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Search Results for " glucose metabolism "

55

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3713	BAY-876	transporter	Metabolism
	BAY-876 是口服有效的，选择性的葡萄糖转运蛋白 1 (GLUT1) 抑制剂（IC50= 2 nM）。BAY-876 对 GLUT1 选择性比 GLUT2，GLUT3 和 GLUT4 高（>130 倍）。BAY-876 对糖酵解代谢和卵巢癌生长也有有效的抑制作用。
T40514	2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid	Others	Others
	2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid 属于酮类化合物，化合物 II-9。它在心血管疾病、血脂异常、蛋白异常和糖代谢紊乱方面具有研究的价值。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T24656	PQ-10 A844337,PQ 10,A-844337,A 844337	PDE	Metabolism
	PQ-10 (A-844337) 是磷酸二酯酶 10A 抑制剂，其IC50=4.6 nM，ED50=13 mg/kg。它能够诱导大脑葡萄糖代谢模式，这可能是潜在的转化生物标志物。它对精神分裂症等精神疾病具有研究潜力。
T7486	Imeglimin hydrochloride EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性，能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。
T19261	D-Glucose-13C6 D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6	Endogenous Metabolite	Metabolism
	D-Glucose-13C6 (Dextrose-13C6) 是一种 D-Glucose 的同位素标记物，可作为代谢示踪剂，可用于研究机体代谢相关疾病和部分物质的代谢过程。
T37958	Acetyl Coenzyme A trisodium Acetyl-CoA trisodium	OXPHOS; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism
	Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) 是糖代谢和脂代谢的重要化合物，参与三羧酸循环。
T22708	Darglitazone CP-86325	PPAR	DNA Damage/DNA Repair; Metabolism
	Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。
T22317	DRB18	transporter	Metabolism
	DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1].
T9768L	Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride(2254741-41-6 Free base)	Others	Others
	Ninerafaxstat trihydrochloride 将细胞代谢由脂肪酸氧化转变为葡萄糖氧化。 Ninerafaxstat trihydrochloride 改善整体线粒体呼吸并减少脂肪酸氧化，从而抑制癌细胞的增殖和生长。
T22459	Xanthinol Nicotinate Angioamin,烟酸占替诺,Complamin	Others	Others
	Xanthinol Nicotinate (Complamin) 是血管扩张剂，可直接作用于小动脉和毛细血管的平滑肌，能够扩大血管，改善血液流变学并降低外周血管阻力。
T37891L	GLP-1(32-36)amide acetate GLP-1(32-36)amide 醋酸盐,GLP-1(32-36)amide acetate(1417302-71-6 Free base)	Others	Others
	GLP-1(32-36)amide acetate 是一种五肽，衍生自糖调节激素 GLP-1 的 C 末端。GLP-1(32-36)amide acetate 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。
T14327	AS1949490	Phosphatase	Metabolism
	AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。
TP2018L	GIP (human) acetate GIP (human) acetate(100040-31-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。
T9558	KL-11743	transporter	Metabolism
	KL-11743 是葡萄糖竞争性 I 类葡萄糖转运蛋白抑制剂，口服有活性，能够抑制GLUT1 (IC50:115 nM) 、GLUT2 (IC50:137 nM) 、GLUT3 (IC50:90 nM) 及GLUT4 (IC50:68 nM) 。它能够特异性阻断葡萄糖代谢，也可与电子传递抑制剂协同作用诱导细胞死亡。
T0988	Trimetazidine dihydrochloride 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F	Autophagy; Fatty Acid Synthase	Autophagy; Metabolism
	Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂，也用作缺血性心脏病或心绞痛的血管扩张剂，具有抗氧化，抗炎，抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。
T60839	SLMP53-1	p53	Apoptosis
	SLMP53-1 是一种 p53 激活剂，具有抗肿瘤活性，抑制 wt 和 mutp53，激活异种移植人肿瘤组织中葡萄糖代谢的重编程，干扰血管生成和迁移。SLMP53-1 抑制肿瘤细胞生长，可用于研究人直肠癌。
TP2258	HNGF6A	Others	Others
	increases glucose stimulated insulin secretion and glucose metabolism
T26583	AJS1669 AJS-1669,AJS 1669
	AJS1669, an activator of muscle glycogen synthase, improves glucose metabolism and reduces body fat mass in mice.
T27751	KSK-120 KSK120,KSK 120
	KSK-120 is a potent Chlamydia trachomatis inhibitor, it targets the glucose-6-phosphate (G-6P) metabolism pathway of Chlamydia trachomatis.
T70373	AS2575959
	AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion.
T26661	AS1708727
	AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level.
T76309	Gastric Inhibitory Peptide, porcine
	Gastric Inhibitory Peptide, porcine 为葡萄糖依赖性胰岛素促进多肽，包含42个氨基酸构成的肠道激素，对脂肪及葡萄糖代谢产生影响。
T73732	D-Fructose 1-phosphate disodium
	D-Fructose 1-phosphate disodium salt 是果糖的衍生物。它是葡萄糖代谢的重要中间体。
T37891	GLP-1(32-36)amide
	GLP-1(32-36)amide is a pentapeptide compound derived from the C terminus of the glucoregulatory hormone GLP-1. This compound has shown potential in inhibiting weight gain and regulating glucose metabolism in diabetic mice[1][2].
