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22
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16801 |
(RS)-(Tetrazol-5-yl)glycine
LY 285265,D,L-(tetrazol-5-yl)glycine |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
(RS)-(Tetrazol-5-yl)glycine (LY 285265) 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。它能够诱导小鼠癫痫发作反应和 Fos。它对 GluN1/GluN2D 和 GluN1/GluN2A 的EC50分别为 99 nM,1.7 μM。 | |||
T0450 |
Fluoxetine
氟西汀,LY-110140 |
5-HT Receptor; Serotonin Transporter; MRP; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Fluoxetine (LY-110140) 是一种高度特异性的血清素摄取抑制剂,是选择性 5-羟色胺 (5-HT) 再吸收抑制剂。Fluoxetine 具有抗抑郁活性。 | |||
T4266 |
LY334370
4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐,LY 334370 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
LY334370 是一种选择性5-HT1F 受体激动剂,Ki 值为 1.6 nM。 | |||
T1567 |
Olanzapine
LY170053,奥氮平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Olanzapine (LY170053) 是一种非典型抗精神病药,目前用于治疗精神分裂症和双相情感障碍。 | |||
T1471 |
Duloxetine hydrochloride
Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl |
Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine | GPCR/G Protein; Neuroscience |
Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI),Ki=4.6 nM,可用于广泛性焦虑症的研究。 | |||
T9078 |
LY3405105
1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester |
CDK | Cell Cycle/Checkpoint |
LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) 是一种新型 CDK7 抑制剂。 | |||
T4310 |
Prexasertib
5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368 |
Apoptosis; Chk | Apoptosis; Cell Cycle/Checkpoint |
Prexasertib (LY2606368) 是一种具有潜在抗肿瘤活性的检查点激酶 1 抑制剂。它可引起双链 DNA 断裂和复制突变,导致细胞凋亡。 | |||
T24423 |
LY5
LY 5,LY-5 |
||
LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells. | |||
T2344 |
LY 344864
LY344864 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
LY 344864 是一种特异性受体激动剂,有对克隆 5-HT1F 受体的亲和力,Ki 为6 nM。 | |||
T2344L |
LY 344864 racemate
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
LY 344864 racemate 是一种 5-HT1F 受体激动剂。 | |||
T22948 |
LY 272015 hydrochloride
|
Others | Others |
LY 272015 hydrochloride is a 5-HT2B receptor antagonist. | |||
T24421 |
LY-2624803
DB-7,LY2624803,HY-10275,LY 2624803 |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
LY-2624803 是一种 5-HT2A 受体拮抗剂和组胺受体反向激动剂,可用于改善慢波睡眠。 | |||
T27918 |
LY 43578
LY-43578,LY43578 |
P450; Aromatase | Endocrinology/Hormones; Metabolism |
LY 43578 是一种具有口服活性的芳香酶 (aromatase) 抑制剂。LY 43578 对大鼠肝微粒体 P-450依赖的 p-nitroanisole 的 O -去甲基化和 ethylmorphine 的 N -去甲基化有抑制作用,IC50 分别为 0.3 和 5 μΜ。LY 43578 可用于研究神经系统疾病和心血管疾病。 | |||
T22947 |
LY266097 hydrochloride
LY 266097 hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
LY266097 hydrochloride (LY 266097 hydrochloride) 是 5-HT2 的拮抗剂,对人 5-HT2A、5-HT2B 和 5-HT2C 的 pKis 分别为 7.7、9.8 和 7.6,可用于抑郁症研究。 | |||
T16977 |
Talampanel
GYKI-53773,LY-300164 |
Apoptosis; GluR | Apoptosis; Neuroscience |
Talampanel (LY-300164) 是一种口服和选择型 AMPA 受体拮抗剂,具有抗癫痫活性。在啮齿动物的中风模型中,它 具有神经保护作用。Talampanel 减弱 caspase-3 依赖性细胞凋亡。 | |||
T27910 |
LY 278584
LY278584,LY-278584 |
||
LY 278584 is an antagonist of 5-HT3-receptor. | |||
T27955 |
LY-426965
LY 426965 |
||
LY-426965 is a selective, potent, orally bioavailable 5-HT1A antagonist. | |||
T27879 |
LY 165163
LY-165,163,LY165,163,LY 165,163 |
||
LY-165163 is a selective antagonists of 5-HT1A and 5-HT1D serotonin receptor. | |||
T11902 |
LY 344864 S-enantiomer
|
Others | Others |
LY 344864 S-enantiomer, the S-enantiomer of LY344864, serves as a 5-HT1F receptor agonist. | |||
T15825 | LY 178002 | Retinoid Receptor | Metabolism |
LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for 5-lipoxygenase). LY 178002 also inhibits cellular production of LTB4 by human polymorphonuclear leukocytes and displays relatively weak inhibition on cycloox | |||
T71374 | LY 178210 | ||
LY 178210 is a 5-hydroxytryptamine receptor agonist. | |||
T27914 |
LY 293284
LY293284,LY-293284 |
||
LY 293284 is a potent, selective full agonist of 5-HT1A receptor with anxiogenic effects in animal studies. | |||
T27894 |
LY 206130
