Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZSET1446 (ST-101) 是一种 T 型钙通道激活剂,用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 745 | 现货 | ||
2 mg | ¥ 1,080 | 现货 | ||
5 mg | ¥ 1,850 | 现货 | ||
10 mg | ¥ 2,590 | 现货 | ||
25 mg | ¥ 4,360 | 现货 | ||
50 mg | ¥ 6,190 | 现货 | ||
100 mg | ¥ 8,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,130 | 现货 |
产品描述 | ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models. |
体内活性 | ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1]. |
动物实验 | ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1]. |
别名 | ZSET-1446, ST-101 |
分子量 | 236.27 |
分子式 | C15H12N2O |
CAS No. | 887603-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29 mg/ml(122.74 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.2324 mL | 21.1622 mL | 42.3245 mL | 105.8111 mL |
5 mM | 0.8465 mL | 4.2324 mL | 8.4649 mL | 21.1622 mL | |
10 mM | 0.4232 mL | 2.1162 mL | 4.2324 mL | 10.5811 mL | |
20 mM | 0.2116 mL | 1.0581 mL | 2.1162 mL | 5.2906 mL | |
50 mM | 0.0846 mL | 0.4232 mL | 0.8465 mL | 2.1162 mL | |
100 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0581 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ZSET1446 887603-94-3 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel AChR ST101 Inhibitor ZSET-1446 ST-101 Nicotinic acetylcholine receptors Ca2+ channels inhibit nAChR ST 101 Ca channels ZSET 1446 inhibitor