T63580	Tubulin polymerization-IN-21
	Tubulin polymerization-IN-21 是微管蛋白聚合抑制剂，能够破坏细胞完整性和影响葡萄糖代谢，具有抗癌作用。
T72092	2-Deoxy-D-glucose 6-phosphate disodium
	2-Deoxy-D-glucose 6-phosphate disodium，一种2-Deoxy-D-glucose的衍生物，是通过己糖激酶在哺乳动物细胞中作用于2-DG而生成。该化合物是葡萄糖代谢的竞争性抑制剂，主要通过抑制己糖激酶从而阻碍糖酵解过程。
T37589L	GIP (3-42), human acetate GIP (3-42), human acetate(1802086-25-4 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (3-42), human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 受体的拮抗剂，可调节体内胰岛素分泌和 GIP 代谢。
T64228	ALDH1A1-IN-3
	ALDH1A1-IN-3 是一种良好的、选择性的醛脱氢酶 1A1 (ALDH1A1) 抑制剂 (IC50: μM)。ALDH1A1-IN-3 可以有效的改善 HepG2 细胞的葡萄糖消耗。ALDH1A1-IN-3 能够用于进行改善糖代谢的研究。
TP2018	GIP, human GIP (human),抑胃肽
	Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and dis
T9768	Ninerafaxstat	Others	Others
	Ninerafaxstat 可以将细胞代谢从脂肪酸氧化转变为葡萄糖氧化，降低脂肪酸氧化，改善线粒体呼吸。
T37827	CAY10506 CAY10506
	Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM.
T35416	α-D-Glucose-1-phosphate (sodium salt hydrate)
	α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen breakdownviaphosphorolytic cleavage of glycogen by glycogen phosphorylase.1It can be converted to glucose-6-phosphate by phosphoglucomutase. α-D-Glucose-1-phosphate is combined with CTP by α-D-glucose-1-phosphate cytidylyltransferase to form CDP-glucose in the first step of CDP-...
T60629	PF-06649298
	PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂，可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运，IC50值为 16.2 μM。
T75390	Aldose 1-epimerase
	Aldose 1-epimerase (mutarotases) 是关键碳水化合物代谢酶，主要催化己糖如葡萄糖及半乳糖的α-与β-端基异构体互转。对于碳水化合物代谢及复杂寡糖生成至关重要。
T75833	HNGF6A TFA
	HNGF6A TFA 是一种人类素类似物。HNGF6A TFA 可以增加葡萄糖刺激的胰岛素分泌和葡萄糖代谢，并可用于糖尿病的研究。HNGF6A TFA 在氧化应激期间抑制ROS 的产生。HNGF6A TFA 可以在体内预防内皮功能障碍和动脉粥样硬化。
T72460	Dimethyl L-glutamate Dimethyl glutamate
	Dimethyl L-glutamate (Dimethyl glutamate), 一种可透膜的谷氨酸类似物，可刺激葡萄糖诱导的胰岛素 (insulin) 释放。Dimethyl L-glutamate 抑制KATP 通道的活性。Dimethyl L-glutamate 抑制E. gracilis 生长并导致细胞异常分裂。Dimethyl L-glutamate 可用于糖尿病、葡萄糖转运、磷酸化和进一步代谢的研究。
T81935	L-Glutamic γ-monohydroxamate
	L-Glutamic γ-monohydroxamate是一种特异性抗肿瘤试剂，能够抑制癌细胞的增殖，并针对性地阻止微血管内皮细胞摄取L-组氨酸。作为钒配体，该化合物还能激活脂肪细胞对葡萄糖的摄取和代谢，进而有效降低血糖水平。
T62576	Darglitazone Sodium
	Darglitazone Sodium 是一种噻唑烷二酮，是一种选择性的、口服具有活力的 PPAR-γ (过氧化物酶体增殖物激活受体)激动剂。Darglitazone Sodium 可以有效控制血糖和脂质代谢，能够用于研究 II 型糖尿病。
T69622	Ritivixibat
	Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂，同时也是胆汁酸调节剂，主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。
T36973	5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)
	5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A
T63019	GKA50 quarterhydrate
	GKA50 quarterhydrate 是一种有效的葡萄糖激酶激活剂，其 EC50 值为 33 nM。GKA50 quarterhydrate 是一种啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，也是一种 Ca2+依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 能够刺激小鼠胰岛分泌胰岛素，可以显著降低高脂喂养的雌性大鼠血糖。
T76192	GLP-1(32-36)amide TFA
	GLP-1(32-36)amide TFA，一种衍生自糖调节激素 GLP-1的 C 末端的五肽。GLP-1(32-36)amide TFA 可抑制糖尿病小鼠的体重增加并调节全身葡萄糖代谢。
T37898	UDP-α-D-Glucose (sodium salt hydrate)
	UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2 1.Jacobson, K.A., Ivanov, A.A., de Castro, S., et al.Development of selective agonists and antagonists of P2Y receptorsPurin...
T60858	MOPIPP
	MOPIPP 是新型的吲哚基查尔酮，可以透过血脑屏障。MOPIPP 对胶质母瘤细胞的肿瘤进展有抑制作用。MOPIPP 诱导细胞空泡化并增加自噬体数量。MOPIPP 还会触发细胞巨泡式死亡，并且中断葡萄糖摄取和糖酵解代谢。
T75787	Amylin, amide, human TFA
	Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽，与胰岛素共同分泌，对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌，延缓胃排空速度，同时作为增加饱腹感的因子。
T76022	Chemerin-9 (149-157) (TFA)
	Chemerin-9 (149-157) TFA 作为趋化因子样受体1 (CMKLR1) 的有效激动剂，展现出抗炎活性，并能促进Akt与ERK磷酸化及活性氧生成，进而改善Aβ1-42诱发的记忆障碍。此外，该化合物还参与调节免疫反应、脂肪细胞分化以及糖代谢。
T37355	CAY10703
	Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip...
T35813	CAY10592
	Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ...
T35547	YW1128
	YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid ac...

