77
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9919 |
Alemtuzumab
|
Others | Others |
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。。 | |||
T3258 |
Ponesimod
ACT-128800 |
S1P Receptor; LPL Receptor | GPCR/G Protein |
Ponesimod (ACT-128800) 是一种选择性 S1P1可口服激动剂,在放射性配体结合试验中的 IC50值为 6 nM。它可高效激活 S1P1介导的信号转导,EC50为5.7 nM。它可预防淋巴细胞介导的组织炎症,具有潜在的免疫调节活性。 | |||
TP2412 |
Tanurmotide
Human lymphocyte antigen 6k-(101-111)-peptide.,Arg-tyr-cys-asn-leu-glu-gly-pro-pro-ile |
||
Tanurmotide is a bioactive chemical. | |||
T9616 |
PD-1/PD-L1-IN-10
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM),显示出抗肿瘤活性。 | |||
T5097 |
Ezatiostat
TER199(free base),TLK199 |
Apoptosis; Glutathione Peroxidase; GST | Apoptosis; Metabolism; oxidation-reduction |
Ezatiostat (TER199(free base)) 是一种谷胱甘肽的三肽类似物,也是一种选择性的口服活性的谷胱甘肽 S-转移酶 P1-1 (GSTP1) 抑制剂。它通过抑制GSTP1导致 JNK 激活,刺激淋巴细胞生成和骨髓祖细胞增殖,可研究骨髓增生异常综合症。 | |||
T22776 |
Ezatiostat hydrochloride
TLK199 HCl,Ezatiostat盐酸盐,TER199 |
Glutathione Peroxidase | Metabolism |
Ezatiostat hydrochloride (TLK199 HCl) 是一种新型谷胱甘肽类似物,可刺激淋巴细胞生成和骨髓祖细胞增殖,可用于治疗血细胞减少症和研究骨髓增生异常综合症。它也是口服活性的选择性谷胱甘肽 S-转移酶 P1-1 抑制剂,通过抑制 GSTP1导致 JNK 激活。 | |||
T15337 |
Forodesine
呋咯地辛,BCX-1777,Immucillin-H |
Others | Others |
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could induce apoptosis in leukemic cells b | |||
T3977 |
Lifitegrast
SHP-606,SAR 1118,立他司特,利非司特 |
Integrin | Cytoskeletal Signaling |
Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂, 抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。 | |||
T10389L |
Aspartyl-alanyl-diketopiperazine acetate
DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base) |
Others | Others |
Aspartyl-alanyl-diketopiperazine acetate (DA-DKP) 可以通过与 T 淋巴细胞无反应有关的分子途径调节炎症免疫反应。 | |||
T9925 |
Ofatumumab
|
Others | Others |
Ofatumumab 是一种人源化靶向抗 CD20单克隆抗体。它作用于表达 CD20 的 B 淋巴细胞,能够诱导产生抗体依赖性细胞介导的细胞毒性和补体依赖性细胞毒性的作用。 | |||
T72528 |
NSC243928 mesylate
|
HuR | Chromatin/Epigenetic |
NSC243928 mesylate 可与人类淋巴细胞抗原 6 (LY6) 结合,是细胞生长抑制剂,具有抗癌活性,以 LY6K 依赖性方式诱导三阴性乳腺癌细胞的细胞死亡。 | |||
T12783 |
RWJ 50271
|
Integrin | Cytoskeletal Signaling |
RWJ 50271 是具有口服活性的选择性LFA-1/ICAM-1相互作用抑制剂,抑制 LFA-1/ICAM-1 介导的细胞粘附,在细胞HL60中的IC50值为 5.0 μM。 | |||
T77466 |
Tremelimumab
Ticilimumab,CP-675206 |
Others | Others |
Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4(CTLA-4)阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。 | |||
TQ0007 |
Cintirorgon
LYC-55716 |
ROR | Metabolism |
Cintirorgon (LYC-55716) 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达,提高效应子功能,降低免疫抑制,抑制肿瘤生长,提高生存率。 | |||
TP1076L |
AUNP-12 acetate
AUNP-12 acetate (1353563-85-5 Free base) |
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
AUNP-12 acetate 是一种 PD-1的多肽抑制剂,在抑制淋巴细胞增殖和效应功能上对 PD-1和 PD-2等效,具有免疫激活和良好的抗肿瘤活性。 | |||
T0944 |
Levamisole hydrochloride
(-)-Tetramisole hydrochloride,盐酸左旋咪唑 |
Phospholipase; AChR; Parasite; HSV | Metabolism; Microbiology/Virology; Neuroscience |
Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。 | |||
T3614 |
Inosine pranobex
Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun |
IL Receptor; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Inosine pranobex (Delimmun) 是一种免疫增强剂,它是一种广谱抗病毒剂,用于 HIV 感染。 | |||
TQ0291 |
Firategrast
