68
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15500 |
HPi1
|
Others; Antibacterial | Microbiology/Virology; Others |
HPi1 是一种有口服活性的,针对幽门螺杆菌的选择性抗菌剂,IC50为 0.24 μM,MIC 为 0.08-0.16 μg/mL。 | |||
T38612 |
Linaprazan glurate
|
Others | Others |
Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。 | |||
T5051 |
Isopropamide Iodide
|
AChR | Neuroscience |
Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病,尤其是胃酸过多和运动过度。 | |||
T6710 |
Troxipide
曲昔派特,曲昔匹特,Aplace |
Others | Others |
Troxipide (Aplace) 是非分泌型胃保护剂,是口服具有活力的胃炎和胃溃疡的防御因子的增强剂,具有抗溃疡、抗炎和粘液分泌作用。 | |||
T0044 |
Oxethazaine
奥昔卡因,Oxetacaine |
HBV; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Oxethazaine (Oxetacaine) 是一种具有耐酸性和口服活性试剂,是芬特明的酸性前体,有潜力缓解消化性溃疡疾病或食管炎引起的疼痛。 | |||
T1562 |
Rebamipide
Proamipide,OPC12759,瑞巴派特 |
Free radical scavengers; COX; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction |
Rebamipide (OPC12759) 是一种粘膜保护剂,可诱导COX-2表达,增加PGE2水平,并以 COX-2 依赖性方式增强胃粘膜防御。 | |||
T0157 |
Roxatidine Acetate hydrochloride
HOE 760,盐酸罗沙替丁醋酸酯,Roxatidine Acetate HCl |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Roxatidine Acetate hydrochloride (HOE 760) 是一种特异性和竞争性的组胺 H2 受体拮抗剂,能抑制胃酸分泌,可用于胃溃疡和十二指肠溃疡的研究。 | |||
TP1035 |
Cyclic somatostatin
SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14 |
Others | Others |
Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子,可用于研究胃十二指肠溃疡出血。 | |||
T6928 |
Pantoprazole
SKF96022,泮托拉唑,BY1023 |
Apoptosis; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。 | |||
T21254 |
Vonoprazan Fumarate
TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂,是口服有效的高效钾竞争性酸阻断剂,具有抗分泌活性。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50为 19 nM。它被开发用于研究酸相关疾病,如消化性溃疡和胃食管反流病。 | |||
T8388 |
Vonoprazan
TAK-438 (free base),沃诺拉赞 |
Proton pump | Membrane transporter/Ion channel |
Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂,是口服活性钾竞争性酸阻断剂,有抗分泌作用。在 pH 为 6.5 时,它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性,IC50值为 19 nM。它可用于研究胃酸相关疾病。 | |||
T19763 |
Cetraxate hydrochloride
DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006 |
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
Cetraxate hydrochloride (DV10062) 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂,Ki 和 IC50分别为 0.94 μM 和 3.3 μM。它是一种口服有活性的抗溃疡试剂 (anti-ulcer),具有粘膜保护作用,可用于研究胃溃疡。 | |||
T0161 |
Pantoprazole Sodium Hydrate
SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) |
Apoptosis; Potassium Channel; Proton pump; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑,是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T6929 |
Pantoprazole sodium
Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc |
Apoptosis; Others; Proton pump; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others |
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。 | |||
T10124 |
Antiulcer Agent 1
|
Others | Others |
Antiulcer Agent 1 是一种用于口服给药的 2-(3,4-二甲氧基苯基)乙胺衍生物。 | |||
T76577 |
Antiulcer Agent 2
|
||
Antiulcer Agent 2 是一种四肽,组成包括天冬氨酸、丙氨酸、组氨酸和赖氨酸,存在于人白蛋白N端,并在溃疡及活性氧生成中显示出潜在应用。 | |||
T28665 |
Saviprazole
Hoe731,Hoe 731,Hoe-731 |
Proton pump | Membrane transporter/Ion channel |
Saviprazole (Hoe-731) 是一种质子泵抑制剂,可用于治疗胃溃疡。 | |||
T5008 |
Teprenone
Tetraprenylacetone,Geranylgeranylacetone,替普瑞酮 |
HSP | Cytoskeletal Signaling; Metabolism |
Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂,有抗溃疡作用。 | |||
T12215 |
Nexopamil racemate
(Rac)-Nexopamil |
Calcium Channel; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nexopamil racemate((Rac)-Nexopamil) 是 Nexopamil 的外消旋体。Nexopamil racemate 具有潜在的抗哮喘和抗溃疡活性。 | |||
T31195 |
Dalcotidine
KU 1257,KU-1257 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Dalcotidine (KU 1257) 是一种新型组胺H2受体拮抗剂,具有组胺H9受体拮抗活性和抗分泌作用,与豚鼠大脑皮层结合的Ki 值为0.040 对分离性豚鼠右心房组胺诱导的正变时反应的拮抗作用的KB 值为0.041。Dalcotidine 提高了溃疡愈合的质量,可能有助于降低溃疡的复发率和复发率。 | |||
T29015 |
Trithiozine
