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Search Results for " local anesthetic "

63

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19644	Benzonatate	Sodium Channel	Membrane transporter/Ion channel
	Benzonatate 是外周口服镇咳药，对咳嗽延伸受体 (cough stretch receptors) 的活性具有抑制作用。它是丁卡因样代谢物，能够阻断呼吸延伸受体的钠通道并产生局部麻醉作用。
T23070	Nisoxetine hydrochloride	Sodium Channel; Monoamine Transporter; Norepinephrine	Membrane transporter/Ion channel; Neuroscience
	Nisoxetine hydrochloride 是一种去甲肾上腺素转运蛋白 (NET) 抑制剂，Kd 值为 0.76 nM。它是抗抑郁药和局部麻药，可以阻断电压门控性钠通道。
T0314	Hexylresorcinol 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol	Apoptosis; Tyrosinase; Antibacterial; Parasite	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物，具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂，有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。
T0946	Mepivacaine hydrochloride Mepivacaine HCl,盐酸甲哌卡因	Sodium Channel	Membrane transporter/Ion channel
	Mepivacaine hydrochloride (Mepivacaine HCl) 是具有局部麻醉特性的酰胺衍生物。Mepivacaine hydrochloride 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。
T0072	Adiphenine hydrochloride Adiphenine HCl,盐酸阿地芬宁,Spasnil,Patrovina,Sentiv	AChR	Neuroscience
	Adiphenine hydrochloride (Patrovina) 是一种烟碱样受体抑制剂，可用作解痉药，对α1、α3β4、α4β2和α4β4的IC50值分别为 1.9、1.8、3.7 和 6.3 µM。
T2131	Articaine hydrochloride Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045	Sodium Channel	Membrane transporter/Ion channel
	Articaine hydrochloride (Hoe-045) 一种牙科局部麻醉剂。
T0325	Diperodon hydrochloride 盐酸地哌冬,Diothane hydrochloride,Proctodon,Diperocaine	Others	Others
	Diperodon hydrochloride (Diperocaine) 是一种局部麻醉剂，能够被血清分解酶分解，进而产生局部麻醉作用。
T17115	Tolycaine
	Tolycaine 是一种局部麻醉剂。
T31716L	Etidocaine	Others	Others
	Etidocaine 是一种氨基酸酰胺，用作局部麻醉剂，具有快速起效和长效特性。
T24451	Mepyramine NSC-13136,NSC13136,NSC 13136
	Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies both parenterally and locally.
T1144L	Lidocaine Hydrochloride hydrate	EGFR; Sodium Channel	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Lidocaine Hydrochloride hydrate 是一种酰胺类局部麻醉剂，具有抗炎作用。
T15653	Ketocaine Rec 7-0518	Others	Others
	Ketocaine（Rec 7-0518）是一种动物实验常用的局部麻醉剂，具有潜在的抗肿瘤活性，可用于缓解疼痛。
T6443	Chloroprocaine hydrochloride 盐酸氯普鲁卡因,Chloroprocaine HCl	ATPase; Others	Membrane transporter/Ion channel; Others
	Chloroprocaine hydrochloride (Chloroprocaine HCl) 是一种 Na/K-ATPase 活性抑制剂，IC50为 13 mM，可阻断外周神经。
T0364	Dibucaine 地布卡因,Cinchocaine	CaMK; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Dibucaine (Cinchocaine) 是钠通道抑制剂和有效的SChE 抑制剂。
T0916	Butamben Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯	Potassium Channel; Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂，用于治疗慢性疼痛。
T1389	Dyclonine hydrochloride 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl	Sodium Channel; Antibacterial; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。
T28829	Soquinolol Soquinolol mucate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Soquinolol (Soquinolol mucate) 是一种β肾上腺素能受体拮抗剂，具有较弱的局部麻醉活性。Soquinolol 具有良好的肠内疗效和较长的作用持续时间。
T7118	Dimethocaine 二甲卡因,Larocaine	Others; Dopamine Receptor	GPCR/G Protein; Neuroscience; Others
	Dimethocaine (Larocaine) 是一种局部麻醉剂，也对中枢神经系统起多巴胺再摄取抑制剂的作用。
T6566	Levobupivacaine hydrochloride Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) 是有效的钠通道阻滞剂。
T68165	Trapencaine
	Trapencaine 是一种新合成的氨基甲酸型局部麻醉剂，诱导的肥大细胞膜上钠通道的构象变化。
T0378	Oxybuprocaine hydrochloride Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐	Sodium Channel	Membrane transporter/Ion channel
	Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂，可防止角膜，结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。
