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314

抑制剂 & 化合物

62

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38236	2′-Deoxy-2′-fluoroguanosine	Nucleoside Antimetabolite/Analog; Influenza Virus	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	2′-Deoxy-2′-fluoroguanosine 是一种核苷类似物，有效抑制流感病毒，抑制A 型和B 型流感病毒的EC90值 <0.35 μM。2′-Deoxy-2′-fluoroguanosine 显著抑制流感病毒在上呼吸道中的复制，从而改善鼻腔炎症和发烧。
T9318	TP0586532	Others	Others
	TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。
T22287	Cefteram pivoxil 头孢特仑新戊酯,Ro 19-5248,T-2588	Antibacterial; Antibiotic	Microbiology/Virology
	Cefteram pivoxil (T-2588) 是一种口服头孢菌素抗生素，可治疗细菌感染。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T5325	Nifurtimox 硝呋替莫,BAY-2502,BAY-A-2502	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	Nifurtimox (BAY-A-2502) 是一种用于锥虫病的抗虫剂，可影响乳酸脱氢酶活性。它有潜力研究神经母细胞瘤细胞。
T10378	Artelinic acid	Others	Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.
T6349L	Sitafloxacin DU6859,DU 6859,DU 6859A,Sitafloxacin anhydrous,DU-6859,DU6859A,DU-6859A,西他沙星
	Sitafloxacin, a new generation of broad-spectrum oral fluoroquinolones, is highly effective against many Gram-positive, Gram-negative, and anaerobic clinical isolates (including strains resistant to other fluoroquinolones).
T10903	CWHM-1552	Parasite	Microbiology/Virology
	CWHM-1552 是一种有效的恶性疟原虫抑制剂。对于 3D7 和 Dd2 菌株，IC50 分别为 51 nM 和 53 nM。
T29187	YM-53403
	YM-53403是具有抗病毒活性，可有效抑制属于A 亚群和B 亚组的RSV 毒株的复制，可用来治疗呼吸道合胞病毒感染。
T7804	Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)	Antibacterial	Microbiology/Virology
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮，具有强抗菌活性，抗呼吸道病原体。
T9580	SB-734117	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	SB-734117 抑制几种 HCMV 菌株的生产性复制。 SB-734117 表现出多种药理作用，是 AGC 和 CMCG 激酶组中几种蛋白质的抑制剂。
T7342	BM212	Antibacterial	Microbiology/Virology
	BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌，抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。
T10329	anti-TB agent 1	Antibiotic	Microbiology/Virology
	anti-TB agent 1是一种有效的口服活性抗结核化合物，对结核分枝杆菌H37Rv、rRMP 和rINH 的MICs＜2nM。
T10356	AQ-13 dihydrochloride	Parasite	Microbiology/Virology
	AQ-13 dihydrochloride 是一种氨基喹啉类抗疟药，对耐药型菌株 Plasmodium falciparum 有抑制作用。
T19825	X-alpha-Gal	Others	Others
	X-alpha-Gal 是 α-半乳糖苷酶的底物。它用于区分酵母的α-半乳糖苷酶阳性菌株。
T1610	Metaxalone Skelaxin,Methaxalonum,美他沙酮,Zorane,NSC170959,AHR438	Others	Others
	Metaxalone (Methaxalonum) 具有肌肉松弛作用。
T14324	Artemisone BAY 44-9585,Artemifone,青蒿酮	Others; Parasite	Microbiology/Virology; Others
	Artemisone (BAY 44-9585) 是一种半合成的有效抗疟疾剂，还是一种人CMV 的有效抑制剂，可抑制多种P. falciparum，平均IC50值为 0.83 nM。
T4063	Delafloxacin ABT492,WQ-3034,德拉沙星,RX-3341	Antibacterial; Antibiotic	Microbiology/Virology
	Delafloxacin (WQ-3034) 是一种广谱氟喹诺酮类抗生素，抑制耐药性的金黄色葡萄球菌，肺炎链球菌和肺炎克雷伯菌。
T8701	GRP-60367	Others	Others
	GRP-60367 是一种小分子狂犬病病毒进入抑制剂，对某些 RABV 株具有纳摩尔作用效果。
T7897	PK150	Others; Antibacterial	Microbiology/Virology; Others
