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Targets Recommended: Apoptosis Others Microtubule Associated

36

抑制剂 & 化合物

4

天然产物

12

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T22661 CHM-1

Apoptosis; Others; Microtubule Associated Apoptosis; Cytoskeletal Signaling; Others
CHM-1 是细胞凋亡的诱导剂,通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T21588 Olomoucine

ERK; CDK Cell Cycle/Checkpoint; MAPK
Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂,IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T2028 NG 52

NG52,NG-52,Compound 52

CDK Cell Cycle/Checkpoint
NG 52 (NG-52) 是可逆和 ATP 相容性且具有口服活性的Cdc28p 和Pho85p 激酶抑制剂,IC50分别为 7 μM 和 2 μM。它还抑制磷酸甘油酸激酶 1 的活性,IC50值为 2.5 μM。
T7167 Purvalanol B

NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇

CDK; Parasite Cell Cycle/Checkpoint; Microbiology/Virology
Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。
T10723 CDC25B-IN-1

ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Phosphatase Metabolism
CDC25B-IN-1 是 CDC25B 的抑制剂,Ki 为 8.5 μM。 CDC25B-IN-1 通过抑制细胞增殖和集落形成来增加 G2/M 期。
T9156 CDC25B-IN-2

Phosphatase; mTOR Metabolism; PI3K/Akt/mTOR signaling
BIA 是一种 cdc25B 抑制剂。
T76458 P34cdc2 Kinase Fragment

P34cdc2 Kinase Fragment,与酵母有丝分裂中DNA复制的完整度相关,并能磷酸化丝裂原激活蛋白MAP2,进而调节爪蟾卵母细胞减数分裂中的微管聚合活性。
T82762 Cdc25A (80-93) (human)

Cdc25A (80-93) (human)为调控细胞周期蛋白D1及G1/S转换中相关蛋白表达,进而控制细胞增殖与肿瘤发生的多肽。该化合物在癌症研究中具应用价值。
T2670 ML167

NCGC00188654,CID44968231

DYRK; CDK Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
ML167 (CID44968231) 是一种高选择性的 Cdc2 样激酶 4 抑制剂,IC50为 136 nM。
T1901 (E/Z)-TG003

TG003

BCL; CDK Apoptosis; Cell Cycle/Checkpoint
(E/Z)-TG003 是一种有效的 ATP 竞争性 Cdc2 样激酶 (Clk) 抑制剂,抑制 Clk1 和 Clk4 的 IC50值分别为 20 和 15 nM。它是 (Z)-TG003 和 (E)-TG003的消旋体。
T2059 Purvalanol A

NG-60

Apoptosis; CDK; Autophagy Apoptosis; Autophagy; Cell Cycle/Checkpoint
Purvalanol A (NG-60) 是一种CDK 抑制剂,对 cdc2-cyclin B、cdc2-cyclin B、cdk2-cyclin E、cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4、70、35、850 和 75 nM。
T2095 Seliciclib

Roscovitine,R-roscovitine,CYC202

CDK Cell Cycle/Checkpoint
Seliciclib (Roscovitine) 是 Cdk2/cyclin E 的有效抑制剂,IC50为0.1 µM。它还抑制 Cdk7/cyclin H、Cdk5/p35 和 Cdc2/cyclin B,IC50为 0.49、0.16和0.65 µM。
T15438 GSK3186899

3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide,DDD-853651

Parasite Microbiology/Virology
GSK3186899 是 Cdc2 相关激酶 12 的抑制剂,对 L. donovani 的 EC50 为 1.4 μM。
T3074 CHIR 98024

CHIR98014

GSK-3; S6 Kinase MAPK; PI3K/Akt/mTOR signaling; Stem Cells
CHIR 98024是一种有效的 GSK-3α/β 抑制剂,在无细胞试验中 IC50 为 0.65 nM/0.58 nM,能够区分 GSK-3 与其接近的同源物 Cdc2 和 ERK2
T6350 CHIR-124

CHIR124,CHIR 124

Apoptosis; GSK-3; FLT; Chk; PDGFR; Src Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
CHIR-124 是一种选择性 Chk1抑制剂,IC50值为 0.3 nM,可有效抑制 PDGFR 和 FLT3,IC50值分别为 6.6 nM 和 5.8 nM。
T9864 Debio-0123