SB 683699 |
Integrin | Cytoskeletal Signaling |
Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输,降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4,CD8和CD19淋巴细胞计数的适度降低有关。 | |||
T3626 |
Acalabrutinib
ACP-196,阿可替尼 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 | |||
T63790 |
Cbl-b-IN-3
|
E1/E2/E3 Enzyme | Ubiquitination |
Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。 | |||
T28708 |
Sch 24937
|
||
Sch 24937 is a potent immunosuppressant on B lymphocyte mediated immune responses. | |||
T70253 |
Nordimaprit
|
||
Nordimaprit is effective agonist in the inhibition of lymphocyte activation. | |||
TP2336 |
Tripalmitoyl pentapeptide
P3C-Ssna,Bpppcssaa,Bppp cssaa,Bppp-cssaa,P3C Ssna P3CSsna |
||
Tripalmitoyl pentapeptide is a Mitogen from E Coli lipoprotein. It also is a potent macrophage B lymphocyte activator. | |||
T26752 |
BC12
BC 12,BC-12 |
||
BC12 exhibits unusually potent immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production. | |||
T26836 | BLL5 Maleate | ||
BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected. | |||
T14558 |
BI-1950
|
Integrin | Cytoskeletal Signaling |
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function and a target for drug discovery[1]. | |||
T68349 |
Lck inhibitor II
|
||
Lck inhibitor II is a cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor | |||
T70944 | Carotegrast methyl HCl | ||
Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM300 dose-dependently inhibited lymphocyte homing to Peyer's patches and increased the peripheral lymphocyte count in the same dose range. AJM300 dose-dependently prevented the development of experimental colitis in mice. | |||
T78309 |
Telitacicept
RC18 |
||
Telitacicept (RC18) 是一种全人源TACI-Fc融合蛋白,兼具BLyS和APRIL抑制作用,有效阻断B淋巴细胞增殖,适用于B细胞自身免疫性疾病研究。 | |||
TP1030 |
Thymus factor X
TFX-Jelfa,胸腺因子X |
||
Thymic factor X (TFX-Jelfa) is an aqueous extract from the thymus of a juvenile calf and is a natural stimulator of lymphocyte function. | |||
T28221 |
NVP-QAV-680
NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid |
||
NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro. | |||
TP1612 |
OVA sequence (323-336)
OVA sequence 323-336 |
||
This peptide is a cognate helper T-lymphocyte peptide that is employed to enhance CTL epitope immunogencity | |||
T82449 |
Eramkafusp Alfa
|
||
Eramkafusp Alfa为针对小鼠B淋巴细胞上CD20 (MS4A1) 抗原的人源化IgG1单克隆抗体。 | |||
T8888 |
Lck-IN-1
|
||
Lck-IN-1 是有效的淋巴细胞蛋白酪氨酸激酶(Lck)抑制剂。 | |||
T38386 |
Drimentine C
|
||
Drimentine C is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 63 and 98% in vitro when used at concentrations of 12.5 and 100 μg/ml, respectively. | |||
T81627 |
Oberotatug
|
||
Oberotatug为针对淋巴细胞抗原LY75的人源化IgG1κ单克隆抗体。 | |||
T27368 |
FR 901235
FR901235,FR-901235 |
||
FR-901235 is an immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 restores the mitogen-induced lymphocyte proliferation to a normal level, which has been suppressed by addition of immunosuppressive factor. | |||
T37675 |
3-Deaza-2'-deoxyadenosine
|
||
3-Deaza-2'-deoxyadenosine strongly inhibits lymphocyte-mediated cytolysis with low cytotoxicity when applied at 100 μM. This nucleoside can also be used to evaluate the role of the adenine N3 nitrogen in DNA structure and function. | |||