	PK150 是一种 Sorafenib 类似物，具有抗菌活性。它抑制甲氧西林敏感金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，万古霉素中介金黄色葡萄球菌的 MIC 分别为 0.3，0.3-1，0.3 µM。
T8620	piperacillin Pipril,Pipracil,哌拉西林,Pipercillin	Antibacterial	Microbiology/Virology
	Piperacillin (Pipercillin) 是半合成青霉素，可以作用于革兰氏阳性和革兰氏阴性需氧和厌氧菌。与其他青霉素相比，它对产生 β-内酰胺酶的菌类表现出更强的活性。
T72037	Anti-Influenza agent 4	Influenza Virus	Microbiology/Virology
	Anti-Influenza agent 4 是一种有效且具有选择性的流感病毒抑制剂，对A/Parma 和 A/Roma 毒株具有抑制作用， EC50 分别为 62 nM 和150 nM。
T28946	Tenofovir exalidex Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157	Antiviral	Immunology/Inflammation
	Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物，对野生型和抗逆转录病毒耐药的 HIV 毒株，包括多药核苷/核苷酸类似物耐药病毒，都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性，EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性，无明显毒性。Tenofovir exalidex 对 HBV 也有活性。
T22438	Tetramethylthiuram monosulfide 一硫化四甲基秋兰姆,TMTM	Others	Others
	Tetramethylthiuram monosulfide 被广泛用作橡胶加工技术中的催化剂，它具有中等毒性，并在菌株 TA 100 和 TA 1535（鼠伤寒沙门氏菌 LT 2）中引起点突变。
T6549	Isepamicin sulfate Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate	Antibacterial; Antibiotic	Microbiology/Virology
	Isepamicin sulfate (sch21420) Sulphate) 是一种广谱氨基糖苷类抗生素，对产生 I 型 6-乙酰转移酶的菌株具有良好的活性，通过靶向细菌 30S 核糖体亚基来抑制细菌蛋白质合成。
T0170	Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (9CI) phosphonomycin calcium,Fosfomycin calcium,磷霉素钙,phosphomycin calcium	Antibiotic	Microbiology/Virology
	Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (9CI) (phosphonomycin calcium)是一种抗生素，用于治疗敏感菌株引起的尿路感染和肠道感染。
T3114	Povidone iodine Betadine,聚乙烯吡酮磺,Povidone-iodine,聚乙烯吡咯烷酮碘,Isodine,PVP iodine,iodopovidone,PVP-I	Antibacterial; Antibiotic	Microbiology/Virology
	Povidone iodine (Povidone-iodine) 有很强的抗细菌活性, 可杀死 MRSA 和 MSSA 菌株，其 MICs 值分别为 31.25 mg/L 和7.82 mg/L。
T14489	Azvudine 4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622	HCV Protease; HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI)，对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株，高效抑制 HIV-1和 HIV-2。
TP1364L	ALX 40-4C acetate ALX 40-4C acetate(143413-49-4 free base)	Apelin receptor; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	ALX 40-4C acetate 是趋化因子受体 (Ki = 1 μM) 的 CXCR4 抑制剂，可抑制 HIV-1 X4 株的复制。 ALX 40-4C acetate 是 APJ 受体的拮抗剂 (IC50 = 2.9 μM)。
T17210L	Vaborbactam ammonium salt RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）	Antibacterial	Microbiology/Virology
	Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂，可以恢复碳青霉烯类药物对 KPC 生产菌株的活性，常与其它药物连用来研究真菌感染。
T12154L	N-Desethyl amodiaquine dihydrochloride	Parasite	Microbiology/Virology
	N-Desethyl amodiaquine dihydrochloride 是一种抗寄生虫剂，是主要的生物活性阿莫地喹代谢物。它对菌株 V1/S 和 3D7 的 IC50值分别为 97 nM 和 25 nM。
T0331L	Moxifloxacin Avelox,Moxeza,莫西沙星	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Moxifloxacin (Avelox) 是一种8-甲氧基喹诺酮类口服有效抗菌药物，用于急性细菌性鼻窦炎，慢性支气管炎的急性细菌性加重和感染性肺炎的研究。
T1312	Nafcillin sodium monohydrate CL 8491,萘夫西林钠,nafcillin sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Nafcillin sodium monohydrate (CL 8491) 是一种抗生素，是可逆的β-lactamase 抑制剂。它用于治疗由耐青霉素的葡萄球菌菌株引起的感染。
