42
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27837 |
Linzagolix
|
GNRH Receptor | GPCR/G Protein |
Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。 | |||
T6713 |
Ulipristal
|
Estrogen/progestogen Receptor; Progesterone Receptor | Endocrinology/Hormones; Others |
Ulipristal 是性孕酮受体 (progesterone receptor) 的选择性调节剂。它能够与孕激素受体结合,抑制 PR 介导的基因表达,降低生殖系统中孕激素的活性。 | |||
T3630 |
Relugolix
RVT-601,瑞卢戈利,TAK-385 |
GNRH Receptor | GPCR/G Protein |
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。 | |||
T2527 |
Ulipristal acetate
Ulipristal,醋酸乌利司他,CDB-2914 |
Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Others |
Ulipristal acetate (CDB-2914) 是一种具有抗孕酮活性的选择性孕酮受体调节剂。它可抑制子宫平滑肌瘤病的生长。它通过抑制或延迟排卵和影响子宫内膜组织,可用作紧急避孕药。 | |||
T22285 |
Carboprost
15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α,卡前列素 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost (15(S)-15-Methyl Prostaglandin F2α) 是一种前列腺素 F2α 的代谢稳定的合成类似物。它能够刺激子宫收缩并引起流产,可用于子宫收缩乏力引起的产后出血,以及在妊娠中期终止妊娠。 | |||
T35054 |
Vilaprisan
BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670 |
Progesterone Receptor | Others |
Vilaprisan (BAY 1002670) 是一种新型可口服且具有选择性的黄体酮受体调节剂 (SPRM),对子宫肌瘤 (UF) 具有抗增殖活性,可用于研究子宫肌瘤。 | |||
T4996 |
Atosiban
阿托西班,RWJ22164,RW22164 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T5148 |
Atosiban acetate
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban acetate (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T23516 |
VU590
|
Potassium Channel | Membrane transporter/Ion channel |
VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1,可调节子宫肌层收缩力和黑皮质素信号传导。 | |||
T28855 |
SSR126768A
SSR-126768A,SSR 126768A |
Oxytocin Receptor | Endocrinology/Hormones; GPCR/G Protein |
SSR126768A 是一种新型且具有选择性、口服活性和有效性的催产素(OT)受体拮抗剂,对子宫收缩有抑制作用,可用于预防早产。 | |||
T25742 |
Linzagolix choline
|
GNRH Receptor | GPCR/G Protein |
Linzagolix choline 是一种可口服的非肽类的促性腺激素释放激素(GnRH)拮抗剂。可用于研究子宫肌瘤和子宫内膜异位症相关疼痛。 | |||
T0324 |
Isoxsuprine hydrochloride
Duvadilan,Isolait,盐酸异克舒令,盐酸苯氧丙酚胺 |
Adrenergic Receptor; iGluR | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Isoxsuprine hydrochloride (Isolait) 是 β 肾上腺素受体激动剂和NMDA 受体拮抗剂,对子宫肌层和胎盘的 β 肾上腺素受体的Ki 值分别为 13.65 和 3.48 μM。 | |||
T1514 |
Norethindrone
Norethisterone,炔诺酮 |
Estrogen/progestogen Receptor; Progesterone Receptor | Endocrinology/Hormones; Others |
Norethindrone (Norethisterone) 是孕激素,能够用于子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经的研究。 | |||
T1433 |
Ritodrine hydrochloride
DU21220,盐酸利托君,Ritodrine HCl,NSC 291565 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。 | |||
T11915 |
LY88074
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
LY88074是一种雷洛昔芬类似物,其基本侧链已被去除。LY88074是ERβ的激动剂(EC50 = 232 nM)。这种化合物刺激子宫细胞增殖。 | |||
T13572 |
Cancer-Targeting Compound 1
|
Others | Others |
Cancer-Targeting Compound 1可用于激素相关癌症的研究,包括治疗或预防肌瘤、子宫平滑肌瘤、多囊卵巢综合征或激素依赖性癌等等。 | |||
T60039 |
KSQ-4279
USP1-IN-1 |
PARP; DUB | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination |
KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性,可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。 | |||
T10379 |
Arzoxifene hydrochloride
SERM 3,LY 353381 HCl |
Others | Others |
Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue. | |||
T21387 |
Nafoxidine HCl(1845-11-0 Free base)
PNU-0011100,PNU0011100,CP5600,CP 5600,CP-5600,PNU 0011100,Nafoxidine HCl |
||
Nafoxidine is a partial estrogen antagonist. It inhibits angiogenesis in some tissues by blocking the effects of VEGF and FGF; paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces calcium signaling, oxidative stress, and p | |||
T34639 | Sigetin | ||
Sigetin affects the transport of calcium and magnesium in uterine smooth muscle and can be used in fetal development. | |||
T32684 |
Leuprolide (1-3)
Leuprorelin |
||
Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty. | |||
T36154 |
15(S)-15-methyl Prostaglandin E2
15(S)-15-methyl Prostaglandin E2 |
||
15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle. | |||
T26669 |
Asoprisnil ecamate
J956,J-956,J 956 |
||
Asoprisnil ecamate is a selective progesterone receptor modulator. Asoprisnil inhibits proliferation and induces apoptosis in cultured human uterine leiomyoma cells in the absence of comparable effects on myometrial cells. Asoprisnil inhibits embryo impla | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... | |||
T0171 |
Norethynodrel
Lynestrol,异炔诺酮 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Norethynodrel (Lynestrol) 是一种合成的孕激素,其作用和用途类似于孕酮。它已被用于治疗功能性子宫出血和子宫内膜异位症。它作为避孕药,通常与 MESTRANOL 联合使用。 | |||
T36771 |
11-deoxy Prostaglandin F1α
11-deoxy Prostaglandin F1α |
||
11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs. | |||
T76996 | Solitomab | ||
