Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM and 0.015 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), respectively.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.13 μM and 0.015 μM for Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS) and Plasmodium falciparum lysyl-tRNA synthetase (PfKRS), respectively. |
靶点活性 | PfKRS:0.015 μM , CpKRS:0.13 μM |
体外活性 | LysRs-IN-2 is active against whole-cell bloodstream P. falciparum 3D7 (EC50=0.27 μM),HepG2 cells (EC50=49 μM) , HsKRS (IC50=1.8 μM), and Cryptosporidium parvum (EC50=2.5 μM)[1]. |
体内活性 | LysRs-IN-2 (20 mg/kg; orally once a day for 7 days) reduces parasite shedding in NOD SCID gamma mice and INF-γ-knockout mice (Cryptosporidium mouse models)[1].LysRs-IN-2 (1.5 mg/kg; orally once a day for 4 days) reduces parasitemia by 90% in the murine P. falciparum SCID model. |
分子量 | 355.31 |
分子式 | C17H16F3NO4 |
CAS No. | 2170696-76-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (168.87 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8144 mL | 14.0722 mL | 28.1444 mL | 70.3611 mL |
5 mM | 0.5629 mL | 2.8144 mL | 5.6289 mL | 14.0722 mL | |
10 mM | 0.2814 mL | 1.4072 mL | 2.8144 mL | 7.0361 mL | |
20 mM | 0.1407 mL | 0.7036 mL | 1.4072 mL | 3.5181 mL | |
50 mM | 0.0563 mL | 0.2814 mL | 0.5629 mL | 1.4072 mL | |
100 mM | 0.0281 mL | 0.1407 mL | 0.2814 mL | 0.7036 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
LysRs-IN-2 2170696-76-9 Others LysRsIN2 LysRs IN 2 Inhibitor inhibitor inhibit