T11815	Lanopepden GSK 1322322,GSK-1322322B,GSK-1322322J	Antibiotic	Microbiology/Virology
	Lanopepden (GSK 1322322) 是一种有效的肽去甲酰酶抑制剂，抑制金黄色葡萄球菌，抑制 ATCC 29213 和 ATCC 25923 菌株，可用于研究肺炎、皮肤病和传染病。
T36692	Fanotaprim	DHFR	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。
T9449	Nitrofural [(E)-(5-nitrofuran-2-yl)methylideneamino,(E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺	Antibacterial	Microbiology/Virology
	Nitrofural 是 20 世纪已在临床应用中确立的硝基呋喃。 Nitrofural 在临床上对广泛的革兰氏阳性和革兰氏阴性细菌（包括许多常见的泌尿道病原体菌株）仍然有效。
T2162	Maribavir BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Maribavir (GW257406X) 是一种可口服的苯并咪唑核苷化合物，具有抗巨细胞病毒的活性。
T11888	LtaS-IN-1	Others; Antibacterial	Microbiology/Virology; Others
	LtaS-IN-1 是多药耐药粪肠球菌中脂磷壁酸合成的有效抑制剂，可改变细胞壁形态。 LtaS-IN-1 对抗肠球菌属 28 菌株，MIC 值从 0.5 μg/mL 到 64 μg/mL 不等。 LtaS-IN-1 抑制菌株 E1630 和 E1590，MIC 值为 0.5 μg/mL。
Fr13587	7-Chloro-4-(piperazin-1-yl)quinoline
	7-Chloro-4-(piperazin-1-yl)quinolone 结构是药物化学中的重要支架，它单独或与其他活性药效团混合显示出多种药理特性。7-Chloro-4-（piperazin-1-yl）quinolone 是有效的sirtuin 抑制剂，并且抑制 5-羟色胺的摄取，IC50值为 50 μM。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性，IC50分别为 1.18 μM 和 0.97 μM。
T18928	Brilliant Black BN 亮黑1,E 151	Others; Virus Protease	Microbiology/Virology; Others
	Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用，是一种很有前途的抗 EV71 感染的抗病毒药物。
T13284L	Vapendavir BTA798	Others	Others
	Vapendavir is a potent enteroviral capsid binder. Vapendavir has an effective antiviral activity for enterovirus 71 replication (EC50: 0.5-1.4 μM in different EV71 strains).
T13284	Vapendavir diphosphate BTA798 diphosphate	Others	Others
	Vapendavir diphosphate is a potent enteroviral capsid binder (CB) and has a potent antiviral activity for enterovirus 71 (EV71) replication (EC50: 0.5-1.4 μM in different EV71 strains).
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T32395	Kidamycin Iyomycin-F
	Kidamycin, obtained from Streptomyces phaeoverticillatus strains, can interfere with RNA synthesis.
T33690	Nitroscanate Lopatol,CGA-23654GS,CGA 23654
	Nitroscanate is an anthelmintic found to be effective in certain strains of parasites in canines.
T39323	Temporin L
	Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties.
T40329	Antifungal agent 14
	Antifungal agent 14 demonstrates potent broad-spectrum antifungal activity, effectively targeting a variety of fungal strains with exceptional minimum inhibitory concentration values.
T26116	Rokitamycin
	Rokitamycin is a macrolide antibiotic produced from strains of Streptomyces kitasatoensis.
T10902	CWHM-1008	Others	Others
	CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.
T25624	Lankamycin Kujimycin B,A20338-N2,Antibiotic A-20338-N2,A-20338-N2,A 20338-N2
	Lankamycin is a macrolide antibiotic from various strains of Streptomyces. It may have significant activity against some Gram positive bacteria.

