101
43
Cat. No. | Product Name | Target | Signaling Pathways |
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T37958 |
Acetyl Coenzyme A trisodium
Acetyl-CoA trisodium |
OXPHOS; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism |
Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) 是糖代谢和脂代谢的重要化合物,参与三羧酸循环。 | |||
T30997 |
Coenzyme Q12
Ubiquinone Q-12,Ubiquinone 12,trans-Coenzyme Q12,Coenzyme Q-12,J93.222A |
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Coenzyme Q10 is a vitamin-like substance found throughout the body, especially in the heart, liver, kidneys, and pancreas. | |||
T32768 |
Linoleoyl-coenzyme A
Coenzyme A,linoleoyl- |
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Linoleoyl-coenzyme A is a substrate used to investigate the specificity and kinetics of acyl-CoA. | |||
T32598 |
Lauroyl-coenzyme A
Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa |
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Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport. | |||
T37978 |
Coenzyme FO
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Coenzyme FO, a deazaflavin chromophore, plays a crucial role as a hydride acceptor/donor in the central methanogenic pathway [1][2]. | |||
T38025 |
Cyclohexanoyl Coenzyme A
|
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Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver. | |||
T36114 |
Coenzyme Q2
|
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Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For... | |||
T35691 | Myristoyl Coenzyme A (hydrate) | ||
Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol . | |||
T37405 | Octanoyl Coenzyme A (sodium salt) | ||
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase. | |||
T38473 |
Malonyl Coenzyme A lithium
|
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Malonyl Coenzyme A (lithium) is a coenzyme A derivative that is utilized in fatty acid and polyketide synthesis and in the transport of α-ketoglutarate across the mitochondrial membrane. Malonyl Coenzyme A (lithium) is formed by the Acetyl CoA Carboxylase-mediated carboxylation of acetyl CoA. Malonyl Coenzyme A (lithium) is exclusively used as the extender unit in the synthesis of bacterial aromatic polyketides. | |||
T37323 |
Succinyl-Coenzyme A sodium salt
Succinyl-CoA sodium salt,Succinyl-Coenzyme A (sodium salt),Succinyl-CoA |
Endogenous Metabolite | Metabolism |
Succinyl-Coenzyme A sodium salt(Succinyl-CoA sodium salt) 参与柠檬酸循环,在柠檬酸循环中转化为琥珀酸。Succinyl-Coenzyme A (sodium salt) 在生物体内参与多种代谢反应,在体内有着举足轻重的作用 Succinyl-Coenzyme A sodium salt 参与血红素的合成,可用于研究由营养性维生素 B12 缺乏症 (致使 Succinyl-Coenzyme A 合成缺乏) 所引起的代谢疾病、神经疾病和血液学异常导致的疾病。 | |||
T36842 |
Isobutyryl Coenzyme A (sodium salt)
|
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Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency. | |||
T37116 |
Ethylmalonyl Coenzyme A (sodium salt)
|
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Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J... | |||
T37249 |
Methylmalonyl-Coenzyme A (sodium salt)
|
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Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C... | |||
T78511 |
Oleoyl coenzyme A lithium
Oleoyl-CoA lithium |
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Oleoyl-CoA lithium是一种由油酸与辅酶A形成的硫酯,它是大肠杆菌和小鼠代谢产物。 | |||
T127402 |
Coenzyme Q0
CoQ0 |
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Coenzyme Q0 (CoQ0),一种从Antrodia cinnamomea提取的口服醌类化合物,具备促进细胞凋亡(apoptosis)与自噬(autophagy)的作用。该化合物通过抑制HER-2/AKT/mTOR信号通路,增强凋亡和自噬机制;同时,调控NFκB/AP-1活化,提升Nrf2稳定性,从而缓解炎症及氧化还原失衡。此外,Coenzyme Q0还表现出抗血管生成特性,通过下降MMP-9/NF-κB并提升HO-1信号路径发挥作用。 | |||