化合物

Cat.No: T3713

Target: transporter

2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid

Cat.No: T40514

Target: Others

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

Cat.No: T24656

Synonym: A844337,PQ 10,A-844337,A 844337

Target: PDE

Imeglimin hydrochloride

Cat.No: T7486

Synonym: EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

Target: Reactive Oxygen Species, Mitochondrial Metabolism

D-Glucose-13C6

Cat.No: T19261

Synonym: D-(+)-Glucose-13C6,Glucose-13C6,Dextrose-13C6

Target: Endogenous Metabolite

Acetyl Coenzyme A trisodium

Cat.No: T37958

Synonym: Acetyl-CoA trisodium

Target: OXPHOS, Endogenous Metabolite, Autophagy

Cat.No: T22708

Synonym: CP-86325

Target: PPAR

Cat.No: T22317

Target: transporter

Ninerafaxstat trihydrochloride

Cat.No: T9768L

Synonym: Ninerafaxstat trihydrochloride(2254741-41-6 Free base)

Target: Others

Xanthinol Nicotinate

Cat.No: T22459

Synonym: Angioamin,烟酸占替诺,Complamin

Target: Others

GLP-1(32-36)amide acetate

Cat.No: T37891L

Synonym: GLP-1(32-36)amide 醋酸盐,GLP-1(32-36)amide acetate(1417302-71-6 Free base)

Target: Others

Cat.No: T14327

Target: Phosphatase

GIP (human) acetate

Cat.No: TP2018L

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: IGF-1R

Cat.No: T9558

Target: transporter

Trimetazidine dihydrochloride

Cat.No: T0988

Synonym: 盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F

Target: Autophagy, Fatty Acid Synthase

Cat.No: T60839

Target: p53

Cat.No: TP2258

Target: Others

Cat.No: T26583

Synonym: AJS-1669,AJS 1669

Cat.No: T27751

Synonym: KSK120,KSK 120

Cat.No: T70373

Cat.No: T26661

Gastric Inhibitory Peptide, porcine

Cat.No: T76309

D-Fructose 1-phosphate disodium

Cat.No: T73732

GLP-1(32-36)amide

Cat.No: T37891

Tubulin polymerization-IN-21

Cat.No: T63580

2-Deoxy-D-glucose 6-phosphate disodium

Cat.No: T72092

GIP (3-42), human acetate

Cat.No: T37589L

Synonym: GIP (3-42), human acetate(1802086-25-4 Free base)

Target: IGF-1R

Cat.No: T64228

Cat.No: TP2018

Synonym: GIP (human),抑胃肽

Cat.No: T9768

Target: Others

Cat.No: T37827

Synonym: CAY10506

α-D-Glucose-1-phosphate (sodium salt hydrate)