化合物

2′-Deoxy-2′-fluoroguanosine

Cat.No: T38236

Target: Nucleoside Antimetabolite/Analog, Influenza Virus

Cat.No: T9318

Target: Others

Cefteram pivoxil

Cat.No: T22287

Synonym: 头孢特仑新戊酯,Ro 19-5248,T-2588

Target: Antibacterial, Antibiotic

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

Cat.No: T5325

Synonym: 硝呋替莫,BAY-2502,BAY-A-2502

Target: Dehydrogenase, Parasite

Cat.No: T10378

Target: Others

Cat.No: T6349L

Synonym: DU6859,DU 6859,DU 6859A,Sitafloxacin anhydrous,DU-6859,DU6859A,DU-6859A,西他沙星

Cat.No: T10903

Target: Parasite

Cat.No: T29187

Garenoxacin mesylate hydrate

Cat.No: T7804

Synonym: Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)

Target: Antibacterial

Cat.No: T9580

Target: HCV Protease

Cat.No: T7342

Target: Antibacterial

anti-TB agent 1

Cat.No: T10329

Target: Antibiotic

AQ-13 dihydrochloride

Cat.No: T10356

Target: Parasite

Cat.No: T19825

Target: Others

Cat.No: T1610

Synonym: Skelaxin,Methaxalonum,美他沙酮,Zorane,NSC170959,AHR438

Target: Others

Cat.No: T14324

Synonym: BAY 44-9585,Artemifone,青蒿酮

Target: Others, Parasite

Cat.No: T4063

Synonym: ABT492,WQ-3034,德拉沙星,RX-3341

Target: Antibacterial, Antibiotic

Cat.No: T8701

Target: Others

Cat.No: T7897

Target: Others, Antibacterial

Cat.No: T8620

Synonym: Pipril,Pipracil,哌拉西林,Pipercillin

Target: Antibacterial

Anti-Influenza agent 4

Cat.No: T72037

Target: Influenza Virus

Tenofovir exalidex

Cat.No: T28946

Synonym: Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157

Target: Antiviral

Tetramethylthiuram monosulfide

Cat.No: T22438

Synonym: 一硫化四甲基秋兰姆,TMTM

Target: Others

Isepamicin sulfate

Cat.No: T6549

Synonym: Isepamicine (Isepamycin,硫酸异帕米星,Isepamicin Sulphate,Isepacin,sch21420) Sulphate

Target: Antibacterial, Antibiotic

Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, calcium salt (9CI)

Cat.No: T0170

Synonym: phosphonomycin calcium,Fosfomycin calcium,磷霉素钙,phosphomycin calcium

Target: Antibiotic

Povidone iodine

Cat.No: T3114

Synonym: Betadine,聚乙烯吡酮磺,Povidone-iodine,聚乙烯吡咯烷酮碘,Isodine,PVP iodine,iodopovidone,PVP-I

Target: Antibacterial, Antibiotic

Cat.No: T14489

Synonym: 4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622

Target: HCV Protease, HBV, HIV Protease, Reverse Transcriptase

ALX 40-4C acetate

Cat.No: TP1364L

Synonym: ALX 40-4C acetate(143413-49-4 free base)

