Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY 344864 hydrochloride 是选择性的受体激动剂,对5-HT1F 受体具有6 nM(Ki)的亲和力。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,410 | 35日内发货 | ||
10 mg | ¥ 2,660 | 35日内发货 |
LY 344864 hydrochloride 的其他形式现货产品:
产品描述 | LY 344864 hydrochloride is a selective receptor agonist with an affinity of 6 nM (Ki) at the 5-HT1F receptor. |
体外活性 | LY344864 is a selective 5-HT1F receptor agonist with an affinity of 6 nM (Ki). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolininduced cyclic AMP accumulation in cells stably transfected with human 5-HT1F receptors, LY344864 is shown to be a full agonist producing an effect similar in magnitude to serotonin itself [1]. |
体内活性 | After an intravenous dose of 1 mg/kg, rat plasma LY344864 levels decrease over time, whereas brain cortex levels remaine relatively constant for the first 6 hours after injection. Oral and intravenous LY344864 administration potently inhibit dural protein extravasation caused by electrical stimulation of the trigeminal ganglion in rats [1]. Co-injection of LY 344864 and systemically ineffective doses of METH significantly decreases preference scores and the rewarding properties of METH during the reinstatement phase. In addition, administration of LY 344864 has no effect on the acquisition of CPP in rats [2]. |
分子量 | 387.88 |
分子式 | C21H23ClFN3O |
CAS No. | 1217756-94-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LY 344864 hydrochloride 1217756-94-9 LY-344864 Hydrochloride LY 344864 Hydrochloride LY344864 Hydrochloride Inhibitor inhibitor inhibit