Tresanil,Sulmetozine,Tritiozinum,舒美吗啉,Tritiozine,Tritiozina |
Others | Others |
Trithiozine (Tritiozinum) 具有抗分泌和抗溃疡能力。 Trithiozine 可用于治疗消化性溃疡病和高分泌障碍的研究。 | |||
T6548 |
Irsogladine
Dicloguamine,伊索拉定 |
PDE; AChR | Metabolism; Neuroscience |
Irsogladine (Dicloguamine) 是抗胃溃疡剂,通过 M1 毒蕈碱乙酰胆碱受体结合促进间隙连接细胞间通讯。 | |||
T4510 |
Polaprezinc
Zinc L-carnosine,聚普瑞锌,L-肌肽锌 |
Others | Others |
Polaprezinc是一种含有锌和L-carnosine的生物可用螯合物,以其胃肠保护性能、抗溃疡、抗氧化和抗炎效果而闻名。 | |||
T6349 |
Sitafloxacin Hydrate
西他沙星水合物,DU-6859a,DU6859a hydrate |
Antibacterial; Antibiotic | Microbiology/Virology |
Sitafloxacin Hydrate (DU-6859a) 是一种口服有效的氟喹诺酮类抗生素,在体外可对抗广泛的革兰氏阳性和阴性细菌有活性。Sitafloxacin 可研究呼吸道感染和尿路感染。 | |||
T77618 |
COX-2-IN-34
|
COX | Immunology/Inflammation; Neuroscience |
COX-2-IN-34 是一种选择性的、口服有效的 COX-2 抑制剂,在小鼠实验过程中显示出抗炎活性且无胃溃疡毒性。 | |||
T1639 |
Amlexanox
氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673 |
IL Receptor; FGFR; Others; IκB/IKK | Angiogenesis; Immunology/Inflammation; NF-κB; Others; Tyrosine Kinase/Adaptors |
Amlexanox (AA673) 是一种特异性的 IKKε和 TBK1抑制剂,其 IC50=1-2 μM。 | |||
T62396 |
KB-5492 free base
|
||
KB-5492 free base 是一种有效的和选择性的sigma 受体抑制剂,抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 与sigma 受体结合,IC50值为 3.15 μM。KB-5492 free base 是一种抗溃疡剂。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T1756L |
Ilaprazole
IY81149,艾普拉唑,IY 81149,IY-81149 |
Proton pump; TOPK | MAPK; Membrane transporter/Ion channel |
Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制H+/K+-ATPase,在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂,用于胃溃疡的研究。 | |||
T10872L |
CP 96021
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
CP 96021是一组5-HT1受体和5-HT2受体拮抗剂,具有抗炎特性,是治疗胃肠道和呼吸道哮喘的非自身抗溃疡化合物。 | |||
T77617 |
MMP-9-IN-6
|
MMP | Proteases/Proteasome |
MMP-9-IN-6 是一种 MMP-9 抑制剂,其 IC50 值为50 μM, 具有较好的抗溃疡功效。MMP-9-IN-6 具有潜在的抗肿瘤活性,可用于研究组织重塑、伤口修复和动脉粥样硬化。 | |||
T21385 |
Cinitapride
西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动,以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。 | |||
T0786 |
Clidinium bromide
克利溴铵,Ro 2-3773 |
AChR | Neuroscience |
Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 | |||
T24728 |
Rosaprostol
C 83 |
||
Rosaprostol is an agent of the anti-ulcer drug. | |||
T33710 |
Nocloprost
|
||
Nocloprost is a prostaglandin E2 analog with local gastroprotective and ulcer-healing activity. | |||
T32599 |
Lauroylglycyrrhetinic acid
BX 24,BX24,BX-24 |
||
Lauroylglycyrrhetinic acid, an analog of carbenoxolone, can be used in the treatment of stomach ulcer. | |||
T23725 | Amicoumacin A | ||
Amicoumacin A has antibacterial activity. It also strongly suppresses inflammatory and ulcer activity. | |||
T10008 | BTM-1086 | Others | Others |
BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent. | |||
T34087 |
Plaunotol
Kelnac,Plaunotolum |
||
Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing. | |||
T34936 |
Tridihexethyl chloride
Propethonum,Pathilon,Tridihexethyl |
||
Tridihexethyl is an anticholinergic, antimuscarinic, and antispasmolytic drug, which can be used to treat acquired nystagmus or peptic ulcer disease. | |||
T68200 |
Roxatidine hydrochloride
|
||
Roxatidine hydrochloride is an anti-ulcer agent and histamine antagonist that suppresses gastric acid secretion. It effectively heals duodenal and gastric ulcers and reduces ulcer pain. Roxatidine acetate has an improved safety profile compared to other similar drugs, in part because lower doses of roxatidine acetate are therapeutically effective. | |||
T69801 | AU-461 | ||
AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent. | |||
T31743 |
Famotine hydrochloride
Famotine HCl,UK-2054 |
||
Famotine Hydrochloride is a histamine H2 receptor antagonist that suppresses acid production in the stomach and commonly treats peptic ulcer disease and gastroesophageal reflux disease. | |||
T69805 | AU-006 | ||