Target: Apelin receptor, CXCR

Vaborbactam ammonium salt

Cat.No: T17210L

Synonym: RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）

Target: Antibacterial

N-Desethyl amodiaquine dihydrochloride

Cat.No: T12154L

Target: Parasite

Cat.No: T0331L

Synonym: Avelox,Moxeza,莫西沙星

Target: Others, Antibacterial, Antibiotic

Nafcillin sodium monohydrate

Cat.No: T1312

Synonym: CL 8491,萘夫西林钠,nafcillin sodium

Target: Antibacterial, Antibiotic

Cat.No: T11815

Synonym: GSK 1322322,GSK-1322322B,GSK-1322322J

Target: Antibiotic

Cat.No: T36692

Target: DHFR

Cat.No: T9449

Synonym: [(E)-(5-nitrofuran-2-yl)methylideneamino,(E)-2-((5-硝基呋喃-2-基)亚甲基)肼甲酰胺

Target: Antibacterial

Cat.No: T2162

Synonym: BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94

Target: Others, HCV Protease

Cat.No: T11888

Target: Others, Antibacterial

7-Chloro-4-(piperazin-1-yl)quinoline

Cat.No: Fr13587

Brilliant Black BN

Cat.No: T18928

Synonym: 亮黑1,E 151

Target: Others, Virus Protease

Cat.No: T13284L

Synonym: BTA798

Target: Others

Vapendavir diphosphate

Cat.No: T13284

Synonym: BTA798 diphosphate

Target: Others

Cat.No: T71856

Cat.No: T32395

Synonym: Iyomycin-F

Cat.No: T33690

Synonym: Lopatol,CGA-23654GS,CGA 23654

Cat.No: T39323

Antifungal agent 14

Cat.No: T40329

Cat.No: T26116

Cat.No: T10902

Target: Others

Cat.No: T25624

Synonym: Kujimycin B,A20338-N2,Antibiotic A-20338-N2,A-20338-N2,A 20338-N2

Cat. No.	Product Name	Target	Signaling Pathways
T13750	L-Fucitol L-岩藻糖醇,1-Deoxy-D-galactitol	Others	Others
	L-Fucitol (1-Deoxy-D-galactitol) 是一种糖醇，从肉豆蔻 (Nutmeg) 中分离得到。
TN1527	(-)-Corynoxidine Corynoxidine	Antibacterial; AChE; Antifection	Microbiology/Virology; Neuroscience
	(-)-Corynoxidine 是一种源自 Stephania succifera 块茎的 AChE 抑制剂。 Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌具有不同程度的抗菌活性。
TN3694	Coniferaldehyde	NOS; COX; Nrf2; PKC; Autophagy	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience
	Coniferaldehyde 能显着抑制酒球菌菌株的生长活力。 Coniferaldehyde 通过诱导血红素加氧酶 1 (HO-1) 发挥抗炎特性。
TN3748	D-Asparagine D-天冬酰胺,H-D-Asn-OH	Others; Endogenous Metabolite	Metabolism; Others
	D-Asparagine (H-D-Asn-OH) 是酵母菌株的氮源。 D-Asparagine 是 L-Asparagine 水解的竞争性抑制剂 (Ki = 0.24 mM)。
TN3790	Dehydroabietinol Pomiferin A,Dehydroabietyl alcohol	Antifection	Microbiology/Virology
	Dehydroabietinol (Pomiferin A) 在体外抑制红细胞中的氯喹敏感及氯喹抵抗型疟原虫，IC50为26-27 μM.
TN2730	2,5-Dihydroxybenzaldehyde Gentisaldehyde,2,5-二羟基苯甲醛	Anti-infection; Antibacterial	Microbiology/Virology
	2,5-Dihydroxybenzaldehyde (Gentisaldehyde) 是一种天然抗微生物剂，可抑制Mycobacterium avium subsp. paratuberculosis 的生长。它还抑制金黄色葡萄球菌菌株，MIC50为 500 mg/L。
TN1524	Continentalic acid	NOS; COX; Antibacterial; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Continentalic acid 是来自 Aralia continentalis 的，对金黄色葡萄球菌的 MIC 约为 8-16 µg/mL，包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。
T7910	4-Methoxybenzaldehyde 大茴香醛,Anisaldehyde,p-Anisaldehyde,Anisic aldehyde,4-Anisaldehyde,4-甲氧基苯甲醛,P-Methoxybenzaldehyde	Others; Endogenous Metabolite	Metabolism; Others
	4-Methoxybenzaldehyde (p-Anisaldehyde) 是一种天然存在的芳香酚类化合物，存在于许多植物物种中，包括辣根，茴香，八角茴香等。它是一种能够能的神经毒物，已经表现出致死亡率，吸引力和干扰宿主寻求的影响。
T3810	Saikosaponin B2 柴胡皂苷 B2,柴胡皂甙 B2	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Saikosaponin B2 是从柴胡根中分离得到的一种活性成分，可抑制 HCV 病毒感染的侵入，有抗癌作用。
T1100	Polymyxin B Sulfate Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX	Antibacterial; Antibiotic	Microbiology/Virology