T37755 |
Phenylacetyl-Coenzyme A (sodium salt)
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Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudo... | |||
T36827 |
Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA |
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Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5] | |||
T73918 |
Lauroyl coenzyme A lithium
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Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体,即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A,用作脂质代谢的中间体,参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。 | |||
T82293 |
Glutaryl coenzyme A lithium
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Glutaryl coenzyme A lithium为Glutaryl coenzyme A的衍生物,后者为一重要内源性代谢物。该化合物常应用于HMG-CoA及Glutaryl coenzyme A相关实验。 | |||
T73796 |
Acetyl coenzyme A lithium
|
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Acetyl-coenzyme A (Acetyl-CoA) lithium 是一种膜非渗透性的中枢代谢中间体,参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A lithium 通过向目标氨基酸残基提供乙酰基团,来完成蛋白质的翻译后乙酰化反应,从而调节各种细胞机制。Acetyl Coenzyme A lithium 也是脂质合成的关键前体。 | |||
T73805 | Acetyl coenzyme A | ||
Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体,参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供乙酰基团,来完成蛋白质的翻译后乙酰化反应,从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。 | |||
T74115 | Decanoyl coenzyme A | ||
Decanoyl coenzyme A (Decanoyl CoA) 是 Mycobacterium smegmat 中脂肪酸延伸系统的引物。 | |||
T74043 |
Hexanoyl coenzyme A trilithium
|
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Hexanoyl coenzyme A trilithium 是一种以己酰为酰基的中链脂肪酰辅酶 A,存在于所有生物体中。Hexanoyl coenzyme A trilithium 可以作为大麻素生物合成前体。可以作为一种竞争性抑制剂,作用于中链酰基辅酶A 脱氢酶 (MCAD)。 | |||
T76124 | Acyl coenzyme A synthetase | ||
Acyl coenzyme A synthetase (ACS),一种生化研究中常用的酶,主要通过两步硫酯化反应激活脂肪酸与辅酶A结合,形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径,以及参与TCA循环中的有氧呼吸提供了关键中间物。 | |||
T64276 | Octanoyl coenzyme A lithium | ||
Octanoyl coenzyme A lithium 是一种脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 能够抑制柠檬酸合成酶和谷氨酸脱氢酶 (IC50: 0.4-1.6 mM)。 | |||
T74172 | Acetoacetyl coenzyme A sodium | ||
Acetoacetyl coenzyme A sodium 是重要内源性代谢物,在pH 7.5时其Km值达1.10 mM,主要用于磷酸转丁基酶 (PTB) 与poly-3-hydroxybutyrate (PHB) 的合成。 | |||
T74038 | Palmitoyl coenzyme A lithium | ||
Palmitoyl coenzyme A lithium,一种酰基-CoA 硫酯,通过肉碱穿梭系统转运至线粒体基质,参与β-氧化,亦作为鞘氨醇生物合成底物。 | |||
T74039 |
Arachidonoyl coenzyme A lithium
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Arachidonoyl coenzyme A lithium是一种由辅酶A的硫醇基与花生四烯酸的羧基缩合生成的不饱和脂肪酰基辅酶A。 | |||
T74036 |
β-Methylcrotonyl coenzyme A lithium
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β-Methylcrotonyl coenzyme A lithium,作为亮氨酸代谢的中间体,可用于研究β-甲基巴豆酰辅酶 A 羧化酶(MCCase)的特异性及动力学,用作底物。 | |||
T3510 |
Olumacostat Glasaretil
|
Acetyl-CoA Carboxylase | Metabolism |
Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。 | |||
T74037 | DL-β-Hydroxybutyryl coenzyme A lithium | ||
DL-β-Hydroxybutyryl coenzyme A lithium,是丁酸发酵以及赖氨酸和色氨酸代谢过程中的中间体,通过β-羟基丁酸经短链-CoA 合成酶作用生成。 | |||
T5046 |
Haloxyfop
Haloxyfop Acid,(±)-Haloxyfop,吡氟氯禾灵 |
Others; Acetyl-CoA Carboxylase | Metabolism; Others |
Haloxyfop (Haloxyfop Acid) 是有效的芳氯氧苯氧丙酸除草剂,广泛应用于阔叶作物的野草。对玉米幼苗叶绿体中乙酰辅酶 A 羧化酶 (EC 6.4.1.2) 具有抑制作用,IC50为 0.5 μM,而对豌豆中该酶无影响。 | |||
TQ0243 |
ND-646
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Acetyl-CoA Carboxylase | Metabolism |
ND-646 是乙酰辅酶 A 羧化酶(ACC)抑制剂,对重组 hACC1 和 hACC2的IC50分别为 3.5 nM 和 4.1 nM。 | |||
T7163 |
PF-05175157
|
Acetyl-CoA Carboxylase | Metabolism |