T16558	Polidocanol Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether	Others	Others
	Polidocanol (Polyoxyethylene lauryl ether) 是月桂醇的烷基聚乙二醇醚，是天然矿物油中天然脂肪醇或烷基醇的衍生物，是一种硬化剂。Polidocanol 可用做局部麻醉，但与其他麻醉药物合用时有增强麻醉药物对心血管系统作用的风险。
T0386	Ropivacaine hydrochloride 盐酸罗哌卡因,Ropivacaine monohydrochloride	Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Ropivacaine hydrochloride (Ropivacaine monohydrochloride) 是钠通道阻断剂，通过可逆地抑制钠离子内流从而引起神经纤维脉冲传导阻滞。Ropivacaine hydrochloride 也是 K2P(双孔钾通道)TREK-1的抑制剂。在动物实验模型中，Ropivacaine hydrochloride 可用于神经性疼痛的缓解。
T6953	Prilocaine Citanest,丙胺卡因,Propitocaine,NSC 40027	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
T1144	Lidocaine hydrochloride Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis; ERK; NF-κB; MEK; Sodium Channel	Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB
	Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T0468	Lidocaine Lignocaine,Alphacaine,Xylocaine,利多卡因	Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Lidocaine (Alphacaine) 是一种酰胺衍生物，抑制涉及复杂电压和依赖性的钠通道，可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。
T1232	Mepyramine maleate 马来酸吡纳明,Pyrilamine maleate,吡拉明马来酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mepyramine maleate (Pyrilamine maleate) 是一种组胺 H1 拮抗剂，对 H1、H2 和 H3 受体的 Kd 值分别为 0.8、5200 和大于 3000 nM，对 H1 受体的 pKd 值为 9.4。它是感冒药的常见成分，具有温和的催眠特性和局部麻醉作用，可用于胃肠外和局部过敏。
T1098	Denatonium benzoate 苯甲地那铵,THS-839	Others	Others
	Denatonium benzoate (THS-839) 是一种已知的最苦的化合物，可作为厌恶剂(苦味剂)，加入到工业酒精、防冻液、咬指甲癖预防、呼吸器面罩配合测试、动物驱虫剂、液体皂和洗发水中，防止不适当的摄取。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T30109	Aptocaine
	Aptocaine is a local anesthetic.
T30023	Amolanone AP 43,AP-43,AP43
	Amolanone is a Local Anesthetic.
T32888	Lotucaine
	Lotucaine is a local anesthetic.
T30031	Amoxecaine
	Amoxecaine is a Local Anesthetic.
T32204	Isobucaine hydrochloride Isobucaine HCl,Isobucaine
	Isobucaine hydrochloride is a local anesthetic.
T30109L	Aptocaine hydrochloride Aptocaine HCl
	Aptocaine hydrochloride is a local anesthetic.
T20260	Risocaine Propylcain,Raythesin,Risocaina
	Risocaine is an agent of local anesthetic.
T34217	Quatacaine LA012 [as hydrochloride],LA 012 [as hydrochloride],LA-012 [as hydrochloride]
	Quatacaine is a local anesthetic.
T2139L	Butacaine sulfate Butyn,AI3 02405,AI302405,AI3-02405
	Butacaine sulfate is applied to mucous membranes as a local anesthetic.
T32719	Levoxadrol HCl CL 912C,Levoxan,Levoxadrol hydrochloride,Relane
	Levoxadrol HCl can be used as smooth muscle relaxant and local anesthetic.
T32032	GYKI-23107 HCl GYKI23107,GYKI23,107,GYKI 23107,GYKI-23107,GYKI 23,107,GYKI-23,107
	GYKI-23107 is an antiarrhythmic agent with a local anesthetic activity.
T82707	Clibucaine
	Clibucaine为哌啶衍生物，作为局部麻醉剂使用，具备局麻效果。
T25189	Butopiprine Butopiprinum
	Butopiprine 是一种镇咳药，具有解痉、局部麻醉和镇咳活性。
T25184	Butalamine Butalamina
	Butalamine is a vasodilator (peripheral) with local anesthetic effects. It suppresses state 3 respiration and decreases ADP/O in the rat liver.
T25184L	Butalamine HCl LA 1221,Hemotrope,Butalamine hydrochloride,Adrevil
	Butalamine HCl is a vasodilator (peripheral) with local anesthetic effects. It suppresses state 3 respiration and decreases ADP/O in the rat liver.
T25757	Lorcainide hydrochloride Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889
	Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppressing reentry phenomena and ectopic
T26830	BK 129 BK-129,BK129
	BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum.
T0378L	Oxybuprocaine Butoxyprocaine,BNX,Benoxinate,Novescine,Novesin
	Oxybuprocaine is an ester-type local anesthetic that is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