	Polymyxin B Sulfate (Poly-RX) 是一个阳离子型表面活性剂抗生素剂，能够提高细胞膜的渗透性。
T8724	6-Methoxydihydrosanguinarine	Others	Others
	6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱，它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。
T4859	1-Monomyristin rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate	Others; FAAH; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal	Autophagy; Metabolism; Microbiology/Virology; Neuroscience; Others
	1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) 是从 Serenoa repens 中提取的，抑制脂肪酸酰胺水解酶活性(IC50=18 μM) 和 2-油酰甘油的水解 (IC50=32 μM)。它对白色念珠菌有抗真菌活性，对金黄色葡萄球菌和聚集性放线菌有抗菌活性。
TN1905	Magnolioside 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷	Antifection	Microbiology/Virology
	Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中，对谷氨酸诱导的毒性有显著的神经保护作用。它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性，对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。
TN3013	4,5-Dimethoxycanthin-6-one Methylnigakinone	P450; Antibacterial; PDE	Metabolism; Microbiology/Virology
	4,5-Dimethoxycanthin-6-one 从 Picrasma quassioides BENNET (Simaroubaceae)是一种从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到生物碱。4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂（IC50 ： 1.7 μM, Ki ： 2.6 μM），对环磷酸腺苷（cAMP）磷酸二酯酶有很强的抑制作用。4,5-Dimethoxycanthin-6-one 具有抗菌活性，对金黄色葡萄球菌及其耐药菌株有抑制作用。4,5-Dimethoxycanthin-6-one 对肿瘤细胞株 U937 和 HepG2 具有细胞毒性。
T36585	Isodeoxycholic Acid isoDCA	Chloride channel; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Isodeoxycholic Acid 是一种胆汁酸，由肠道细菌通过脱氧胆酸的表聚作用形成。Isodeoxycholic acid 的临界胶束浓度高于二氯苯甲醚，这表明它的去污活性降低了，而且在抑制七种肠道共生细菌生长方面的活性低于二氯苯甲醚。Isodeoxycholic Acid（0.1%）能抑制几种艰难梭菌菌株在牛磺胆酸诱导下的孢子萌发，并能降低艰难梭菌培养上清对 Vero 细胞的细胞毒性。在高脂饮食诱发肥胖的大鼠模型中，血浆中的Isodeoxycholic acid 水平比正常饮食的大鼠低。
TN4596	Musellactone	Antifection	Microbiology/Virology
	Musellactone shows different effects against five bacteria strains.
T12712	Reutericyclin Reutericycline	Others	Others
	Reutericyclin is a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri.
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
TN1906	Magnoloside A 厚朴苷A，木兰苷A	Antifection	Microbiology/Virology
	Magnoloside A has potent antifungal activities against various Cryptococcus strains with minimum inhibitory concentration values ranging from 1.0 to 4.0 ug/ml.
TN3921	Effusanin B	Antifection	Microbiology/Virology
	Effusanin B shows antibacterial activity. It exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
T3831	Licoricone	Antifection	Microbiology/Virology
	Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
TN2271	Thalrugosaminine	Antifection	Microbiology/Virology
	Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active against Mycobacterium smegmatis.
TN4944	Santamarine	Caspase	Apoptosis; Proteases/Proteasome
	Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis.
T16942	Sterigmatocystine	Others	Others
	Sterigmatocystine is an inhibitor of G1 Phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor.
TQ0072	Warangalone Scandenolone,攀登鱼藤异黄酮	PKA	Tyrosine Kinase/Adaptors
	Warangalone is an anti-malarial compound that can inhibit the growth of both strains of parasite 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively.
TMA2418	1-Methoxyphaseollidin	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	1-Methoxyphaseollidin exhibits anti-Helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. 1-Methoxyphaseollidin may show moderate cytotoxic activity against KB and L1210 cells. 1-Methoxyphaseollidin also shows inhibition of lysoPAF acetyltransferase activity.
