97
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2137L |
pp60 c-src (521-533) (phosphorylated) acetate
|
Others | Others |
pp60 c-src (521-533) (phosphorylated) acetate 是粘着斑形成和细胞扩散的调节剂。它还调节细胞运动,是由促运动透明质酸受体 RHAMM 触发的信号通路中的关键成分。 | |||
T39185 |
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated |
||
pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate. It serves as a valuable tool for quantifying phosphorylated substrates in screening EGFR Kinase inhibitors. | |||
TP1590 |
MARCKS Peptide(151-175), Phosphorylated
|
||
Myristoylated Alanine-Rich C Kinase Substrate peptide (151-175) is a high affinity Protein Kinase C substrate. | |||
TP2137 |
pp60 c-src (521-533) (phosphorylated)
|
||
Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potential. | |||
T81578 |
p60c-src substrate II, phosphorylated
|
||
p60c-src substrate II, phosphorylated 是磷酸化的五肽,为 p60c-src substrate II 的磷酸化形式。其代表了蛋白质翻译后修饰的一种,对生物调控具有重要作用。 | |||
T7704 |
KY-226
|
Phosphatase | Metabolism |
KY-226 是选择性的,口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂,IC50=0.25 μM,且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。 | |||
T3071 |
Olverembatinib
GZD 824 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Olverembatinib (GZD 824) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂,具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。 | |||
T2429 |
Olverembatinib dimesylate
GZD824 Dimesylate,HQP1351 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Olverembatinib dimesylate (GZD824 Dimesylate) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂,具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。 | |||
T31929 |
Giripladib
PLA 695,PLA-695,PLA695 |
Phospholipase | Metabolism |
Giripladib (PLA695)(PLX-695)是一种cPLA2特异性抑制剂,可抑制辐射诱导的内皮细胞磷酸化ERK 和磷酸化Akt 的增加。 | |||
T26193 |
SKLB-163
SKLB163 |
MAPK; Akt; Caspase; Rho; JNK | Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
SKLB-163 通过下调 RhoGDI、激活 JNK-1 信号通路和 caspase-3 以及减少磷酸化 Akt 和 p44/42 MAPK 发挥作用。 | |||
TP1789L |
Malantide acetate(86555-35-3 free base)
|
PKA; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Malantide acetate(86555-35-3 free base) 是一种由环 AMP 依赖性蛋白激酶 (PKA) 磷酸化的十二肽,可增加 PKA 活性。 Malantide 是一种由 PKA 磷酸化的合成肽,用于在体外测量 PKA 活性。 | |||
T67772 |
Phos-tag Acrylamide AAL-107
|
||
Phos-tag Acrylamide AAL-107 是一种丙烯酰胺悬垂物,可用作可视化磷酸化蛋白质的工具。 | |||
T3438 |
S107
|
Others | Others |
S107 是一种 RyR 选择性 1, 4-苯并硫氮杂卓衍生物,通过增强 calstabin2 与突变和/或 PKA 磷酸化通道的结合亲和力来稳定 RyR2 通道。 | |||
T26078 |
Rhodblock 6
Rhodblock6,Rhodblock-6 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Rhodblock 6 是一种 Rho 激酶 (ROCK) 抑制剂,可抑制磷酸化 MRLC(肌球蛋白调节轻链)定位,通过特异性抑制 Rho 激酶的活性发挥作用。 | |||
T6762 |
AS1842856
|
Autophagy; FOXO1 | Apoptosis; Autophagy |
AS1842856 是一种特异性的Foxo1抑制剂,IC50为 30 nM。它抑制自噬,直接与 FoxO1 结合而降低 FoxO1 的活性。 | |||