PF 05175157 是一种广谱的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 具有抑制作用,IC50分别为 27.0, 33.0, 23.5 和 50.4 nM。 | |||
T14991 |
CMS-121
CMS121 |
Acetyl-CoA Carboxylase | Metabolism |
CMS-121 是喹诺酮衍生物,对乙酰辅酶 A 羧化酶 1 具有抑制作用,具有口服活性。CMS-121具有保护 HT22 细胞免受缺血和氧化损伤的活性,EC50分别为7 nM 和200 nM。CMS-121具有强大的抗炎,抗氧化,神经保护和肾保护作用。 | |||
T3988 |
TOFA
MDL14514,RMI14514 |
Acetyl-CoA Carboxylase | Metabolism |
TOFA (MDL14514) 是有效的乙酰辅酶 A 羧化酶-α (ACCA)的变构抑制剂。 | |||
T1889 |
CP-640186
CP 640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂,抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。 | |||
T0412 |
Idebenone
艾地苯醌,CV-2619 |
Apoptosis; Antioxidant; Mitochondrial Metabolism | Apoptosis; Metabolism; oxidation-reduction |
Idebenone (CV-2619) 是一种线粒体保护剂,具有神经保护功效,可用于研究阿尔茨海默病、亨廷顿舞蹈病,可透过血脑屏障,诱导细胞凋亡。 | |||
T7184 |
Firsocostat
ND-630,NDI-010976,GS-0976 |
Acetyl-CoA Carboxylase | Metabolism |
Firsocostat (GS-0976) 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂,抑制人类 ACC1 和 ACC2 的IC50分别为2.1和6.1 nM。 | |||
T3622 |
CP-640186 hydrochloride
CP 640186 HCl,盐酸CP-640186 |
Acetyl-CoA Carboxylase | Metabolism |
CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶(ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。 | |||
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T35659 |
3'-Dephosphocoenzyme A
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3'-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A from pantothenic acid .1 It is phosphorylated by CoA synthase in humans to form CoA. 3'-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription.2,3 References1. Leonardi, R., Zhang, Y.M., Rock, C.O., et al. Coenzyme A: Back in action. Prog. Lipid Res. 44(2-3), 125-153 (2005).2. Huang, F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcripti... | |||
T25651 |
Lecimibide
DuP128,DuP-128,DuP 128 |
Acyltransferase | Metabolism |
Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂,可用于研究由于高脂带来的疾病。 | |||
T30961 |
CL 277082
CL277082,CL-277082,Ddpmhu |
Others | Others |
CL 277082 (Ddpmhu) 是一种酰基辅酶A:胆固醇O-酰基转移酶抑制剂,抑制肉芽肿组织 ACAT 活性。 | |||
T8754 |
CPD2028
|
Others | Others |
CPD2028 是ND630的中间体。ND-630 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂。 | |||
T8314 |
RP-64477
RP64477 |
Acyltransferase | Metabolism |
RP-64477 是有效的胆固醇酯化酶酰基辅酶 A:胆固醇 O-酰基转移酶 (ACAT) 抑制剂。 | |||
T28009 |
ME-3221
ME3221 |
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Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-meth | |||
T6450 |
Clinofibrate
克利贝特,S-8527,Lipoclin |
HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Clinofibrate (Lipoclin) 是一种降脂剂,可抑制羟甲基戊二酰辅酶 A 还原酶。它用于控制血液中的高胆固醇和甘油三酯水平。 | |||
T25276 |
Crilvastatin
PMD387,PMD 387,PMD-387 |
HMG-CoA Reductase | Metabolism |
Crilvastatin (PMD 387) 是一种新型非竞争性羟甲基戊二酰辅酶 A 还原酶抑制剂,具有降胆固醇活性,可抑制遗传性高胆固醇血症大鼠的胆固醇吸收。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2796 |
Coenzyme Q10
Ubiquinone-10,辅酶Q10,CoQ10 |
Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
T10857 |
Coenzyme A
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Endogenous Metabolite | Metabolism |
Coenzyme A 是所有活细胞中必需的辅助因子,由泛酸,三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制,通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢,合成代谢途径和基因表达调控的关键参与者。 | |||
T5573 |
Coenzyme Q9
辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。 | |||
T14128 |
Adenosylcobalamin
Cobamamide,Coenzyme B12,腺苷钴胺,AdoCbl |
Endogenous Metabolite | Metabolism |
Adenosylcobalamin (AdoCbl) 是一种 Vitamin B12的特性形式,其中 Vitamin B12 是是甲基丙二酰 CoA 突变酶的辅助因子。 | |||
T75699 | Coenzyme Q6 | ||
Coenzyme Q6 (Ubiquinone 30),一种异戊二烯化的苯醌脂质,主要在呼吸电子传输链中发挥作用,并作为脂质抗氧化剂,具备抗氧化性能,能够防止自由基生成和氧化损伤。 | |||