T11509	Guanfu base H Atisinium chloride	Others	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN1814	Juncusol 6-甲基灯心草二酚,灯心草酚	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cells. Juncusol has anti-microbial activity, it shows significant activity against MRSA strains.
TN5012	Shizukaol C	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	1. Shizukaol C shows anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. <br/> 2. Shizukaol C has significant cytotoxicities against C8166 cells. <br/>
T79942	Terpenomycin
	Terpenomycin是从Nocardia分离物中提取的一种多烯化合物，具有细胞毒性和抗真菌活性。
TN2278	Torachrysone 决明柯酮	Antifection	Microbiology/Virology
	Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-
T13970	Xinjiachalcone A	Others	Others
	Xinjiachalcone A is a natural product isolated from Glycyrrhiza inflata Batalin. Xinjiachalcone A shows both a low MIC and a strong bactericidal activity against H. pylori(MIC : 12.5 to 50 µM, seventeen H. pylori strains).
TN1526	Corydalmine	P450; Antifection	Metabolism; Microbiology/Virology
	Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
TN4202	(-)-Heraclenol	Antifection	Microbiology/Virology
	(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.
T66935	1-Aminopropan-2-ol	Endogenous Metabolite	Metabolism
	1-Aminopropan-2-ol 参与枯草芽孢杆菌菌株中的苏氨酸代谢，可作为真菌培养基上的氮源。
T74200	Glicophenone
	Glicophenone 作为一种抗细菌(antibacterial)剂，对MRSA OM481、MRSA OM505、MRSA OM584、MRSA OM623 以及MSSA 209P的MIC值均为32 μg/mL。
TN4097	Gancaonin G	Antifection	Microbiology/Virology
	Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.
TN4387	Khellactone	Antifection	Microbiology/Virology
	Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM.
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
T82750	Cellooctaose
	Cellooctaose，由8个葡萄糖残基构成的低聚糖，作为低成本的多糖，在发酵中能促进重组乳酸菌的生长。
T22468	1-Deoxymannojirimycin hydrochloride	Others; Influenza Virus; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。
TN3995	Erythrabyssin II	Antifection	Microbiology/Virology
	Erythrabyssin II actives against several strains of Staphylococcus and Streptococcus with an MIC range of 0.78-1.56 microg/ml. It inhibits bacterial neuraminidase in a dose-dependent manner with significant inhibition (IC(50)=0.09-3.25 μM).
T62625	11-O-Methylpseurotin A
	11-O-Methylpseurotin A为一种(PKS/NRPS)混合聚酮合成酶-非核糖体肽合成酶化合物，其特性为选择性抑制Hof1缺失菌株。
T79943	6-C-Methylquercetin-3,4'-dimethyl ether	Antibiotic	Microbiology/Virology
	6-C-Methylquercetin-3,4'-dimethyl etheris 是一种黄酮醇衍生物，提取自Bauhinia thonningii Schum叶。本化合物对多重耐药的革兰氏阴性细菌及耐甲氧西林金黄色葡萄球菌（MRSA）表现出抗菌活性。
T36990	Moenomycin Complex
	Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases. [1] The minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.[1]
TN1728	Hellebrigenin	PARP; Akt; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes.
TN5245	Vitexolide D	Antifection	Microbiology/Virology
	Vitexolide D shows moderate antibacterial activity against a panel of 46 Gram-positive strains. It also shows cytotoxic activities against the HCT-116 cancer cell line and human fetal lung fibroblast MRC5 cell line (1 < IC50s < 10 uM).
T80351	Maximin 28
	Maximin 28为源自蟾蜍大脑的抗菌肽，对金黄色葡萄球菌(Staphylococcus aureus)、大肠杆菌(Escherichia coli)及枯草芽孢杆菌(Bacillus subtilis)表现出抗菌活性，其MIC值分别为4.7、9.4、75 μg/mL。
TN4319	Isopimaric acid	Antifection	Microbiology/Virology
	Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
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天然产物

Cat.No: T13750

Synonym: L-岩藻糖醇,1-Deoxy-D-galactitol

Target: Others

(-)-Corynoxidine

Cat.No: TN1527

Synonym: Corynoxidine

Target: Antibacterial, AChE, Antifection

Coniferaldehyde

Cat.No: TN3694

Target: NOS, COX, Nrf2, PKC, Autophagy

Cat.No: TN3748

Synonym: D-天冬酰胺,H-D-Asn-OH

Target: Others, Endogenous Metabolite

Dehydroabietinol

Cat.No: TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

2,5-Dihydroxybenzaldehyde

Cat.No: TN2730

Synonym: Gentisaldehyde,2,5-二羟基苯甲醛

Target: Anti-infection, Antibacterial

Continentalic acid

Cat.No: TN1524

Target: NOS, COX, Antibacterial, Prostaglandin Receptor

4-Methoxybenzaldehyde

Cat.No: T7910

Synonym: 大茴香醛,Anisaldehyde,p-Anisaldehyde,Anisic aldehyde,4-Anisaldehyde,4-甲氧基苯甲醛,P-Methoxybenzaldehyde

Target: Others, Endogenous Metabolite

Saikosaponin B2

Cat.No: T3810

Synonym: 柴胡皂苷 B2,柴胡皂甙 B2

Target: Others, HCV Protease

Polymyxin B Sulfate

Cat.No: T1100

Synonym: Aerosporin,硫酸多粘菌素 B,PMB,Polymyxin B sulphate,硫酸多粘菌素B,Polymyxin B sulfate (1404-26-8 free base),Poly-RX

Target: Antibacterial, Antibiotic

6-Methoxydihydrosanguinarine

Cat.No: T8724

Target: Others

Cat.No: T4859

Synonym: rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate

Target: Others, FAAH, Endogenous Metabolite, Antibacterial, Autophagy, Antifungal

Cat.No: TN1905

Synonym: 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷

Target: Antifection

4,5-Dimethoxycanthin-6-one

Cat.No: TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

Isodeoxycholic Acid

Cat.No: T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

Cat.No: TN4596

Target: Antifection

Cat.No: T12712

Synonym: Reutericycline

Target: Others

Cat.No: TN6010

Cat.No: TN1906

Synonym: 厚朴苷A，木兰苷A

Target: Antifection

Cat.No: TN3921

Target: Antifection

Cat.No: T3831

Target: Antifection

Thalrugosaminine

Cat.No: TN2271

Target: Antifection

Cat.No: TN4944

Target: Caspase

Sterigmatocystine

Cat.No: T16942

Target: Others

Cat.No: TQ0072

Synonym: Scandenolone,攀登鱼藤异黄酮

Target: PKA

1-Methoxyphaseollidin

Cat.No: TMA2418

Target: PAFR, Antifection

Cat.No: T11509

Synonym: Atisinium chloride

Target: Others

Cat.No: TN4716

Target: Influenza Virus

Cat.No: TN1814

Synonym: 6-甲基灯心草二酚,灯心草酚

Target: Caspase, Antifection

Cat.No: TN5012

Target: HIV Protease, Antifection

Cat.No: T79942

Cat.No: TN2278

Synonym: 决明柯酮

Target: Antifection

Xinjiachalcone A

Cat.No: T13970

Target: Others

Cat.No: TN1526

Target: P450, Antifection

Cat.No: TN4202

Target: Antifection

1-Aminopropan-2-ol

Cat.No: T66935

Target: Endogenous Metabolite

Cat.No: T74200

Cat.No: TN4097

Target: Antifection

Cat.No: TN4387

Target: Antifection

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

Cat.No: T82750

1-Deoxymannojirimycin hydrochloride

Cat.No: T22468

Target: Others, Influenza Virus, HIV Protease

Erythrabyssin II

Cat.No: TN3995

Target: Antifection

11-O-Methylpseurotin A

Cat.No: T62625

6-C-Methylquercetin-3,4'-dimethyl ether

Cat.No: T79943

Target: Antibiotic

Moenomycin Complex

Cat.No: T36990

Cat.No: TN1728

Target: PARP, Akt, CDK

Cat.No: TN5245

Target: Antifection

Cat.No: T80351

Isopimaric acid

Cat.No: TN4319

Target: Antifection

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