102
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
T28750 |
Sembragiline
RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302 |
MAO | Metabolism; Neuroscience |
Sembragiline (EVT-302) 是一种具有选择性的 MAO-B 抑制剂,可用于研究阿尔茨海默病(AD)。 | |||
T28441 |
PPI-1019
PPI1019,Apan |
Beta Amyloid | Neuroscience |
PPI-1019 是一种 APP( β -淀粉状蛋白 A4 )抑制剂,可用于治疗神经系统疾病和研究阿尔茨海默病(AD)。 | |||
T21956 |
GSK3β inhibitor II
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
GSK3β inhibitor II 是 GSK3β 的抑制剂。GSK3β inhibitor II 可用于研究阿尔茨海默病 (AD)。 | |||
TP1140L |
Neuropeptide Y (29-64), amide, human acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。 | |||
T9379 |
L-Threonic acid magnesium salt
|
Others | Others |
L-Threonic acid magnesium salt 可增加老年大鼠和晚期阿尔茨海默病 (AD) 模型小鼠的突触密度和记忆能力。 | |||
T8583 |
Tenilsetam
替尼西坦,3-(2-thienyl)- (9CI),Piperazinone |
Others | Others |
Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂;一种促智剂和晚期糖基化终产物 (AGE) 抑制剂,具有治疗阿尔茨海默病 (AD) 的潜力。 | |||
T77054 |
Lecanemab
BAN-2401 |
Beta Amyloid | Neuroscience |
Lecanemab (BAN-2401) 是一种靶向可溶性聚集性 β 淀粉样蛋白 (Abeta)的 IgG1 单克隆抗体,对寡聚体、原纤维和不溶性原纤维具有活性,可用于研究阿尔茨海默病 (AD) 引起的轻度认知障碍和轻度 AD 痴呆。 | |||
T8448 |
ZSET1446
ZSET-1446,ST-101 |
Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
ZSET1446 (ST-101) 是一种 T 型钙通道激活剂,用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。 | |||
TP2194L |
Neuropeptide Y (scrambled) Acetate
Pro-Neuropeptide Y (scrambled) Acetate,NPY (scrambled) Acetate |
Others | Others |
Neuropeptide Y (scrambled) Acetate (Pro-Neuropeptide Y (scrambled) Acetate) 是一种 Neuropeptide Y 的杂序肽,Neuropeptide Y 参与阿尔茨海默病 (AD) ,可能具有神经保护作用。 | |||
T63540 |
Astrophloxine
|
Beta Amyloid | Neuroscience |
Astrophloxine 是一种荧光成像探针,靶向反平行二聚体。Astrophloxine 能够用于检测阿尔茨海默症 (AD) 小鼠脑组织和脑脊液样本中聚集的 Aβ。 | |||
T2507 |
Azeliragon
TTP488,阿齐瑞格 |
Beta Amyloid; advanced glycation end products | Neuroscience; Others |
Azeliragon (TTP488) 是一种生物可利用的、可穿过血脑屏障 (BBB)的晚期糖基化终产物 (RAGE) 受体抑制剂,可缓解轻度阿尔茨海默病 (AD) 的发展。 | |||
T77042 |
Aducanumab
BIIB037 |
Beta Amyloid | Neuroscience |
Aducanumab (BIIB037),一种选择性人免疫球蛋白γ-1(IgG1)单克隆抗体,靶向β淀粉样蛋白 (Aβ) 的聚集形式。Aducanumab 显示出脑渗透性,可用于治疗阿尔茨海默病 (AD) 。 | |||
T9062 |
CA77.1
|
Autophagy | Autophagy |
CA77.1 是一种新型伴侣介导的自噬激活剂,用于治疗阿尔茨海默病。它是 AR7 的衍生物,可以增加溶酶体受体在溶酶体中的表达。 | |||
T60150 |
(1S,2R)-Alicapistat
|
Cysteine Protease | Proteases/Proteasome |
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound effectively addresses the metabolic liability associated with carbonyl reduction, while demonstrating potent inhibition of calpain 1 with an IC50 value of 395 nM [2]. | |||
T60739L |
Y13g dihydrochloride
Y13g 2HCl(T60739 Free base) |
IL Receptor; AChE | Immunology/Inflammation; Neuroscience |
Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂(这两个靶点阿尔茨海默症 (AD) 进展的有关)。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。 | |||
T80622 |
Trontinemab
|
||
Trontinemab为一种双特异性人源IgG1-κ抗体,靶向Aβ前体蛋白(APP)与转铁蛋白受体p90, CD71 (TFRC)。该抗体主要应用于阿兹海默症研究。 | |||
T7003 |
Leucomethylene blue mesylate
N3,N3,N7,N7-四甲基-10H-吩噻嗪-3,7-二胺二甲磺酸盐,TRx0237 mesylate,TRx0237 (LMTX) mesylate,Methylene blue leuco base mesylate salt,Leucomethylene Blue Dimesylate |
