Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 29,300 | 10-14周 | ||
50 mg | ¥ 39,300 | 10-14周 | ||
100 mg | ¥ 51,500 | 10-14周 |
产品描述 | Pyripyropene A is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)(IC50 of 0.07 μM). |
靶点活性 | ACAT2:0.07 µM |
体外活性 | Pyripyropene A inhibits VEGF (20 ng/ml)-induced migration and tubular formation of HUVECs in dose-dependent fashion. Pyripyropene A do not show growth inhibitory effects against KB3-1, K562 and Neuro2A cells.Pyripyropene A exhibits anti-proliferative activity against HUVECs(IC50 value of 1.8 μM)[1]. |
体内活性 | Pyripyropene A-treated mice display reduction of atherogenic lesion areas in the aortae and heart. Pyripyropene A inhibits the hepatic e acyl–coenzyme A:cholesterol acyltransferase 2 (ACAT2) activity in vivo[3]. Pyripyropene A displays a half-life (t1/2) of 0.693/λ, where λ represented the terminal slope of the log-linear portion of concentration time profile[4]. |
分子量 | 583.63 |
分子式 | C31H37NO10 |
CAS No. | 147444-03-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pyripyropene A 147444-03-9 Others Inhibitor inhibitor inhibit