T17205 |
UNC2541
|
Others; FLT; TAM Receptor | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
UNC2541 是 Mer 酪氨酸激酶特异性抑制剂,与 MerTK ATP 结合口袋结合的IC50值为 4.4 nM,对其选择性远高于 Axl,Tyro3 和 Flt3。它能够抑制磷酸化的 MerTK (pMerTK;EC50,510 nM)。 | |||
T14569 |
BI8626
|
E1/E2/E3 Enzyme | Ubiquitination |
BI8626 是一种泛素连接酶 HUWE1 抑制剂,对 NOD/ShiLtj 小鼠自发性干燥综合征具有保护作用。BI8626 抑制细胞内胆固醇并降低磷酸化 ZAP-70、CD25 和其他激活标志物的表达,抑制 CD4 T 细胞的增殖。 | |||
T1790 |
Fosaprepitant dimeglumine
福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T7280 |
CAY10594
|
Phospholipase | Metabolism |
CAY10594 是磷脂酶 D2 抑制剂 (体外IC50=140 nM,细胞IC50=110 nM)。它在体外显著阻碍乳腺癌细胞的侵袭性迁移,并调节磷酸化 GSK-3β/JNK 轴改善扑热息痛诱导的急性肝损伤。 | |||
T27242 |
EF24
EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone |
ERK; MEK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物,口服生物利用度高,抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平,并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路,从而发挥抗肿瘤作用。 | |||
T16961 |
Supinoxin
RX-5902 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂,是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长,IC50的范围为 10 nM 至 20 nM。 | |||
T15378L |
Gemcitabine elaidate hydrochloride
CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride |
Others | Others |
Gemcitabine elaidate (CP-4126) hydrochloride 是 Gemcitabine 的亲脂性前药。Gemcitabine elaidate hydrochloride 通过酯酶转化为 Gemcitabine 以被磷酸化。Gemcitabine elaidate hydrochloride 可以口服给药,具有抗肿瘤活性。 | |||
T1643 |
Penciclovir
喷昔洛韦,BRL 39123,VSA 671 |
HCV Protease; Antifection; HSV | Microbiology/Virology; Proteases/Proteasome |
Penciclovir (BRL 39123) 是一种疱疹病毒核苷类似物 DNA 聚合酶抑制剂。它作用于HSV1 和 2,IC50分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。 | |||
T9636 |
Dalpiciclib
SHR-6390 |
CDK | Cell Cycle/Checkpoint |
Dalpiciclib (SHR-6390) 是一种高选择性、口服生物利用度和相当效力的 CDK4 和 CKD6 抑制剂,IC50 分别为 12.4 nM 和 9.9 nM。它通过抑制磷酸化 Rb 蛋白和诱导 G1 细胞周期阻滞在食管鳞状细胞癌中发挥有效的抗肿瘤活性。 | |||
T37207L |
Cdk5 Substrate acetate
|
CDK | Cell Cycle/Checkpoint |
Cdk5 Substrate acetate 是一种丝氨酸/苏氨酸激酶,主要在神经元组织中具有活性。与 p25 或 p35 一起,Cdk5 磷酸化一系列蛋白质,包括组蛋白 H1 和 tau。 它是一种合成肽 (PKTPKKAKKL),对应于组蛋白 H1 的序列。它被 Cdk5 磷酸化,Km 值为 5 µM。 | |||
T6501 |
Fludarabine Phosphate
NSC 312887 Phosphate,fludara Phosphate,F-ara-A (NSC 312887) Phosphate,F-ara-AMP,磷酸氟达拉滨 |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Fludarabine Phosphate (NSC 312887 Phosphate) 是一种腺苷和脱氧腺苷类似物,与 dATP 竞争,并入到 DNA,可以抑制 DNA 聚合酶 α、核糖核苷酸还原酶和 DNA 引发酶,从而中断 DNA 合成并抑制肿瘤细胞生长。 | |||
T6446 |
Clevudine
L-FMAU,克拉夫定,Levovir |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物,是一种与聚合酶结合的非竞争性抑制剂,具有较强的抗 HBV 活性,半衰期长,毒性低的特点。 | |||
T27709 |
K67
K 67,K-67 |
||
K67 is a specific inhibitor against the interaction between KEAP1 DC domain and S349-phosphorylated KIR of p62/SQSTM1. | |||
TP1789 |
Malantide
|
||
Malantide is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activity in vitro. | |||
T40829 |
D-Erythritol 4-phosphate
|
||
D-erythritol 4-phosphate is a phosphorylated component isolated from the hydrolysate. | |||
T29731 |
Agrocinopine
Agrocinopine A |
||
Agrocinopine is an Opine phosphorylated sugar synthesized by crown gall tumors. | |||
T27655 |
JG-48
|
||
JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells. | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T73179 |
HDAC-IN-50
|
||
HDAC-IN-50是一种口服活性的有效FGFR和HDAC双重抑制剂,其IC50值针对FGFR1、FGFR2、FGFR3、FGFR4、HDAC1、HDAC2、HDAC6、HDAC8分别为0.18、1.2、0.46、1.4、1.3、1.6、2.6、13 nM。该化合物能诱导(Apoptosis)及使细胞周期在G0/G1期停滞,降低pFGFR1、pERK、pSTAT3的表达,展现出抗肿瘤活性。 | |||
T83052 | Anti-inflammatory agent 60 | NF-κB | NF-κB |
Anti-inflammatory agent 60 (compound 21) 的 IC50 值针对一氧化氮生成为 12.95 μM。此化合物通过浓度依赖性方式降低 iNOS、phosphorylated p65 以及 β-catenin 的表达。 | |||
TP1602 |
[pThr3]-CDK5 Substrate
|
||
[pThr3]-CDK5 Substrate is an effective Phospho-Thr3CDK5 Substrate.[pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM[1]. | |||
TP1660 |
[pThr3]-CDK5 Substrate (TFA)
|
||
[pThr3]-CDK5 Substrate TFA is an effective Phospho-Thr3CDK5 Substrate. [pThr3]-CDK5 Substrate is phosphorylated by CDK5 with a Km value of 6 µM. | |||
T40447 | T-705RMP | ||
T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM. | |||
T35652 |
2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
|
||
2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome. | |||
T37602 | GSK 143 | ||
Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines. Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 |Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 9... | |||
T10407 |
Gartisertib
ATR inhibitor 2 |
ATM/ATR | DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM). | |||
T22421 |
S107 hydrochloride
|
Others | Others |
S107 hydrochloride, a RyR-selective 1,4-benzothiazepine derivative, could stabilize RyR2 channels via enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels. | |||
T73303 |
BTK-IN-17
|
||
BTK-IN-17是一种选择性且具有BTK 抑制剂,IC50值为 13.7 nM。BTK-IN-17 降低 p-BTKY223和 p-PLCγ2Y1217的表达。BTK-IN-17 具有抗炎作用。 | |||
T76475 |
Casein Kinase II Substrate
|
||
Casein KinaseII Substrate 是一种酪蛋白激酶 II (CK2) 肽底物,可被CK2选择性磷酸化。 | |||
T39586 |
Cantrixil
TRX-E-002-1 |
||
Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes. | |||
TP1716 |
Calmodulin-Dependent Protein Kinase II (281-309)
Calmodulin-Dependent Protein Kinase II 281-309 |
||
Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM). | |||
T78131 |
Emtricitabine triphosphate tetrasodium salt
(-)-Emtricitabine triphosphate tetrasodium salt |
Reverse Transcriptase | Microbiology/Virology |
Emtricitabinetriphosphatetetrasodium salt 为 Emtricitabinetriphosphate 的四钠盐。 Emtricitabinetriphosphate 本身为 Emtricitabine 的磷酸化代谢物,后者作为核苷类逆转录酶抑制剂对抗 HIV 与 HBV。 | |||