Beta Amyloid; Microtubule Associated | Cytoskeletal Signaling; Neuroscience |
Leucomethylene blue mesylate (TRx0237 mesylate) 是一种 Methylene blue (亚甲基蓝)的还原形式, 亚甲基蓝是一种化学指示剂和生物染色剂。它是一种具有口服活性的二代 tau 蛋白聚集的抑制剂 (Ki=为0.12 μM),可用于阿尔兹海默症的研究。 | |||
T11175 |
Elenbecestat
E2609 |
Beta-Secretase; BACE | Neuroscience |
Elenbecestat (E2609) 是一种高效、有口服活性的,能透过 CNS 的 BACE-1抑制剂,它有用于阿尔茨海默病 (AD) 的研究潜力。 | |||
T4364 |
Aftin-4
Aftin 4,Aftin4 |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。 | |||
T22243 |
Anserine
L-鹅肌肽,L-Anserine |
Endogenous Metabolite | Metabolism |
Anserine (L-Anserine) 是 Carnosine 的甲基化形式,是口服具有活性的天然二肽,存在于脊椎动物的骨骼肌。它不会被血清肌肽酶裂解,能够作为生化缓冲液,螯合剂,抗糖化剂和抗氧化剂。它能够改善阿尔茨海默氏病模型小鼠的记忆功能。 | |||
T68950 | Hepta-histidine | ||
Hepta-histidine is a novel inhibitor of Tau aggregation against Tau-related neurodegenerative diseases including Alzheimer's disease (AD). | |||
T31090 |
CRANAD-102
CRANAD 102 |
||
CRANAD-102 is a probe for selectively detecting sAβ species in Alzheimer's disease (AD). | |||
T41102 |
BSc3094
|
||
BSc3094 is a potent Tau aggregation inhibitor that demonstrates the potential for Alzheimer's disease (AD) research. | |||
T14178 |
Alicapistat
ABT-957 |
Others | Others |
Alicapistat (ABT-957) is a human calpains 1 and 2 inhibitor. It can potentially be used to treat Alzheimer's disease (AD). | |||
T36446 |
Neuropeptide Y (human) (TFA)
|
||
Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons. | |||
T30266 |
AZD8926
AZD 8926,AZD-8926 |
||
AZD8926 is a potent and selective inhibitor of GSK3β(glycogen synthase kinase-3β). AZD8926 is potential for treating Alzheimer’s disease (AD), schizophrenia, and chronic as well as acute neurodegenerative diseases. | |||
T80878 |
Vanutide cridificar
PF 05236806,ACC-001 |
||
Vanutide cridificar (ACC-001)是一种氨基末端Aβ1-7肽的偶联物,用于阿尔茨海默病(AD)的研究。 | |||
TP1673 |
β-Amyloid (11-22)
β-Amyloid 11-22 |
||
β-Amyloid (11-22) is a peptide fragment of β-Amyloid.Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerat | |||
T76738 | Bapineuzumab | ||
Bapineuzumab,一种针对β-淀粉样蛋白(APP)的单克隆抗体,适用于阿尔茨海默病(AD)的研究。 | |||
T69872 |
TM-9
|
||
TM-9 is a novel multi-function inhibitor for the treatment of Alzheimer's disease (AD). TM-9 exhibits potent and balanced inhibitory activities against ChE and MAO-B. | |||
T68257 |
Hydromethylthionine HBr
|
||
Hydromethylthionine, also known as LMTM and Leucomethylene Blue, is a apotent tau aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Hydromethylthionine showed pharmacological activity on brain structure and function as both monotherapy and as an add-on to symptomatic treatment in certain patients with Alzheimer’s disease. | |||
T39678 | Multitarget AD inhibitor-1 | ||
Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, d... | |||
T79752 |
DDC 2′,3′-O-disulfate
|
||
DDC 2′,3′-O-disulfate (compound 4) 可防止Aβ42纤维化和寡聚化,显示出在阿尔茨海默病(AD)研究中的应用潜力。 | |||
T61408 | BChE-IN-2 | ||
BChE-IN-2 (compound 22) is a highly effective inhibitor of BChE, exhibiting a Ki value of 0.099 μM. This compound represents a promising pyrimidine and pyridine derivative for investigating Alzheimer's disease (AD). [1] | |||
T30876 |
CHF 2819
Ganstigmine HCl,CHF-2819,Ganstigmine hydrochloride,CHF2819 |
||
CHF 2819 is a novel orally active acetylcholinesterase inhibitor (AChE) developed for the treatment of Alzheimer's disease (AD). CHF 2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE). | |||
T73495 | q-FTAA | ||
q-FTAA 与 Aβ1-42 原纤维结合,对 Aβ1-42 原纤维和阿尔茨海默病 PIB 结合复合物 (ADPBC) 的 EC50值分别为 330-630,300-500 nM。q-FTAA 具有研究阿尔茨海默病 (AD) 的潜力。 | |||
T80118 |
α-Synuclein (61-95) (human)
|
||
α-Synuclein(61-95) (human) 是 α-Synuclein 的疏水核心区段,具有诱导神经元死亡的能力。该肽段在神经退行性疾病的研究中有应用,涉及阿尔茨海默病 (AD) 与帕金森病 (PD)。 | |||
T77028 | Gosuranemab | ||
Gosuranemab (BMS-986168) 是一种人源化 IgG4抗tau 单克隆抗体。Gosuranemab 与人 N 端 tau 残基 15-22 结合。Gosuranemab 具有用于阿尔茨海默病 (AD) 研究的潜力。 | |||
T79010 | Lp-PLA2-IN-12 | Phospholipase | Metabolism |
Lp-PLA2-IN-12(compound 19)为一种Lp-PLA2抑制剂,主要应用于神经退行性疾病(如AD、青光眼、AMD)及心血管疾病(诸如动脉粥样硬化)的研究。 | |||
T80700 |
β Amyloid(17-28) human
|
||
β Amyloid(17-28) human 为β-淀粉样肽(Abeta)的一段核心片段,其结构受脂质诱导。本化合物能够促进β Amyloid40全长肽段的聚集,导致阿尔茨海默病(AD)中具毒性的聚集体形成。 | |||
T79011 |
TrkB-IN-1
|
Trk receptor | Tyrosine Kinase/Adaptors |
TrkB-IN-1为一种有效的口服活性TrkB激动剂,展现出优良的药代动力学特性。该化合物能够逆转AD模型小鼠的认知功能缺陷,适用于阿尔茨海默病的研究。 | |||
T76926 | Bepranemab | ||
Bepranemab (UCB 0107)为人源化全长IgG4单克隆抗体,特异性结合中央tau表位(氨基酸235-250)。该化合物适用于阿尔茨海默病(AD)研究。 | |||
T35892 |
Q134R
Q134R |
||
Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer’s disease (AD) and aging-related disorders research[1]. Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo... | |||
TP1228 |
β-Amyloid (1-16)
Amyloid β-Protein (1-16),β-Amyloid 1-16 |
||
β-Amyloid (1-16) is an amyloidogenic protein fragment with a sequence derived from β-amyloid. It exhibits the ability to bind to metal ions, indicating its involvement in metal-binding processes. β-Amyloid, a peptide, is responsible for the formation of amyloid plaques in the brains of individuals affected by Alzheimer's disease (AD). | |||
TP1338 |
Neuropeptide Y (29-64), amide, human TFA
|
||
Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t | |||
T76372 |
TRAF6 peptide
|
||
TRAF6 peptide 是一种特异性的TRAF6-p62相互作用抑制剂。TRAF6 peptide 能消除 NGF 依赖性TrkA 泛素化。TRAF6 peptide 在诸如阿尔茨海默症 (AD)、帕金森、ALS、头部外伤、癫痫和中风等神经系统性疾病中具有较好的研究潜力。 | |||
T61785 |
BChE-IN-6
|
||
BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serves as a valuable tool for researchers in the field of Alzheimer's disease (AD) [1]. | |||
T62728 | AChE-IN-24 | ||
AChE-IN-24 是一种有效的、能透过血脑屏障的 AChE 抑制剂。AChE-IN-24 可以较强的抑制 hAChE (IC50: 0.053 μM)。AChE-IN-24 能够用于研究阿尔茨海默病 (AD)。 | |||
T61342 | BChE-IN-13 | ||
BChE-IN-13 (Compound 17c) is an orally active, potent, and selective inhibitor of Butyrylcholinesterase (BChE). It exhibits IC50 values of 0.22 μM and 0.016 μM for eqBChE and hBChE, respectively. BChE-IN-13 demonstrates the capability to enhance memory and cognitive impairments, making it valuable for Alzheimer's disease (AD) research [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0086 |
Galanthamine hydrobromide
Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏 |
AChR; AChE | Neuroscience |
Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂,IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂,IC50值为 0.35 µM,可用于阿尔茨海默症的研究。 | |||
TN1341 |
8-Deoxygartanin
8-脱氧藤黄苷 |
Beta Amyloid; NF-κB; Parasite | Microbiology/Virology; Neuroscience; NF-κB |
8-Deoxygartanin 是山竹果中的异戊烯化呫吨酮。它是丁基胆碱酯酶选择性抑制剂,对阿尔茨海默病 (AD) 具有多功能活性,可能是有希望治疗 AD 的化合物。 | |||
T4955 |
saponaretin
Isovitexin,Apigenin-6-C-glucoside,异牧荆素 |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
saponaretin 是许多中药的活性成分,具有多种活性,如抗氧化、抗炎、抗阿尔茨海默病(AD)作用等。 | |||
TN1472 |
Cassiaside
|
Beta-Secretase; BACE | Neuroscience |
Cassiaside 是一种萘甲酮糖苷,抑制 BACE1 (IC50= 4.45 μM; Ki=9.85 μM)。Cassiaside 对半乳糖胺损伤具有明显的肝脏保护作用, 具有潜在的抗阿尔茨海默病 (AD) 活性。 | |||
TN1725 |
Hederacolchiside E
革叶常春藤皂苷E |
Beta Amyloid; ROS | Immunology/Inflammation; Neuroscience |
Hederacolchiside E 具有抗氧化活性,并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。 | |||
T3392 |
Sinapine thiocyanate
|
P-gp; AChE | Membrane transporter/Ion channel; Neuroscience |
Sinapine thiocyanate 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
T3026 |
(-)-Huperzine A
HupA,石杉碱,Huperzine A,石杉碱甲 |
Apoptosis; AChR; AChE; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱,具有神经保护活性。它是高特异性可逆的,具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂, 其IC50值为 82 nM。 它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂,可研究神经退行性疾病,如阿尔茨海默病。 | |||
T4881 |
Phosphorylethanolamine
O-Phosphorylethanolamine,乙醇胺磷酸酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体,也是磷脂分解的产物。与其他器官相比,大脑中磷酸单酯的含量要高得多。在大脑发育过程中,磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯,在阿尔茨海默病患者的大脑中减少。 | |||
TN1450 |
Brassicasterol
菜籽甾醇,油菜 |
Others | Others |
Brassicasterol may be a relevant additional biomarker in Alzheimer's disease (AD). | |||
TN3218 |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
|
Beta Amyloid; PI3K; mTOR | Neuroscience; PI3K/Akt/mTOR signaling |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD). | |||
T75511 | BChE-IN-10 | ||
BChE-IN-10 (compound 6),一种从白芨 (Bletilla striata) 分离提取的丁酰胆碱酯酶 (BChE) 混合型抑制剂,具有 6.4 μM 的IC50,适用于阿尔兹海默症 (AD) 研究。 | |||
T75512 | Bleformin A | ||
Bleformin A 是一种有效的BChE 抑制剂,其IC50值为 5.2 μM。Bleformin A 是可以从Bletilla striata 中分离得到的天然产物。Bleformin A 可用于研究阿尔茨海默病 (AD)。 | |||
T75514 | Blestrin D | ||
Blestrin D,作为一种丁酰胆碱酯酶(BChE)的有效混合型抑制剂,具有8.1 μM的IC50值,可从白芨(Bletilla striata)中分离提取,适用于阿尔兹海默症(AD)研究。 | |||
T73202 |
BChE-IN-11
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BChE-IN-11 是一种有效的、选择性的、非竞争性BChE(丁基胆碱酯酶)抑制剂,其IC50为 2.1 μM。BChE-IN-11 可用于阿尔茨海默病 (AD) 的研究。 | |||
T75513 | BChE-IN-12 | ||
BChE-IN-12 (compound 12) 为一种高效BChE非竞争性抑制剂,其IC50值为2.3 μM。该化合物可从白芨(Bletilla striata)中分离提取,适用于阿尔兹海默症(AD)的研究。 | |||
T75628 | Methyl ganoderate A acetonide | ||
Methyl ganoderate A acetonide,羊毛甾烷三萜类化合物,是一种可从灵芝子实体中分离得到天然产物。Methyl ganoderate A acetonide 是一种有效的 AChE 抑制剂,IC50值为 18.35 μM。Methyl ganoderate A acetonide 可用于阿尔茨海默病 (AD) 的研究。 | |||
T75544 | AChE/BChE-IN-11 | ||
AChE/BChE-IN-11 (compound 1) 是一种有效的 AChE 和 BChE 双重抑制剂,AChE 和BChE 的IC50值为分别为 70 和 71 μM。AChE/BChE-IN-11 是一种天然产物,可以从朝鲜蓟叶中分离得到。AChE/BChE-IN-11 可用于阿尔茨海默病 (AD) 研究。 |