WEE1-IN-5

Wee1 Cell Cycle/Checkpoint
Debio-0123 (WEE1-IN-5) 是一种口服有效且高度特异性的WEE1抑制剂,IC50值在低纳摩尔范围内。Debio-0123 抑制磷酸化 CDC2。Debio-0123 可增强卡铂在体内的抗肿瘤活性,而这两种药物单独使用都没有活性。
T2310L CHIR-99021 HCl

CT99021 HCl,Laduviglusib HCl

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T2608 CHIR-98014

CHIR 98014,CT98014,CHIR98014

FGFR; GSK-3; Src; S6 Kinase Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
CHIR-98014 (CT98014) 是有效的,细胞通透的GSK-3抑制剂,可抑制 GSK-3α (IC50:0.65 nM) 和 GSK-3β (IC50:0.58 nM) 的活性,对 cdc2 和 erk2 的作用较弱。
T10836 CLK1-IN-1

CDK Cell Cycle/Checkpoint
CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
T15657 KH-CB19

Others Others
KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).
T62049 CTX-712

CTX-712 是 有效的cdc2 样激酶 (CLK) 抑制剂。CTX-712 可以抑制癌症存活和癌细胞生长。
T16848 SB-218078

Chk; PKC Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM).
T24402 Leucettine L41

LeucettineL41,Leucettine-L41

Leucettine L41 is an effective dual cdc2-like kinase and DYRKs inhibitor.
T68453 HY-52

HY-52 is a selective inhibitor of CDC2 kinase.
T22657 Laduviglusib trihydrochloride

CT99021 trihydrochloride,CHIR 99021 trihydrochloride,CHIR 99021 trihydrochloride (252917-06-9 free base)

GSK-3; Wnt/beta-catenin Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
Laduviglusib trihydrochloride (CT99021 trihydrochloride) 是一种选择性糖原合成酶激酶 3 (GSK-3) 抑制剂,对 GSK-3α 和 GSK-3β 的 IC50 分别为 10 nM 和 6.7 nM。 Laduviglusib trihydrochloride 抑制人 GSK-3β,Ki 为 9.8 nM。 Laduviglusib trihydrochloride 是 Wnt/β-catenin 信号通路的激活剂。 Laduviglusib trihydrochloride 诱导自噬。
T70527 DAT-230

DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated ...
T69091 CBP501

CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.
T69316 DA 3003-2

NSC663285

DA 3003-2为一种高效的选择性Cdc25抑制剂,展示了抗增殖活性,能诱导细胞周期在G2/M期停滞,并提高P-tyr15Cdc2表达量,显示出对前列腺癌研究的应用潜力。
T60737 LG308

LG308 是一种新型合成化合物,具有抗微管活性。LG308 诱导细胞凋亡和细胞死亡,并且显著抑制肿瘤生长,具有前列腺癌的研究潜力。LG308 诱导有丝分裂阻滞并显着抑制 G2/M 的进程,这与细胞周期蛋白 B1 和有丝分裂标志物 MPM-2 的上调以及 cdc2 的去磷酸化有关。
T21950 K 00546

K00546 是一种有效的细胞周期蛋白依赖性激酶CDK1和CDK2抑制剂,对CDK1/cyclin B 和CDK2/cyclin A 的IC50分别为 0.6 nM 和 0.5 nM。K00546 也是一种有效的 CDC2 样激酶 1 (CLK1) 和CLK3抑制剂,IC50分别为 8.9 nM 和 29.2 nM。
T28092 MPT0B206

MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2.
T71217 MPT0B214

MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...
TP2192 Cdk2/Cyclin Inhibitory Peptide I

Others Others
Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevis
T69200 CGP74514A

CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T62484 Aurora Kinases-IN-2

Aurora Kinases-IN-2 (compound 12Aj) 是一种 Aurora 激酶的有效抑制剂 (Aurora kinases),能够作用于 Aurora A (IC50: 90 nM) 和 Aurora B (IC50: 152 nM)。Aurora Kinases-IN-2 能够调节细胞周期蛋白 B1 和 cdc2 ,将细胞周期阻滞在 G2/M 期。Aurora Kinases-IN-2 能够用于研究癌症。
T36689 KuWal151

Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations. Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID:29723265

化合物

CHM-1
Cat.No: T22661
Synonym:
Target: Apoptosis, Others, Microtubule Associated
Olomoucine
Cat.No: T21588
Synonym:
Target: ERK, CDK
NG 52
Cat.No: T2028
Synonym: NG52,NG-52,Compound 52
Target: CDK
Purvalanol B
Cat.No: T7167
Synonym: NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇
Target: CDK, Parasite
CDC25B-IN-1
Cat.No: T10723
Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate
Target: Phosphatase
CDC25B-IN-2
Cat.No: T9156
Synonym:
Target: Phosphatase, mTOR
P34cdc2 Kinase Fragment
Cat.No: T76458
Synonym:
Target:
Cdc25A (80-93) (human)
Cat.No: T82762
Synonym:
Target:
ML167
Cat.No: T2670
Synonym: NCGC00188654,CID44968231
Target: DYRK, CDK
(E/Z)-TG003
Cat.No: T1901
Synonym: TG003
Target: BCL, CDK
Purvalanol A
Cat.No: T2059
Synonym: NG-60
Target: Apoptosis, CDK, Autophagy
Seliciclib
Cat.No: T2095
Synonym: Roscovitine,R-roscovitine,CYC202
Target: CDK
GSK3186899
Cat.No: T15438
Synonym: 3,3,3-trifluoro-N-[4-[[3-[(2R)-2-methylmorpholin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]propane-1-sulfonamide,DDD-853651
Target: Parasite
CHIR 98024
Cat.No: T3074
Synonym: CHIR98014
Target: GSK-3, S6 Kinase
CHIR-124
Cat.No: T6350
Synonym: CHIR124,CHIR 124
Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src
Debio-0123
Cat.No: T9864
Synonym: WEE1-IN-5
Target: Wee1
CHIR-99021 HCl
Cat.No: T2310L
Synonym: CT99021 HCl,Laduviglusib HCl
Target: GSK-3
CHIR-98014
Cat.No: T2608
Synonym: CHIR 98014,CT98014,CHIR98014
Target: FGFR, GSK-3, Src, S6 Kinase
CLK1-IN-1
Cat.No: T10836
Synonym:
Target: CDK
KH-CB19
Cat.No: T15657
Synonym:
Target: Others
CTX-712
Cat.No: T62049
Synonym:
Target:
SB-218078
Cat.No: T16848
Synonym:
Target: Chk, PKC
Leucettine L41
Cat.No: T24402
Synonym: LeucettineL41,Leucettine-L41
Target:
HY-52
Cat.No: T68453
Synonym:
Target:
Laduviglusib trihydrochloride
Cat.No: T22657
Synonym: CT99021 trihydrochloride,CHIR 99021 trihydrochloride,CHIR 99021 trihydrochloride (252917-06-9 free base)
Target: GSK-3, Wnt/beta-catenin
DAT-230
Cat.No: T70527
Synonym:
Target:
CBP501
Cat.No: T69091
Synonym:
Target:
DA 3003-2
Cat.No: T69316
Synonym: NSC663285
Target:
LG308
Cat.No: T60737
Synonym:
Target:
K 00546
Cat.No: T21950
Synonym:
Target:
MPT0B206
Cat.No: T28092
Synonym:
Target:
MPT0B214
Cat.No: T71217
Synonym:
Target:
Cdk2/Cyclin Inhibitory Peptide I
Cat.No: TP2192
Synonym:
Target: Others
CGP74514A
Cat.No: T69200
Synonym:
Target:
Aurora Kinases-IN-2
Cat.No: T62484
Synonym:
Target:
KuWal151
Cat.No: T36689
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T25192 Butyrolactone I

Olomoucin,丁酸内酯I

CDK Cell Cycle/Checkpoint
Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。
T5S1467 Cucurbitacin E

CDK; Autophagy Autophagy; Cell Cycle/Checkpoint
Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性,具有预防神经变性,具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T3824 Jaceosidin

Apoptosis; BCL; COX; UGT Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。
TN5639 Rocaglaol