Solitomab (AMG 110) 是一种针对CD3与上皮细胞粘附分子(EpCAM)的双特异性抗体,适用于研究原发性子宫癌与卵巢癌肉瘤。 | |||
T69303 |
Isoxsuprine Free Base
|
||
Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor. | |||
T60575 |
Ritodrine
|
||
Ritodrine (DU21220) 是一种β 肾上腺素能激动剂,也是一种有效的子宫松弛剂。Ritodrine 可用于阻止早产相关的研究。 | |||
T36155 |
15(S)-15-methyl Prostaglandin F2α isopropyl ester
15(S)-15-methyl Prostaglandin F2α isopropyl ester |
||
15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2α isopropyl ester is a lipophilic analog of 15(S)-15-methyl PGF2α methyl ester, which may be hydrolyzed in vivo to the fully active free acid. | |||
T21308 |
Histrelin
Supprelin LA,组氨瑞林,Histrelin Acetate |
Others | Others |
Histrelin (Supprelin LA) 是促性腺激素释放激素 (GnRH) 的九肽类似物,具有增加的效力。它被认为是 GnRH 激动剂。 Histrelin 用于治疗对激素敏感的男性前列腺癌和女性子宫肌瘤。 | |||
T71149 | Triptorelin pamoate | ||
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es... | |||
T26665 |
AS604872
AS-604872,AS 604872 |
||
AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic lamina and promoted IA and aortic di | |||
T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1/16:0) |
||
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien... | |||
T80955 |
Trastuzumab duocarmazine
(vic)-Trastuzumab duocarmazine |
||
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) 是一款HER2靶向ADC,它通过组织蛋白酶B的识别和裂解作用,选择性地作用于肿瘤细胞。此化合物在子宫和卵巢癌肉瘤等癌症的研究中显示出抗肿瘤活性。 | |||
T76211 |
[Asp5]-Oxytocin acetate
|
||
[Asp5]-Oxytocin acetate 是一款功能强大的5位 (5-position) 神经垂体激素类似物,能引发体外大鼠子宫收缩,其效果可被 Mg2+ 增强。此化合物展现出在大鼠子宫收缩、禽血管抑制及大鼠抗利尿作用方面的活性。 | |||
T72990 |
BAY 1214784
|
||
BAY 1214784是一种针对人促性腺激素释放激素受体(hGnRH-R)的高效、选择性口服活性拮抗剂,属于螺二氢吲哚衍生物化合物。该化合物能显著降低血浆促黄体激素水平,最高可达49%,同时显示出较低的药代动力学变异性和良好的耐受性,表现出研究子宫肌瘤的潜力。 | |||
T35669 |
Neuromedin C (trifluoroacetate salt)
|
||
Neuromedin C is a bombesin-like neuropeptide that stimulates uterine smooth muscle contraction and the release of gastrin , somatostatin, and amylase in rats. Neuromedin C is a truncated form of gastrin-releasing peptide corresponding to the GRP amino acids 18-27. It inhibits GRP and bombesin binding to rat pancreatic membranes (IC50s = 0.4 and 2.2 nM, respectively), which can be reduced by sodium chloride and guanylyl imidodiphosphate . Neuromedin C induces scratching and mast cell degranulatio... | |||
T68525 | Nafarelin acetate hydrate | ||
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu... | |||
T69492 |
Ozarelix
|
||
Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,... | |||
T76565 |
PDC31
|
||
PDC31 (THG113.31; ILGHXDYK) 是FPProstaglandin Receptor 的变构和非竞争性抑制剂。PDC31是基于D-氨基酸的寡肽,用作平滑肌收缩剂。PDC31 在体内降低子宫收缩的强度和持续时间,可用于早产和原发性痛经 (PD) 的研究。PDC31 还增强人子宫肌层细胞中 Ca2+依赖性大电导 K+通道。 | |||
T19811 |
Nomegestrol
|
||
Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
T1048 |
Estradiol
雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。 | |||
TN4422 |
Lauterine
|
Topoisomerase | DNA Damage/DNA Repair |
Lauterine is a DNA topoisomerase inhibitor. | |||
TN1248 |
3-Epioleanolic acid
|
AChR | Neuroscience |
3-Epioleanolic acid 是一种分离自马鞭草的有效成分,具有抗炎作用。 | |||
T14865 |
Carboprost tromethamine
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物,能有效促进子宫的规律收缩,显着减少产中及产后出血量。 | |||
T1549 |
Raloxifene hydrochloride
LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl |
Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others |
Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂,用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用,但对乳腺和子宫组织具有完全的雌激素拮抗作用。 | |||
TN1918 |
Medicarpin
美迪紫檀素 |
Apoptosis; BCL; ROS; JNK | Apoptosis; Immunology/Inflammation; MAPK |
Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流,诱导白血病 P388 细胞凋亡并克服多药耐药性。 | |||
T4S1335 |
Daphnoretin
Dephnoretin,西瑞香素,Thymelol |
Influenza Virus; Caspase; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物,具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
T20217 |
Grandiflorenic acid
|
||
Grandiflorenic acid can reproduce the uterine responses induced by aqueous extract of zoapatle leaves. It is suggested that grandiflorenic acid may have an antifertility effect. | |||
T39003 |
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
|
||
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, exhibits a significant binding affinity for the estrogen receptor in bovine uterine tissue, with an IC50 value of 15 μM. | |||
T83454 |
13-Hydroxylupanine hydrochloride
Hydroxylupanine hydrochloride |
||
13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。 | |||
T35667 |
Napyradiomycin A1
Napyradiomycin A1 |
||
Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM... | |||
TN4277 | Isocupressic acid | cAMP; P450; PKA | GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors |
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce |