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54

抑制剂 & 化合物

9

天然产物

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Cat. No. Product Name Target Signaling Pathways
T7107 δ-Sleep Inducing Peptide

DSIP,Delta-Sleep Inducing Peptide,依米地肽

Antioxidant oxidation-reduction
δ-Sleep Inducing Peptide (DSIP) 是一种具有抗氧化和抗焦虑活性的神经肽。
T78005 δ-Sleep Inducing Peptide acetate

Delta-Sleep Inducing Peptide acetate

δ-Sleep Inducing Peptide acetate为具备抗氧化及抗焦虑功能的神经肽。
T82587 Delta (Phospho) Sleep Inducing Peptide

DSIP-P

Delta (Phospho) Sleep Inducing Peptide (DSIP-P) 是促进睡眠效应持久的多肽,能诱导大鼠昼夜运动行为的改变。
T7694 6-fluoro-DL-Tryptophan

5-HT Receptor GPCR/G Protein; Neuroscience
6-fluoro-DL-Tryptophan 是血清素 (5-HT) 合成的抑制剂。
T7413 JNJ-5207852

Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
JNJ-5207852 是一种新型的非咪唑组胺 H3 受体拮抗剂,其对大鼠和人 H3 受体的 pKi 值分别为 8.9 和9.24。
T36949 Niaprazine

5-HT Receptor; Adrenergic Receptor; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
Niaprazine 是有效的组胺 H1 受体拮抗剂,具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T16421 p-MPPI hydrochloride

5-HT Receptor GPCR/G Protein; Neuroscience
p-MPPI hydrochloride 是一种选择性的,具有高亲和力的5-HT1A 受体拮抗剂,能穿过血脑屏障,具有抗抑郁和抗焦虑样作用。
T8944 TTA-A2

Calcium Channel Membrane transporter/Ion channel; Metabolism
TTA-A2 是一种选择性 T 型钙通道拮抗剂,是一种有效的抗惊厥药,可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用,IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究,包括睡眠障碍和癫痫。
T12877L Seltorexant

JNJ-42847922

OX Receptor GPCR/G Protein; Neuroscience
Seltorexant (JNJ-42847922) 是一种可口服,高亲和性以及选择性的 orexin-2 受体(OX2R)拮抗剂,对人和大鼠中的 OX2R 的pKi 值分别为 8.0 和 8.1。它穿过血脑屏障,迅速占据大鼠大脑中的 OX2R 结合位点。
T8822 JNJ-5207852 dihydrochloride

Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
JNJ-5207852 dihydrochloride 是一种新型的非咪唑组胺 H3 受体拮抗剂,对大鼠和人类 H3受体的 pKi 值分别为 8.9 和 9.24。
T3722 MK-1064

Urokinase inhibitor 1,MK 1064

OX Receptor GPCR/G Protein; Neuroscience
MK-1064 (Urokinase inhibitor 1) 是一种选择性食欲素 2 (2-SORA)受体拮抗剂,可用于失眠患者的研究。
T33824 Orotirelin

CG 3509,Orotireline

Others Others
Orotirelin(CG 3509) 是促甲状腺激素释放激素类似物,可逆转了戊巴比妥诱导的睡眠时间。Orotirelin 可能对局灶性脑缺血的动物有益。
T63736 Bafrekalant

Others Others
Bafrekalant 是一种二氮杂双环取代的咪唑并[1,2-a]嘧啶衍生物。Bafrekalant 可用于研究阻塞性和中枢性睡眠呼吸暂停和打鼾等与睡眠相关的呼吸障碍类疾病。
T14974 Citenamide

Cytenamide,AY-15613

Others Others
Citenamide (AY-15613) 具有抗癌和抗惊厥活性,具有促进睡眠的作用,可用于研究神经系统疾病。
T24421 LY-2624803

DB-7,LY2624803,HY-10275,LY 2624803

5-HT Receptor; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
LY-2624803 是一种 5-HT2A 受体拮抗剂和组胺受体反向激动剂,可用于改善慢波睡眠。
T37979 N-Desmethyl Pimavanserin