Ferrugin,Aglaiastatin A

Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Butyrolactone I
Cat.No: T25192
Synonym: Olomoucin,丁酸内酯I
Target: CDK
Cucurbitacin E
Cat.No: T5S1467
Synonym:
Target: CDK, Autophagy
Jaceosidin
Cat.No: T3824
Synonym:
Target: Apoptosis, BCL, COX, UGT
Rocaglaol
Cat.No: TN5639
Synonym: Ferrugin,Aglaiastatin A
Target:
Cat. No. Product Name Species Expression System
TMPY-04775 CDK1 Protein, Mouse, Recombinant (His & GST)

CDC2>,Cdc2,Cdc

Mouse Baculovirus Insect Cells
CDK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 61.9 kDa and the accession number is P11440.
TMPY-04549 CDK1 Protein, Human, Recombinant (GST)

CDC2,P34CDC2,CDC

Human Baculovirus Insect Cells
CDK1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 60 kDa and the accession number is P06493-1.
TMPY-04450 CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST)

P34CDC2 & CCNE1,CDC2,CDK...

Human Baculovirus Insect Cells
CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 109.7 kDa and the accession number is NP_001777.1&NP_001229.1.
TMPY-04463 CDKL2 Protein, Human, Recombinant (His)

KKIAMRE,P56,cyclin-dependent kinase-like 2 (CDC...

Human Baculovirus Insect Cells
Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus.
TMPH-01167 CDK1 Protein, Human, Recombinant (His)

p34 protein kinase,Cell division control protein 2 ...

Human E. coli
CDK1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01074 CDC20 Protein, Human, Recombinant (His & Myc)

Cell division cycle protein 20 homolog,CDC...

Human E. coli
CDC20 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.2 kDa and the accession number is Q12834.
TMPH-01703 CDC25C Protein, Human, Recombinant (His)

Dual specificity phosphatase Cdc25C,M-phas...

Human E. coli
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307.
TMPY-04548 CDK4 Protein, Human, Recombinant (GST)

CMM3,PSK-J3,cyclin-dependent kinase 4

Human Baculovirus Insect Cells
CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-02238 MAD2L1 Protein, Human, Recombinant (His)

MAD2 mitotic arrest deficient-like 1 (yeast),HSMAD<...

Human E. coli
Mitotic spindle assembly checkpoint protein MAD2A, also known as HsMAD2, Mitotic arrest deficient 2-like protein 1, MAD2-like protein 1, MAD2L1, and MAD2, is a nucleus and cytoplasm protein that belongs to the MAD2 family. MAD2L1 is a component of the spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle atta...
TMPY-04556 CDK5 Protein, Human, Recombinant (GST)

PSSALRE,cyclin-dependent kinase 5

Human Baculovirus Insect Cells
Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was jo...
TMPY-02150 GADD45A Protein, Human, Recombinant (His & GST)

GADD45,growth arrest and DNA-damage-inducible, alpha,growth ...

Human Baculovirus Insect Cells
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular ...
TMPY-04542 CDK2 Protein, Human, Recombinant (His)

CDKN2,cyclin-dependent kinase 2,p33(CDK

Human Baculovirus Insect Cells
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...

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CDK1 Protein, Mouse, Recombinant (His & GST)
Cat.No: TMPY-04775
Species: Mouse
Expression System: Baculovirus Insect Cells
CDK1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04549
Species: Human
Expression System: Baculovirus Insect Cells
CDK1 & CCNE1 Heterodimer Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04450
Species: Human
Expression System: Baculovirus Insect Cells
CDKL2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04463
Species: Human
Expression System: Baculovirus Insect Cells
CDK1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01167
Species: Human
Expression System: E. coli
CDC20 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01074
Species: Human
Expression System: E. coli
CDC25C Protein, Human, Recombinant (His)
Cat.No: TMPH-01703
Species: Human
Expression System: E. coli
CDK4 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04548
Species: Human
Expression System: Baculovirus Insect Cells
MAD2L1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02238
Species: Human
Expression System: E. coli
CDK5 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04556
Species: Human
Expression System: Baculovirus Insect Cells
GADD45A Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02150
Species: Human
Expression System: Baculovirus Insect Cells
CDK2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04542
Species: Human
Expression System: Baculovirus Insect Cells
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