Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ulipristal 是性孕酮受体 (progesterone receptor) 的选择性调节剂。它能够与孕激素受体结合,抑制 PR 介导的基因表达,降低生殖系统中孕激素的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 327 | 现货 | ||
2 mg | ¥ 469 | 现货 | ||
5 mg | ¥ 775 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,260 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,450 | 现货 | ||
500 mg | ¥ 11,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 987 | 现货 |
产品描述 | Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure. |
体外活性 | Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.[1] |
体内活性 | Based on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception. [2][3] |
分子量 | 433.58 |
分子式 | C28H35NO3 |
CAS No. | 159811-51-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/mL (177.6 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 12 mg/mL (27.7 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.3064 mL | 11.5319 mL | 23.0638 mL | 57.6595 mL |
5 mM | 0.4613 mL | 2.3064 mL | 4.6128 mL | 11.5319 mL | |
10 mM | 0.2306 mL | 1.1532 mL | 2.3064 mL | 5.7659 mL | |
20 mM | 0.1153 mL | 0.5766 mL | 1.1532 mL | 2.883 mL | |
DMSO | 50 mM | 0.0461 mL | 0.2306 mL | 0.4613 mL | 1.1532 mL |
100 mM | 0.0231 mL | 0.1153 mL | 0.2306 mL | 0.5766 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ulipristal 159811-51-5 Endocrinology/Hormones Others Estrogen/progestogen Receptor Progesterone Receptor emergency Deacetyl CDB2914 inhibit contraception CDB 3236 CDB3236 Deacetyl CDB 2914 NR3C3 leiomyoma anti-progestational Inhibitor CDB-3236 uterine Deacetyl CDB-2914 anti-glucocorticoid anti-fertility inhibitor