T3977L |
Lifitegrast sodium
SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra |
||
Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel | |||
T39292 |
NS2 (114-121), Influenza
NS2 (114-121), Influenza |
||
NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses. | |||
TP1515 |
HPV16-E711-20 epitope
|
||
HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. | |||
T28838 |
SPM-242
SPM 242 |
||
SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and lymphocyte trafficking, by activat | |||
T11313 |
Forodesine hydrochloride
BCX-1777 hydrochloride,Immucillin-H hydrochloride |
Others | Others |
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP. | |||
T78298 |
Alefacept
LFA 3TIP,Human LFA 3IgG fusion protein,BG 9273 |
||
Alefacept (BG 9273)为一种人类淋巴细胞功能相关抗原3/免疫球蛋白1融合蛋白,主要在慢性斑块状银屑病研究中使用。 | |||
T80573 |
Firastotug
|
||
Firastotug为针对CTLA4的IgG1κ抗体。CTLA4作为细胞毒性T淋巴细胞相关抗原,它在自身免疫和癌症研究中扮演着重要的免疫检查点角色。 | |||
T77103 | Nurulimab | ||
Nurulimab (BCD-145) 是一种抗细胞毒性 T 淋巴细胞抗原 4 (抗 CTLA-4) 人源化单克隆抗体。Nurulimab 可用于黑色素瘤的研究。 | |||
T38227 |
Quin C1
|
||
Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory. Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 |Corminboeuf et al (2014) FPR2/ALXR agonist... | |||
T35736 |
Drimentine B
|
||
Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast, and has anthelmintic properties. Drimentine B inhibits proliferation of NS-1 murine β lymphocyte myeloma cells by 41 and 59% in vitro when used at concentrations of 50 and 100 μg/ml, respectively. | |||
T79816 |
S1P1 agonist 6
|
LPL Receptor | GPCR/G Protein |
S1P1 agonist 6 (Compound I) 是一种可以通过阻断淋巴细胞迁移来减弱免疫反应的S1P1激动剂,常用于研究自身免疫性疾病的免疫抑制剂。 | |||
T79817 |
S1P1 agonist 6 hemicalcium
|
LPL Receptor | GPCR/G Protein |
S1P1 agonist 6 hemicalcium (Compound I) 为一S1P1激动剂,其通过抑制淋巴细胞迁移而降低免疫反应,适用于自身免疫性疾病研究中的免疫抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7981 |
2-Fluoroadenosine
|
Others | Others |
2-Fluoroadenosine 是淋巴细胞介导的细胞溶解的有效抑制剂。 | |||
TN1443 |
Biorobin
Kaempferol 3-O-robinobioside |
||
Biorobin (Kaempferol 3-O-robinobioside) 在体外显著抑制人类淋巴细胞增殖。 | |||
TN2283 |
Tripterifordin
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Tripterifordin 在 H9 淋巴细胞中显示出抗 HIV 复制活性,EC50值为 3100 nM。 | |||
T10117 |
3'-O-Acetylhamaudol
|
Others | Others |
3'-O-Acetylhamaudol 是提取于 Angelica japonica 根部,能够抗血管生成和激活肠上皮淋巴细胞,具有抗肿瘤活性。 | |||
T3S1513 |
(20R)-Protopanaxadiol
Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol |
Others; Antibacterial | Microbiology/Virology; Others |
(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长,有抗肿瘤活性和细胞毒性。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
T81735 |
Mycestericin C
|
||
Mycestericin C, 分离自 Mycelia sterilia ATCC 20349 的培养液, 能在小鼠同种异体混合淋巴细胞反应中抑制淋巴细胞的增殖。 | |||
TN2116 |
Pteropodine
|
BCL; Calcium Channel; 5-HT Receptor | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic lymphoblasts. | |||
TN4934 |
Salaspermic acid
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells. | |||
TN4646 |
Neotripterifordin
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125. | |||
TN1194 | 16beta,17-Dihydroxy-ent-kaurane-19-oic acid | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosi |