗炎、抗氧化和抗增殖作用，能够抑制 MDA-MB-231 肿瘤细胞的增殖(IC50:12.1 μM)。
T3884	Neoandrographolide Neoandrographiside,新穿心莲内酯	NOS; COX	Immunology/Inflammation; Neuroscience
	Neoandrographolide (Neoandrographiside) 是一种二萜类化合物，从穿心莲中分离得到。
T5S1895	Norisoboldine Laurelliptine,去甲异波尔定,(+)-Laurelliptine	MAPK; Adenosine Receptor	GPCR/G Protein; MAPK; Neuroscience
	Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂，是乌药中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。
T5S1097	Neferine (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱	Apoptosis; NF-κB; Autophagy	Apoptosis; Autophagy; NF-κB
	Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱，可强效抑制NF-κB 激活，具有抗肿瘤活性。
TCS2170	2,5-Dihydroxyacetophenone Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP	ERK; NF-κB; Tyrosinase	MAPK; NF-κB; Proteases/Proteasome
	2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1/2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TN4785	Picrasidine I	NF-κB; ROS; MAPK	Immunology/Inflammation; MAPK; NF-κB
	Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-ÎºB and ROS generation followed by suppressing the gene expression of c-Fos and NFATc1 in osteoclast precursors.
TN2123	Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside Hyperin 6''-gallate,槲皮素3-O-(6''-没食子酰基)-Β-D-半乳糖苷,Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside	MAPK; p53	Apoptosis; MAPK
	Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN1504	Citreorosein 羟基大黄素	cAMP; NF-κB; PI3K	GPCR/G Protein; NF-κB; PI3K/Akt/mTOR signaling
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
TN2327	Zedoarondiol 蓬莪二醇	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Zedoarondiol has anti-inflammatory activity, inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway.
TN1645	Flavokawain C	NADPH-oxidase; MAPK; AChR	Immunology/Inflammation; MAPK; Neuroscience
	Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticulum stress and regulation of MAPKs and Akt signaling pathways in HCT 116 human colon carcinoma cells.
TN2243	Sugiol 10-Deoxoxanthoperol	IL Receptor; TNF; ROS	Apoptosis; Immunology/Inflammation
	Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜，可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性，可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu
TN4877	Quercetin 3,4'-dimethyl ether	ERK; BCL; MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ether could be useful in the development of novel anticancer agents, it has high cytotoxic aga
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Cat.No: T6S0107

Synonym: 贝母素甲,Wanpeinine A,Dihydroisoimperialine,Verticine,贝母甲素

Target: Others

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Lucideric acid A

Cat.No: TN1879

Synonym: Lucidenic acid A,赤芝酸A

Target: MMP, p38 MAPK, JNK

Cat.No: T3908

Synonym: 10-姜酚

Target: Apoptosis

Neoandrographolide

Cat.No: T3884

Synonym: Neoandrographiside,新穿心莲内酯

Target: NOS, COX

Cat.No: T5S1895

Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Cat.No: T5S1097

Synonym: (R)-1,2-Dimethoxyaporphine,(-)-Neferine,甲基莲心碱

Target: Apoptosis, NF-κB, Autophagy

2,5-Dihydroxyacetophenone

Cat.No: TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP

Target: ERK, NF-κB, Tyrosinase

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Cat.No: TN4785

Target: NF-κB, ROS, MAPK

Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside

Cat.No: TN2123

Synonym: Hyperin 6''-gallate,槲皮素3-O-(6''-没食子酰基)-Β-D-半乳糖苷,Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside

Target: MAPK, p53

Cat.No: TN1504

Synonym: 羟基大黄素

Target: cAMP, NF-κB, PI3K

Cat.No: TN2327

Synonym: 蓬莪二醇

Target: NOS, NF-κB, COX

Cat.No: TN1645

Target: NADPH-oxidase, MAPK, AChR

Cat.No: TN2243

Synonym: 10-Deoxoxanthoperol

Target: IL Receptor, TNF, ROS

1,3,5-Trihydroxy-4-prenylxanthone

Cat.No: T4700

Quercetin 3,4'-dimethyl ether

Cat.No: TN4877

Target: ERK, BCL, MAPK, Caspase, JNK

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

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