T5283 |
NADH disodium salt
Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠 |
Others; Endogenous Metabolite | Metabolism; Others |
NADH disodium salt (Disodium NADH) hydrate 是氧化还原酶的辅酶。NADH disodium salt hydrate 在分解代谢过程中起到再生电子供体的作用,包括糖酵解,柠檬酸循环和β-氧化。 | |||
T8083 |
Pyridoxal 5'-phosphate monohydrate
Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛 |
Others | Others |
Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式,也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体,能够与其他变异体(如 PNP 、 PMP)发生互换。 | |||
T4817 |
Methylmalonic acid
NSC 25201,MMA,Isosuccinic acid,甲基丙二酸,Methylpropanedioic acid,Methylmalonate |
Others; Endogenous Metabolite | Metabolism; Others |
Methylmalonic acid (Isosuccinic acid) 是癌症患者缺乏维生素 B-12的指标。 | |||
T4761 |
Pyridoxal hydrochloride
|
Others; Endogenous Metabolite | Metabolism; Others |
Pyridoxal hydrochloride 是内源性代谢产物的一种。 | |||
T17048 |
Tetradecanoylcarnitine
L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine |
Endogenous Metabolite | Metabolism |
Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱,参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。 | |||
T0973L |
Pyridoxine hydrochloride
Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6 |
Nrf2; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中,通过 Nrf-2/HO-1 途径发挥抗氧化作用。 | |||
T5067 |
Flavin adenine dinucleotide disodium salt
Flavin Adenine Dinucleotide Disodium,黄素腺嘌呤二核苷酸二钠,FAD sodium salt,FAD-Na2 |
Others; Endogenous Metabolite | Metabolism; Others |
Flavin adenine dinucleotide disodium salt (FAD sodium salt) 是一种辅酶,作用是促进细胞氧化还原反应中黄素酶的电子转移。 | |||
T2812 |
ATP disodium salt hydrate
ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐 |
Others; Endogenous Metabolite | Metabolism; Others |
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。 | |||
T4766 |
3-Methylglutaric acid
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Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
T4874 |
Thiamine pyrophosphate
Cocarboxylase,焦磷酸硫胺素,Aneurinepyrophosphoric acid,Thiamine pyrophosphate chloride |
Endogenous Metabolite | Metabolism |
Thiamine pyrophosphate (Cocarboxylase) 是维生素 B1 的辅酶形式,是丙酮酸脱氢酶复合物和酮戊二酸脱氢酶复合物的必需中间体,能够用于研究评估生物系统中的脱羧机制。 | |||
T1609 |
NAD+
烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD |
NADPH; Endogenous Metabolite | Metabolism |
NAD+ (β-Nicotinamide Adenine Dinucleotide) 即烟酰胺腺嘌呤二核苷酸,是转递氢离子的辅酶。 | |||
T0894 |
Thiamine hydrochloride
盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride |
Apoptosis; HBV; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology |
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T64980 |
ATP disodium trihydrate
Adenosine-5'-triphosphate disodium trihydrate |
Endogenous Metabolite | Metabolism |
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。 | |||
T0200 |
α-Lipoic Acid
Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸 |
Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子,是一种抗氧化剂,可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。 | |||
T0069 |
Uracil
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Others; Endogenous Metabolite | Metabolism; Others |
Uracil 是普遍存在的天然嘧啶衍生物,是 RNA 核酸中的四个碱基之一。 | |||
T1664 |
Meglutol
Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托 |
Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Autophagy; Metabolism |
Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂,可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T6480 |
D-Pantothenic acid
vitamin B5,pantothenate,D-泛酸 |
Others | Others |
D-Pantothenic acid (vitamin B5) 是必需的微量营养素,是辅酶 A 的前体,在很多生物过程中发挥关键作用,如调节碳水化合物,脂质,蛋白和核酸代谢。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T4867 |