Cat.No: T35416

Cat.No: T60629

Aldose 1-epimerase

Cat.No: T75390

Cat.No: T75833

Dimethyl L-glutamate

Cat.No: T72460

Synonym: Dimethyl glutamate

L-Glutamic γ-monohydroxamate

Cat.No: T81935

Darglitazone Sodium

Cat.No: T62576

Cat.No: T69622

5-Phospho-D-ribose 1-diphosphate (sodium salt hydrate)

Cat.No: T36973

GKA50 quarterhydrate

Cat.No: T63019

GLP-1(32-36)amide TFA

Cat.No: T76192

UDP-α-D-Glucose (sodium salt hydrate)

Cat.No: T37898

Cat.No: T60858

Amylin, amide, human TFA

Cat.No: T75787

Chemerin-9 (149-157) (TFA)

Cat.No: T76022

Cat.No: T37355

Cat.No: T35813

Cat.No: T35547

Cat. No.	Product Name	Target	Signaling Pathways
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T0800	Danthron Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol	Virus Protease; Antibacterial; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物，可通过激活 AMPK 来调节葡萄糖和脂质代谢。
T14149	AICAR phosphate AICA Riboside phosphate,Acadesine phosphate	Mitophagy; NOS; YAP; AMPK	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂，也是一种腺苷类似物，可调节糖代谢和脂代谢，抑制促炎细胞因子和 iNOS 的产生。
T4743	Uridine 5′-diphosphoglucose disodium salt 二磷酸尿苷葡萄糖二钠盐,UDP-Glucose sodium salt,UDPG sodium salt,UDP-α-D-Glucose sodium salt,Uridine 5'-diphosphoglucose disodium sal	Endogenous Metabolite; P2Y Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) 是一种内源性核苷酸糖，参与代谢中的糖基转移酶反应。它是 P2Y14 受体的激动剂，EC50为 0.35 μM。
T0591	D-Galactose D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose	Endogenous Metabolite	Metabolism
	D-Galactose (Alpha-D-galactose) 是一种天然的己糖，是葡萄糖的C-4差向异构体。
T3403	Glabridin 光甘草定,Q-100692,KB-289522,LS-176045	Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Glabridin (KB-289522) 能够结合并激活PPARγ，EC50值为 6115 nM，是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。
TJO2758	D-Glucuronic acid D-葡萄糖醛酸,Aldehydo-D-Glucuronic Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) 是一种从许多树胶中分离出的重要中间体。它对皮肤具有抗炎作用。它及其衍生物葡萄糖醛酸内酯作为预防人类健康的肝脏解毒剂。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T34143	Pronuciferine (+)-Pronuciferine
	Pronuciferine ameliorate the glucose and lipid metabolism in insulin-resistant 3T3-L1 adipocytes.
T35415	α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
	α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol...
T81741	Multiflorin A
	Multiflorin A，源于Pruni semen的活性成分，具泻药效果，能够抑制肠道葡萄糖吸收并促进细菌代谢。
TN1208	2-Amino-3-carboxy-1,4-naphthoquinone	NADPH-oxidase	Immunology/Inflammation
	2-Amino-3-carboxy-1,4-naphthoquinone 是电子转移介质，可改变同型发酵乳酸菌的葡萄糖代谢，可作为双歧杆菌生长刺激剂，它通过NAD(P)H 介导的氧化作用影响双歧杆菌的终产物形态。

天然产物

Cat.No: T9352

Target: Others

Cat.No: T0800

Synonym: Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol

Target: Virus Protease, Antibacterial, AMPK, Autophagy

AICAR phosphate

Cat.No: T14149

Synonym: AICA Riboside phosphate,Acadesine phosphate

Target: Mitophagy, NOS, YAP, AMPK

Uridine 5′-diphosphoglucose disodium salt

Cat.No: T4743

Synonym: 二磷酸尿苷葡萄糖二钠盐,UDP-Glucose sodium salt,UDPG sodium salt,UDP-α-D-Glucose sodium salt,Uridine 5'-diphosphoglucose disodium sal

Target: Endogenous Metabolite, P2Y Receptor

Cat.No: T0591

Synonym: D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose

Target: Endogenous Metabolite

Cat.No: T3403

Synonym: 光甘草定,Q-100692,KB-289522,LS-176045

Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR

D-Glucuronic acid

Cat.No: TJO2758

Synonym: D-葡萄糖醛酸,Aldehydo-D-Glucuronic Acid

Target: Others, Endogenous Metabolite

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

Cat.No: T34143

Synonym: (+)-Pronuciferine

α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)

Cat.No: T35415

Cat.No: T81741

2-Amino-3-carboxy-1,4-naphthoquinone

Cat.No: TN1208

Target: NADPH-oxidase

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