化合物

Cat.No: T19644

Target: Sodium Channel

Nisoxetine hydrochloride

Cat.No: T23070

Target: Sodium Channel, Monoamine Transporter, Norepinephrine

Hexylresorcinol

Cat.No: T0314

Synonym: 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

Mepivacaine hydrochloride

Cat.No: T0946

Synonym: Mepivacaine HCl,盐酸甲哌卡因

Target: Sodium Channel

Adiphenine hydrochloride

Cat.No: T0072

Synonym: Adiphenine HCl,盐酸阿地芬宁,Spasnil,Patrovina,Sentiv

Target: AChR

Articaine hydrochloride

Cat.No: T2131

Synonym: Ultracaine,盐酸阿替卡因,阿替卡因,Articaine HCl,Hoe-045

Target: Sodium Channel

Diperodon hydrochloride

Cat.No: T0325

Synonym: 盐酸地哌冬,Diothane hydrochloride,Proctodon,Diperocaine

Target: Others

Cat.No: T17115

Cat.No: T31716L

Target: Others

Cat.No: T24451

Synonym: NSC-13136,NSC13136,NSC 13136

Lidocaine Hydrochloride hydrate

Cat.No: T1144L

Target: EGFR, Sodium Channel

Cat.No: T15653

Synonym: Rec 7-0518

Target: Others

Chloroprocaine hydrochloride

Cat.No: T6443

Synonym: 盐酸氯普鲁卡因,Chloroprocaine HCl

Target: ATPase, Others

Cat.No: T0364

Synonym: 地布卡因,Cinchocaine

Target: CaMK, Sodium Channel, AChR

Cat.No: T0916

Synonym: Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯

Target: Potassium Channel, Calcium Channel, Sodium Channel

Dyclonine hydrochloride

Cat.No: T1389

Synonym: 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl

Target: Sodium Channel, Antibacterial, Antifungal

Cat.No: T28829

Synonym: Soquinolol mucate

Target: Adrenergic Receptor

Cat.No: T7118

Synonym: 二甲卡因,Larocaine

Target: Others, Dopamine Receptor

Levobupivacaine hydrochloride

Cat.No: T6566

Synonym: Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride

Target: Sodium Channel

Cat.No: T68165

Oxybuprocaine hydrochloride

Cat.No: T0378

Synonym: Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐

Target: Sodium Channel

Cat.No: T16558

Synonym: Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether

Target: Others

Ropivacaine hydrochloride

Cat.No: T0386

Synonym: 盐酸罗哌卡因,Ropivacaine monohydrochloride

Target: Potassium Channel, Sodium Channel

Cat.No: T6953

Synonym: Citanest,丙胺卡因,Propitocaine,NSC 40027

Target: ATPase, Sodium Channel

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

Lidocaine hydrochloride

Cat.No: T1144

Synonym: Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T0468

Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Mepyramine maleate

Cat.No: T1232

Synonym: 马来酸吡纳明,Pyrilamine maleate,吡拉明马来酸盐

Target: Histamine Receptor

Denatonium benzoate

Cat.No: T1098

Synonym: 苯甲地那铵,THS-839

Target: Others