AC-279

5-HT Receptor GPCR/G Protein; Neuroscience
N-Desmethyl Pimavanserin (AC-279) 是 Pimavanserin (一种 5-HT2A 受体反向激动剂)的活性代谢物,可用于治疗失眠等睡眠障碍。
T26559 ACT-462206

OX Receptor GPCR/G Protein; Neuroscience
ACT-462206 是一种可口服且可穿过血脑屏障的Orexin 1/Orexin 2 受体拮抗剂。ACT-462206 具有高效性,可用于研究睡眠和焦虑。
T3495 Tasimelteon

他司美琼,VEC-162,BMS-214778

Melatonin Receptor; MT Receptor GPCR/G Protein; Neuroscience
Tasimelteon (BMS-214778) 是一种褪黑激素受体激动剂,用于治疗盲人的非 24 小时睡眠-觉醒障碍。
T30188L1 (Iso)-Atagabalin HCl

(Iso)-Atagabalin HCl((Iso)-223445-75-8)

Others Others
(Iso)-Atagabalin HCl(isomer-Atagabalin HCl) 是一种可用于治疗非恢复性睡眠的α -2- δ配体。
TQ0023 Lorediplon

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Lorediplon 是一种新型催眠药物,作为 GABAA 受体调节剂,在 α1 亚基上具有差异活性,与促进睡眠有关。
T10002 (E)-Crotylbarbital

Kalypnon

Others Others
(E)-Crotylbarbital (Kalypnon) 是Crotylbarbital 的异构体,是一种巴比妥酸衍生物,具有镇静、催眠和抗惊厥的作用。(E)-Crotylbarbital 可用于促进精神安定和睡眠的研究。
T67966 Triflubazam

Triflubazam 具有广泛的生物活性,可影响睡眠,可用于治疗焦虑综合征和心理疾病。
T30188L Atagabalin HCl

PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base)

Calcium Channel Membrane transporter/Ion channel; Metabolism
Atagabalin HCl 是一种新型电压依赖性钙通道(VDCC)α2δ亚基(1 和 2)配体,会影响慢波睡眠,可用于治疗失眠。
T6552 Istradefylline

伊曲茶碱,KW-6002

Adenosine Receptor GPCR/G Protein; Neuroscience
Istradefylline (KW-6002) 是选择性的可口服的腺苷 A2A 受体拮抗剂,可用于研究药物滥用、睡眠障碍、肝损伤、帕金森病和不安腿综合征等的治疗和基础科学的试验。
T76867 Ravulizumab

ALXN1210

Complement System Immunology/Inflammation
Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体,它以高亲和力特异性结合人补体蛋白 C5,可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。
T34081 Piromelatine

NEU-P-11,NEU-P 11,NEU-P11

P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂,也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性,对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用,可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。
T22530 6-Chloromelatonin

Melatonin Receptor; Dopamine Receptor GPCR/G Protein; Neuroscience
6-Chloromelatonin 是一种有效的褪黑素受体 (melatonin receptor) 激动剂,是一种5-甲氧基吲哚化合物,可竞争兔视网膜中相同的突触前褪黑激素受体位点 ,可抑制[3H]多巴胺的钙依赖性释放 具有比褪黑素更高的代谢稳定性。6-Chloromelatonin 竞争 [3H] 褪黑素 与 MT2 受体结合 (pKi=9.77),可能用于研究与抑郁症相关的失眠和睡眠障碍。
T30629 Butoctamide semisuccinate

M 2H,Butoctamide hydrogen succinate,M-2H,M2H

Butoctamide semisuccinate enhances REM sleep in chronically prepared cats.
T36591 ABD459

ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM). It inhibits food consumption in nonfasted mice without affecting motor activity. ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep.
T37664 Emideltide (acetate)

Emideltide, also known as delta sleep-inducing peptide (DSIP), is a synthetic nonapeptide sedative.1
T68327 Dexnafenodone Free Base

Dexnafenodone Free Base is a potent inhibitor of noradrenaline, and to a lesser degree of serotonin reuptake, induced changes in the pattern of sleep which are comparable to those of non‐sedating tricyclic antidepressants.
T68685 Mioflazine hydrochloride

Mioflazine hydrochloride is a nucleoside transport inhibitor that acts on adenosine to improve sleep.
T16076 Mioflazine

Others Others
Mioflazine suppresses nucleoside uptake. Mioflazine is an orally active nucleoside transport inhibitor. It has the potential for sleep disorders treatment.
TP1188 Cortistatin 14, human, rat

CST-14, human, rat

Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus.
T27430 GR 196429

GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429

GR 196429, a melatonin receptor agonist, exhibits selectivity for the MT1 subtype. This compound not only promotes sleep and alters circadian rhythms but also stimulates melatonin release in mice.
T68603 Mioflazine hydrochloride anhydrous

Mioflazine hydrochloride anhydrous is a nucleoside transport inhibitor that acts on adenosine to improve sleep.
T17095 TIK-301

PD-6735,LY-156735

5-HT Receptor GPCR/G Protein; Neuroscience
TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM, respectively). TIK-301 is also a 5-HT2B/5-HT2C receptor antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.
T80392 NEMURI

NEMURI是一种抗菌肽,具有促进睡眠的功能。
T38143 Elaidamide

Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).3 In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats.1References1. Cravatt, B.F., Prospero-Garcia, O., Siuzdak, G., et al. Chemical characterization of a family of brain lipids that induce sleep. Science 268(5216), 1506-150...
T34752 Samelisant dihydrochloride

SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.
TP1550 Orexin A (human, rat, mouse) (TFA)

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
T38172 RO 5263397 hydrochloride

Potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice. Espinoza et al (2018) Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 9 645 PMID:29977204 |Galley et al (2015) Discovery ...
T39004 Vornorexant

ORN-0829,TS-142

Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.
T71209 CGS 12066A

CGS 12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT₂ receptor subtypes. It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.
T38257 PGDM

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. PGDM is a major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization. It is used as a biomarker to assess endogenous production of PGD2.
T71423 AZD5213

AZD5213 是一种选择性和竞争性的人H3 受体拮抗剂,对 hH3R 的pKi 为 9.3。AZD5213 可用于睡眠与认知调节的研究。
T75925 Orexin B, rat, mouse TFA

Orexin B, rat, mouse (Rat orexin B) TFA,作为一种内源性促进食欲的(Orexin receptor)激动剂,通过结合并激活两个亲密相关的孤儿G蛋白偶联受体OX1-R和OX2-R,促进食物摄入和能量消耗,并在睡眠-觉醒调节中扮演关键角色。
T75970 Melanin Concentrating Hormone, salmon TFA

Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽,它调节食物摄入,能量平衡,睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24和 MCHR2的配体。
T38341 11(Z),14(Z)-Eicosadienoic Acid methyl ester

11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid , a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5'-monophosphate dehydrogenase (Ki = 3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki = 3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance. Eicosadienoic acids are converted by desaturases, in vi...
T70035 Tasimelteon-d5

Tasimelteon-d5 is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist. It selectively binds MT1 and MT2 receptors over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50 values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1 or MT2 receptor, respectively. Formulations containing tasimelteon have been used in the treatment of no...

化合物

δ-Sleep Inducing Peptide
Cat.No: T7107
Synonym: DSIP,Delta-Sleep Inducing Peptide,依米地肽
Target: Antioxidant
δ-Sleep Inducing Peptide acetate
Cat.No: T78005
Synonym: Delta-Sleep Inducing Peptide acetate
Target:
Delta (Phospho) Sleep Inducing Peptide
Cat.No: T82587
Synonym: DSIP-P
Target:
6-fluoro-DL-Tryptophan
Cat.No: T7694
Synonym:
Target: 5-HT Receptor
JNJ-5207852
Cat.No: T7413
Synonym:
Target: Histamine Receptor
Niaprazine
Cat.No: T36949
Synonym:
Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor
p-MPPI hydrochloride
Cat.No: T16421
Synonym:
Target: 5-HT Receptor
TTA-A2
Cat.No: T8944
Synonym:
Target: Calcium Channel
Seltorexant
Cat.No: T12877L
Synonym: JNJ-42847922
Target: OX Receptor
JNJ-5207852 dihydrochloride
Cat.No: T8822
Synonym:
Target: Histamine Receptor
MK-1064
Cat.No: T3722
Synonym: Urokinase inhibitor 1,MK 1064
Target: OX Receptor
Orotirelin
Cat.No: T33824
Synonym: CG 3509,Orotireline
Target: Others
Bafrekalant
Cat.No: T63736
Synonym:
Target: Others
Citenamide
Cat.No: T14974
Synonym: Cytenamide,AY-15613
Target: Others
LY-2624803
Cat.No: T24421
Synonym: DB-7,LY2624803,HY-10275,LY 2624803
Target: 5-HT Receptor, Histamine Receptor
N-Desmethyl Pimavanserin
Cat.No: T37979
Synonym: AC-279
Target: 5-HT Receptor
ACT-462206
Cat.No: T26559
Synonym:
Target: OX Receptor
Tasimelteon
Cat.No: T3495
Synonym: 他司美琼,VEC-162,BMS-214778
Target: Melatonin Receptor, MT Receptor
(Iso)-Atagabalin HCl
Cat.No: T30188L1
Synonym: (Iso)-Atagabalin HCl((Iso)-223445-75-8)
Target: Others
Lorediplon
Cat.No: TQ0023
Synonym:
Target: GABA Receptor
(E)-Crotylbarbital
Cat.No: T10002
Synonym: Kalypnon
Target: Others
Triflubazam
Cat.No: T67966
Synonym:
Target:
Atagabalin HCl
Cat.No: T30188L
Synonym: PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base)
Target: Calcium Channel
Istradefylline
Cat.No: T6552
Synonym: 伊曲茶碱,KW-6002
Target: Adenosine Receptor
Ravulizumab
Cat.No: T76867
Synonym: ALXN1210
Target: Complement System
Piromelatine
Cat.No: T34081
Synonym: NEU-P-11,NEU-P 11,NEU-P11
Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel
6-Chloromelatonin
Cat.No: T22530
Synonym:
Target: Melatonin Receptor, Dopamine Receptor
Butoctamide semisuccinate
Cat.No: T30629
Synonym: M 2H,Butoctamide hydrogen succinate,M-2H,M2H
Target:
ABD459
Cat.No: T36591
Synonym:
Target:
Emideltide (acetate)
Cat.No: T37664
Synonym:
Target:
Dexnafenodone Free Base
Cat.No: T68327
Synonym:
Target:
Mioflazine hydrochloride
Cat.No: T68685
Synonym:
Target:
Mioflazine
Cat.No: T16076
Synonym:
Target: Others
Cortistatin 14, human, rat
Cat.No: TP1188
Synonym: CST-14, human, rat
Target:
GR 196429
Cat.No: T27430
Synonym: GR-196429,GR 196,429,GR-196,429,GR196429,GR196,429
Target:
Mioflazine hydrochloride anhydrous
Cat.No: T68603
Synonym:
Target:
TIK-301
Cat.No: T17095
Synonym: PD-6735,LY-156735
Target: 5-HT Receptor
NEMURI
Cat.No: T80392
Synonym:
Target:
Elaidamide
Cat.No: T38143
Synonym:
Target:
Samelisant dihydrochloride
Cat.No: T34752
Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl
Target:
Orexin A (human, rat, mouse) (TFA)
Cat.No: TP1550
Synonym:
Target:
RO 5263397 hydrochloride
Cat.No: T38172
Synonym:
Target:
Vornorexant
Cat.No: T39004
Synonym: ORN-0829,TS-142
Target:
CGS 12066A
Cat.No: T71209
Synonym:
Target:
PGDM
Cat.No: T38257
Synonym:
Target:
AZD5213
Cat.No: T71423
Synonym:
Target:
Orexin B, rat, mouse TFA
Cat.No: T75925
Synonym:
Target:
Melanin Concentrating Hormone, salmon TFA
Cat.No: T75970
Synonym:
Target:
11(Z),14(Z)-Eicosadienoic Acid methyl ester
Cat.No: T38341
Synonym:
Target:
Tasimelteon-d5
Cat.No: T70035
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S1999 Valepotriate

戊曲酯/缬草素,Valtrate

Apoptosis; HIV Protease Apoptosis; Microbiology/Virology; Proteases/Proteasome
Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物,是一类新的细胞毒剂和抗肿瘤剂,对 HTC 肝癌细胞是非常有效的细胞毒剂。 它可能对焦虑的精神症状具有潜在的抗焦虑作用。
TN3910 Ecdysone

Apoptosis; ATPase; Glucocorticoid Receptor; Potassium Channel; Sodium Channel; Endogenous Metabolite; Autophagy Apoptosis; Autophagy; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism
Ecdysone 是存在于昆虫和草药中的主要类固醇激素,可以激活盐皮质激素受体并诱导细胞凋亡。Ecdysone 的活性代谢物 20-羟基蜕皮激素在协调发育过渡和体内稳态睡眠调节中起重要作用。
T2S0842 Scutellarin methyl ester

Scutellarin methylester,野黄芩苷甲酯

Others Others
Scutellarin methyl ester (3-Oxotirucallenoic Acid) 是一种灯盏花素的成分, 其中灯盏花素是灯盏花中几种黄酮类化合物的粗提物。
T5756 Hastatoside

戟叶马鞭草苷

Others Others
Hastatoside 是一种环烯醚萜苷,分离自 Verbena officinalis 中,具有促进睡眠的效果。
T4876 2-(1H-Indol-3-yl)ethan-1-ol

Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇

Others; Endogenous Metabolite Metabolism; Others
2-(1H-Indol-3-yl)ethan-1-ol (3-(2-Hydroxyethyl)indole) 是在双硫仑治疗后在肝脏中形成的代谢物,可诱导人类睡眠。它也是酒精发酵的二次产物。
T2175 Apigenin

C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,金银花,Apigenol,芹菜素,LY 080400

P450; Autophagy Autophagy; Metabolism
Apigenin (NSC 83244) 是从韩信草中提取的一种天然产物,是一种竞争性CYP2C9抑制剂,Ki 为 2 μM。它被用作镇静剂、温和的镇痛剂和安眠药。
T0439 L-Tryptophan

(S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸

Amino Acids and Derivatives; Endogenous Metabolite Metabolism
L-Tryptophan (Tryptophane) 是一种必需氨基酸,是褪黑素、血清素和维生素B3的前体。
T1659 Melatonin

Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素

CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience
Melatonin (Melatonine) 是一种由松果体制成的激素,可激活褪黑激素受体。它在睡眠中起作用,有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂,可诱导细胞凋亡。
T13831 Prostaglandin D2

PGD2

Endogenous Metabolite Metabolism
Prostaglandin D2 (PGD2) (PGD2) 是哺乳动物大脑中主要产生的前列腺素之一,为最有效的内源性睡眠促进剂之一,并通过抑制炎症发挥保护作用。

天然产物

Valepotriate
Cat.No: T4S1999
Synonym: 戊曲酯/缬草素,Valtrate
Target: Apoptosis, HIV Protease
Ecdysone
Cat.No: TN3910
Synonym:
Target: Apoptosis, ATPase, Glucocorticoid Receptor, Potassium Channel, Sodium Channel, Endogenous Metabolite, Autophagy
Scutellarin methyl ester
Cat.No: T2S0842
Synonym: Scutellarin methylester,野黄芩苷甲酯
Target: Others
Hastatoside
Cat.No: T5756
Synonym: 戟叶马鞭草苷
Target: Others
2-(1H-Indol-3-yl)ethan-1-ol
Cat.No: T4876
Synonym: Tryptophol,3-(2-Hydroxyethyl)indole,Indole-3-ethanol,色醇
Target: Others, Endogenous Metabolite
Apigenin
Cat.No: T2175
Synonym: C.I. Natural Yellow 1,4',5,7-Trihydroxyflavone,NSC 83244,金银花,Apigenol,芹菜素,LY 080400
Target: P450, Autophagy
L-Tryptophan
Cat.No: T0439
Synonym: (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane,L-色氨酸
Target: Amino Acids and Derivatives, Endogenous Metabolite
Melatonin
Cat.No: T1659
Synonym: Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素
Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy
Prostaglandin D2
Cat.No: T13831
Synonym: PGD2
Target: Endogenous Metabolite
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