Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIA 是一种 cdc25B 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 227 | 现货 | ||
5 mg | ¥ 566 | 现货 | ||
10 mg | ¥ 898 | 现货 | ||
25 mg | ¥ 1,480 | 现货 | ||
50 mg | ¥ 2,230 | 现货 | ||
100 mg | ¥ 3,330 | 现货 | ||
500 mg | ¥ 7,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 583 | 现货 |
产品描述 | BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression. |
体外活性 | The proliferation and cell viability of all cell lines were inhibited by treatment with 5?μM BIA.The IC50 values at 3 days were 1.7?±?0.1?μM for HT1080, 2.6?±?0.4?μM for MCF cells, 2.6?±?0.5?μM for MDA-MB-231 cells, and 2.4?±?0.4?μM for SKBR3 cells. Moreover, HT1080 cells stably overexpressing TMBIM6 showed high sensitivity to BIA[1].BIA decreases the binding between TMBIM6 and mTORC2, we performed a gel filtration assay in TMBIM6-overexpressing HT1080 cells after treatment with BIA during 24?h[1]. |
分子量 | 268.27 |
分子式 | C15H12N2O3 |
CAS No. | 134271-74-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/ml (242.29 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.7276 mL | 18.6379 mL | 37.2759 mL | 93.1897 mL |
5 mM | 0.7455 mL | 3.7276 mL | 7.4552 mL | 18.6379 mL | |
10 mM | 0.3728 mL | 1.8638 mL | 3.7276 mL | 9.319 mL | |
20 mM | 0.1864 mL | 0.9319 mL | 1.8638 mL | 4.6595 mL | |
50 mM | 0.0746 mL | 0.3728 mL | 0.7455 mL | 1.8638 mL | |
100 mM | 0.0373 mL | 0.1864 mL | 0.3728 mL | 0.9319 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
CDC25B-IN-2 134271-74-2 Metabolism PI3K/Akt/mTOR signaling Phosphatase mTOR Inhibitor CDC-25B-IN-2 CDC25BIN2 CDC25B IN 2 inhibit inhibitor