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Cat.No: T30109

Cat.No: T30023

Synonym: AP 43,AP-43,AP43

Cat.No: T32888

Cat.No: T30031

Isobucaine hydrochloride

Cat.No: T32204

Synonym: Isobucaine HCl,Isobucaine

Aptocaine hydrochloride

Cat.No: T30109L

Synonym: Aptocaine HCl

Cat.No: T20260

Synonym: Propylcain,Raythesin,Risocaina

Cat.No: T34217

Synonym: LA012 [as hydrochloride],LA 012 [as hydrochloride],LA-012 [as hydrochloride]

Butacaine sulfate

Cat.No: T2139L

Synonym: Butyn,AI3 02405,AI302405,AI3-02405

Cat.No: T32719

Synonym: CL 912C,Levoxan,Levoxadrol hydrochloride,Relane

Cat.No: T32032

Synonym: GYKI23107,GYKI23,107,GYKI 23107,GYKI-23107,GYKI 23,107,GYKI-23,107

Cat.No: T82707

Cat.No: T25189

Synonym: Butopiprinum

Cat.No: T25184

Synonym: Butalamina

Cat.No: T25184L

Synonym: LA 1221,Hemotrope,Butalamine hydrochloride,Adrevil

Lorcainide hydrochloride

Cat.No: T25757

Synonym: Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889

Cat.No: T26830

Synonym: BK-129,BK129

Cat.No: T0378L

Synonym: Butoxyprocaine,BNX,Benoxinate,Novescine,Novesin

Cat. No.	Product Name	Target	Signaling Pathways
T1407	(-)-Menthol L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor	Opioid Receptor; Endogenous Metabolite; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Menthol (Levomenthol) 分离自薄荷油，L-Menthol 是瞬时受体电位 M8 (TRPM8)的激活剂，TRPM8 是 Ca2+-可渗透的非选择性阳离子通道，并增加 [Ca2+]i。L-Menthol 具有抗肿瘤活性。
T0012	Cinchonine LA40221,(8R,9S)-Cinchonine,奎宁树,辛可宁	Apoptosis; P-gp; Parasite	Apoptosis; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Cinchonine (LA40221) 是金鸡纳树皮中的一种天然产物。它可激活内质网应激诱导的人肝癌细胞凋亡。它是一种酰胺类局部麻醉剂。
T5723	Menthol 薄荷脑,DL-Menthol	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Menthol (DL-Menthol) 是从薄荷或薄荷油中得到的一种天然产物，具有调味和局部麻醉特性。它通过抑制神经元细胞膜的 Ca++电流，刺激冷感受器，从而产生清凉的感觉。
T1301	Guaiacol O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol,愈创木酚	NF-κB; COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Guaiacol (2-Methoxyphenol) 是从小叶栲中提取的一种酚类，可抑制 LPS 刺激的COX-2表达和NF-κB 激活，具有抗炎活性。
TN6028	Gardneramine
	Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.

天然产物

Cat.No: T1407

Synonym: L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor

Target: Opioid Receptor, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T0012

Synonym: LA40221,(8R,9S)-Cinchonine,奎宁树,辛可宁

Target: Apoptosis, P-gp, Parasite

Cat.No: T5723

Synonym: 薄荷脑,DL-Menthol

Target: Others, Calcium Channel

Cat.No: T1301

Synonym: O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol,愈创木酚

Target: NF-κB, COX, Endogenous Metabolite

Cat.No: TN6028

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