Erucic acid
Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid |
PI3K; Endogenous Metabolite | Metabolism; PI3K/Akt/mTOR signaling |
Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸,分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障,使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。 | |||
T1437 |
D-Panthenol
D-泛醇,D-Pantothenyl alcohol,Ilopan,Dexpanthenol,Pantothenol |
Endogenous Metabolite | Metabolism |
D-Panthenol (D-Pantothenyl alcohol) 是 D-pantothenic acid 和胆碱能剂的酒精类似物。D-Panthenol 作为乙酰化反应所必需的辅酶A的前体,参与乙酰胆碱的合成。虽然 D-Panthenol 作用的确切机制尚不清楚,但它可能增强乙酰胆碱的作用。D-Panthenol 作用于胃肠道,增加下肠蠕动。它也适用于局部皮肤,以缓解瘙痒和促进愈合。 | |||
T5287 |
N-Acetyl-L-aspartic acid
AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-aspartic acid (AC-ASP-OH) 是天冬氨酸的衍生物, 是由氨基酸天冬氨酸和乙酰辅酶 A 在神经元中合成的。 | |||
T2O2721 |
L-Cysteine
Thioserine,L-半胱氨酸,cysteine,半胱氨酸,L-(+)-Cysteine |
Endogenous Metabolite | Metabolism |
L-Cysteine (L-(+)-Cysteine) 是人体非必需的含硫氨基酸。L-Cysteine 对蛋白质合成、解毒和多种代谢功能很重要。L-Cysteine 存在于指甲、皮肤和头发的主要蛋白质-角蛋白中,对胶原蛋白的生成、皮肤弹性和质地都很重要。L-Cysteine 是抗氧化剂谷胱甘肽的一种成分,在辅酶A、肝素和生物素等基本生化物质的代谢中起着重要作用,也是氨基酸牛磺酸的制造所必需的。 | |||
T12592 |
Pyripyropene A
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Others | Others |
Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 µM). | |||
T19594 |
Ubiquinone-1
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Others | Others |
Ubiquinone-1 is an intermediate for coenzyme Q synthesis. | |||
TN1751 | Hydroxycitric acid | ERK; p38 MAPK; Fatty Acid Synthase | MAPK; Metabolism |
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis. | |||
T75552 | Pomonic acid | ||
Pomonic酸,作为一种三萜化合物,能显著抑制胆固醇酯的积累,并降低酰基辅酶A:胆固醇酰基转移酶(ACAT)的活性。 | |||
T36776 |
Terpendole C
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Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. | |||
TN4860 |
Pueroside B
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COX; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2 | |||
T40526 |
ATP dipotassium
腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium |
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ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation. | |||
T36931 |
Penicillide
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Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. | |||
T36226 |
Beauveriolide I
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Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T83582 |
(±)-Pantothenic acid
(±)-Vitamin B5,(±)-Pantothenate |
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(±)-Pantothenic acid ((±)-Pantothenate) 作为 B 组维生素的一员,对于哺乳动物细胞中辅酶 A (CoA) 的生物合成是不可或缺的。此外,该化合物能防护丙戊酸 (VPA) 在 CD-1 小鼠中引起的神经管缺陷 (NTD)。 | |||
T38250 | L-Sepiapterin | ||
L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrates its efficacy by improving endothelial dysfunction in small mesenteric arteries from db/db mice and promoting angiogenesis. Moreover, L-Sepiapterin exerts inhibitory effects on cellular proliferation and migration in ovarian cancer cells through the down-regulation of p70S6K-de... | |||
T37690 |
Phenylpyropene A
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Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36227 | Beauveriolide III | ||
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... | |||
T5066 |
Nε,Nε,Nε-Trimethyllysine chloride
Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。 | |||
T36329 |
Terpendole I
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Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... |