LY206130,LY-206130 |
||
LY 206130 is an antagonist of serotonin 5-HT1A. | |||
T27878 |
LY 164929
LY-164929,LY164929 |
||
LY 164929 is a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site. | |||
T27915 |
LY 302148
LY-302148,LY302148 |
||
LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics. | |||
T27921 |
LY 53857
LY-53857,LY53857 |
||
LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor. | |||
T41295 |
LY 344864 hydrochloride
|
||
LY 344864 hydrochloride 是选择性的受体激动剂,对5-HT1F 受体具有6 nM(Ki)的亲和力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05748 |
CD45 Protein, Human, Recombinant (aa 26-577, His)
L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3. | |||
TMPJ-00455 |
SLAMF5 Protein, Mouse, Recombinant (His)
CD84 molecule,SLAM family member 5,Leukocy... |
Mouse | HEK293 Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato... | |||
TMPY-03270 |
CD45 Protein, Mouse, Recombinant (aa 453-1152, His & GST)
Ly-5,CD45R,Lyt-4,T200,lo... |
Mouse | Baculovirus Insect Cells |
CD45 Protein, Mouse, Recombinant (aa 453-1152, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 108.2 kDa and the accession number is AAA39458.1. | |||
TMPY-04277 |
CD45 Protein, Mouse, Recombinant (hFc)
Cd45,protein tyrosine phosphatase, receptor type, C... |
Mouse | HEK293 Cells |
CD45 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.7 kDa and the accession number is P06800-6. | |||
TMPY-03468 |
CD45 Protein, Mouse, Recombinant (aa 453-1152)
loc,Lyt-4,protein tyrosine phosphatase, receptor ty... |
Mouse | Baculovirus Insect Cells |
CD45 Protein, Mouse, Recombinant (aa 453-1152) is expressed in Baculovirus insect cells. The predicted molecular weight is 81 kDa and the accession number is AAA39458.1. | |||
TMPK-00183 |
CD20 Protein, Human, Recombinant (His & Avi)
MS4A2,Ly-44,LEU-16,MS4A1,Bp35,CD20 recepto... |
Human | E. coli |
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. CD20... | |||
TMPK-00447 |
CD45 Protein, Human, Recombinant (aa 26-577, hFc)
CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,... |
Human | HEK293 Cells |
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577... | |||
TMPK-00423 |
CD45 Protein, Human, Recombinant (His & Avi)
CD45R,LY5,EC 3.1.3.48,B220,CD4 |
Human | HEK293 Cells |
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi... | |||
TMPK-00424 |
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
LCA,LY5,EC 3.1.3.48,CD45,L-CA,T20... |
Human | HEK293 Cells |
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi... | |||
TMPY-00711 |
CD45 Protein, Human, Recombinant (hFc)
GP180,L-CA,LY5,T200,protein tyrosine phosp... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4. | |||
TMPJ-00794 |
CD45 Protein, Mouse, Recombinant (His)
CD45,receptor-type tyrosine-protein phosphatase C,C... |
Mouse | HEK293 Cells |
CD45 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 120-160 KDa and the accession number is P06800. | |||
TMPJ-00808 |
CD45RA Protein, Human, Recombinant (His)
PTPRC,CD45R,CD45,LCA,protein tyrosine phos... |
Human | HEK293 Cells |
CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8. | |||
TMPJ-00410 |
CD45R0 Protein, Human, Recombinant (His)
CD45 antigen,L-CA,protein tyrosine phosphatase, rec... |
Human | HEK293 Cells |
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4. | |||
TMPY-02440 |
SAP/SH2D1A Protein, Human, Recombinant (His)
XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2 domain containing... |
Human | E. coli |
SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell... | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate... |
Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPY-05387 |
SLAMF7 Protein, Human, Recombinant (hFc)
SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPY-05547 |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... | |||
TMPY-05498 |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas... |
Human | HEK293 Cells |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5. | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... |