AU-006 is an anti-ulcer drug which is effective in the treatment of gastric ulcers by inhibiting gastric acid secretion. | |||
T28613 |
RP73870
RP 73870,RP-73870 |
||
RP73870 is a gastrin/cholecystokinin-B receptor antagonist and H2 receptor antagonist with potent anti-ulcer activity. | |||
T24254 |
KB-5492 anhydrous
KB-5492,KB5492,KB 5492 |
||
KB 5492 is an agent of anti-ulcer. It preventing cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion. | |||
T19929 |
Ranitidine-S-oxide
|
||
Ranitidine-S-oxide is a metabolite of Ranitidine. It is commonly used in the treatment of peptic ulcer disease, Zollinger–Ellison syndrome,and gastroesophageal reflux disease. | |||
T70127 |
Famotine
|
||
Famotine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T70090 |
Nizatidine amide
|
||
Nizatidine amide is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. | |||
T71049 | Famotidine disulfide | ||
Famotidine disulfide is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3605 |
Gastrodenol
Bismuth tripotassium dicitrate,枸橼酸铋钾,Bismuth subcitrate |
Others | Others |
Gastrodenol (Bismuth tripotassium dicitrate) 是一种对溃疡和胃不适具有潜在的应用价值的药物。 | |||
T2833 |
Dehydrocostus Lactone
Epiligulyl oxide,去氢木香内酯,(-)-Dehydrocostus lactone,去氢木香烃内酯 |
IκB/IKK | NF-κB |
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) 是一种倍半萜内酯,从云木香中分离得到。 | |||
TN6577 |
Bletilloside A
3-Methoxyshancigusin I |
Others | Others |
Bletilloside A(3-Methoxyshancigusin I) 是从条纹苜蓿的块茎中分离出一种新型葡萄糖苷,具有抗胃溃疡活性。 | |||
TN1568 |
Deoxyartemisinin
2-deoxyartemisinin |
||
Deoxyartemisinin (2-deoxyartemisinin) 是一种口服有效的抗炎和抗溃疡化合物,可从青蒿素青蒿中分离得到。 | |||
T21651 |
Lansoprazole sodium
兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium |
Proton pump; Phospholipase; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂,是中性鞘磷脂酶的外泌体抑制剂,能抑制胃酸生成。 | |||
TN2233 |
Spathulenol
|
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Spathulenol 是一种来自 Aristolochia yunnanensis 的天然成分,具有抗炎、抗氧化、抗增殖、抗溃疡和抗分枝杆菌活性。 Spathulenol 在 DPPH 系统中显示出显著的抗氧化活性,IC50 为 85.60 μg/mL。 | |||
T12681 |
(±)-Vasicine
(±)-Peganine |
Others | Others |
(±)-Vasicine is the racemate of Vasicine. Vasicine isolated from Peganum harmala seeds, with anti-ulcer activity. | |||
TN1893 | Luteolin-3',7-di-O-glucoside | Others | Others |
Luteolin-3',7-di-O-glucoside has anti-ulcer and antioxidant activities. | |||
TN3852 |
Dihydrolicoisoflavone
|
Antifection | Microbiology/Virology |
Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN1302 |
6,8-Diprenylorobol
6,8-二异戊烯基香豌豆苷元 |
Others; HIV Protease; Antifection | Microbiology/Virology; Others; Proteases/Proteasome |
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN3926 | Eicosanyl caffeate | Others | Others |
Eicosanyl caffeate has anti-ulcer and moderate antioxidant properties, it exhibits potent elastase inhibitory activity, with the IC(50) value of 0.99 microg/mL. | |||
TN1913 |
Marmin
|
Calcium Channel; Antifection; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine. | |||
T73653 |
Pexiganan
|
||
Pexiganan(MSI 78 free base),maganin 2 的合成类似物,是一种具有口服活性的广谱强效抗菌肽,主要用于研究糖尿病足溃疡等相关感染。 | |||
TN4322 |
Isopulegol
|
ATPase; Potassium Channel; GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isopulegol presents depressant- and anxiolytic-like effects, it also has anticonvulsant and bioprotective effects against PTZ-induced convulsions are possibly related to positive modulation of benzodiazepine-sensitive GABAA receptors and to antioxidant properties.Isopulegol presents significant gastroprotective effects in both ethanol- and indomethacin-induced ulcer models, which appear to be mediated, at least in part, by endogenous prostaglandins, K(ATP) channel opening, and antioxidant proper... | |||
TN4223 |
Homopterocarpin
|
Antifection | Microbiology/Virology |
Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property |