TP1641 |
[pSer2, pSer5, pSer7]-CTD TFA
|
||
[pSer2, pSer5, pSer7]-CTD (TFA) is a substrate for CDK7(cyclin-dependent protein kinase), a phosphorylated polypeptide at ser2, ser5, and ser7 of RNA polymerase II carboxyl terminus (CTD). | |||
T62519 | SW02 | ||
SW02 是一种有效的 Hsp70 的 ATPase 活性激活剂 (EC50: 150 μM)。SW02 能够积累总 tau 和磷酸化 tau (pTau)。 | |||
T35928 |
NVS-PAK1-C
NVS-PAK1-C |
||
NVS-PAK1-C 是一种有效的、ATP 竞争的特异性变构 PAK1抑制剂探针。NVS-PAK1-C 可抑制去磷酸化的 PAK1(IC50= 5 nM) 和磷酸化的 PAK1(IC50= 6 nM)。NVS-PAK1-C 也可以抑制去磷酸化的 PAK2 (IC50=270 nM) 和磷酸化的 PAK2 (IC50=720 nM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5113 |
L-GLUCOSE
L-葡萄糖,L-(-)-Glucose |
Others | Others |
L-Glucose (L-(-)-Glucose) 是一种 D-glucose 的对映体,可促进食物的摄取。 | |||
T3262 |
Phosphocreatine disodium
Disodium phosphocreatine,Phosphocreatine disodium salt,Creatine phosphate disodium salt,磷酸肌酸钠 |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphocreatine disodium (Phosphocreatine disodium salt) 是一种磷酸化的肌酸分子,在肌肉、骨骼和大脑中作为一种可快速动员的高能磷酸盐储备。 | |||
T0894 |
Thiamine hydrochloride
盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride |
Apoptosis; HBV; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology |
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T4726 |
D-Glucose 6-phosphate sodium
G6P sodium salt,D-Glucose 6-phosphate sodium salt,D-葡萄糖-6-磷酸钠盐,Sodium Glucose-6-Phosphate |
Others; Endogenous Metabolite | Metabolism; Others |
D-Glucose 6-phosphate sodium (G6P sodium salt) 是内源性代谢产物的一种。 | |||
T5057 |
DL-O-Phosphoserine
DL-O-磷酸丝氨酸,DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP |
Others; Endogenous Metabolite | Metabolism; Others |
DL-O-Phosphoserine (DL-SOP) 是丝氨酸和磷酸的酯,是人类生物流体中的正常代谢物。 | |||
T78473 |
Sphingosine (d17:1)
C17 Sphingosine |
||
Sphingosine (d17:1) (C17 Sphingosine)是一种存在于人类皮肤中的17碳鞘脂,可被鞘氨醇激酶的磷酸化。Sphingosine C-17作为内标可用于进行鞘脂类化合物的光谱分析。 | |||
T7989 |
Trimethyl phosphate
|
Others | Others |
Trimethyl phosphate 是一种有机磷化合物,是催化磷酸化化合物水解的酶的抑制剂,已被用作合成肽和其他蛋白质的反应物,用作合成有机和无机化合物的催化剂,以及用作合成药物的试剂。 | |||
T5069 |
D-Glucose 6-phosphate potassium salt
|
Others | Others |
在细胞中,当葡萄糖被己糖激酶或葡萄糖激酶磷酸化或在糖原分解过程中通过磷酸葡萄糖变位酶转化葡萄糖 1-磷酸时,会产生D-glucose 6-phosphate (G6P)。 G6P 位于糖酵解和戊糖磷酸途径的起点。当血糖水平高时,它也可以作为糖原储存。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
TL0008 |
Gigantol
|
Wnt/beta-catenin; Glucosidase | Cytoskeletal Signaling; Metabolism; Stem Cells |
Gigantol 是一种联苄基化合物,从几种药用兰花中获得,是一种Wnt/β-catenin 通路抑制剂,具有抗肿瘤活性。 | |||
T19263 | D-Glucose 6-phosphate | Others | Others |
D-glucose 6-phosphate is glucose that is phosphorylated on the carbon 6 hydroxyl group. | |||
T35415 | α-D-Glucose-1,6-bisphosphate (potassium salt hydrate) | ||
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... |